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GS Paper: GS3-17.Awareness in the fields of IT, Space, Computers, Robotics, Nano-technology, Bio-technology and issues relating to Intellectual Property Rights.

  • PresVu: India’s First Eye Drop for Presbyopia

    Why in the News?

    Mumbai-based Entod Pharmaceuticals has announced that the Drug Controller General of India (DCGI) has approved its new eye drop, PresVu, aimed at reducing the dependency on reading glasses for individuals with presbyopia.

    What is Presbyopia?

    • Presbyopia is an age-related condition where the eyes gradually lose the ability to focus on nearby objects, typically developing after the age of 40.
    • Spectacles are one of the most commonly recommended solutions for managing presbyopia.

    How does PresVu work? 

    • The active ingredient in PresVu is pilocarpine, a compound that contracts the iris muscles, controlling the size of the pupil and helping individuals focus better on nearby objects.
    • PresVu also uses an advanced dynamic buffer technology to adapt to the pH levels of tears, ensuring consistent efficacy and safety for extended use over the years.
    • However, PresVu’s effects are temporary, typically lasting between four to six hours, and it is prescription-only.
    • PresVu should not be used by individuals with iris inflammation.
    • Regular use may lead to side effects such as:
      • Itching and redness
      • Eyebrow pain
      • Muscle spasms in the eyes

    Is this a Novel Therapy?

    • Although Entod claims PresVu is novel, the main compound, pilocarpine, has been available in India for decades and is commonly used as a first-line therapy for cataracts.
    • Pilocarpine’s ability to temporarily improve the depth of focus has been explored in other countries, including the United States, where the FDA approved a pilocarpine eye drop for presbyopia in 2021.
    • In India, the government regulates the ceiling price of pilocarpine in 4% and 2% concentrations, whereas PresVu contains 1.25%.

    PYQ:

    [2018] Appropriate local community-level healthcare intervention is a prerequisite to achieve ‘Health for All’ in India. Explain.

  • BepiColombo Mission

    BepiColombo

    Why in the News?

    • On Thursday, the ESA-Japan spacecraft “BepiColombo” made its closest approach to Mercury, capturing detailed images of its sunrise-lit surface and revealing the planet’s south pole.

    Highlights of the Latest Flyby:

      • BepiColombo uses flybys of Earth, Venus, and Mercury to slow down and enter orbit around Mercury. This approach gives scientists new information about Mercury’s south pole and its unusual peak ring craters, which haven’t been studied much before.

      Note: Flybys are close passes of a spacecraft near a planet or celestial body

    About BepiColombo Mission:

    Details
    Collaboration  European Space Agency (ESA) and Japan Aerospace Exploration Agency (JAXA)
    Launch Date
    • October 20, 2018
    • Expected to enter Mercury’s orbit by late 2026.
    Launch Vehicle Ariane 5 Rocket
    Objectives
    • Study Mercury’s magnetic field
    • Investigate surface composition and geology
    • Analyze Mercury’s interaction with solar wind
    • Study exosphere and geological history
    Spacecraft Components
    • ESA’s Mercury Planetary Orbiter (MPO):  Focus on surface and interior study
    • JAXA’s Mercury Magnetospheric Orbiter (MIO): Focus on magnetic field and surrounding space
    Planned Flybys
    • 6 (Flybys of Earth, Venus, and Mercury)
    • Ongoing, with 4 out of 6 Mercury flybys completed
    Craters Studied Vivaldi Crater, Stoddart Crater
    Significance Second mission ever to orbit Mercury (after NASA’s Messenger, 2004)
    Challenges
    • Mercury’s proximity to the Sun accelerates spacecraft, requiring multiple flybys to slow down
    • Thruster issues causing mission delay

     

    PYQ:

    [2008] What is the purpose of the US Space Agency’s Themis Mission, which was recently in the news?

    (a) To study the possibility of life on Mars.

    (b) To study the satellites of Saturn.

    (c) To study the colourful display of high latitude skies.

    (d) To build a space laboratory to study the stellar explosions.

  • What is Helium and why is it used in Rockets?

    Why in the News?

    Two NASA astronauts aboard Boeing’s Starliner will remain on the International Space Station (ISS) for an extended period due to issues with a faulty propulsion system, including helium leaks.

    helium

    About Helium

    • Helium is inert, meaning it does not react or combust when exposed to other substances.
    • This makes it ideal for pressurization and cooling systems in rockets and spacecraft.
    • With an atomic number of 2, Helium is second lightest element after hydrogen, helping to keep the rocket’s weight low, which is crucial for achieving the necessary speeds and altitudes to reach orbit.
    • It has an extremely low boiling point (-268.9°C), allowing it to stay in a gaseous state in super-cold environments, where many rocket fuels are stored.
    • Though non-toxic, helium cannot be inhaled on its own as it displaces oxygen, which is vital for human respiration.

