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GS Paper: GS3-17.Awareness in the fields of IT, Space, Computers, Robotics, Nano-technology, Bio-technology and issues relating to Intellectual Property Rights.

  • [pib] BiPAP Non-Invasive Ventilator “SwasthVayu”

    National Aerospace Laboratories (NAL) Bangalore, a constituent of the lab of CSIR has developed a Non-Invasive BiPAP Ventilator ‘SwasthVayu ’in a record time of 36 days to treat COVID-19 patients.

    The name ‘SwasthVayu’ can be tricky to guess, specially after some days. In prelims, UPSC may throw some options related to air pollution.

    SwasthVayu

    • A ventilator is a machine that provides mechanical ventilation by moving breathable air into and out of the lungs, to deliver breaths to a patient who is physically unable to breathe, or breathing insufficiently.
    • BiPAP (Bilevel Positive Airway Pressure) Non-Invasive ventilator is a microcontroller-based precise closed-loop adaptive control system.
    • It is a built-in biocompatible “3D printed manifold & coupler” with HEPA filter (Highly Efficient Particulate Air Filter).

    Benefits of SwasthVayu

    • The major advantage of this machine is that it is simple to use without any specialized nursing, cost-effective, compact and configured with the majority of indigenous components.
    • This is ideal for treating COVID -19 patients in Wards, Makeshift Hospitals, dispensaries and home in current Indian COVID 19 scenario.

  • Indigenous antibody test: COVID Kavach ELISA

    Indian Council of Medical Research (ICMR)-National Institute of Virology (NIV) at Pune has developed and validated the indigenous IgG ELISA test “COVID KAVACH ELISA” for antibody detection for COVID-19.

    Our thumb rule suggests that the ELISA test is being used only for the diagnosis of HIV infection. Right?

    But the ELISA test is a broader term to diagnose antibody-antigen interaction after certain virus infection to a person.  UPSC can test your basic knowledge of core biology with a question based on this concept.

    What is ELISA test?

    • ELISA (enzyme-linked immunosorbent assay) is a plate-based assay technique designed for detecting and quantifying substances such as peptides, proteins, antibodies and hormones.
    • Other names, such as enzyme immunoassay (EIA), are also used to describe the same technology.
    • In an ELISA, an antigen must be immobilized on a solid surface and then complexed with an antibody that is linked to an enzyme.
    • Detection is accomplished by assessing the conjugated enzyme activity via incubation with a substrate to produce a measurable product.
    • The most crucial element of the detection strategy is a highly specific antibody-antigen interaction.

    What are antibodies?

    • An antibody is a large, Y-shaped protein produced mainly by plasma cells that are used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
    • There are five immunoglobulin classes (isotypes) of antibody molecules found in serum: IgG, IgM, IgA, IgE and IgD.
    • They are distinguished by the type of heavy chain they contain.

    Application of ELISA

    • Presence of antigen or the presence of antibody in a sample can be evaluated
    • Determination of serum antibody concentrations in a virus test
    • Used in the food industry when detecting potential food allergens
    • Applied in disease outbreaks- tracking the spread of disease e.g. HIV, bird flu, common, colds, cholera, STD etc

    Significance

    • Robust antibody tests are critical for surveillance to understand the proportion of the population exposed to infection.
    • The test will have the advantage of testing 90 samples together in a single run of 2.5 hours.
    • Moreover, ELISA based testing is easily possible even at the district level as the ELISA kit has an inactivated virus.
    • There are also minimal bio-safety and bio-security requirements as compared to the real-time RT-PCR test.
    • The test has the advantage of having much higher sensitivity and specificity as compared to the several rapid test kits which have recently flooded the Indian market.

    Limitations

    • Since the ELISA test is based on the detection of antibodies, it can only help in knowing if the person has been previously infected by a coronavirus.
    • It takes one-three weeks for the antibodies to develop in response to infection.
    • So, if a person who has been recently infected by the virus is tested during the window period (the time taken to develop antibodies) the result will turn out to be negative.
    • But a repeat test after a couple of weeks will indicate the true infection status.

    How it is different from the PCR test?

    • While the RT-PCR, which detects the RNA of the coronavirus, enables detection of current infection, it will not be useful if the testing is carried out days after the infection clears as the virus will no longer be present.
    • However, antibodies developed in response to the coronavirus infection will be present in the blood for a longer duration and hence the ELISA test can help detect past infection.
    • The maximum time the antibodies will be present in the body is not known for coronavirus.

