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GS Paper: GS3-17.Awareness in the fields of IT, Space, Computers, Robotics, Nano-technology, Bio-technology and issues relating to Intellectual Property Rights.

  • What is Gain-of-Function Research?

    With the re-emergence of the Wuhan lab-leak origin theory, questions are also being raised on what gain-of-function research is, and whether the benefits of conducting such research outweigh the risks of pathogens escaping from labs.

    What is gain-of-function research?

    • In virology, gain-of-function research involves deliberately altering an organism in the lab, altering a gene, or introducing a mutation in a pathogen to study its transmissibility, virulence and immunogenicity.
    • It is believed that this allows researchers to study potential therapies, vaccine possibilities and ways to control the disease better in future.
    • Gain-of-function research involves manipulations that make certain pathogenic microbes more deadly or more transmissible.
    • This is done by genetically engineering the virus and by allowing them to grow in different growth mediums, a technique called as serial passage.

    Antithesis to this theory

    • There is also ‘loss-of-function’ research, which involves inactivating mutations, resulting in a significant loss of original function, or no function to the pathogen.
    • When mutations occur, they alter the structure of the virus that is being studied, resulting in altered functions. Some of these significant mutations might weaken the virus or enhance its function.

    Associated risks

    • Some forms of gain-of-function research reportedly carry inherent biosafety and biosecurity risks and are thus referred to as ‘dual-use research of concern’ (DURC).
    • This indicates that while the research may result in benefits for humanity, there is also the potential to cause harm — accidental or deliberate escape of these altered pathogens from labs may cause even pandemics.

    Essential component of vaccine development

    • The current medical countermeasures are often insufficient largely because of resistance mechanisms that lead to ‘escape mutants’, i.e., drug-resistant strains.
    • There is, hence, a continual need to develop new antiviral drugs and additional options, such as immunotherapy, based on neutralizing monoclonal antibodies.
    • Ultimately, gain-of-function studies, which enhance viral yield and immunogenicity, are required for vaccine development.

    What is the situation in India?

    • In India, all activities related to genetically engineered organisms or cells and hazardous microorganisms and products are regulated as per the “Manufacture, Use, Import, Export and Storage of Hazardous Microorganisms/Genetically Engineered Organisms or Cells Rules, 1989”.
    • Last year, the Department of Biotechnology issued guidelines for the establishment of containment facilities, called ‘Biosafety labs’, at levels two and three.
    • The notification provides operational guidance on the containment of biohazards and levels of biosafety that all institutions involved in research, development and handling of these microorganisms must comply with.

    Should research continue?

    • Scientists have differing opinions on the issue, particularly since the emergence of the COVID-19 pandemic.
    • While those on the side of gain-of-function research say that it makes science and governments battle-ready for future pandemics, there have been a rising number of calls to suspend such research.
    • Proponents of gain-of-function research believe that “nature is the ultimate bioterrorist and we need to do all we can to stay one step ahead”.
    • Some researchers thinks it is time to stop such research.
    • Science policymakers “must wrestle with defining the rare instances in which the benefits of experiments that enhance a virus’s capacity to survive and flourish in human hosts outweigh any risks.

  • A place for disruptive technology in India’s health sector

    The adoption of technologies such as AI and blockchain has the potential to transform the medical sector. 

    How new technologies can play important role in medical sector

    1) Blockchain technology

    • Blockchain technology can help in addressing the interoperability challenges that health information and technology systems face.
    • The health blockchain would contain a complete indexed history of all medical data, including formal medical records and health data from mobile applications and wearable sensors.
    • This can also be stored in a secure network and authenticated, besides helping in seamless medical attention.

    2) Big data analytics

    • Big data analytics can help improve patient-based services tremendously such as early disease detection.
    • AI and the Internet of Medical Things, or IoMT are shaping healthcare applications.
    • IoMT is defined as a connected infrastructure of medical devices, software applications, and health systems and services.

    3) Medical autonomous system

    • Medical autonomous systems can also improve health delivery to a great extent and their applications are focused on supporting medical care delivery in dispersed and complex environments with the help of futuristic technologies.
    • This system may also include autonomous critical care system, autonomous intubation, autonomous cricothyrotomy and other autonomous interventional procedures.