    How is Helium used for space applications?

    • Fuel Tank Pressurization: Helium pressurizes fuel tanks, ensuring a consistent flow of fuel to the rocket’s engines, even as the fuel is burned.
    • Cooling Systems: It also plays a key role in cooling systems, particularly in environments where rocket fuel and oxidizer need to be stored at extremely low temperatures.
    • Maintaining Tank Pressure: As fuel and oxidizer are consumed, helium fills the empty space left behind, ensuring the overall pressure inside the tanks remains stable.

    Is Helium prone to leaks?

    • Helium’s small atomic size and low molecular weight make it prone to leaking through tiny gaps or seals in storage tanks and fuel systems.
    • Since helium is rare in Earth’s atmosphere, even minor leaks are easily detectable, making it a valuable tool for spotting potential faults in spacecraft fuel systems.
    • Examples of Leaks:
      • In May, hours before Boeing’s Starliner spacecraft attempted its first astronaut launch, sensors detected a small helium leak in one of its thrusters.
      • After Starliner launched in June, additional leaks were found in space, prompting NASA to return the spacecraft to Earth without its crew.

    Alternatives to Helium

    • Argon and Nitrogen: Some rocket launches have experimented with other inert gases like argon and nitrogen, which are sometimes cheaper, but helium remains the industry standard.
    • Ariane 6’s Novel System: Europe’s new Ariane 6 rocket abandoned helium in favor of a pressurization system that converts small amounts of its liquid oxygen and hydrogen into gas for pressurizing the fuel.
      • However, during Ariane 6’s debut launch, this system failed in space, adding to the global rocket industry’s pressurization challenges.

    PYQ:

    [2012] A team of scientists at Brookhaven National Laboratory included those from India created the heaviest anti-matter (anti-helium nucleus). What is/are the implication/implications of the creation of anti-matter?

    1. It will make mineral prospecting and oil exploration easier and cheaper.

    2. It will help prove the possibility of the existence of stars and galaxies made of anti-matter.

    3. It will help understand the evolution of the universe.

    Select the correct answer using the codes given below:

    (a) 1 only

    (b) 2 and 3 only

    (c) 3 only

    (d) 1, 2 and 3

  • What is the Principle of Planetary Protection?

    Why in the News?

    • Planetary protection is a crucial principle in space missions that travel from Earth to other planetary bodies, such as the Moon or Mars.
      • The goal is to preserve both Earth’s biosphere and the planetary body’s environment from contamination by alien microbial life.

    About Planetary Protection:

    Details
    Definition Safeguarding Earth’s biosphere and other planetary bodies from microbial contamination during space missions.
    Objective Prevent contamination of Earth’s environment and other planets by alien microbes or Earth-origin microorganisms.
    Legal Basis Article IX of Outer Space Treaty (1967) mandates avoiding harmful contamination in space exploration.
    Importance
    • Protects integrity of scientific research on other planets.
    • Prevents potential biological threats to Earth.
    Methods of Implementation
    • Spacecraft sterilization (e.g. baking in a dry room at 120°C for 3 days).
    • Planning missions to avoid cross-contamination.
    Key Applications Missions to Mars, Moon, Europa and other celestial bodies where contamination may disrupt research or pose risks.
    Challenges Increased costs and technical demands for maintaining sterile spacecraft and environments.
    Recent Example China’s Tianwen-3 Mars sample-return mission (2028) confirmed adherence to planetary protection principles.
    Global Cooperation International space agencies follow planetary protection guidelines for sustainable and safe space exploration.

  • Yellow Food Dye can improve Cancer Treatment

    Why in the News?

    Recent research reveals that FD&C Yellow 5, a common food dye, can temporarily make tissue transparent, with potential implications for cancer treatment and medical procedures.

    About Yellow Food Dye 

    • FD&C Yellow 5, also known as Tartrazine, is a widely used synthetic food dye found in various snacks, drinks, and processed foods.
    • Approved by the FDA, it is commonly used to give products a vibrant yellow color.

    How does it work?

    • The dye has the ability to make tissue transparent is based on its interaction with light, specifically through the Kramers-Kronig relations, a principle in physics.
    • It absorbs blue light, leaving only the red-orange spectrum visible.
    • This alters the refractive index of water, causing it to match the refractive index of fats and proteins in tissue.
    • When the refractive indices match, light can pass through tissue with less scattering, creating the appearance of transparency.

