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GS Paper: GS3-17.Awareness in the fields of IT, Space, Computers, Robotics, Nano-technology, Bio-technology and issues relating to Intellectual Property Rights.

  • Endocrine Disruptors in Plastic Waste

    Why in the News?

    Microplastics and endocrine-disrupting chemicals (EDCs) are infiltrating the human body, affecting everything from reproduction to cancer risk, metabolism, and child development.

    About Endocrine-Disrupting Chemicals:

    • What They Are: Endocrine-Disrupting Chemicals interfere with the body’s hormone system, affecting growth, reproduction, mood, and metabolism.
    • How They Work: They mimic or block natural hormones like estrogen, testosterone, thyroid hormones, and cortisol, leading to disrupted hormonal signals.
    • Why They’re Dangerous: Even low-level exposure during pregnancy or puberty can cause lasting harm.
    • How We’re Exposed: Through eating contaminated food, inhaling polluted air, or skin contact with certain plastics or cosmetics.
    • Where They’re Found: In plastic bottles (Bisphenol A), toys and cosmetics (phthalates like Di(2-ethylhexyl) phthalate), food wrappers (Per- and Polyfluoroalkyl Substances), and pesticides (dioxins, Polychlorinated Biphenyls).
    • Hidden Harm: They act silently, with long-term effects such as fertility loss, hormonal disruption, or cancer.

    Impact on Human Health:

    • Reproductive Harm: Reduced sperm quality disrupted menstrual cycles, and increased miscarriage risk. Found in semen, placenta, and breast milk.
    • Hormonal Disruption: Chemicals like Bisphenol A trigger early puberty, thyroid issues, and hormonal imbalances.
    • Cancer Risk: Linked to cancers of the breast, uterus, testicles, and prostate. Several are labeled probable carcinogens by global health agencies.
    • Metabolic Effects: Interfere with insulin, promote obesity and type 2 diabetes. PFAS chemicals are linked to liver and heart disease.
    • Brain and Behavior: Associated with ADHD, learning issues, and lower IQ in children, especially when exposure happens early in life.
    • Across Generations: May cause gene expression changes that affect health in future generations—even without direct exposure.
    [UPSC 2020] Why is there a great concern about the ‘microbeads’ that are released into environment?

    Options: (a) They are considered harmful to marine ecosystems * (b) They are considered to cause skin cancer in children (c) They are small enough to be absorbed by crop plants in irrigated fields. (d) They are often found to be used as food adulterants.

     

  • [pib] Breakthrough in Altermagnets Study

    Why in the News?

    Researchers at S N Bose National Centre for Basic Sciences (SNBNCBS) have discovered a novel transport behaviour in chromium antimonide (CrSb), a member of the emerging class of magnetic materials called altermagnets.

    What are Altermagnets?

    • Definition: Altermagnets are a new class of magnetic materials that combine properties of ferromagnets (which show external magnetism) and antiferromagnets (which don’t).
    • Unique Feature: They don’t attract metals like fridge magnets but still have active internal magnetic behavior, useful in advanced technology.
    • Use in Spintronics: These materials are ideal for spintronics, a technology that uses electron spin (not just charge) to make faster and energy-efficient devices.
    • No Magnetic Interference: Altermagnets do not create external magnetic fields, so they are stable and safe for nearby electronics.
    • Energy Efficient: Their structure helps reduce heat and energy loss, which is perfect for modern low-power gadgets.
    • Scientific Rarity: Very few altermagnets are known, making each discovery important for materials science.
    • Potential Applications: They could help build smaller memory chips, faster processors, and even support quantum computing.
    • Internal Action: Think of them as “quiet magnets” — they work inside devices without magnetic noise.

