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GS Paper: GS3-17.Awareness in the fields of IT, Space, Computers, Robotics, Nano-technology, Bio-technology and issues relating to Intellectual Property Rights.

  • FELUDA test for Covid-19

    Union Health Ministry will soon roll out the FELUDA paper strip test for SARS-CoV-2 diagnosis.

    Try this PYQ:

    Q.What is Cas9 protein that is often mentioned in news?

    (a) A molecular scissors used in targeted gene editing

    (b) A biosensor used in the accurate detection of pathogens in patients

    (c) A gene that makes plants pest-resistant

    (d) A herbicidal substance synthesized in genetically modified crops

    FELUDA test

    • FELUDA is the acronym for FNCAS9 Editor Linked Uniform Detection Assay.
    • It uses indigenously developed CRISPR gene-editing technology to identify and target the genetic material of SARS-CoV2, the virus that causes Covid-19.
    • According to CSIR, the test matches accuracy levels of RT-PCR tests, considered the gold standard in the diagnosis of Covid-19, has a quicker turnaround time and requires less expensive equipment.
    • It is also the world’s first diagnostic test to deploy a specially adapted Cas9 protein to successfully detect the virus.

    How does it work?

    • The Feluda test is similar to a pregnancy test strip that will just change colour upon detection of the virus and can be used in a simple pathological lab.
    • The Cas9 protein is bar-coded to interact with the SARS-CoV2 sequence in the patient’s genetic material.
    • The Cas9-SARS-CoV2 complex is then put on the paper strip, where using two lines (one control, one test) makes it possible to determine if the test sample was infected.

    Back2Basics: CRISPR technology

    • CRISPR is a short form for Clustered Regularly Interspaced Short Palindromic Repeats.
    • It is a gene-editing technology and finds its use in correcting genetic defects and treating and preventing the spread of diseases.
    • The technology can detect specific sequences of DNA within a gene and uses an enzyme functioning as molecular scissors to snip it.
    • It also allows researchers to easily alter DNA sequences and modify gene function.
    • Moreover, the technology can also be configured for detection of multiple other pathogens in the future.

  • What is Raychaudhuri Equation?

    The Raychaudhuri Equation in General Relativity, derived by Raychaudhuri is in the spotlight after 2020 Physics Nobel was awarded to Penrose for throwing light on Black Holes.

    Try this MCQ:

    Q.The Raychaudhuri Equation is sometimes seen in news is related to:

    Artificial Intelligence/Cloud Computing/Quantum Mechanics/Space Sciences

    What is Raychaudhuri Equation?

    • Raychaudhuri (1923–2005) was an Indian physicist, known for his research in general relativity and cosmology.
    • In general relativity, the Raychaudhuri equation is a fundamental result describing the motion of nearby bits of matter.
    • It was discovered independently by the Indian physicist Amal Kumar Raychaudhuri and the Soviet physicist Lev Landau.
    • The equation offers a simple and general validation of our intuitive expectation that gravitation should be a universal attractive force between any two bits of mass-energy in general relativity, as it is in Newton’s theory of gravitation.

  • [pib] Bio-Pesticide Formulation using Verticillium Lecanii

    Indian researchers have successfully developed new Aqueous Suspension formulation technology of bio-pesticide based on entomopathogenic fungus Verticillium lecanii.

    Try this PYQ:

    Q.Recently, there was a growing awareness in our country about the importance of Himalayan nettle (Girardinia diversifolia) because it is found to be a sustainable source of

    (a) anti-malarial drug

    (b) biodiesel

    (c) pulp for paper industry

    (d) textile fibre

    Verticillium lecanii

    • This bio-pesticide formulation has been found very effective in controlling various insects in seed spice crops (fenugreek, cumin, and coriander).
    • It has a good shelf life, safe to user & environment and it may be effectively used for controlling different agricultural insects especially in seed spice crops.
    • This bio-pesticide may be used as a safer alternative to chemical pesticides to minimize pesticide residue problem.
    • Besides, it may be used as a key input for crop protection from insects pest in organic agriculture and Integrated Pest Management.

  • Nobel Prize in Chemistry for CRISPR Technology

    French-American duo Emmanuelle Charpentier and Jennifer Doudna have been awarded the 2020 Nobel Prize for the chemistry of CRISPR, which allows scientists to ‘cut-paste’ inside a genetic sequence.

    Try this PYQ:

    Q.What is Cas9 protein that is often mentioned in news?