    Potential Medical Applications of Yellow Food Dye

    • Cancer Treatment: By making tissues transparent, FD&C Yellow 5 could enhance photodynamic and photothermal therapies, allowing laser light to reach deeper tissues and target cancerous cells more effectively.
    • Vein Visibility: Transparent tissues could help make veins more visible, aiding in procedures like venepuncture for blood draws or injections, particularly in patients with hard-to-see veins.
    • Non-invasive Diagnostics: The dye could allow doctors to visualize internal organs and structures without the need for invasive procedures like biopsies or expensive imaging technologies like CT scans or MRIs.

    PYQ:

    [2018] Consider the following statements:

    1. The Food Safety and Standards Act, 2006 replaced the Prevention of Food Adulteration Act, 1954.

    2. The Food Safety and Standards Authority of India (FSSAI) is under the charge of Director General of Health Services in the Union Ministry of Health and Family Welfare.

    Which of the statements given above is/are correct?

    (a) 1 only

    (b) 2 only

    (c) Both 1 and 2

    (d) Neither 1 nor 2

  • Project Strawberry by OpenAI

    Why in the News?

    OpenAI has planned to release its most powerful AI model likely as part of ChatGPT-5. Initially called Project Q* (Q-star), it is now codenamed Project Strawberry.

    What is Project Strawberry?

    • Nearly six months ago, OpenAI’s secretive Project Q* (Q-Star) gained attention for its innovative approach to AI training.
    • OpenAI is now working on a new reasoning technology under the code name “Strawberry” believed to be the new name for Project Q*.
    • Strawberry aims to enable AI models to plan ahead, autonomously search the internet, and conduct deep research.

    What are Large Language Models (LLMs)?

    • LLMs are advanced artificial intelligence (AI) systems designed to understand, generate, and process human language.
    • They are built using deep learning techniques, particularly neural networks, and are trained on vast amounts of text data.

    Difference from Existing AI Models

    • Existing Large Language Models (LLMs) can summarize texts and compose prose but struggle with common sense problems and multi-step logic tasks.
    • Current LLMs cannot plan ahead effectively without external frameworks.
    • Strawberry models are expected to enhance AI reasoning, allowing for planning and complex problem-solving.
    • These models could enable AI to perform tasks that require a series of actions over an extended time, potentially revolutionizing AI’s capabilities.

    Potential Applications of Strawberry Models

    • Advanced AI models could conduct experiments, analyze data, and suggest new hypotheses, leading to breakthroughs in sciences.
    • In medical research, AI could assist in drug discovery, genetics research, and personalized medicine analysis.
    • AI could solve complex mathematical problems, assist in engineering calculations, and participate in theoretical research.
    • AI could contribute to writing, creating art and music, generating videos, and designing video games.

    PYQ:

    [2020] With the present state of development, Artificial Intelligence can effectively do which of the following?

    1. Bring down electricity consumption in industrial units.
    2. Create meaningful short stories and songs.
    3. Disease diagnosis.
    4. Text-to-Speech Conversion.
    5. Wireless transmission of electrical energy.

    Select the correct answer using the code given below:

    (a) 1, 2, 3 and 5 only
    (b) 1, 3 and 4 only
    (c) 2, 4 and 5 only
    (d) 1, 2, 3, 4 and 5

  • Gut molecule in C. Elegans Worms slows fat burning

    Why in the News?

    Researchers have discovered a mechanism in Caenorhabditis elegans (C. elegans) worms that explains why fat loss slows down during fasting.

    Fasting and Fat Metabolism

    • The brain is known to regulate fat production and breakdown in humans, other mammals, and model organisms like C. elegans.
    • In 2017, researchers identified FLP-7 hormone in the brain that triggers fat burning in the gut of C. elegans.
    • However, it was unclear how the gut communicates back to the brain, as C. elegans lacks sensory nerves in their intestines.
    • The study reveals that during fasting, the gut produces a form of insulin called INS-7, which signals the brain to halt fat burning.
    • Unlike traditional insulin, which activates insulin receptors, INS-7 blocks these receptors, leading to a cascade of events that stop the production of the fat-burning hormone FLP-7.

