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Subject: Science and Technology

  • Evidence of non-Mendelian inheritance in mice

    Why in the News

    Researchers have reported evidence of non-Mendelian inheritance in mice, involving DNA methylation, genomic imprinting and paramutation. Nanopore sequencing helped detect these epigenetic marks.

    What is Epigenetic Inheritance?

    1. Definition: Transmission of heritable changes in gene activity without altering the underlying DNA sequence.
    2. Major mechanism: Chemical modifications such as DNA methylation can influence whether genes are switched on or off.
    3. Non-Mendelian: Unlike classical Mendelian inheritance, the inherited information is not limited to changes in the DNA sequence.
    4. Genomic imprinting: Expression of certain genes depends on whether they are inherited from the mother or father.
    5. Paramutation: One allele can induce a heritable change in the expression of another allele without changing its DNA sequence.
    6. Nanopore sequencing: Can detect certain DNA modifications, including methylation, while sequencing DNA.

    Why does it matter?

    • Expands inheritance theory: Heritable information can involve regulatory/epigenetic states in addition to DNA sequence.
    • Environment and inheritance: Some environmental factors can influence epigenetic states, though not every acquired epigenetic change is necessarily inherited.
    • Disease relevance: Abnormal epigenetic regulation is associated with cancers and other diseases.
    • Biotechnology: Advanced sequencing can help identify epigenetic modifications alongside DNA sequences.

    “[2021, GS3, 15 marks] What are the research and developmental achievements in applied biotechnology? How will these achievements help to uplift the poorer sections of society?

    [2021] In the context of hereditary diseases, consider the following statements:
    1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg.
    2. A child inherits mitochondrial diseases entirely from mother and not from father.
    Which of the statements given above is/are correct?

    [A] 1 only

    [B] 2 only

    [C] Both 1 and 2

    [D] Neither 1 nor 2

  • AI tool can shrink and rewrite proteins

    Why in the News

    A university team has developed Raygun, an AI tool that can redesign and miniaturise proteins while retaining their function. This could improve the delivery of protein-based therapies and accelerate drug development.

    What is AI-based Protein Engineering?

    1. Protein engineering: Designing or modifying proteins to obtain desired properties such as smaller size, stability or specific biological functions.
    2. AI-based design: AI models trained on protein sequences can predict and generate redesigned protein structures.
    3. Raygun: The tool can shrink proteins while attempting to preserve their function, potentially making them easier to deliver.

    Why does it matter?

    • Gene therapy: Delivery vectors have limited cargo capacity. Smaller functional proteins can make therapeutic delivery easier.
    • Drug development: AI can reduce dependence on lengthy trial-and-error approaches in protein design.
    • Precision medicine: Engineered proteins could potentially be tailored for specific therapeutic functions.
    • Biosafety: Powerful AI-enabled biological design raises concerns regarding misuse, unintended effects and governance.

    Protein engineering ≠ gene editing

    • Protein engineering: Modifies/designs the protein to alter its properties.
    • Gene editing: Directly modifies DNA sequences.
    • AI protein design: Uses computational models to predict or generate useful protein sequences/structures.
    • Gene therapy: Uses genetic material or biological mechanisms to treat disease.

    [2026] Which of the following statements with regard to genetic medicine is/are correct ?
    1. Genetic medicines correct/compensate for the faulty genes responsible for disease.
    2. Engineered viruses and lipid nanoparticles are used as carriers of the genetic medicine.
    3. Genetic medicines alter the entire DNA sequence.
    Select the answer using the code given below :

    [A] 1 only

    [B] 2 and 3 only

    [C] 1 and 2 only

    [D] 1, 2 and 3

  • AI agents flagged as a new cybersecurity risk

    Why in the News

    Leading AI developers and a national safety institute reported that AI agents took unauthorised actions during controlled cyber tests, highlighting a new category of AI safety and cybersecurity risk.

    What is an AI Agent?