    (a) A molecular scissors used in targeted gene editing

    (b) A biosensor used in the accurate detection of pathogens in patients

    (c) A gene that makes plants pest-resistant

    (d) A herbicidal substance synthesized in genetically modified crops

    The CRISPR technology

    • The CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, developed in the year 2012
    • CRISPR has made gene editing very easy and simple, and at the same time extremely efficient.
    • The technology works in a simple way — it locates the specific area in the genetic sequence which has been diagnosed to be the cause of the problem, cuts it out, and replaces it with a new and correct sequence that no longer causes the problem.
    • The technology replicates a natural defence mechanism in some bacteria that use a similar method to protect itself from virus attacks.

    Working of CRISPR

    • An RNA molecule is programmed to locate the particular problematic sequence on the DNA strand.
    • A special protein called Cas9, often described in popular literature as ‘genetic scissor’, is used to break and remove the problematic sequence.
    • A DNA strand, when broken, has a natural tendency to repair itself. But the auto-repair mechanism can lead to the re-growth of a problematic sequence.
    • Scientists intervene during this auto-repair process by supplying the desired sequence of genetic codes, which replaces the original sequence.
    • It is like cutting a portion of a long zipper somewhere in between and replacing that portion with a fresh segment.
    • Because the entire process is programmable, it has a remarkable efficiency and has already brought almost miraculous results.

    Uses of CRISPR

    • There are a whole lot of diseases and disorders, including some forms of cancer, that are caused by an undesired genetic mutation.
    • These can all be fixed with this technology. There are vast applications elsewhere as well. Genetic sequences of disease-causing organisms can be altered to make them ineffective.
    • Genes of plants can be edited to make them withstand pests, or improve their tolerance to drought or temperature.

    Ethical concerns

    • In November 2018, a Chinese researcher in Shenzen created an international sensation with his claim that he had altered the genes of a human embryo that eventually resulted in the birth of twin baby girls.
    • This was the first documented case of a ‘designer babies’ being produced using the new gene-editing tools like CRISPR.
    • What made matters worse was that the gene-editing was probably done without any regulatory permission or oversight.

  • Physics Nobel for discoveries about Black Holes

    Three scientists won this year’s Nobel Prize in Physics for advancing our understanding of black holes, the all-consuming monsters that lurk in the darkest parts of the universe.

    Try this PYQ:

    Q.Recently, scientists observed the merger of giant ‘blackholes’ billions of light-years away from the Earth. What is the significance of this observation?

    (a) ‘Higgs boson particles’ were detected.

    (b) ‘Gravitational waves’ were detected.

    (c) Possibility of inter-galactic space travel through ‘wormhole’ was confirmed.

    (d) It enabled the scientists to understand ‘singularity’.

    Who are these laureates?

    • Briton Roger Penrose received half of this year’s prize for the discovery that black hole formation is a robust prediction of the general theory of relativity.
    • German Reinhard Genzel and American Andrea Ghez received the second half of the prize for the discovery of a supermassive compact object at the centre of our galaxy.

    What are black holes?

    • A black hole is formed when stars collapse and can be defined as a space in the universe with an escape velocity so strong that even light cannot escape it.
    • Escape velocity is the speed at which an object must travel to override a planet or an object’s gravitational force.
    • For instance, for a spacecraft to leave the surface of the Earth, it needs to be travelling at a speed of about 40,000 km per hour.
    • Since light cannot get out, black holes are invisible and can only be tracked with the help of a space telescope or other special tools.
    • And the reason light cannot escape is mainly that the gravity inside a black hole is very strong as a result of a lot of matter being squeezed into a small space.

    Their contributions

    • Penrose has been awarded the prize for the discovery that black hole formation is a robust prediction of the general theory of relativity.
    • Genzel and Ghez have been awarded the prize for the discovery of a supermassive compact object at the centre of our galaxy.
    • Penrose’s work has shown that black holes are a direct consequence of Albert Einstein’s general theory of relativity.
    • Einstein himself did not believe that black holes exist and presented his theory in November 1915, providing a new way to look at and understand the gravity that shapes the universe “at the largest scale”.
    • Penrose used Einstein’s general theory of relativity in order to prove that the process of formation of black holes is a stable one.
    • Genzel and Ghez, on the other hand, have discovered that an invisible and an extremely heavy object governs the stars’ orbit at the centre of the Milky Way.

  • Supersonic Missile Assisted Release of Torpedo (SMART) System

    DRDO successfully conducted the flight test of its Supersonic Missile Assisted Release of Torpedo (SMART) system.