    About Caenorhabditis elegans (C. elegans):

    Details
    Overview A small, free-living nematode (roundworm) used as a model organism in biological research.
    Size Approximately 1 millimeter in length.
    Habitat Found in soil environments worldwide.
    Reproduction Primarily self-fertilizing hermaphrodites; males make up a small percentage and can mate with hermaphrodites.
    Genome First multicellular organism to have its genome fully sequenced; about 20,000 genes.
    Chromosomes Six chromosomes (five autosomes, one sex chromosome).
    Body Plan Approximately 1,000 cells in an adult hermaphrodite; transparent body allows for easy microscopic observation.
    Lifespan Around 2 to 3 weeks under laboratory conditions.
    Research Contributions Instrumental in discoveries related to apoptosis, RNA interference, gene regulation, and human diseases.

     

    PYQ:

    [2013] Improper handling and storage of cereal grains and oilseeds result in the production of toxins known as aflatoxins which are not generally destroyed by normal cooking process. Aflatoxins are produced by:

    (a) Bacteria

    (b) Protozoa

    (c) Moulds

    (d) Viruses

  • [pib] Novel Nanopolymer developed by INST Mohali

    Why in the News

    Researchers at the Institute of Nano Science and Technology (INST) Mohali, have developed novel electrochemical and optical sensors using a new group of nano polymer materials.

    About the Novel Nanopolymer:

    Novel nanopolymers are innovative polymer materials that incorporate nanostructures or nanoparticles to impart unique properties.

    • They are prepared using various methods like vapor condensation, vacuum evaporation, electrospinning, and chemical synthesis to create nanofibers, core-shell structures, hollow fibers, and tubes with diameters down to a few nanometers.
    • Examples: Silicon nanospheres that are much harder than regular silicon, with hardness between sapphire and diamond, and bio-based N-heterocyclic poly(aryl ether ketone) with high biomass content and superior properties
    • Applications of Novel Nanopolymers:
      • Biosensors and optoelectronics utilizing the fluorescence and magnetic properties of nanoparticles.
      • Drug delivery, tissue engineering, and gene therapy using biodegradable nanoparticle systems.
      • Forensics for drug detection, fingerprinting, DNA analysis, and sensors.
      • High-temperature-resistant plastics with improved properties.

    These are the Novel Nanopolymers developed by INST:

    Metal-Organic Frameworks (MOFs) 2-dimensional (2D) Materials
    Details Crystalline materials with metal ions and organic ligands form porous structures. Materials a few atomic layers thick with unique electrical, optical, and mechanical properties.
    Surface Area Extremely high (over 10,000 m²/g), ideal for adsorption. High surface-to-volume ratio, enhancing interactions for sensing and energy storage.
    Versatility Customizable for gas storage, separation, catalysis, and sensing. Functionalizable for bio-sensing and environmental monitoring.
    Properties High porosity and stability in harsh environments. Excellent conductivity, flexibility, and strength, useful in electronics and optoelectronics.
    Sensing Applications Detects gases, toxins, and biomarkers with high sensitivity. Detects gases, biomolecules, and pollutants quickly and efficiently.
    Examples Various MOFs designed for specific uses. Includes graphene, MoS2, MXenes.

     

    PYQ:

    [2015] With reference to the use of nanotechnology in health sector, which of the following statements is/are correct?

    1. Targeted drug delivery is made possible by nanotechnology.

    2. Nanotechnology can largely contribute to gene therapy.

    Select the correct answer using the codes given below:

    (a) 1 only

    (b) 2 only

    (c) Both 1 and 2

    (d) Neither 1 nor 2

  • Study reveals intriguing Magnetic behavior on Mars

    Why in the News?

    A study conducted by the Indian Institute of Geomagnetism (IIG) revealed significant variations in the strength of Mars’ crustal magnetic field between day and night.

    Notable facts about Mars:

    • Mars is the fourth planet from the Sun and the second-smallest in the Solar System, larger only than Mercury.
    • Named after the Roman god of war, Mars is often called the “Red Planet” due to its reddish appearance from iron oxide on its surface.
    • It is a terrestrial planet with a thin atmosphere, featuring surface characteristics like impact craters, valleys, deserts, and polar ice caps.
    • Mars shares similar days and seasons to Earth because of its comparable rotational period and axial tilt.
    • It hosts Olympus Mons, the largest volcano and highest mountain on any planet, and Valles Marineris, one of the largest canyons in the Solar System.

    Key Findings on Mars’s Magnetic 

    • Mars’ crustal magnetic field is significantly stronger during the daytime and nearly non-existent at night-time.
      • This suggests a diurnal variation in the magnetic field strength on the Martian surface.
    • The crustal magnetic field of Mars is primarily located in the southern hemisphere, specifically poleward of 30°S latitude.
    • The magnetic fields are scattered within a region between 120° E and 240° E, indicating uneven distribution across the Martian surface.
    • The daytime crustal magnetic field plays a crucial role in controlling the ionosphere in Mars’ southern hemisphere.
    • This influence impacts communication and navigation systems of future missions.