    Recent Discovery- Chromium Antimonide (CrSb):

    • Indian Breakthrough: Indian scientists found CrSb, a new altermagnet, showing rare direction-dependent conduction.
    • Directional Behavior: CrSb acts as an n-type material when current flows along its layers, and as a p-type when current flows across them.
    • First of its Kind: This is the first time an altermagnet has shown such dual conduction behavior in different directions.
    • Device Simplification: Since CrSb can behave as both p-type and n-type, it can reduce circuit size and eliminate the need for doping.
    • Eco-friendly Material: CrSb is made from non-toxic, common elements, making it ideal for sustainable electronics.
    • Potential Applications:
      • Future Potential: CrSb could be used in solar cells, batteries, and processors to make them greener and more efficient.
      • Environment-Friendly Tech: CrSb enables low-cost and eco-friendly electronics without sacrificing performance.
    [UPSC 2021] Magnetite particles, suspected to cause neurodegenerative problems, are generated as environmental pollutants from which of the following? 1. Brakes of motor vehicles 2. Engines of motor vehicles 3. Microwave stoves within homes 4. Power plants 5. Telephone lines Select the correct answer using the code given below.

    Options: (a) 1, 2, 3 and 5 only (b) 1, 2 and 4 only* (c) 3, 4 and 5 only (d) 1, 2, 3, 4 and 5

     

  • India’s first Genomic Atlas reveals deep Ancestry and Health Risks

    Why in the News?

    A landmark study published in the ‘Cell’ journal has sequenced the genomes of 2,762 Indians from 23 states and union territories, creating the most comprehensive genomic map of India to date.

    About the Genomic Atlas:

    • Overview: The Genomic Atlas is the most comprehensive genetic mapping of Indian populations, covering caste, tribe, language, geography, and urban-rural distinctions.
    • Collaboration: It was conducted by Indian and international institutions, aiming to understand how ancient migrations and social structures shaped Indian genomes.
    • Use of Molecular Clocks: Researchers used genetic mutations as molecular clocks to trace human ancestry and map the evolutionary history of diverse groups in India.
    • Focus on Disease and Ancestry: The study explores recessive disorders, disease-linked mutations, and interbreeding with archaic humans like Neanderthals and Denisovans.
    • Scope: Plans include expanding coverage to more isolated communities and building tools to track disease origins within genetically distinct Indian groups.
    • Impact on Precision Medicine: It aims to improve personalised healthcare by incorporating Indian genetic diversity into global medical research.

    Key Highlights of the Study:

    • Discovery of New Gene Variants: Over 2.6 crore previously undocumented genetic variants were discovered, many of which are absent from international gene databases.
    • Single-origin migration: Indians descend primarily from a single out-of-Africa migration ~50,000 years ago, not earlier human groups.
    • Three major ancestral components:
      • Ancient Ancestral South Indians (AASI) – early hunter-gatherers.
      • Iranian-related Neolithic farmers – from Sarazm (~4th millennium BCE).
      • Eurasian Steppe pastoralists – arrived around 2000 BCE, tied to Indo-European languages.
    • Additional East Asian ancestry: Found in East, Northeast, and some Central Indian populations (e.g., 5% in West Bengal), likely post-Gupta or rice cultivation-related (~520 CE).
    • Caste endogamy impacts: Long-term inbreeding within castes has led to high homozygosity, raising the risk of recessive genetic diseases.
    • Archaic DNA: Indian genomes show rich Neanderthal and Denisovan segments, especially in immune-related genes like MHC, TRIM, and BTNL2.
    • Unique health risks: A BCHE variant linked to anaesthetic reaction is enriched in Telangana; 7% of discovered protein-altering variants relate to serious genetic disorders.
    • Every individual had at least one genetic relative in the sample—revealing extreme interrelatedness and strong founder effects, particularly in South India.
    • Unmatched Neanderthal diversity: India harbours the widest variety of Neanderthal-derived genetic fragments among global populations.
    [UPSC 2021] In the context of hereditary diseases, consider the following statements:

    1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of the egg.

    2. A child inherits mitochondrial diseases entirely from the mother and not from the father.

    Options: Which of the statements given above is/are correct?