    Back2Basics: Reverse Transcriptase – Polymerase Chain Reaction (PCR) Test

    • It uses a technique that creates copies of a segment of DNA. ‘Polymerase’ refers to the enzymes that make the copies of DNA.
    • Kary Mullis, the American biochemist who invented the PCR technique, was awarded the Nobel Prize for Chemistry in 1993.
    • The ‘chain reaction’ is how the DNA fragments are copied, exponentially — one is copied into two, the two are copied into four, and so on.
    • However, SARS-COV-2 is a virus made of RNA, which needs to be converted into DNA. For this, the technique includes a process called reverse transcription.
    • A ‘reverse transcriptase’ enzyme converts the RNA into DNA. Copies of the DNA are then made and amplified.
    • A fluorescent DNA binding dye called the “probe” shows the presence of the virus. The test also distinguishes SARS-COV-2 from other viruses.

  • Luhman 16A: A binary brown-dwarf system

    A group of international astrophysicists have identified cloud bands on the surface of Luhman 16A, one of a pair of binary brown dwarfs in the Vela constellation.

    Space terminology has gained importance in prelims. The Luhman 16A coupled with few more examples of space concepts like binary star and dwarf star are discussed in this newscard.

    Luhman 16A

    • Luhman 16 is a binary star system, the third closest system to the Sun after Alpha Centauri and Barnard’s star.
    • At a distance of about 6.5 light-years from the Sun, this pair of brown dwarfs referred to as Luhman 16A and Luhman 16B orbit each other, casting a dim light.
    • Brown dwarfs are also called failed stars because their masses are intermediate to the largest planets and the smallest main sequence stars.
    • Their masses being too small, they are unable to sustain fusion of their hydrogen to produce energy.
    • It is believed that some of the more massive brown dwarfs fuse deuterium or lithium and glow faintly.

    The cloud band over Luhman

    • The group, by using the Very Large Telescope at European Southern Observatory, Chile, found that Luhman 16A had band-like clouds in its atmosphere, whereas the same was not true of Luhman 16B.
    • Many astronomers detected polarization of brown dwarfs.
    • But what is special in the newest study of Luhman 16 is that the researchers have found the actual structure of the clouds — that they form bands over one of the pair.
    • Understanding the cloud system over a brown dwarf can shed light on the pressure, temperature and climate on the surface of the celestial body.

    Why it has made into a headline?

    • The researchers have used an idea put forth nearly two decades ago by Indian astrophysicist Sujan Sengupta, who works at the Indian Institute of Astrophysics, Bengaluru.
    • Sengupta had propounded the light emitted by a cloudy brown dwarf, or reflected off an extrasolar planet, will be polarized.
    • He then suggested that a polarimetric technique could serve as a potential tool to probe the environment of these objects.

    Back2Basics: Binary Star System

    • A binary star is a star system consisting of two stars orbiting around their common barycenter.
    • Systems of two or more stars are called multiple star systems.
    • These systems, especially when more distant, often appear to the unaided eye as a single point of light, and are then revealed as multiple by other means.
    • Binary star systems are very important in astrophysics because calculations of their orbits allow the masses of their component stars to be directly determined.

  • ‘The Long March 5B’ rocket

    China has successfully launched a new rocket and prototype spacecraft in a major test of the country’s ambitions to operate a permanent space station and send astronauts to the Moon.

    Can you recall the historical link between the name “The Long March” and China’s History.

    The Long March 5B

    • Long March 5 or Chang Zheng 5 is a Chinese heavy-lift launch system developed by the China Academy of Launch Vehicle Technology (CALT).
    • It is the first Chinese launch vehicle designed from the ground up to focus on non-hypergolic liquid rocket propellants.
    • The maximum payload capacities of the base variant are ~25,000 kilograms to Low Earth Orbit and ~14,000 kilograms to Geosynchronous Transfer Orbit.
    • The spaceship is expected to transport astronauts to a space station that China plans to complete by 2022 — and eventually to the Moon. It will have a capacity for a crew of six.

