[pib] CSIR’s new patented Clot buster, PEGylated Streptokinase set to revolutionize the treatment of Strokes

Note4students

Mains Paper 3: Science & Technology | Awareness in the fields of IT, Space, Computers, robotics, nano-technology, bio-technology.

From UPSC perspective, the following things are important:

Prelims level: PEGylated Streptokinase

Mains level: Read the attached story.


News

What is Clot Buster?

A clot buster is used to break-up the clot that causes a blockage or disruption in the flow of blood to the brain and helps restore the blood flow to the area of the brain.

PEGylated Streptokinase

  1. It is a new clot buster developed by at CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh.
  2. It is all set to revolutionize the treatment of ischemic strokes.
  3. Ischemic stroke is a condition caused by a dysfunction in the supply of blood to the brain due to emboli, thrombus or atherosclerosis occurring in cerebral arteries.
  4. PEGylated Streptokinase, the novel recombinant protein Thrombolytic molecule has been precisely engineered through decades of research for enhanced proteolytic stability.
  5. Its advantages are reduced probability of hemorrhage over current treatment regimens of thrombolytic drugs for acute stroke.

Developed under PPP

  1. CSIR-IMTECH and Epygen Biotech Pvt. Ltd., Mumbai, have entered into an agreement for the latter to develop PEGylated Streptokinase for treatment of Ischemic Stroke.
  2. Epygen is the first company in India with exclusive license of this Novel Biological Entity (NBE) thrombolytic protein for ischemic stroke.

Brain Stroke- the second biggest killer

  1. According to the American Stroke Association (ASA), brain strokes are the second leading cause of death in the world with a staggering 15 million people effected.
  2. It is causing 11 million people either die or become permanently disabled.
  3. Surprisingly, the prevalence of stroke is much higher in India than the West and about 87% of all strokes are ischemic strokes.

Back2Basics

Council of Scientific and Industrial Research

  1. The Council of Scientific and Industrial Research was established by the Government of India in 1942 is an autonomous body that has emerged as the largest research and development organisation in India
  2. It runs thirty-eight laboratories and thirty-nine field stations or extension centres throughout the nation, with a collective staff of over 12,000 scientists and scientific and technical personnel
  3. Although it is mainly funded by the Ministry of Science and Technology, it operates as an autonomous body through the Societies Registration Act, 1860
  4. The research and development activities of CSIR include aerospace engineering, structural engineering, ocean sciences, life sciences, metallurgy, chemicals, mining, food, petroleum, leather, and environmental science.

 

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