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GS Paper: GS3-17.Awareness in the fields of IT, Space, Computers, Robotics, Nano-technology, Bio-technology and issues relating to Intellectual Property Rights.

  • How remote sensing system LiDAR helped discover a lost Mayan city?

    Why in the News?

    Scientists have used LiDAR technology to find an ancient Mayan city hidden for centuries under a thick jungle in Mexico.

    What is LiDAR?

    • LiDAR (Light Detection and Ranging) is a remote sensing technology that uses laser light pulses to measure distances between a sensor (often airborne) and Earth’s surface.
    • It produces high-resolution, 3D models of ground elevation with up to 10 cm vertical accuracy, as per the US Geological Survey.

    How Does LiDAR Work?

    • LiDAR Setup: Includes a laser, a scanner, and a GPS receiver. The laser emits rapid pulses of light that reflect off surfaces on the ground, including natural features and man-made structures.
    • Data Collection: The reflected light returns to the sensor, and the LiDAR system calculates the two-way travel time to determine the distance to each point on Earth’s surface.
    • Data Processing: GPS and Inertial Measurement System (IMS) data are used to create accurate maps. The initial data forms a “point cloud” representing surfaces like vegetation, buildings, and terrain.
    • “Bare Earth” Model: By filtering out structures and vegetation, LiDAR can create a Digital Elevation Model that shows just the ground terrain.

    Applications of LiDAR

    • Geography and Mapping: Creates precise 3D information for topographic mapping.
    • Urban Planning and Infrastructure: Used in planning transportation routes, assessing flood risk, and managing natural resources.
    • Conservation: Helps monitor forest health, manage habitats, and detect environmental changes.
    • Engineering and Policy: Provides data for infrastructure design, environmental policy making, and land-use planning.

    Why is LiDAR Useful for Archaeologists?

    • Large-Area Surveying: LiDAR enables archaeologists to study extensive areas quickly, bypassing the need for labor-intensive, on-ground exploration.
    • Vegetation Penetration: LiDAR can “see through” dense tree canopies by using the reflections that pass through gaps, allowing mapping of hidden structures and terrain.
    • Detailed Site Mapping: With “bare earth” models, archaeologists can strip away vegetation layers to reveal hidden archaeological sites.
    • Case Study – Maya Civilization: Archaeologists discovered the lost Mayan city of Valeriana in Mexico by analyzing publicly available LiDAR data, uncovering plazas, temple pyramids, a ballcourt, and other features indicative of a Classic Maya capital.

    Where is the Indian Government using LiDAR ?

    • High-Speed Rail Projects: NHSRCL (National High-Speed Rail Corporation Limited) uses aerial LiDAR surveys for the Delhi-Varanasi High-Speed Rail Corridor, reducing survey time from 10-12 months to 3-4 months by capturing detailed topographical data within a 300-meter corridor.
    • National Highways: NHAI mandates Mobile LiDAR for feasibility studies and project reports, enhancing the accuracy and efficiency of highway surveys across extensive networks.
    • Forest Mapping: The Ministry of Environment is piloting LiDAR-based forest mapping across states to improve forest management and accurately monitor forest cover changes.
    • Water Resource Management: WAPCOS is using LiDAR to identify groundwater recharge zones, aiding water resource management and mitigating human-animal conflicts in forested areas.
    • Urban Planning: Chandigarh and Gujarat are using LiDAR for GIS mapping and drone-based surveys, respectively, supporting detailed city models, urban planning, and infrastructure mapping.

    Conclusion: LiDAR technology has revolutionized fields from archaeology to urban planning by providing precise 3D mapping. In India, it’s enhancing infrastructure projects, environmental monitoring, and urban planning, proving invaluable for efficient, large-scale data collection and analysis.

  • [pib] Exercise VAJRA PRAHAR

    Why in the News?

    The Indian Army contingent departed today for the 15th edition of VAJRA PRAHAR, a joint Special Forces exercise with the US Army.

