Innovations in Biotechnology and Medical Sciences

Indian scientists discover how serotonin helps brain cells cope with stress

Note4Students

From UPSC perspective, the following things are important :

Prelims level : Serotonin

Mains level : Serotonin and its uses

  • Indian scientists have discovered that serotonin boosts energy production in brain cells and helps them survive under stress. This new knowledge can potentially be used to develop anti-stress drugs in future.

Role of Serotonin

  • Serotonin is a chemical that relays information from one part of the brain to another and is known to play a key role in a number of functions ranging from sleep to social behaviour.
  • The study by scientists at the Mumbai-based Tata Institute of Fundamental Research (TIFR) has found that the neurotransmitter boosts the number of mitochondria in brain cells.
  • Mitochondria in brain cells generate energy to carry out cellular functions and play a role in survival of brain cells under stress.
  • In addition, serotonin also increases production of energy by mitochondria.
  • This role of serotonin in regulating neuronal energetics was not known till now.

Benefits of Serotonin

  • Serotonin reduces toxic reactive oxygen species in neurons, boosts anti-oxidant enzymes and buffers neurons from the damaging effects of cellular stress.
  • The study has uncovered an unprecedented role of serotonin in energy production in neurons, directly impacting how neurons handle stress.
  • It has also identified novel therapeutic targets for the treatment of neurodegenerative and psychiatric disorders.

Energy boosting function

  • Researchers have also found out the mechanism through which serotonin carries out its energy boosting function.
  • It has emerged that generation of new mitochondria in neurons by serotonin is accompanied by increased cellular respiration and energy chemical ATP.
  • These effects of serotonin involve the serotonin2A receptor and master regulators of mitochondrial generation – SIRT1 and PGC-1a.
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