    (a) 1 only (b) 2 only (c) Both 1 and 2* (d) Neither 1 nor 2

     

  • Type 2 diabetes rising among young people, posing lifetime risks: Lancet

    Why in the News?

    A new series by The Lancet highlights a major shift in global health. Type 2 diabetes, which earlier affected mostly older people, is now increasing quickly among those under 40. Around 260 million young adults worldwide already have the disease.

    What distinguishes early-onset type 2 diabetes from adult-onset in impact?

    • Longer disease duration with increased complications: Being diagnosed at a younger age means living longer with the disease, increasing the risk of complications like kidney failure, heart disease, and nerve damage throughout life. A 25-year-old with diabetes may face multiple health issues by age 40, compared to someone diagnosed at 55.
    • Greater loss in life expectancy: Individuals diagnosed before the age of 30 can lose up to 15 years of life expectancy, whereas older adults diagnosed later typically lose fewer years. A young adult may not survive past their 60s if the disease is poorly managed, while an older adult may live well into their 70s or 80s.
    • More disruption to personal and economic life: Early onset affects critical life stages like education, job opportunities, and family planning, placing greater mental and financial stress. A person in their 20s may have to drop out of college or limit employment due to frequent medical care needs.

    Why is early-onset diabetes a major concern for Indian health systems?

    • Rising burden on already stretched public healthcare: India’s healthcare system is under pressure from both infectious and non-communicable diseases. Early-onset diabetes increases the demand for long-term care, monitoring, and medication. A 2023 ICMR study found that more than 25% of diabetes cases in India are now diagnosed before the age of 40.
    • Economic impact on productivity and workforce: Early-onset diabetes reduces an individual’s healthy working years and impacts productivity, especially in labour-intensive sectors. According to the ICMR 2023 study, diabetic workers lose an average of 7–8 additional workdays annually, leading to reduced output, absenteeism, and rising employer costs.
    • Greater lifetime healthcare costs and complications: Early diagnosis leads to decades-long care, including medication, check-ups, and complication management, increasing costs for families and public health insurance. Eg: A young diabetic using insulin, requiring eye and kidney screenings, adds a heavy burden on schemes like Ayushman Bharat.

    How do socio-economic and environmental factors drive its rise?

    • Unhealthy food environments and marketing: Easy availability and aggressive marketing of processed and sugary foods through social media influence poor dietary habits among youth. Eg: Fast food delivery apps and influencer-driven trends promote ultra-processed snacks in urban areas like Delhi and Mumbai.
    • Inequality in access to healthcare and lifestyle management: Low-income groups lack access to nutritious food, safe exercise spaces, and preventive healthcare, increasing risks of obesity and diabetes. Eg: Children in urban slums of Kolkata face limited health awareness and inactivity, raising early-onset diabetes risk.
    • Impact of early-life undernutrition and developmental challenges: Poor maternal nutrition, low birth weight, and childhood undernourishment raise the chance of developing type 2 diabetes later, even without obesity. Eg: In rural Madhya Pradesh, undernourished children show insulin resistance despite having a low BMI.

    Why is prevention more effective than treatment in tackling this issue?

    • Reduces lifelong health burden and complications: Preventing diabetes avoids decades of medication, monitoring, and risks of complications like kidney or heart disease. Eg: Promoting physical activity and healthy diets in schools can reduce diabetes risk and future hospital visits.
    • More cost-effective for individuals and health systems: Prevention strategies like awareness campaigns and food policies cost less than long-term drug therapy and hospitalisation. Eg: Taxing sugar-sweetened beverages, adopted in over 100 countries, has reduced sugary drink sales and lowered obesity-related costs.
    • Addresses root causes and promotes healthy behaviours: Focusing on prevention changes social and environmental conditions that lead to obesity and diabetes. Eg: Urban planning with parks, pedestrian paths, and fitness centres encourages active lifestyles, lowering diabetes risk.