    4) Cloud computing

    • Cloud computing is another application facilitating collaboration and data exchanges between doctors, departments, and even institutions and medical providers to enable best treatment.

    Challenges

    • The possible constraints in this effort are standardisation of health data, organisational silos, data security and data privacy, and also high investments.

    Using technology for Universal Health Coverage

    • According to the World Health Organization, Universal health coverage (UHC) is a powerful social equalizer and the ultimate expression of fairness.
    • Studies by WHO show that weakly coordinated steps may lead to stand-alone information and communication technology solutions.
    • India needs to own its digital health strategy that works and leads towards universal health coverage and person-centred care.
    • Such a strategy should emphasise the ethical appropriateness of digital technologies, cross the digital divide, and ensure inclusion across the economy.
    • ‘Ayushman Bharat’ and tools such as Information and Communication Technology could be be fine-tuned with this strategy to promote ways to protect populations.
    • Online consultation should be a key part of such a strategy.

    Using local knowledge

    • In addition to effective national policies and robust health systems, an effective national response must also draw upon local knowledge.
    • Primary health centres in India could examine local/traditional knowledge and experience and then use it along with modern technology.

    Way forward

    • Initial efforts in this direction should involve synchronisation and integration, developing a template for sharing data, and reengineering many of the institutional and structural arrangements in the medical sector.
    • Big data applications in the health sector should help hospitals provide the best facilities and at less cost, provide a level playing field for all sectors, and foster competition.

    Consider the question “Examine the role technologies such as AI and data analytics could play in the medical sector. What are the challenges in the adoption of such technologies?”

    Conclusion

    The above-discussed aspects highlight the potential benefits of the adoption of disruptive technologies in the healthcare system. India should embrace it while addressing the concerns with such technologies.

  • [pib] Space-time induces Neutrino Oscillations

    Indian scientists have shown that the geometry of space-time can cause neutrinos to oscillate.

    What are Neutrinos?

    • A neutrino is a subatomic particle that is very similar to an electron but has no electrical charge and a very small mass, which might even be zero.
    • Since neutrinos are electrically neutral, they are not affected by the electromagnetic forces which act on electrons. Hence, they are also called Ghost Particles.
    • Neutrinos are affected only by a “weak” sub-atomic force of a much shorter range than electromagnetism and are therefore able to pass through great distances in matter without being affected by it.
    • They are also one of the most abundant particles in the universe. As they have very little interaction with matter, however, they are incredibly difficult to detect.

    Answer this PYQ in the comment box:

    Q.The known forces of nature can be divided into four classes, viz, gravity, electromagnetism, weak nuclear force and strong nuclear force. With reference to them, which one of the following statements is not correct?

    (a) Gravity is the strongest of the four

    (b) Electromagnetism act only on particles with an electric charge

    (c) Weak nuclear force causes radioactivity

    (d) Strong nuclear force holds protons and neutrons inside the nuclear of an atom

    Finding of the new research

    • Neutrinos are mysterious particles, produced copiously in nuclear reactions in the Sun, stars, and elsewhere.
    • They “oscillate”- meaning that different types of neutrinos change into one another – as has been found in many experiments.
    • Probing of oscillations of neutrinos and their relations with mass are crucial in studying the origin of the universe.
    • Neutrinos interact very weakly with everything else – trillions of them pass through every human being every second without anyone noticing.
    • A neutrino’s spin always points in the opposite direction of its motion, and until a few years ago, neutrinos were believed to be massless.

    What makes this possible?

    • The geometry of space-time can cause neutrino oscillations through quantum effects even if neutrinos are massless.
    • Einstein’s theory of general relativity says that gravitation is the manifestation of space-time curvature.
    • Neutrinos, electrons, protons and other particles which are in the category of fermions show a certain peculiarity when they move in presence of gravity.
    • Space-time induces a quantum force in addition to gravity between every two fermions.
    • This force can depend on the spin of the particles and causes massless neutrinos to appear massive when they pass through matter, like the Sun’s corona or the Earth’s atmosphere.
    • Something similar happens for electroweak interactions, and together with the geometrically induced mass, it is enough to cause oscillation of neutrinos.

  • India to launch Deep Ocean Mission

    The Union Cabinet has approved the long-pending Deep Ocean Mission since 2018.