    • AI Agent: An AI system that can perceive, plan, decide and act toward a goal with limited human supervision.
    • Unlike a conventional AI model that mainly generates an output, an agent can use tools, access systems and execute actions.
    • Core feature: Autonomy + goal-directed action

    What did the Tests Reveal?

    • Agents sometimes acted beyond their given instructions.
    • Such behaviour indicates that increasing autonomy can create risks beyond conventional software bugs or model errors.
    • Findings involved OpenAI, Anthropic, Meta and the UK AI Security Institute.

    Alignment Failure vs Capability Failure

    Alignment Failure

    • AI’s behaviour or strategy conflicts with human intent.
    • The system may technically pursue its objective but do so in an unauthorised or undesirable manner.

    Capability Failure

    • AI fails because of inadequate capability, reasoning or execution.
    • The problem is inability rather than deliberate deviation from the intended objective.

    “[2020] With the present state of development, Artificial Intelligence can effectively do which of the following?
    1. Bring down electricity consumption in industrial units
    2. Create meaningful short stories and songs
    3. Disease diagnosis
    4. Text-to-Speech Conversion
    5. Wireless transmission of electrical energy
    Select the correct answer using the code given below:
    (a) 1, 2, 3 and 5 only
    (b) 1, 3 and 4 only
    (c) 2, 4 and 5 only
    (d) 1, 2, 3, 4 and 5

  • RDI deep-tech fund: most beneficiaries linked to selection panel

    Why in the News

    An investigation found that 15 of the 22 companies receiving the first round of assistance from the Research, Development and Innovation (RDI) Fund had investment links with members of the fund’s selection committee. The panel approved Rs 2,192 crore in soft loans, raising concerns over conflict of interest and transparency.

    What is the Research, Development and Innovation (RDI) Fund?

    • Definition: A Rs 1 lakh crore fund to support private sector research in strategic and deep tech sectors.
    • Focus Areas: Artificial Intelligence, Quantum Technology, Space, Defence, Robotics, Clean Energy, Semiconductors and Digital Healthcare.
    • Financial Support: Collateral free loans up to 50% of project cost, at 2 to 4% interest for up to 15 years.
    • Custodian: Managed through a Special Purpose Fund under the Anusandhan National Research Foundation (ANRF).
    • Fund Managers: Loans are disbursed through Second Level Fund Managers (SLFMs), currently the Technology Development Board (TDB) and Biotechnology Industry Research Assistance Council (BIRAC).

    How are companies selected?

    • Investment Committees: Each SLFM forms an independent investment committee to evaluate proposals.
    • Composition: The TDB committee had 12 members, largely from private equity and technology, with one non voting government representative.
    • Eligibility: Projects must have achieved at least Technology Readiness Level (TRL) 4, meaning laboratory validation is complete.
    • Selection Criteria: Scientific, technological, financial and commercial viability, with decisions taken by majority vote.

    What did the investigation reveal?

    • Conflict Links: 15 of 22 beneficiaries had investment ties with 7 committee members.
    • Funding Concentration: These firms received over Rs 1,377 crore of the total approved amount.
    • Chairman’s Role: Nine selected firms were linked to the committee chairman, who reportedly also held a personal stake in one beneficiary.
    • Committee’s Defence: Members stated that interests were disclosed and they recused themselves from related decisions.
    • Governance Concern: The episode has renewed demands for stronger safeguards in the use of public funds.

    Existing safeguards

    • Mandatory disclosure of financial interests by committee members.
    • Recusal from decisions involving associated companies.
    • Background verification of applicants by fund managers.
    • Expert driven selection to improve technical assessment.
    • However, only two SLFMs currently operate the scheme, concentrating decision making and highlighting the need for greater transparency.

    Back2Basics: Research, Development and Innovation (RDI) Fund

    • Launched: 2025
    • Corpus: Rs 1 lakh crore
    • Nodal Framework: Operates under the Anusandhan National Research Foundation (ANRF)
    • Objective: Provide long term, low cost financing for private sector research in deep tech and strategic sectors.
    • Implementing Agencies: Technology Development Board (TDB) and Biotechnology Industry Research Assistance Council (BIRAC) as Second Level Fund Managers.
    • Key Feature: Collateral free loans covering up to 50% of project cost through independent investment committees.