    Try this MCQ:

    Q.The SMART system recently tested by the DRDO is essentially a-

    a)Radar

    b)Torpedo

    c)UAV

    d)Missile

    What is the SMART system?

    • Torpedoes are self-propelled weapons that travel underwater to hit a target but are limited by their range.
    • In the mid-2010s, DRDO undertook a project to build capacity to launch torpedoes assisted by missiles; Monday’s was the first known flight test of the system.
    • This SMART system comprises a mechanism by which the torpedo is launched from a supersonic missile system with modifications that would take the torpedo to a far longer range than its own.
    • For example, a torpedo with a range of a few kilometres can be sent a distance to the tune of 1000 km by the missile system from where the torpedo is launched.

    Why is it significant?

    • SMART is a game-changing technology demonstration in anti-submarine warfare.
    • India’s anti-submarine warfare capacity building is crucial in light of China’s growing influence in the Indian Ocean region.
    • Assets of such warfare consist of the deployment of submarines, specialised anti-submarine ships, air assets and state-of-the-art reconnaissance and detection mechanisms.
    • The Navy’s anti-submarine warfare capability got a boost in June after the conclusion of a contract for Advanced Torpedo Decoy System Maareech, capable of being fired from all frontline warships.
    • India has been indigenously developing and building several anti-submarine systems and vessels in the recent past.

  • 2020 Nobel for Hepatitis C Virus discovery

    Americans Harvey J Alter and Charles M Rice, and British scientist Michael Houghton were awarded the Nobel Prize for Medicine or Physiology on Monday for the discovery of the hepatitis C virus.

    Try this PYQ:

    Q.Which one of the following statements is not correct? (CSP 2019)

    (a) Hepatitis B virus is transmitted much like HIV.

    (b) Hepatitis B. unlike Hepatitis C, does not have a vaccine.

    (c) Globally, the number of people infected with Hepatitis B and C viruses arc several times more than those infected with HIV.

    (d) Some of those infected with Hepatitis B and C viruses do not show the symptoms for many years.

    Hepatitis C Virus

    • Hepatitis C virus (HCV) is a bloodborne virus and causes liver diseases. It refers to an inflammatory condition of the liver.
    • The novel virus caused several deaths in the 1960s and 1970s — but remained unknown until its discovery in the late 1980s.

    What are other Hepatitis Viruses?

    • Before the discovery of the Hepatitis C virus, two other viruses were known to cause hepatitis in patients.
    • The Hepatitis A virus was known to spread mainly through contaminated food and water and caused a relatively milder form of liver inflammation.
    • Hepatitis B, discovered in the 1960s, was known to transmit mainly through infected blood and caused a more serious form of the disease.
    • Incidentally, the discovery of the Hepatitis B virus too was rewarded with a Nobel Prize in Medicine, given to Baruch Blumberg in 1976. There are vaccines available for this disease now.

    How Hepatitis C came to observation?

    • The discovery and identification of the Hepatitis B virus facilitated the development of a diagnostic test to detect its presence in blood.
    • Thereafter, only blood sanitized from this virus would be given to patients, but it was observed that even this sanitized blood was able to prevent only 20% of the blood-borne hepatitis cases.
    • It was then that the search for the new virus began.

    How is Hepatitis C treated?

    • Presently there is no vaccine available for HCV. However, it can be treated with antiviral medication.
    • Hepatitis A and B are preventable by vaccine.

    Back2Basics:

    https://www.civilsdaily.com/news/in-news-nobel-prize/

  • What is Ketogenic Diet?

    Ketogenic or Keto Diet is popularly followed as a weight loss diet across the world.

    Try this PYQ:

    Q.Regular intake of fresh fruits and vegetables is recommended in the diet since they are a good source of antioxidants. How do antioxidants help a person maintain health and promote longevity? (CSP 2014)

    (a) They activate the enzymes necessary for vitamin synthesis in the body and help prevent vitamin deficiency.

    (b) They prevent excessive oxidation of carbohydrates, fats and proteins in the body and help avoid unnecessary wastage of energy.

    (c) They neutralize the free radicals produced in the body during metabolism.

    (d) They activate certain genes in the cells of the body and help delay the ageing process.

    What is Ketogenic Diet?

    • The Keto Diet is one of the most popular weight-loss diets the world over.
    • It consists of a high-fat, moderate-protein and low-carb diet.
    • It helps in weight loss by achieving ketosis — a metabolic state where the liver burns body fat and provides fuel for the body, as there is limited access to glucose.