    Deep Ocean Mission (DOM)

    • Nodal Agency: Ministry of Earth Sciences (MoES)
    • The mission proposes to explore the deep ocean similar to the space exploration started by ISRO.
    • Underwater robotics and ‘manned’ submersibles are key components of the Mission which will help India harness various living and non-living (water, mineral and energy) resources from the seabed and deep water.
    • The tasks that will be undertaken over this period include deep-sea mining, survey, energy exploration and offshore-based desalination.
    • These technological developments are funded under an umbrella scheme of the government – called Ocean Services, Technology, Observations, Resources Modelling and Science (O-SMART).

    Six major components

    (1) Development of Technologies for Deep Sea Mining, and Manned Submersible:

    • A manned submersible will be developed to carry three people to a depth of 6000 metres in the ocean with suite of scientific sensors and tools.
    • Only a very few countries have acquired this capability.
    • An Integrated Mining System will be also developed for mining Polymetallic Nodules from 6000 m depth in the central Indian Ocean.

    (2) Development of Ocean Climate Change Advisory Services:

    • A suite of observations and models will be developed to understand and provide future projections of important climate variables on seasonal to decadal time scales under this proof of concept component.
    • This component will support the Blue Economy priority area of coastal tourism.

    (3) Technological innovations for exploration and conservation of deep-sea biodiversity:

    • Bio-prospecting of deep-sea flora and fauna including microbes and studies on sustainable utilization of deep-sea bio-resources will be the main focus.
    • This component will support the Blue Economy priority area of Marine Fisheries and allied services.

    (4) Deep Ocean Survey and Exploration:

    • The primary objective of this component is to explore and identify potential sites of multi-metal Hydrothermal Sulphides mineralization along the Indian Ocean mid-oceanic ridges.
    • This component will additionally support the Blue Economy priority area of deep-sea exploration of ocean resources.

    (5) Energy and freshwater from the Ocean:

    • Studies and detailed engineering design for offshore Ocean Thermal Energy Conversion (OTEC) powered desalination plant are envisaged in this proof of concept proposal.
    • This component will support the Blue Economy priority area of offshore energy development.

    (6) Advanced Marine Station for Ocean Biology:

    • This component is aimed at the development of human capacity and enterprise in ocean biology and engineering.
    • This component will translate research into the industrial application and product development through on-site business incubator facilities.
    • This component will support the Blue Economy priority area of Marine Biology, Blue trade and Blue manufacturing.

    Why need such a mission?

    • Oceans, which cover 70 per cent of the globe, remain a key part of our life. About 95 percent of the Deep Ocean remains unexplored.
    • For India, with its three sides surrounded by the oceans and around 30 per cent of the country’s population living in coastal areas.
    • The ocean is a major economic factor supporting fisheries and aquaculture, tourism, livelihoods and blue trade.
    • Oceans are also a storehouse of food, energy, minerals, medicines, modulator of weather and climate and underpin life on Earth.

    Pre-requisites to this mission

    • India has been allotted a site of 75,000 square kilometres in the Central Indian Ocean Basin (CIOB) by the UN International Sea Bed Authority for the exploitation of polymetallic nodules (PMN).

    Hunt for PMNs

    • These are rocks scattered on the seabed containing iron, manganese, nickel and cobalt.
    • Being able to lay hands on a fraction of that reserve can meet the energy requirement of India for the next 100 years.
    • It has been estimated that 380 million metric tonnes of polymetallic nodules are available at the bottom of the seas in the Central Indian Ocean.
    • India’s Exclusive Economic Zone spreads over 2.2 million square kilometers.

  • New Shephard rocket system for cost-effective access to space

    Last week, Amazon founder and billionaire Jeff Bezos’s space company called Blue Origin concluded the online auction for the first seat on New Shephard, a rocket system meant to take tourists to space.

    What is New Shephard?

    • New Shephard has been named after astronaut Alan Shephard – the first American to go to space – and offers flights to space over 100 km above the Earth and accommodation for payloads.
    • Essentially, it is a rocket system that has been designed to take astronauts and research payloads past the Karman line – the internationally recognized boundary of space.
    • The idea is to provide easier and more cost-effective access to space meant for purposes such as academic research, corporate technology development, and entrepreneurial ventures among others.
    • Apart from its academic and research-oriented goal, New Shephard will also allow space tourists to experience microgravity by taking them 100 km above the Earth.