    About Exercise VAJRA PRAHAR:

    Details
    What is it? A joint Special Forces exercise between India and the US aimed at enhancing military cooperation.
    Inception
    • Started in 2010 as part of bilateral defense cooperation between India and the US.
    • No exercises held between 2012 and 2015 and in 2020.
    Frequency Conducted annually, alternately in India and the United States.
    15th Edition Dates Scheduled from 2nd to 22nd November 2024 at the Orchard Combat Training Centre, Idaho, USA.
    Participants 45 personnel from each country; Indian Army’s Special Forces and US Army’s Green Berets.
    Objectives • Enhance military cooperation
    • Promote interoperability and tactical exchange
    • Improve combined capabilities in joint operations
    Key Focus Areas • High physical fitness standards
    • Joint planning and tactical drills
    Significance • Joint Team Mission Planning
    • Reconnaissance Missions
    • Use of Unmanned Aerial Systems (UAS)
    • Execution of Special Operations
    • Roles of Joint Terminal Attack Controllers
    • Psychological Warfare

  • What is Chronic Wasting Disease (CWD)?

    What is Chronic Wasting Disease (CWD)?

    Why in the News?

    A case of Chronic Wasting Disease (CWD) was confirmed in the US.

    About Chronic Wasting Disease (CWD)

    • CWD is a fatal, transmissible disease that affects the brain and central nervous system of deer, elk, and moose.
    • First identified in 1967, CWD is a prion disease where normal proteins misfold, leading to symptoms that eventually cause death.
    • Transmission occurs through animal-to-animal contact or contamination of feed or water by infected saliva or bodily waste.
    • Environmental contamination can occur through soil exposure from infected carcasses or bodily fluids.
    • High-risk areas include places where deer and elk gather closely, like feeding or watering sites.
    • Species affected: CWD does not naturally infect cows, other livestock, or pets.
    • Although no strong evidence exists that it can spread to humans, officials advise against eating meat from infected animals.

    Symptoms of CWD:

    • Symptoms: Drastic weight loss, lack of coordination, drooling, listlessness, and excessive thirst. Infected animals may also show drooping ears and lose their fear of humans.
      • Prevention: To prevent the spread of CWD, avoid handling or eating sick animals, use synthetic lures, dispose of carcass waste in landfills, and report any sick or unusual deer to local wildlife authorities.

    PYQ:

    [2012] Vultures which used to be very common in Indian countryside some years ago are rarely seen nowadays. This is attributed to:

    (a) The destruction of their nesting sites by new invasive species

    (b) A drug used by cattle owners for treating their diseased cattle

    (c) Scarcity of food available to them

    (d) A widespread, persistent and fatal disease among them

  • How Tardigrades are able to resist high levels of radiation?

    Why in the News?

    • A team of researchers has discovered the genetic mechanisms that allow a newly identified tardigrades species—Hypsibius henanensis—to withstand high levels of radiation.

    About Tardigrades

    • Tardigrades, often called “water bears” or “moss piglets,” are tiny, water-dwelling microorganisms known for their remarkable ability to survive extreme conditions.
    • They can withstand environments that would be lethal for most life forms, including:
      • Extremely high and low temperatures (from near absolute zero to over 150°C),
      • High levels of radiation and vacuum conditions found in space,
      • Extreme dehydration (losing nearly all water in their bodies),
      • High pressures (up to six times that of the ocean’s deepest trenches).
    • This adaptability makes them a subject of interest for scientists, especially in understanding survival mechanisms in extreme conditions.

    How Tardigrades resist High Radiations?

    The researchers identified 2,801 genes involved in DNA repair. Three key factors contributing to radiation tolerance include:

    • DNA Repair Protein (TRID1): Enabled the species to repair double-strand DNA breaks due to radiation.
    • Gene Activation for Mitochondrial Proteins: Radiation exposure activated a gene that produced two proteins vital for mitochondrial synthesis and DNA repair.
    • Antioxidant Pigments (Betalains): These pigments neutralize harmful chemicals generated by radiation within cells.