    Back2Basics: Geosynchronous Transfer Orbit

     

    • About 35,786 kilometers above the Earth’s surface, satellites are in geostationary orbit. From the center of the Earth, this is approximately 42,164 kilometers. This distance puts it in the high Earth orbit category.
    • At any inclination, a geosynchronous orbit synchronizes with the rotation of the Earth.
    • While geosynchronous satellites can have any inclination, the key difference to geostationary orbit is the fact that they lie on the same plane as the equator.
    • GTO is a an elliptical orbit used to transfer between two circular orbits of different radiuses in the same plane—used to reach geosynchronous or  geostationary orbit using high-thrust chemical engines.

  • How Remdesivir tricks coronavirus?

    A new research has found how Remdesivir treats coronavirus and described the exact mechanism of interaction between the virus and the drug.   Remdesivir is an experimental antiviral made by American pharmaceutical firm Gilead Sciences that was first developed to treat Ebola.

    DNA/RNA related terminologies, Genes and Genomes, etc. always find their way in UPSC Prelims.  Most recent one was-

    With reference to the recent developments in science, which one of the following statements is not correct? (CSP 2019)

    (a) Functional chromosomes can be created by joining segments of DNA taken from cells of different species.

    (b) Pieces of artificial functional DNA can be created in Iaboratories.

    (c) A piece of DNA taken out from an animal cell can be made to replicate outside a living cell in a laboratory.

    (d) Cells taken out from plants and animals can be made to undergo cell division in laboratory petri dishes.

    How Remdesivir kills coronavirus?

    • Remdesivir is designed to obstruct the stage of replication, when the virus creates copies of itself, followed endlessly by the copies creating copies of themselves.

    How does replication take place?

    • Once the virus enters the human cell, it releases its genetic material, which is then copied using the body’s existing mechanism.
    • At every stage of infection, various human proteins, virus proteins, and their interactions come into play.
    • At the replication stage, the key viral protein at play is an enzyme called RdRp (an enzyme is a kind of protein that speeds up chemical reactions within a cell).
    • It is RdRp that makes the copies, by processing components of the RNA of the virus.
    • University of Alberta researchers called it the “engine” of the virus in a paper last week, in which they described the action of Remdesivir against this “engine”.
    • In scientific literature, such an enzyme is called a polymerase (the p is RdRp stands for polymerase) or a replica.
    • In any case, this is the enzyme that is targeted by Remdesivir.

    And how exactly does Remdesivir target this enzyme?

    • In order to replicate, the virus processes raw material from the virus RNA, broken down by another enzyme with that specific function.
    • When a patient is given Remdesivir — the inhibitor — it mimics some of this material and gets incorporated in the replication site.
    • With Remdesivir replacing the material it needs, the virus fails to replicate further.
    • These coronavirus polymerases are sloppy and they get fooled, so the inhibitor gets incorporated many times and the virus can no longer replicate.

  • E-Renminbi: China’s Official Digital Currency

    China in a significant move has launched a trial of digital yuan in four urban centres of the country for specific services even as the world grapples with the containment of Covid.

    What is a cryptocurrency? Discuss how a vibrant cryptocurrency segment could add value to India’s financial sector. (250 W)

    Prelims Perspective:-

    1. Subtle differences btn digital and virtual currency – e.g. Regulatory issues

    2. Which countries have official virtual currency – e.g. Petro of Venezuela

    e-RMB

    • It will be the electronic form of the renminbi, with a value equivalent to the paper notes and coins in circulation.
    • The People’s Bank of China, the country’s central bank, will be the sole issuer of the digital yuan, initially offering the digital money to commercial banks and other operators.
    • It will be launched in major cities of Shenzhen, Suzhou and Chengdu, as well as the Xiong’an New Area.
    • It aims to change the financial system in big ways — by cutting costs and making transactions easier, more convenient and more transparent.
    • The public would be able to convert money in their bank accounts to the digital version and make deposits via electronic wallets.

    Back2Basics: Cryptocurrency

    • A Cryptocurrency is an internet-based medium of exchange which uses cryptographical functions to conduct financial transactions.
    • It leverages blockchain technology to gain decentralization, transparency, and immutability.
    • The most important feature of a cryptocurrency is that it is not controlled by any central authority: the decentralized nature of the blockchain makes cryptocurrencies theoretically immune to the old ways of government control and interference.
    • It can be sent directly between two parties via the use of private and public keys.
    • Unlike decentralized cryptocurrencies, such as bitcoin, that allow users to transfer value with no central authority or third party involved, the government-backed digital currency is preferred.

    What are Blockchains?