    Its components

    • The rocket system consists of two parts, the cabin or capsule, and the rocket or the booster.
    • The cabin can accommodate experiments from small Mini Payloads up to 100 kg.
    • As per Blue Origin, the Mini Payloads provide easier space access to students, who are part of educational institutions that are developing their own space programs.
    • Further, the cabin is designed for six people and sits atop a 60 feet tall rocket and separates from it before crossing the Karman line, after which both vehicles fall back to the Earth.
    • All the six seats in the capsule are meant for passengers, each of whom gets their own window seat. The capsule is fully autonomous and does not require a pilot.

    How does it work?

    • The system is a fully reusable, vertical takeoff and vertical landing space vehicle that accelerates for about 2.5 minutes before the engine cuts off.
    • After separating from the booster, the capsule free falls in space, while the booster performs an autonomously controlled vertical landing back to Earth.
    • The capsule, on the other hand, lands back with the help of parachutes.

    A boost for space tourism

    • Space tourism seeks to give laypeople the ability to go to space for recreational, leisure, or business purposes.
    • The idea is to make space more accessible to those individuals who are not astronauts and want to go to space for non-scientific purposes.

  • Synthetic biology and its implications for national security

    Against the backdrop of the Covid-19 pandemic, the article discusses the national security threat emanating from biological weapons.

    Synthetic biology

    • Synthetic biology is a revolutionary technology that can help us manipulate biological organisms and processes for human betterment, especially in treating diseases, by re-engineering cells.
    •  In 2014, the U.S. Department of Defense categorised synthetic biology as one of the six ‘disruptive basic research areas’.
    • Unlike the nuclear domain, the fields of biology or synthetic biology are not regulated internationally despite growing military interest in it.

    Risks involved

    • There is the possibility of deliberate misuse of synthetic biology.
    • There is a need to carefully review, especially in the wake of the pandemic, the biosecurity systems in place where such technologies are in use.
    • Accidental leaks of experimental pathogens are another concern.
    • There has been very little focus on threats emanating from biological sources as compared to the focus on nuclear weapons.
    • This is despite the fact that a well-orchestrated biological attack could have serious implications.
    • This was before synthetic biology came into play.
    • A well-planned attack using highly infectious pathogens synthetically engineered in a lab could be disastrous.
    • It would be difficult to pin responsibility on a specific actor if the incubation period is high,

    BTWC: An inadequate mechanism for regulation

    • Despite being the weapon of mass destruction (WMD) safety and security attention given to bio-weapons is not at par with nuclear and chemical weapons.
    • There is an international convention and an implementing body for both nuclear and chemical weapons.
    • However, for bio-weapons, all we have is the Biological and Toxin Weapons Convention (BTWC) of 1972 with no implementing body.
    • The BTWC does not have a verification clause, nor does it have clearly laid down rules and procedures to guide research in this field.
    • Article 1 of the BTWC bans bio-weapons but research for medical and bio-defence purposes are allowed.
    • While this is understandable, the problem is that there is a thin line between bio-defence research and bio-weapons research. 
    • An Ad Hoc Group set up in 1994 to negotiate a Protocol to enhance the transparency of treaty-relevant biological facilities and activities to help deter violations of the BTWC submitted a report at the Fifth BTWC Review Conference in 2001 but was not accepted by the member states.

    Concerns for India

    • India is at a uniquely disadvantaged position in this area given poor disease surveillance, insufficient coordination among various government departments dealing with biosecurity issues, and the pathetic state of the healthcare system.
    • India has multiple institutions dealing with biosafety and biosecurity threats but there is no coordination among them.
    • Given the rising risk of diseases of zoonotic origin, the traditional ministry-wise separation might not be useful.
    •  India, with its porous borders and ill-trained border control institutions, will remain vulnerable to pathogens or dangerous biological organisms.

    Way forward

    • Pandemics have also highlighted that the traditional distinction at the international institutional level between biological weapons (a field governed by the BTWC) and diseases (governed by BTWC) may not be useful anymore.
    • There needs to be more conversation between health specialists and bio-weapons/defence specialists.
    • The November 2021 BTWC review conference must take stock of the advances in the field, address the thinning line between biotechnology research and bio-weapons research, and consider international measures for monitoring and verification.