  • Betelgeuse, one of the Brightest Stars predicted to Explode

    Recent research has revealed a surprising finding about Betelgeuse (which was believed to explode): the star’s unusual brightening and dimming patterns may be influenced by an unseen companion star.

    Why in the News?

    Recent research has revealed a surprising finding about Betelgeuse (which was believed to explode): the star’s unusual brightening and dimming patterns may be influenced by an unseen companion star.

    About Betelgeuse

    • Betelgeuse is a red supergiant star in the Orion constellation, marking Orion’s left shoulder.
    • It is among the brightest and largest stars visible in the night sky, located about 650 light-years from Earth.
    • The star is nearing the end of its life, and when it dies, its explosion is expected to be visible during the day for several weeks.
    • Betelgeuse is vast, measuring more than 700 million miles (1.2 billion kilometers) in diameter.
    • Known for its periodic dimming and brightening, Betelgeuse has two distinct pulsation cycles:
      • A short-term cycle of about one year.
      • A longer six-year cycle called a long secondary period.
    • Researchers believe this longer cycle may be caused by Betelbuddy (an unseen companion star) moving through the dust surrounding Betelgeuse.

    Indicators and Scientific Evidence

    • Betelgeuse’s cyclic dimming and brightening patterns indicate it is nearing the end of its life.
    • Its massive size and expansion as a red supergiant suggest it is in a late stellar stage.
    • Cooling surface temperature and mass loss through stellar winds signal increasing instability.
    • Spectral analysis shows heavy elements in Betelgeuse’s layers, typical of late-stage fusion.
    • An unseen companion star, or “Betelbuddy,” may be influencing its brightness and internal structure.

    Potential Effects of Betelgeuse’s Supernova on Earth and Our Solar System

    • Betelgeuse’s supernova will likely be visible in daylight for weeks and brighter than the Moon at night.
    • At 650 light-years away, dangerous radiation would dissipate before reaching Earth, posing no harm.
    • Space missions and satellites may experience minor interference from increased cosmic rays.
    • The explosion will enrich the interstellar medium with heavy elements, contributing to new star formation.
    • The supernova will provide valuable scientific insights into stellar life cycles and cosmic element formation.

    PYQ:

    [2017] The terms ‘Event Horizon’, ‘Singularity’, ‘String Theory’ and ‘Standard Model’ are sometimes seen in the news in the context of:

    (a) Observation and understanding of the Universe

    (b) Study of the solar and the lunar eclipses

    (c) Placing satellites in the orbit of the Earth

    (d) Origin and evolution of living organisms on the Earth

  • West Nile Virus

    Why in news?

    Ukraine is currently dealing with a serious outbreak of West Nile virus (WNV), with health officials raising alarms as the death toll rises.

    About West Nile Virus

    Details
    Virus Type Member of the flavivirus genus, family Flaviviridae
    First Isolated 1937 in a woman in the West Nile district of Uganda
    Geographical Distribution Commonly found in Africa, Europe, Middle East, North America, and West Asia
    Transmission Primarily transmitted through infected mosquito bites; mosquitoes become infected by feeding on infected birds. Can also spread through infected animal tissues.
    Symptoms – Asymptomatic: ~80% of infected individuals show no symptoms
    – West Nile Fever: ~20% develop symptoms like fever, headache, fatigue, body aches, nausea, vomiting, and occasional skin rash.
    Peak Infection Period Typically spikes between June and September (summer to autumn)
    Reported Outbreaks 19 countries have reported outbreaks, including Albania, Austria, Bulgaria, Croatia, Cyprus, Czechia, France, Germany, Greece, Hungary, Italy, North Macedonia, Romania, Serbia, Slovakia, Slovenia, Spain, Türkiye, and Kosovo.
    Treatment No vaccine available; supportive treatments provided for neuroinvasive WNV patients

     

    PYQ:

    [2017] Consider the following statements:

    1. In tropical regions, Zika virus disease is transmitted by the same mosquito that transmits dengue.

    2. Sexual transmission of Zika virus disease is possible.

    Which of the statements given above is/are correct?