  • BioE3 Policy Reports Early Biomanufacturing Gains

    Why in the News

    The Government has highlighted the early achievements of the Biotechnology for Economy, Environment and Employment (BioE3) Policy, demonstrating growing investments and capacity in India’s biomanufacturing sector.

    What is the BioE3 Policy?

    • Full form: Biotechnology for Economy, Environment and Employment (BioE3) Policy.
    • Approved: 2024 by the Union Cabinet.
    • Implementing Agency: Department of Biotechnology (DBT).
    • Objective: Promote high capacity biomanufacturing to drive economic growth, environmental sustainability, and employment generation.

    Key Features of the Policy

    • Focus Areas: The policy identifies six thematic sectors:
      • Bio based chemicals.
      • Smart proteins.
      • Precision biotherapeutics.
      • Climate resilient agriculture.
      • Biofuels and carbon capture.
      • Marine and space biotechnology.
    • Funding Pattern:
      • Government support of up to 70% of project cost.
      • Remaining contribution from the private sector.
    • Industry Participation:
      • Over 600 beneficiaries have utilised BioE3 facilities.
      • Private investment commitments have reached about ₹602 crore.
    • Long term Goal: Support India’s vision of a $300 billion bioeconomy by 2030.

    What is Biomanufacturing?

    • Definition: The production of chemicals, fuels, materials, pharmaceuticals and other products using biological systems such as microorganisms, enzymes or engineered cells.
    • Benefits:
      • Reduces dependence on fossil fuel based manufacturing.
      • Promotes sustainable industrial production.
      • Supports the circular bioeconomy.

    What is a Biofoundry?

    • A highly automated research facility that designs, builds, tests and analyses biological systems.
    • Accelerates the development of new biotechnology products through automation and artificial intelligence.

    [2026] Which of the following statements with regard to GenomeIndia Project is/are correct ?
    1. It is a part of the Human Genome Project.
    2. The project is funded by the Department of Biotechnology (DBT), Government of India.
    3. Its primary aim is to build a catalogue of genetic diversity of the Indian population.
    Select the answer using the code given below:

    [A] 1 only

    [B] 2 and 3 only

    [C] 1 and 2 only

    [D] 1, 2 and 3

  • Indian Scientists Develop a Protocol to Densify Quantum Networks

    Why in the News

    Indian scientists have developed a new routing protocol called General Concurrence Percolation (GCP) to improve the efficiency and connectivity of quantum networks, marking a significant advance in quantum communication.

    What is the General Concurrence Percolation (GCP) Protocol?

    • Innovation: A routing protocol designed to strengthen quantum entanglement across a quantum network.
    • Approach: Uses localized geometric routing to identify the shortest communication paths.
    • Key feature: Preserves intermediate network nodes instead of disconnecting them, improving network stability.
    • Outcome: Simulations show the protocol reduces the minimum entanglement required to connect an entire quantum network.

    What is Quantum Entanglement?

    • Definition: A quantum phenomenon in which two or more particles remain correlated so that the state of one is intrinsically linked to the state of the other, regardless of distance.
    • Challenge: Entanglement weakens over long distances, making reliable quantum communication difficult.
    • Importance: It is the foundation of quantum communication, quantum cryptography, and quantum computing.

    Why is the Development Significant?

    • Improves the efficiency of long distance quantum communication.
    • Reduces the amount of entanglement needed for network connectivity.
    • Makes future quantum internet infrastructure more robust and scalable.
    • Supports secure communication through quantum encryption technologies.
    • Strengthens India’s capabilities in advanced quantum technologies.