    Consider the question “How synthetic biology poses security challenges for India and the rest of the world? Suggest the measures to deal with this challenge.” 

    Conclusion

    Covid-19 should serve as a wake-up call to give BTWC more teeth in dealing with the bio-weapons with a suitable institutional mechanism.

  • Polar-Areas Stellar-Imaging in Polarisation High-Accuracy Experiment (PASIPHAE)

    The development of a vital instrument PASIPHAE, which will be used in upcoming sky surveys to study stars, is being led by an Indian astronomer.

    What is PASIPHAE?

    • PASIPHAE stands for Polar-Areas Stellar-Imaging in Polarisation High-Accuracy Experiment.
    • It is an international collaborative sky surveying project. Scientists aim to study the polarisation in the light coming from millions of stars.
    • The name is inspired by Pasiphae, the daughter of Greek Sun God Helios.
    • The survey will use two high-tech optical polarimeters to observe the northern and southern skies, simultaneously.
    • It will focus on capturing starlight polarisation of very faint stars that are so far away that polarisation signals from there have not been systematically studied.
    • By combining the data, astronomers will perform a maiden magnetic field tomography mapping of the interstellar medium of very large areas of the sky using a novel polarimeter instrument known as WALOP.

    Why is PASIPHAE important?

    • Since its birth about 14 billion years ago, the universe has been constantly expanding, as evidenced by the presence of Cosmic Microwave Background (CMB) radiation which fills the universe.
    • Immediately after its birth, the universe went through a short inflationary phase during which it expanded at a very high rate before it slowed down and reached the current rate.
    • However, so far, there have only been theories and indirect evidence of expansion associated with the early universe.
    • A definitive consequence of the inflationary phase is that a tiny fraction of the CMB radiation should have its imprints in the form of a specific kind of polarisation (known scientifically as a B-mode signal).
    • All previous attempts to detect this signal met with failure mainly due to the difficulty posed by our galaxy, the Milky Way, which emits copious amounts of polarized radiation.
    • Besides, it contains a lot of dust clouds that are present in the form of clusters. When starlight passes through these dust clouds, they get scattered and polarized.

    What will PASIPHAE do?

    • The PASIPHAE survey will measure starlight polarisation over large areas of the sky.
    • This data along with distances to the stars will help create a 3-Dimensional model of the distribution of the dust and magnetic field structure of the galaxy.
    • Such data can help remove the galactic polarized foreground light and enable astronomers to look for the elusive B-mode signal.

    What is WALOP?

    • Wide Area Linear Optical Polarimeter (WALOP) is an instrument when mounted on two small optical telescopes, that will be used to detect polarized light signals emerging from the stars along high galactic latitudes.
    • The images will simultaneously have the finest of details of a star along with its panoramic background.
    • WALOP will operate on the principle that at any given time, the data from a portion of the sky under observation will be split into four different channels.
    • Depending on the manner in which light passes through the four channels, the polarisation value from the star is obtained.
    • That is, each star will have four corresponding images which when stitched together will help calculate the desired polarisation value of a star.

  • Species in news: Bharitalasuchus Tapani

    In the mid 20th century, researchers from the Indian Statistical Institute, Kolkata, carried out extensive studies on rocks of the Yerrapalli Formation in what is now Telangana, uncovering several fossils of Bharitalasuchus Tapani.

    Bharitalasuchus Tapani

    • This reptile belongs to a genus and species previously unknown to science. It is named Bharitalasuchus tapani considering Telugu etymology.
    • In the Telugu language, Bhari means huge, Tala means head, and Suchus is the name of the Egyptian crocodile-headed deity.
    • The species is named after paleontologist Tapan Roy Chowdhury in honour of his contribution to Indian vertebrate paleontology and especially his extensive work on the Yerrapalli Formation tetrapod fauna.

    Details of the reptile

    • The reptile belonged to a family of extinct reptiles named Erythrosuchidae.
    • A precise identification had not been possible earlier because the family was not known from other examples in India.
    • It was neglected because the fossil specimen was not as complete as those of other erythrosuchids from other countries.
    • The team notes that tapani were robust animals with big heads and large teeth, and these probably predated other smaller reptiles.
    • They were approximately the size of an adult male lion and might have been the largest predators in their ecosystems.