    Way forward:

    • Strengthen preventive public health strategies: Implement nationwide programs promoting healthy eating, physical activity, and early screening in schools and communities to reduce risk factors from a young age.
    • Ensure equitable access to care and awareness: Expand access to affordable diagnosis, lifestyle counselling, and essential medicines in both urban and rural areas, especially targeting low-income and high-risk groups.

    Mains PYQ:

    [UPSC 2022] The increase in life expectancy in the country has led to newer health challenges in the community. What are those challenges, and what steps need to be taken to meet them?

    Linkage: This question directly addresses “newer health challenges” and the steps required to meet them. The need for “urgent investment in prevention, early diagnosis and targeted care” mentioned in the article directly aligns with the “steps to be taken” aspect of this question.

  • Agricultural Fungicides causing C. Tropicalis Infections

    Why in the News?

    Researchers at Fudan University found that overuse of the fungicide tebuconazole is causing azole-resistant Candida tropicalis to emerge — a deadly fungus with a 55–60% mortality rate.

    About Candida tropicalis:

    • Overview: Candida tropicalis is a fungal pathogen prevalent in tropical and subtropical regions, including India.
    • Type: It is a yeast species that causes invasive candidiasis, affecting the bloodstream and internal organs.
    • High-Risk Groups: The fungus is opportunistic, primarily infecting immunocompromised individuals such as cancer patients and those in ICUs.
    • Mortality Rate: The infection has a high mortality rate, estimated at 55–60% when it becomes systemic.
    • Drug Treatment: Standard treatments include azole-class antifungals such as fluconazole and voriconazole (widely used during COVID-19 induced Black Fungus).
    • Adaptability: The pathogen shows strong genomic plasticity, allowing it to survive hostile environments and develop drug resistance.

    Reasons for Spread and Resistance:

    • Agricultural Influence: Studies show that azole fungicides like tebuconazole, used in farming, contribute to azole-resistant C. tropicalis
    • Environmental Exposure: These fungicides accumulate in soil and water, promoting the evolution of resistant strains.
    • Genetic Adaptations: Resistant strains develop aneuploidy (extra chromosomes), aiding resistance but reducing growth in drug-free environments.
    • Efflux Pumps: Some strains duplicate genes like TAC1, boosting drug-efflux pumps (e.g., ABC transporters) to eject antifungals from the cell.
    • Increased Virulence: Resistant strains have proven more virulent in animal studies, posing greater public health risks.

     

  • Substandard Cancer Drugs: A Global Public Health Alarm

    Why in the News?

    A global investigation has revealed that vital chemotherapy drugs used in over 100 countries have failed quality tests, posing life-threatening risks to cancer patients.

    Various Drugs Used for Cancer Treatment:

    • Cisplatin is a platinum-based drug discovered in the 1960s. It binds to DNA in cancer cells and is widely used to treat testicular, ovarian, bladder, and lung cancers. It is known to cause kidney damage, hearing loss, and immune suppression.
    • Oxaliplatin is another platinum compound mainly used to treat advanced colorectal cancer. It works similarly to cisplatin but may also cause nerve-related side effects.
    • Cyclophosphamide is used for treating breast cancer, leukaemia, sarcoma, and lymphoma. It damages cancer cell DNA and lowers white blood cell counts, weakening the immune system. It can also cause bladder inflammation.
    • Doxorubicin, known as the “Red Devil”, is derived from soil bacteria and used against breast cancer, leukaemia, and sarcomas. It disrupts DNA replication but has serious side effects, including heart damage and hair loss.
    • Methotrexate blocks enzymes involved in DNA synthesis and is used for leukaemia, lymphoma, and various tumors. It is often followed by leucovorin, which helps protect normal cells from damage.
    • Leucovorin is not a chemotherapy drug but a supportive agent used with methotrexate to reduce toxicity. It is a form of vitamin B9 introduced in the 1950s.