    (a) 1 only

    (b) 2 only

    (c) Both 1 and 2

    (d) Neither 1 nor 2

  • Drugs Technical Advisory Board (DTAB)

    Why in the News?

    The Drugs Technical Advisory Board (DTAB), the highest statutory body on technical drug-related matters in India, has recommended including all antibiotics under the definition of ‘New Drugs’ in the New Drugs and Clinical Trial (NDCT) Rules, 2019.

    What are ‘New Drugs’?

    • According to Rule 122 E of the Drugs and Cosmetics Rules, 1945, a new drug is one that:
      • Has not been used in the country.
      • Has not been recognized as effective and safe by the licensing authority.
      • May also be an already approved drug with modified claims such as new indications, dosages, or routes of administration.

    Implications of Including Antibiotics in the New Drug Category:

    • If antibiotics are classified as new drugs:
      • Their manufacturing, marketing, and sale will be documented.
      • Clearance for manufacturing and marketing will need to be obtained from the Central government instead of State drug administrations.
      • Antibiotics will only be sold to patients on prescription.

    Additional Recommendations:

    • The board is considering amending the labelling rules under the Drugs Rules, 1945, by adding a blue strip or box for antimicrobial products.
    • It has recommended that antimicrobials should not be sold to non-pharmaceutical industries unless they have the necessary licences.

    About the Drugs Technical Advisory Board:

    Details
    Authority Highest statutory decision-making body on technical matters related to drugs in India
    Establishment Constituted under the Drugs and Cosmetics Act, 1940
    Affiliation Part of the Central Drugs Standard Control Organization (CDSCO)
    Nodal Ministry Ministry of Health and Family Welfare
    Functions – Advises the Central and State Governments on technical matters related to the Drugs and Cosmetics Act
    – Carries out functions assigned by the Act
    Role of CDSCO – Approval of drugs
    – Conduct of clinical trials
    – Establishing standards for drugs
    – Quality control of imported drugs
    – Coordination with State Drug Control Organizations
    Specialized Licenses Responsible for granting licenses for critical categories of drugs, including blood products, IV fluids, vaccines, and sera
    Decision-Making Provides expert advice and technical recommendations to ensure drug safety, efficacy, and quality

     

    PYQ:

    [2019] Which of the following are the reasons for the occurrence of multi-drug resistance in microbial pathogens in India?

    1. Genetic predisposition of some people
    2. Taking incorrect doses of antibiotics to cure diseases
    3. Using antibiotics in livestock farming
    4. Multiple chronic diseases in some people

    Select the correct answer using the code given below.

    (a) 1 and 2
    (b) 2 and 3 only
    (c) 1, 3 and 4
    (d) 2, 3 and 4

  • Mycobacterium Tuberculosis Bacteria

    Why in the News?

    • Due to increasing antimicrobial resistance in Mycobacterium tuberculosis (Mtb), many existing antibiotics are becoming less effective.
      • As a result, researchers are studying Mtb to identify key proteins and design new drugs to target them.

    What is Mycobacterium tuberculosis (Mtb)?

    • Mtb is the bacterium that causes tuberculosis (TB), affecting the lungs and sometimes spreading to other organs.
    • It spreads through airborne droplets from coughing or sneezing by an infected person.
    • Mtb can remain dormant in the body for years without causing active disease.
    • It infects macrophages, immune cells designed to destroy invaders, but instead, Mtb survives and multiplies inside them.

    What do various studies say?