    [2026] Which of the following statements with regard to the National Quantum Mission (NQM) is/are correct?
    1. It aims at developing intermediate-scale quantum computers with 50 – 1000 physical qubits.
    2. Its implementation includes setting up of four Thematic Hubs (T-Hubs) in academic and national R&D institutes across India.
    Select the answer using the code given below :

    [A] 1 only

    [B] 2 only

    [C] Both 1 and 2

    [D] Neither 1 nor 2

  • Government Strengthens Rules Against AI Generated Deepfakes

    Why in the News

    The Government has strengthened the regulatory framework against AI generated deepfakes by amending the Information Technology (Intermediary Guidelines and Digital Media Ethics Code) Rules, 2021.

    What are the New Amendments?

    • Legal framework: Amendments have been made to the Information Technology (Intermediary Guidelines and Digital Media Ethics Code) Rules, 2021, framed under the Information Technology Act, 2000.
    • New definition: Introduces the concept of Synthetically Generated Information (SGI), covering deepfakes and other AI generated content.
    • Mandatory labelling: Platforms must clearly label synthetic content and embed traceable metadata to identify AI generated material.
    • User declaration: Significant Social Media Intermediaries (SSMIs) must obtain a declaration from users on whether uploaded content is synthetic.
    • Verification tools: SSMIs are required to deploy tools to verify user declarations.
    • Harmful content: The framework specifically targets:
      • Child Sexual Abuse Material (CSAM)
      • Non consensual intimate imagery
      • AI enabled impersonation and fraud

    What is a Deepfake?

    • Definition: Deepfakes are AI generated synthetic media in which a person’s face, voice, or likeness is created or manipulated using deep learning techniques.
    • Uses: Can be used for entertainment, education and content creation, but also for misinformation, identity theft, financial fraud and cybercrime.

    [2020] With the print state of development, Artificial Intelligence can effectively do which of the following?
    1. Bring down electricity consumption in industrial units
    2. Create meaningful short stories and songs
    3. Disease diagnosis
    4. Text -to -Speech Conversion
    5. Wireless transmission of electrical energy
    Select the correct answer using the code given below:

    [A] 1, 2, 3 and 5 only

    [B] 1, 3 and 4 only

    [C] 2, 4 and 5 only

    [D] 1, 2, 3, 4 and 5

  • How ‘ghost particles’ can point the way to spent nuclear fuel

    Why in the News

    Scientists have achieved the first high precision measurement of the neutrino signature from spent nuclear fuel, enabling remote monitoring of nuclear material and strengthening global nuclear non proliferation efforts.

    What is a neutrino?

    • Ghost particle: A neutrino is a nearly massless, electrically neutral subatomic particle that interacts only through the weak nuclear force and gravity.
    • Produced in nuclear reactions: They are emitted in large numbers during nuclear fission, radioactive decay, and reactions inside stars.
    • Highly penetrating: Since neutrinos rarely interact with matter, they can pass through the Earth almost unaffected, making them extremely difficult to detect.

    What did the study achieve?

    • First precise measurement: Researchers in France made the first high precision measurement of the neutrino emissions from spent nuclear fuel.
    • Remote monitoring: The neutrino signal can be measured without physically opening or handling the spent fuel.
    • Scientific validation: The findings were published in a leading peer reviewed physics journal.

    Why is this important for nuclear non proliferation?

    • Supports IAEA safeguards: Enables the International Atomic Energy Agency (IAEA) to verify spent nuclear fuel remotely.
    • Detects diversion: Changes in the neutrino signal can indicate diversion of plutonium or other fissile material for weapons.
    • Strengthens nuclear safeguards: Provides a non intrusive and tamper resistant method to improve verification of nuclear material.
    • Enhances transparency: Builds confidence in peaceful civilian nuclear programmes.

    Prelims Pointers

    • The International Atomic Energy Agency (IAEA) is the UN agency responsible for promoting peaceful uses of nuclear energy and implementing nuclear safeguards.
    • Neutrinos are electrically neutral, nearly massless particles that interact via the weak nuclear force.
    • Nuclear reactors and spent nuclear fuel continuously emit neutrinos.
    • Spent nuclear fuel contains plutonium that can potentially be separated for nuclear weapons, making its monitoring important.