    Recent Quality Test Failure

    • Investigation: A 2024 investigation revealed that chemotherapy drugs sold in over 100 countries failed basic quality standards.
    • Failure of Generics: The drugs tested were generics. Also, 189 unexpired samples were tested; 20% failed.
    • Indian Pharma Under Radar: 17 manufacturers were flagged, with 16 based in India. Drugs failed for containing either too little (under 88%) or too much (over 112%) active ingredient.
    [UPSC 2005] It begins as a single cell and grows into a merciless disease that claims millions of lives year after year. But scientists are steadily unlocking its mysteries, and the fight against it may now have reached a dramatic turning point. New discoveries promise better therapies and hope in the war against …” The disease referred to in the above quotation is:

    Options: (a) Cancer (b) AIDS (c) Tuberculosis (d) Alzheimer’s disease

     

  • Sam Altman’s World ID Project

    Why in the News?

    World ID is Sam Altman’s ambitious project to create a secure, biometric-based digital identity for everyone in the age of AI.

    What is World ID?

    • World ID is a digital identity system launched by Sam Altman’s company Tools for Humanity as part of the Worldcoin project in July 2023.
    • It aims to verify that a person is a real, unique human being—especially in an age of AI-generated bots—using biometric iris scans.
    • How Does It Work?
      • The identity is created using a device called the Orb, which captures the iris pattern and generates a unique cryptographic code (not storing the image itself).
      • This ID is then linked to the World App, and the user can access various services while proving they are human—without revealing their actual identity.
      • The system is decentralized and uses blockchain technology to store identity proofs securely.

    Key Features of World ID:

    • Biometric Verification: Uses iris scanning through the Orb to establish a unique identity.
    • Global Access: Users from over 160 countries have access to Worldcoin and World ID features.
    • Decentralized Protocol: Built on open-source, privacy-preserving cryptography, such as zero-knowledge proofs.
    • World App Integration: Enables users to locate Orbs, receive Worldcoins, and use the digital ID across apps.
    • World Chain: A blockchain linked to World ID that supports apps and services tied to identity.
    • Crypto Incentive: Users may receive Worldcoin (WLD) tokens for enrolling.
    • Privacy Controls: Promises anonymity, non-surveillance use, and code transparency.
    • Hardware Dependency: Requires a physical Orb or the new Orb Mini to generate IDs.

    How it differs from Aadhaar?

    World ID Aadhaar
    Ownership Private project by Tools for Humanity Government of India
    Launch Year 2023 2009
    Technology Used Iris scan via Orb; Blockchain-based ID Biometric + Demographic data via central database
    Legal Framework No national law backing it yet Aadhaar Act, 2016
    Purpose Global ID to prove human uniqueness National ID for accessing services & welfare
    Data Privacy Claims privacy via zero-knowledge cryptography Data regulated by UIDAI under Indian law
    Adoption Level 12 million users globally Over 1.3 billion users in India
    Hardware Needed Orb device Fingerprint/iris scanners at enrollment centers
    Verification Use AI-bot detection, global ID use Government subsidies, banking, KYC, etc.

     

  • In-Body CAR T-Cell Therapy

    Why in the News?

    A new study published in Science journal shows that “In-Body CAR T-Cell Therapy” marks a breakthrough by enabling direct immune cell reprogramming for faster, safer treatment of cancer and autoimmune diseases.

    What is CAR T-Cell Therapy?

    • Overview: CAR T-cell therapy is a treatment where a patient’s own T cells are genetically modified to detect and kill cancer cells.
    • Science behind it: Scientists extract T cells and add a Chimeric Antigen Receptor (CAR) gene, which enables them to identify cancer cells.
    • Working: These modified T cells are infused back into the patient, where they multiply and actively attack cancer.
    • Effectiveness: The therapy has shown high success against certain blood cancers and is now being studied for autoimmune disorders like lupus.
    • Issues: The traditional therapy is expensive (₹60–70 lakh), slow, and requires chemotherapy and specialised lab facilities.