    Data Utilization from MAVEN Satellite:

    • The study utilized data from the MAVEN (Mars Atmosphere and Volatile EvolutioN) Satellite, which has been orbiting Mars since 2014.
    • MAVEN’s data on electron density and magnetic field were critical in investigating how Mars’ crustal magnetic field affects its plasma environment and ionosphere.

    Significance of the Study

    • Understanding Mars’ crustal magnetic field is essential for future robotic and manned missions, as it provides natural magnetic shielding against space radiation.
    • The insights from the study can help in developing strategies to mitigate the effects of space weather on spacecraft and astronauts.

    PYQ:

    [2016] The Mangalyaan launched by ISRO

    1. is also called the Mars Orbiter Mission.
    2. made India the second country to have a spacecraft orbit the Mars after USA
    3. made India the only country to be successful in making its spacecraft orbit Mars in its very first attempt.

    Which of the statements given above is/are correct?

    (a) 1 only
    (b) 2 and 3 only
    (c) 1 and 3 only
    (d) 1, 2 and 3

  • Sharpening India’s anti-tuberculosis fight     

    Why in the News?

    In the present context, in India, there are groundbreaking new treatments available, but we need to rethink and update the program to eliminate TB.

    Current status of TB in India: 

    • Incidence Rate: As of 2022, the incidence rate of TB in India was reported at 199 cases per 100,000 population, a decline from 237 per lakh population in 2015. This reflects a 16% decrease in new TB cases since 2015.
    • Prevalence: The estimated prevalence of tuberculosis infection (TBI) among individuals over 15 years of age was around 31% according to a national survey conducted from 2019 to 2021. 
    • Global Contribution: India accounted for approximately 26% of the global incidence of TB cases in 2020. In that year, India also represented 38% of global TB deaths among HIV-negative individuals.
    • Mortality Rate: The mortality rate due to TB decreased from 28 per lakh population in 2015 to 23 per lakh population in 2022, indicating progress in managing the disease.
    • Total Cases: Estimates suggest that the total number of TB cases in India has increased from 2.2 million to 2.6 million in recent years, reflecting ongoing challenges in detection and treatment.

    What were the problems with previous Extended Treatment Regimen?

    • Lengthy and Complex: Traditional TB treatment regimens are long and require patients to take 13 to 14 tablets daily for 9 to 11 months, or 4 to 5 tablets daily for 18 to 24 months.
    • Severe Side Effects: These regimens are physically and psychologically draining, causing side effects like loss of hearing and psychosis.
    • Economic Impact: Prolonged treatment leads to loss of employment and drives many families into poverty due to the need for frequent clinic visits.

    WHO-Recommended Effective Regimen:

    • BPaL/M Regimen: WHO has recommended a shorter, safer, and more effective regimen called BPaL/M for drug-resistant TB patients.
    • Advantages: This regimen requires only 3 to 4 tablets daily for six months, with fewer side effects and higher success rates (89% compared to 68% for traditional treatments).
      • Close to 80 countries have procured the BPaL/M regimen, and 20 high-burden countries are already rolling it out.

     

    Present TB Elimination Policy in India:

    • The deficiency in the NTP was identified in 1963 and the Revised National TB Control Programme was developed.
    • Presently, India’s National TB Elimination Programme 2023 is leading the effort to meet the goal of eliminating TB by 2025, five years ahead of the SDGs.
    • Ending the TB epidemic by 2030 is among the health targets of the UN’s Sustainable Development Goals.

    How India can make the best use of new treatments?

    • Proactive Screening and Diagnosis: Focus on modernizing health datasets, GIS mapping, and conducting targeted multi-disease screening drives, especially in vulnerable populations (e.g., those with comorbidities, slum dwellers, and prisoners).
    • Advanced Diagnostic Tools: Expand the use of portable X-ray machines with AI-driven tools and rapid molecular tests for faster and more accurate detection and drug resistance profiling.
    • Early Detection and Treatment: Leveraging new technologies and proactive measures will help improve TB detection rates, reduce delays, and enhance treatment outcomes, ultimately aiding in the elimination of TB in India.

    Conclusion: India need to invest in advanced diagnostic tools like AI-driven portable X-ray machines and rapid molecular tests to ensure early and accurate detection of TB, particularly in high-risk and underserved populations, to support timely treatment and reduce TB incidence.

    Mains PYQ:

    Q Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved. (UPSC IAS/2014)