    • Blockchain, sometimes referred to as Distributed Ledger Technology (DLT), makes the history of any digital asset unalterable and transparent through the use of decentralization and cryptographic hashing.
    • Blockchain consists of three important concepts: blocks, nodes and miners.
    • Nodes can be any kind of electronic device that maintains copies of the blockchain and keeps the network functioning.
    • Miners create new blocks on the chain through a process called mining.

  • Plasma therapy is no silver bullet

    The article discusses the issues with convalescent plasma therapy. The therapy has been in the news as a cure to Covid-19. The lack of conclusive evidence is a major issue. There are certain risks involved in large scale adoption. All such issues are dealt with in detail here.

    Importance of scientific research in dealing with Covid-19

    • The COVID-19 pandemic has posed unprecedented challenges to governments, health professionals and the general public at large, around the world.
    • Every response, administrative, social, economic or medical is being subjected to intense public scrutiny, as it rightly should be in the spirit of mature democracy.
    • Scientific research in medicine is the only means to overcome novel and complex diseases such as COVID-19 and that too thrives on the same spirit of debate and criticism.
    • Difficulty in establishing protocols: The difference is that the standards of evidence required, to generate consensus and arrive at the most optimal protocols, are far more rigorous and time-taking than in most other walks of life.

    Issues with plasma therapy

    • The convalescent plasma therapy, that is being currently studied by the Indian Council of Medical Research, through open-label, randomised controlled trial to evaluate it for both safety and efficacy.
    • The problem with the therapy is of the lack of established protocols.
    • What is involved in therapy? The therapy involves infusing patients suffering from COVID-19 with plasma from recovered patients.
    • In theory, the antibodies of the recovered person may help that patient’s immune system fight the virus.
    • While showing great promise, it is a line of treatment that is yet to be validated for efficacy and safety and cannot be deployed widely without caution.
    • The current evidence to conclude anything about the true benefits of this therapy is very thin.
    • Till date, there have been only three published case series for convalescent plasma in COVID-19 with a cumulative of 19 patients.
    • Given the very small number of patients involved in these studies and a publication bias in medicine, we cannot conclude the therapy will work on all patients all the time or even believe that the convalescent plasma was the only reason for their improvement.
    • The most important principle in medical ethics is “do no harm”.
    • The transfusion of convalescent plasma is also not without risks, which range from mild reactions like fever, itching, to life-threatening allergic reactions and lung injury.
    • To recommend a therapy without studying it thoroughly with robust scientific methods may cause more harm than good.
    • Further, convalescent plasma therapy requires intensive resources, healthy COVID-19 survivors to donate, a blood bank with proper machinery and trained personnel to remove plasma, equipment to store it and testing facilities to make sure it has an adequate amount of antibodies.

    Need for the Randomised Controlled Trials (RCT)

    • To say with certainty whether a drug is truly effective or not, the gold standard in medicine is to conduct a randomised controlled trial.
    • In RCT half the patients get the experimental drug and the other half do not.
    • Only if patients in the first half show substantial improvement over those in the second half, it indicates the drug is beneficial.

    Exploring other options and focusing on health infrastructure

    • Too much focus on one approach can take away the focus from other important therapeutic modalities like the use of oxygen therapy, antivirals, and antibiotics for complicated hospital courses.
    • To overcome the pandemic comprehensively, we should focus on strengthening health systems at all levels, including referral systems, supply chain, logistics and inventory management.
    • We need to work on protecting our healthcare workers, improving prevention methods, promoting cough etiquettes, effective quarantining and accurate testing.

    A direct question based on the therapy like- “What is convalescent plasma therapy and what are the issues involved in its adoption?” can be asked by the UPSC.

    Conclusion

    Even these times of collective uncertainty are no reason to lower scientific temper. Science should be driven by reason and evidence with hope as a catalyst but not by either fear or populism. Pushing one or the other therapy without evidence or caution can only set back our larger fight against COVID-19.

  • [pib] Earth’s Magnetosphere and its dynamics

    Scientists at the Indian Institute of Geomagnetism (IIG) have developed a generalized one-dimensional fluid simulation code capable of studying a wide spectrum of coherent electric field structures of earth’s magnetosphere which can be useful in the planning of future space missions.

    The newscard talks of not so new phenomenon but a basic terminology of space sciences. Kindly make a note of what the Magnotesphere is, how it is formed, role of solar winds, Geodynamo etc.