    Recent Breakthrough: In-Body CAR T-Cell Therapy

    • Approach: A new technique uses mRNA-loaded lipid nanoparticles (LNPs) to deliver instructions directly inside the body.
    • Targeting Cells: These nanoparticles are programmed to locate and enter killer T cells, converting them into CAR T-cells internally.
    • Benefits offered: This method eliminates the need for cell extraction, chemotherapy, or viral vectors, making it faster and safer.

    Significance for India:

    • Scalable Innovation: This platform may lower treatment costs and offer wider access in countries like India with high cancer and autoimmune burdens.
    • Infrastructure Relief: Its in-body nature avoids dependence on advanced labs, making it suitable for resource-constrained settings.
    [UPSC 2019] What is Cas9 protein that is often mentioned in news?

    Options: (a) A molecular scissors used in targeted gene editing* (b) A biosensor used in the accurate detection of pathogens in patients (c) A gene that makes plants pest-resistant (d) A herbicidal substance synthesized in genetically modified crops

     

  • Quantum 5G Fixed Wireless Access Broadband

    Why in the News?

    BSNL announced the soft launch of Quantum 5G Fixed Wireless Access (FWA) broadband in Hyderabad.

    About Quantum 5G FWA:

    • Overviews: It is India’s first SIM-less, fixed wireless access broadband service.
    • Development: It delivers fibre-like internet over 5G radio and was developed entirely by Indian vendors under the Atmanirbhar Bharat initiative.
    • How does it work?
      • Customers are provided with a CPE (Customer Premises Equipment) device that connects wirelessly to the nearest BSNL 5G base station.
      • The CPE auto-authenticates without requiring a SIM card, using Direct-to-Device technology.
      • Internet is delivered over the air, eliminating the need for trenching or fibre installation.
      • The service currently reaches 85% of Hyderabad households using BSNL’s existing tower infrastructure.

    Key Features:

    • Indigenous: Includes core network, RAN, and CPE, all developed by Indian vendors.
    • High Performance: Achieves up to 980 Mbps download, 140 Mbps upload, and <10 ms latency—ideal for streaming, gaming, and remote work.
    • Quick Setup: Customers can self-install the device with no need for physical fibre connections.
    • Enterprise Capability: Supports network slicing and Service Level Agreement (SLA)-backed links for MSMEs and industrial clusters.
    • Strategic Vision: Positions BSNL as a leader in next-generation broadband and enhances rural and urban connectivity.
    [UPSC 2019] With reference to communication technologies, what is/are the difference/differences between LTE (Long-Term Evolution) and VoLTE (Voice over Long-Term Evolution)?

    1. LTE ‘is commonly marketed as 3G, and VoLTE is commonly marketed as advanced 3G.

    2. LTE is data-only technology, and VoLTE is voice-only technology.

    Options: (a) 1 only (b) 2 only (c) Both 1 and 2 (d) Neither 1 nor 2*

     

  • Rice reveals surprise ability to adapt to cold faster than evolution 

    Why in the News?

    In a major study, scientists proved that cold exposure in rice plants can cause changes that improve stress tolerance and are inherited by the next five generations, supporting Lamarck’s old theory.

    What was Lamarck’s theory of acquired characteristics?

    This idea was formally presented by Jean-Baptiste Lamarck in 1809, and it was one of the earliest theories of evolution. When the traits developed during an organism’s lifetime due to use, disuse, or environmental influence could be inherited by its offspring. Eg: A giraffe stretching its neck to reach higher leaves would result in its offspring having longer necks.

    How did later scientific discoveries challenge it?

    • Weismann’s Tail-Cutting Experiment: August Weismann demonstrated that acquired traits are not inherited by cutting the tails of mice for five generations, yet their offspring were still born with tails.
    • Mendel’s Laws of Heredity: Gregor Mendel showed that traits are inherited through stable units (genes) passed unchanged from parents to offspring, rather than traits acquired during life. Eg: In pea plants, traits like flower colour were inherited predictably, regardless of environmental changes.
    • Discovery of DNA and Mutations: The discovery of DNA as the genetic material and that mutations cause heritable changes explained inheritance scientifically, without relying on acquired characteristics. Eg: Genetic disorders like sickle cell anemia are caused by specific DNA mutations, not by environmental use or disuse.