    • A 2024 CSIR-CCMB study showed that Mtb uses cysteine synthase enzymes to survive oxidative stress.
    • A 2017 Karolinska Institute study identified 71 compounds that inhibit these enzymes, improving the effectiveness of antibiotics like isoniazid.
    • Researchers found that Mtb’s ability to evade the immune system is due to its long evolution with humans.
    • Other studies focus on Mtb’s phosphate and carbon metabolism, critical for its survival in hostile environments.
    • Ways for effective medicine development:
      • Target enzymes like CysK2 and CysM to weaken Mtb’s defence mechanisms.
      • Study Mtb’s metabolic pathways to identify vulnerabilities for new drug development.
      • Explore how Mtb develops antibiotic resistance and find ways to overcome it.
      • Investigate how Mtb evades immune responses by manipulating immune cells.
      • Combine new inhibitors with existing antibiotics to enhance treatment efficacy.

    PYQ:

    [2014] Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.

  • Why precision medicine in India can’t advance without biobank laws?

    Why in the News?

    Precision medicine is ushering in a new era of personalized healthcare, with its foundations taking shape during the completion of the Human Genome Project by scientists.

    What is the current legal framework governing biobanks in India?

    • Lack of Comprehensive Legislation: India lacks specific, comprehensive laws governing biobanks. The current framework consists of guidelines rather than enforceable laws, creating gaps in the regulation of biobanking practices.
    • National Ethical Guidelines by ICMR: The Indian Council for Medical Research (ICMR) has issued guidelines on ethical practices in biomedical research involving human participants. However, these guidelines are not legally binding and do not address all aspects of biobanking, such as long-term storage and data sharing.
    • Department of Biotechnology (DBT) Standards: The DBT has certain practices in place for data storage and analysis, but these also lack enforceability and do not fully cover issues such as informed consent and privacy.
    • Absence of a Single Regulatory Authority: India currently does not have a dedicated regulatory authority to oversee biobanks, which leads to inconsistencies and limited oversight in biobanking activities.

    How do privacy concerns impact biobank operations and precision medicine?

    • Informed Consent Issues: Participants often give consent without detailed information about how their biological samples and associated data will be used, who will have access, and for how long. This lack of transparency raises privacy concerns.
    • Genetic Data Privacy Risks: Genetic information can reveal intimate details about an individual’s health and predisposition to diseases, potentially affecting their family members. If data privacy is not robustly protected, it may lead to genetic discrimination in insurance or employment.
    • Data Sharing Without Proper Regulation: In the absence of clear legal provisions, data or samples could be shared without proper consent, risking misuse by pharmaceutical companies or research organizations, including foreign entities.
    • Impact on Public Trust: Weak data and privacy protections may reduce public willingness to participate in biobank projects, thus limiting the scale and diversity necessary for effective precision medicine research.

    What are the ethical implications of biobanking practices in India?

    • Ownership and Benefit Sharing: Without legal protections, there is ambiguity regarding the ownership of biological samples. Individuals contributing samples may not receive benefits from commercial applications resulting from their data, raising ethical concerns about fair compensation.
    • Consent Transparency: Participants may not fully understand the scope of their consent, especially regarding future uses of their samples and data. This lack of clarity can be considered ethically problematic, as it may involve the exploitation of participants’ contributions.
    • Risk of Misuse or Mismanagement: Inconsistent regulations and the absence of penalties for ethical violations create a risk of mishandling samples, unauthorized data access, and exploitation, which may compromise research integrity.
    • Discrimination Risks: Genetic information obtained from biobanks could be used to discriminate against individuals based on their health risks or genetic traits, which raises concerns about ethical and legal safeguards.

    Way forward: 

    • Establish Comprehensive Legislation: Develop and implement a comprehensive legal framework specifically governing biobanks, including clear guidelines on informed consent, data protection, ownership rights, and benefit sharing.
    • Create a Regulatory Authority: Establish a dedicated regulatory authority to oversee biobank operations, ensuring compliance with ethical standards and legal requirements.