    Earth’s Magnetosphere

    • The magnetosphere is the region of space surrounding Earth where the dominant magnetic field is the magnetic field of Earth, rather than the magnetic field of interplanetary space.
    • It is generated by the interaction of the solar wind with Earth’s magnetic field.

    Features of the Earth’s magnetosphere

    1) Bow shock,

    2) Magnetosheath,

    3) Magnetopause,

    4) Northern tail lobe,

    5) Southern tail lobe,

    6) Plasmasphere,

    7) Solar wind.

    How is it formed?

    • Sun is the major source of plasma deposition in space around the Earth. Sun forces some of its plasma towards the earth in the form of the solar wind.
    • The speed of this wind varies between 300 to 1500 km/s, which carries with it solar magnetic field, called as Interplanetary Magnetic Field (IMF).
    • The magnetic field is generated by electric currents due to the motion of convection currents of a mixture of molten iron and nickel in the Earth’s outer core.
    • These convection currents are caused by heat escaping from the core, a natural process called a geodynamo.

    Why study the magnetosphere?

    • The Earth’s magnetosphere is a vast region which has a finite number of satellites hurtling through this realm.
    • The morphology of the plasma processes around the satellite can be understood quite well.
    • However, when they leave the observational domain of one satellite to enter into another, a vast blind arena is created.
    • How the morphology of these processes changes over space and time can be ideally deciphered only through computer simulations.

    Outcome of the study

    • Almost 99% of matter in the universe is in the form of plasma, Earth’s magnetosphere, too, contains this material and the plasma.
    • They have the ability to hamper the working of a number of satellites that have been placed in orbit in the magnetospheric region.

    Significance

    • Apart from the well being of these expensive satellites, the academic understanding of this region is quite essential to comprehend the cosmos in its entirety.
    • The study will help advance the knowledge of plasma waves, instabilities, and coherent effects associated with wave-particle interactions that are useful in planning of future space missions.
    • It can also lead to precisely controlled fusion laboratory experiments for ever-expanding energy needs of humanity.

  • [pib] HCARD robot to assist frontline COVID-19 healthcare warriors

    HCARD, a robot, to assist frontline COVID-19 healthcare warriors has been developed by a CSIR lab.

    It is very unlikely to create a prelim question on HCARD. However, developments as such help in exemplifying the scientific developments which helped contain such highly contagious outbreaks.

    What is HCARD?

    • The robotic device HCARD, an acronym for Hospital Care Assistive Robotic Device, can help frontline healthcare workers in maintaining physical distance from those infected by the coronavirus.
    • The device is equipped with various state-of-the-art technologies and works both in automatic as well as manual modes of navigation.
    • This robot can be controlled and monitored by a nursing booth with a control station having such features as navigation, drawer activation for providing medicines and food to patients, sample collection and audio-visual communication.
    • The cost of this device is less than Rs 5 lakh and the weight is less than 80 kilograms.

  • GW190412: The first merger of two black holes with unequal masses

    For the first time since it started functioning, the gravitational wave observatories at LIGO scientific collaboration have detected a merger of two unequal-mass black holes.

    This newscard contains few basic terms that one must know-

    Gravitational waves

    General Relativity

    Black Holes

    GW190412

    • The event, dubbed GW190412, was detected nearly a year ago, and this is almost five years after the first-ever detection of gravitational-wave signals by these powerful detectors.
    • Subsequent analysis of the signal coming from the violent merger showed that it involved two black holes of unequal masses coalescing.
    • One of them was some 30 times the mass of the Sun and the other which had a mass nearly 8 times the solar mass.
    • The actual merger took place at a distance of 2.5 billion light-years away.

    Significant feature observed

    • The detected signal’s waveform has special extra features in it when it corresponds to the merger of two unequal-sized black holes as compared with a merger of equal-sized black holes.
    • These features make it possible to infer many more things about the characters such as- a more accurate determination of the distance from the event, the spin or angular momentum of the more massive black hole and the orientation of the whole event with respect to viewers on Earth.
    • While the mass of the black hole bends the space-time close to it, the spin or angular momentum of this inscrutable object drags the nearby space-time, causing it to swirl around, along with it.
    • Hence both these properties are important to estimate.

    Confirmed General Relativity

    • An Indian team consisting of researchers verified the consistency of the signal with the prediction of General Relativity.
    • The existence of higher harmonics was itself a prediction of General Relativity.

    Must refer for an easy and illustrated understanding of General Relativity-