    How did Mendel’s work and DNA discovery change heredity understanding?

    • Introduction of Stable Hereditary Units: Mendel’s experiments introduced the concept of “genes” as stable, particulate units of inheritance passed from parents to offspring. Eg: Mendel’s pea plant experiments showed traits like seed shape and flower color followed predictable patterns.
    • Law of Segregation and Independent Assortment: Mendel proposed that alleles segregate independently, ensuring genetic variation without influence from acquired traits. Eg: A plant with one tall and one short gene could pass either to its offspring, not a mix of the two.
    • DNA Identified as Genetic Material: Later discoveries identified DNA as the carrier of genetic information, solidifying the molecular basis of heredity. Eg: Avery, MacLeod, and McCarty’s experiments in 1944 showed that DNA—not proteins—was responsible for heredity.
    • Mutation Explained Heritable Variation: The understanding that mutations in DNA cause changes in traits clarified how new heritable variations arise. Eg: Mutations in the hemoglobin gene lead to sickle cell anemia, a heritable disorder.
    • Disproved Lamarckian Inheritance: These findings rejected the idea that characteristics acquired during life could be inherited, as proposed by Lamarck. Eg: A bodybuilder’s muscular physique isn’t passed to their children genetically.

    Why is the Cell study on cold-tolerant rice significant?

    • Proof of Heritable Epigenetic Change Induced by Environment: The study demonstrated that cold exposure triggered an epigenetic modification (methylation) in rice plants, which was inherited for five generations. Eg: Rice plants exposed to cold passed on improved cold tolerance without any DNA sequence change.
    • Reinforced the Role of Epigenetics in Evolution: It showed that gene expression can be regulated by epigenetic marks rather than genetic mutations, suggesting Lamarck’s idea of environmental inheritance has merit. Eg: The ACT1 gene stayed active in cold-tolerant rice due to the absence of a methylation tag, helping them survive cold stress.
    • New Direction for Crop Improvement and Climate Resilience: The findings open doors for non-genetic crop adaptation methods to deal with climate change. Eg: Epigenetically trained rice varieties could be developed to withstand colder environments, improving food security.

    What are the steps taken by the Indian Government? 

    • Multigenerational Cold-Stress Breeding: Researchers implemented a directional selection process over multiple generations by exposing rice to cold during the vulnerable meiotic stage, breeding for improved cold resistance. Eg: After three generations, they developed rice lines with stable cold tolerance that persisted for at least five generations.
    • Epigenetic Mapping and Editing of the ACT1 Promoter: Through multi-omics analysis, scientists identified hypomethylation at the ACT1 promoter as the molecular basis for cold adaptation. They then used precision DNA methylation editing to confirm that removing methyl tags restored cold tolerance.  

    Way forward:

    • Incorporate Epigenetic Breeding in National Crop Improvement Programs: Government research bodies and agricultural universities should integrate epigenetic trait selection and editing into mainstream breeding to develop climate-resilient varieties, especially for stress-prone regions.
    • Strengthen Investment in Multi-Generational Stress Trials: Increase funding for long-term, controlled environment trials to identify and stabilize heritable epigenetic traitsacross major crops, ensuring sustainable food security under climate change.

    Mains PYQ:

    [UPSC 2019] How can biotechnology improve the living standards of farmers?

    Linkage: The core of the article reveals a novel mechanism for plant adaptation—epigenetic inheritance of cold tolerance in rice plants. This scientific breakthrough, falling under the broad umbrella of biotechnology, demonstrates a potential pathway to develop crops that can adapt to challenging environmental conditions (like cold stress) more rapidly than through traditional breeding or genetic modification.