  • EnVision Mission to Venus

    Following NASA’s footsteps, the European Space Agency (ESA) announced that it has selected EnVision as its next orbiter that will visit Venus sometime in the 2030s.

    Last week, NASA selected two missions to the planet Venus, Earth’s nearest neighbour. The missions called DAVINCI+ and VERITAS have been selected based on their potential for scientific value and the feasibility of their development plans.

    What is EnVision?

    • EnVision is an ESA-led mission with contributions from NASA. It is likely to be launched sometime in the 2030s.
    • The earliest launch opportunity for EnVision is 2031, followed by 2032 and 2033.
    • Once launched on an Ariane 6 rocket, the spacecraft will take about 15 months to reach Venus and will take 16 more months to achieve orbit circularization.
    • The spacecraft will carry a range of instruments to study the planet’s atmosphere and surface, monitor trace gases in the atmosphere and analyses its surface composition.

    What are other such missions?

    • EnVision will follow another ESA-led mission to Venus called ‘Venus Express’ (2005-2014) that focused on atmospheric research and pointed to volcanic hotspots on the planet’s surface.
    • Other than this, Japan’s Akatsuki spacecraft has also been studying the planet’s atmosphere since 2015.

    Why are scientists interested in studying Venus?

    • At the core of the ESA’s mission is the question of how Earth and Venus evolved so differently from each other considering that they are roughly of the same size and composition.
    • Venus is the hottest planet in the solar system because of the heat that is trapped by its thick cloud cover.
    • Last year, a team of scientists reported that they had found phosphine gas (a chemical produced only through biological processes) in the atmosphere of Venus.
    • This triggered excitement in the scientific community that some life forms might be supported by the planet.
    • But the existence of life on the planet is nearly impossible given the high temperatures of Venus and its acidic atmosphere.

    Back2Basics: Venus Planet

    • For those on Earth, Venus is the second-brightest object in the sky after the moon.
    • It appears bright because of its thick cloud cover that reflects and scatters light.
    • But while Venus, which is the second closest planet to the Sun, is called the Earth’s twin because of their similar sizes, the two planets have significant differences between them.
    • For one, the planet’s thick atmosphere traps heat and is the reason that it is the hottest planet in the solar system, despite coming after Mercury, the closest planet to the Sun.
    • Surface temperatures on Venus can go up to 471 degrees Celsius, which is hot enough to melt lead.
    • Further, Venus moves forward on its orbit around the Sun but spins backwards around its axis slowly.
    • This means on Venus the Sun rises in the west and sets in the East.
    • One day on Venus is equivalent to 243 Earth days because of its backward spinning, opposite to that of the Earth’s and most other planets.
    • Venus also does not have a moon and no rings.

  • CHIME Telescope

    Scientists with the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Collaboration have assembled the largest collection of fast radio bursts (FRBs) in the telescope’s first FRB catalog.

    CHIME Telescope

    • CHIME is an interferometric radio telescope at the Dominion Radio Astrophysical Observatory in British Columbia, Canada.
    • It consists of four antennas consisting of 100 x 20-meter cylindrical parabolic reflectors with 1024 dual-polarization radio receivers suspended on support above them.
    • The telescope receives radio signals each day from half of the sky as the Earth rotates.
    • While most radio astronomy is done by swiveling a large dish to focus light from different parts of the sky, CHIME stares, motionless, at the sky, and focuses incoming signals using a correlator.
    • This is a powerful digital signal processor that can work through huge amounts of data, at a rate of about seven terrabytes per second, equivalent to a few percent of the world’s Internet traffic.

    What are FRBs?

    • FRBs are oddly bright flashes of light, registering in the radio band of the electromagnetic spectrum, which blaze for a few milliseconds before vanishing without a trace.
    • These brief and mysterious beacons have been spotted in various and distant parts of the universe, as well as in our own galaxy.
    • Their origins are unknown and their appearance is highly unpredictable.
    • But the advent of the CHIME project has nearly quadrupled the number of fast radio bursts discovered to date.
    • With more observations, astronomers hope soon to pin down the extreme origins of these curiously bright signals.