  • Issues in the treatment of ‘rare diseases’, and what the govt can do?

    Why in the News?

    The Delhi High Court recently issued directives to enhance the availability of “orphan drugs” to combat rare diseases.

    About the Delhi High Court Verdict:

    • The Delhi High Court issued directions aimed at improving the availability of “orphan drugs,” which are used to treat rare diseases.
    • This intervention seeks to address challenges related to the high cost of these treatments and the barriers to access for patients with rare diseases in India.

    Rare Diseases in India and Their Classification:

    • Definition: According to the World Health Organization (WHO), rare diseases are debilitating, lifelong conditions that affect 1 or fewer individuals in 1,000.
    • Conditions Recognized as Rare Diseases in India: Approximately 55 conditions, including Gaucher’s disease, Lysosomal Storage Disorders (LSDs), and certain muscular dystrophies, are classified as rare diseases.
    • National Registry: The Indian Council of Medical Research (ICMR) manages the National Registry for Rare and Other Inherited Disorders (NRROID), which has documented 14,472 patients with rare diseases.

    Classification of Rare Diseases in India:

    • Group 1: Diseases that can be treated with a one-time curative procedure (e.g., certain enzyme replacement therapies).
    • Group 2: Conditions requiring long-term or lifelong treatment, which are relatively less expensive and have documented benefits. Regular medical check-ups are necessary for patients.
    • Group 3: Diseases for which effective treatments are available, but they are highly costly and require ongoing, lifelong therapy. Selecting beneficiaries for these treatments presents a challenge due to the high costs.

    Current Funding Policy in India:

    • National Policy for Rare Diseases (NPRD) 2021: Launched to provide financial support for the treatment of rare diseases. Patients receiving treatment at designated Centres of Excellence (CoE) can get financial assistance up to Rs 50 lakh.
    • Centres of Excellence: The CoEs include institutions such as AIIMS in Delhi, PGIMER in Chandigarh, and the Institute of Postgraduate Medical Education and Research at Kolkata’s SSKM Hospital.
    • Crowdfunding and Voluntary Donations Portal (2022): The Health Ministry launched a digital platform that allows donors to contribute toward the treatment of rare disease patients at CoEs. The portal provides details about patients, their conditions, estimated treatment costs, and bank account information of the CoEs.
     

    Did you know?

    • Murine Typhus (a rare disease) is a flea-borne bacterial disease caused by Rickettsia typhi, transmitted through infected flea bites, primarily from rodents and not contagious between humans.
    • A 75-year-old man from Kerala’s capital Thiruvananthapuram was recently diagnosed with Murine Typhus after travelling to Vietnam and Cambodia.

    Challenges Associated with Orphan Drugs:

    • Limited Treatment Options: Therapies are available for fewer than 5% of rare diseases, resulting in less than 10% of patients receiving disease-specific treatment.
    • High Treatment Costs: Many existing therapies for rare diseases are prohibitively expensive, putting a significant financial burden on patients and their families.
    • Regulatory Delays: Approval processes, such as those from the Drug Controller General of India (DCGI), can be slow. For instance, delays in approving US-based Sarepta Therapeutics’ medicines in India have affected the timely availability of treatments.
    • Bureaucratic Hurdles: Decision-making delays and administrative red tape further complicate access to necessary drugs, impacting patient care.
    • Challenges in Beneficiary Selection: Due to high treatment costs, identifying and prioritizing beneficiaries for financial assistance is difficult, potentially leaving some patients without support.

    Way forward: 

    • Streamline Regulatory Approvals: Expedite the approval process for orphan drugs by reducing bureaucratic hurdles and establishing a fast-track mechanism for essential treatments, ensuring timely access to life-saving medications.
    • Increase Financial Support and Expand Coverage: Enhance the funding cap under the National Policy for Rare Diseases and extend financial assistance to more patients, while encouraging public-private partnerships and innovative funding mechanisms like insurance coverage for rare disease treatments.