    “[2020] In India, why are some nuclear reactors kept ‘IAEA Safeguards’ while others are not?
    (a) Some use uranium and others use thorium
    (b) Some use imported uranium and others use domestic supplies
    (c) Some are operated by foreign enterprises and others are operated by domestic
    (d) Some are State-owned and others are privately-owned

  • SpaceX Falcon 9 upper stage set to strike the Moon, exposing gaps in space law

    Why in the News

    A spent SpaceX Falcon 9 upper stage is expected to impact the Einstein Crater on the Moon on 5 August 2026. The event provides a rare scientific opportunity while highlighting gaps in international laws governing lunar activities and space debris.

    What is the Outer Space Treaty?

    • The Outer Space Treaty (1967) is the foundation of international space law.
    • Governs activities in outer space, including the Moon and other celestial bodies.
    • Prohibits national sovereignty claims over outer space (Article II).
    • Requires exploration for the benefit of all countries and peaceful purposes.

    What is a Controlled Source Impact?

    • An impact where the mass, speed, and trajectory of the object are known beforehand.
    • Helps scientists accurately study:
      • Crater formation.
      • Lunar dust (ejecta) behaviour.
      • Surface composition.

    What is ATLAC?

    • Action Team on Lunar Activity Consultation (ATLAC) is a United Nations (UN) working group.
    • Works on developing norms for: Lunar landing coordination, Lunar dust mitigation, and Space debris management.

    Why is the Impact Significant?

    • Rare opportunity to study the Moon through a known artificial impact.
    • Improves understanding of lunar dust, crucial for future lunar missions and habitats.
    • Similar to NASA’s Lunar Crater Observation and Sensing Satellite (LCROSS) Mission (2009), which confirmed the presence of water ice.

    Challenges

    • No treaty specifically regulates lunar debris or spent rocket stages.
    • No legal protection for lunar heritage sites (e.g., Shiv Shakti Point).
    • Increasing commercial and national missions raise collision risks.
    • Slow consensus-based UN rule-making.

    Chandrayaan-3

    • Launched by: Indian Space Research Organisation (ISRO) in 2023.
    • Achievement: First soft landing near the Moon’s south pole; India became the 4th country to achieve a soft landing on the Moon.
    • Shiv Shakti Point: Name of the Vikram lander’s landing site.
    • Components: Vikram Lander and Pragyan Rover.

    [2009] India has recently landed its Moon Impact Probe (MIP) on the Moon. Among the following countries, which one landed such probe on the Moon earlier?

    (a) Australia

    (b) Canada

    (c) China

    (d) Japan.

  • Why lab-grown diamonds are a sustainable alternative to mined stones

    Why in the News?

    With natural diamond reserves declining and concerns over environmental damage, conflict diamonds and forced labour, India is promoting Lab-Grown Diamonds (LGDs) through the India Centre for Lab-Grown Diamond (InCent-LGD) at Indian Institute of Technology (IIT) Madras.

    What is the Kimberley Process?

    • Kimberley Process Certification Scheme (KPCS): An international certification system launched in 2003 to prevent conflict (blood) diamonds from entering global trade.
    • Limitation: Difficult to trace the geographic origin of diamonds, enabling smuggling.

    Significance of Lab-Grown Diamonds

    • Lower water, land and environmental footprint.
    • Fully traceable and ethically sourced.
    • More affordable than mined diamonds.
    • Used in jewellery, cutting tools, drilling, semiconductors and quantum computing.

    India’s Initiative

    • Union Budget 2023-24 announced support for indigenous LGD production.
    • InCent-LGD established at IIT Madras with a ₹243 crore grant from the Ministry of Commerce and Industry.
    • Focuses on developing indigenous diamond seeds, machinery and manufacturing technology.

    [2018] Which one of the following foreign travellers elaborately discussed about diamonds and diamond mines of India?

    [A] Francois Bernier

    [B] Jean-Baptiste Tavernier

    [C] Jean de Thevenot

    [D] Abbe Barthelemy Carre