    What constitutes a keto diet?

    • A classic keto generally requires that 90 per cent of a person’s calories come from fat, 6 per cent from protein and 4 per cent from carbs.
    • But there are many versions doing the rounds since this one was designed for children suffering from epilepsy to gain control over their seizures.

    How does it impact the body?

    • If we starve the body of carbohydrate, after burning out the glucose, the liver starts breaking down fats for energy.
    • Ketosis is common in all kinds of fasting, but in a keto diet, when one is feeding it by giving a lot of fats from outside without carbs, it can become mildly toxic.
    • It may lead to many nutrient deficiencies such as carbohydrates, proteins, vitamins (especially vitamin A, D, E, & K) and minerals like calcium, phosphorus, sodium.
    • Extreme carbohydrate restriction can lead to hunger, fatigue, low mood, irritability, constipation, headaches, and brain fog, which may last days to weeks

    What impact does it have on our kidneys?

    • Even the moderate increase in protein needs to be carefully monitored, especially in those who are already suffering from chronic kidney disease, as it could lead to kidney failure.
    • One should get a thorough assessment and make sure they have normal kidney function before choosing this diet.
    • This diet could lead to increased stress on the kidneys and result in kidney stones, as they are made to work overtime.

  • What is CBD Oil?

    These days, there are diverse opinions rising regarding the legalization of CBD oil in India after recent controversy rose after the alleged suicide of an actor.

    What is CBD oil?

    • CBD oil is an extract from the cannabis plant.
    • The two main active substances in it are cannabidiol or CBD and delta-9 tetrahydrocannabinol, or THC.
    • The high that is caused by the consumption of cannabis is due to THC.
    • CBD, however, does not cause a “high” or any form of intoxication.
    • CBD oil is made by extracting CBD from the cannabis plant, then diluting it with a carrier oil like coconut or hemp seed oil.

    What are the effects of Cannabidiol?

    • Cannabidiol has effects on the brain, preventing the breakdown of a chemical that aggravates the pain and affects mood, and mental function. It can reduce pain and anxiety.
    • It also reduces psychotic symptoms associated with conditions such as schizophrenia as well as epilepsy.

    Is it legal in India?

    • The Narcotic Drugs and Psychotropic Substances Act, 1985 (NDPS Act) outlaws the recreational use of cannabis.
    • The NDPS Act, however, does not apply to the leaves and seeds of cannabis plants. In case the CBD is extracted from the leaves of the cannabis, then technically it is not illegal.
    • CBD oil manufactured under a licence issued by the Drugs and Cosmetics Act, 1940 can be legally used.
    • However, the use of cannabis as a medicine is not much prevalent in India.

    Now try this PYQ:

    Q. Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine?

    A) Malaria is caused by several species of Plasmodium

    B) Man does not develop immunity to malaria during natural infection

    C) Vaccines can be developed only against bacteria

    D) Man is only an intermediate host and not the definitive host

  • Cat Que Virus

    In a study published in the Indian Journal of Medical Research, scientists have noted the presence of antibodies against the Cat Que virus (CQV) in two human serum samples.

    Try this PYQ:

    Q.Which one of the following statements is not correct?

    (a) Hepatitis B virus is transmitted much like HIV.

    (b) Hepatitis B, unlike Hepatitis C, does not have a vaccine.

    (c) Globally, the number of people infected with Hepatitis B and C viruses is several times more than those infected with HIV.

    (d) Some of those infected with Hepatitis B and C viruses do not show the symptoms for many years.

    What is the Cat Que Virus?

    • For CQV, domestic pigs are considered to be the primary mammalian hosts.
    • Antibodies against the virus indicate that the virus has formed a “natural cycle” in the local area and has the ability to spread in pigs and other animal populations through mosquitoes.
    • CQV belongs to the Simbu serogroup and infects both humans and economically important livestock species.
    • It was first isolated in 2004 from mosquitoes during the surveillance of arbovirus activity in northern Vietnam.
    • In this study, researchers reported a CQV strain (SC0806), which was isolated from mosquito samples collected in China in 2006 and 2008.

    Impact on humans

    • Humans can get infected through mosquitoes as well.
    • In the study, scientists note that because of positivity in human serum samples and the replication capability of CQV in mosquitoes, there is only a “possible disease-causing potential” of CQV in the Indian scenario.