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GS Paper: GS3

  • AI-designed Proteins to generate Immune Cells

    Why in the News?

    Harvard Scientists have recently used AI to design synthetic proteins that activate T Cells, offering a new path for cancer treatment and vaccine development.

    What are T Cells?

    • They are a type of white blood cell that play a central role in the immune system.
    • Types of T Cells:
      • Helper T cells (CD4+): Activate and direct other immune cells.
      • Killer T cells (CD8+): Destroy infected or cancerous cells.
      • Memory T cells: “Remember” past invaders for faster response in the future.

    About the Study:

    • Used artificial intelligence (AI) to design soluble proteins that activate ‘Notch Signalling’, a key immune pathway.
      • These are synthetic molecular activators designed using advanced AI-driven protein design technologies.
    • Unlike older lab-only methods, these proteins work inside the body (in vivo) and in lab settings.
    • Result: Significant boost in T cell production from human progenitor cells.

    What is Notch Signalling?

    • A cell-to-cell signalling system that guides cell development.
    • Crucial for forming T cells, which fight infections and cancers.
    • No reliable therapeutic activator existed earlier.

    Key Benefits Offered:

    • Mass T Cell Generation: Meets clinical needs for CAR T Cell Therapy.
    • Vaccine Support: Boosted Memory T cells in mice, improving long-term immunity.
    • Cancer Therapy: Helps fight immune-suppressive tumour environments.
    • Scalable & Soluble: Works in humans, not just in lab dishes.
    • AI in Medicine: Shows AI’s growing role in designing immune therapies.
    [UPSC 2022] Which one of the following statements best describes the role of B cells and T cells in the human body?

    Options: (a) They protect the body from environmental allergens.

    (b) They alleviate the body’s pain and inflammation.

    (c) They act as immunosuppressants in the body.

    (d) They protect the body from the diseases caused by pathogens

     

  • Species in news: Alpine Musk Deer

    Why in the News?

    A Central Zoo Authority (CZA) report reveals a major conservation error — the critically endangered Alpine musk deer was wrongly replaced by the Himalayan musk deer in India’s breeding programmes.

    Species in news: Alpine Musk Deer

    Back2Basics: Central Zoo Authority (CZA):

    • Establishment: Formed in 1992 under Wildlife (Protection) Act, 1972.
    • Mandate: Captive breeding, zoo oversight, and assigning species to zoos.
    • Expanded Scope (2022): Includes rescue centres, off-display facilities, and conservation breeding centres.

    About Alpine Musk Deer (Moschus chrysogaster):

    • Not a true Deer: closer to goats and antelopes (Bovidae).
    • Musk Sac: Males have a visible musk sac between the testes.
    • Canines: Grows fang-like canines during the mating season.
    • Habitat: Found at 3,000–5,000 m in forests of the Himalayas.
    • Range: India (J&K, HP, Uttarakhand, Sikkim, Arunachal), Nepal, Bhutan, China.
    • Diet: Eats grasses, leaves, lichens, mosses, and twigs.
    • Behaviour: Solitary and crepuscular (active at dawn/dusk).
    • Legal Protection:  IUCN Status Critically Endangered (2014), CITES Appendix I; Indian Wildlife Act- Schedule I.
    • Threats: Poaching for musk and habitat loss.
    • Key Habitats: Askot, Gangotri & Kedarnath Wildlife Sanctuaries (Uttarakhand).
    [UPSC 2020] Which of the following are the most likely places to find the musk deer in its natural habitat?

    1. Askot Wildlife Sanctuary 2. Gangotri National Park

    3. Kishanpur Wildlife Sanctuary 4. Manas National Park

    Options: (a) 1 and 2 only * (b) 2 and 3 only (c) 3 and 4 only (d) 1 and 4 only

     

  • Human Outer Planet Exploration (HOPE)

    Why in the News?

    India has taken a significant step towards interplanetary human missions with the launch of the Human Outer Planet Exploration (HOPE) analogue station at Tso Kar, Ladakh.

    hope

    About HOPE (Human Outer Planet Exploration):

    • Purpose: Simulates Moon and Mars conditions to prepare for future human missions.
    • Developer: Built by Protoplanet (Bengaluru); partially funded by ISRO.
    • Location: Tso Kar, Ladakh (14,500 ft) — chosen for its lunar/Martian-like terrain.
    • Features: Enables isolation research, tech trials, and crew training; 1 of 33 such stations globally.
    • First Mission (2025): Two scientists (Rahul Mogalapalli, Yaman Akot) conducted a 10-day simulation focusing on resilience and mental health.
    • Significance:
      • Boosts India’s human spaceflight readiness.
      • Supports goals like Bharatiya Antariksh Station (2035) and Moon mission (2040).

    India’s Astronomical Assets in Ladakh:

    • Location: Indian Astronomical Observatory (IAO), at Mt. Saraswati (4,500 m), Hanle; run by Indian Institute of Astrophysics.
    • Key Instruments:
      • Himalayan Chandra Telescope (optical/infrared)
      • HAGAR (gamma rays, with Tata Institute of Fundamental Research)
      • MACE (Cherenkov telescope, with Bhabha Atomic Research Centre)
    • Stargazing hubs: Hanle, Nubra Valley, Pangong, Tso Moriri.
    • Advantages & Recognition:
      • 270+ clear nights; low humidity; dark skies.
      • Declared India’s 1st Dark-Sky Reserve (2022) to curb light pollution.
    [UPSC 2012] The world’s highest ground based telescopic observatory is located in

    Options: (a) Colombia (b) India* (c) Nepal (d) Switzerland

     

  • Biologics & Biosimilars: The next frontier in Affordable Medicines

    Why in the News?

    While most medicines are small molecule drugs with simple structures, a newer class—biologics and biosimilars—is reshaping modern medicine with their complex, targeted action.

    What are Small Molecule Drugs?

    • Definition: Chemically synthesised, low molecular weight compounds.
    • Features: Fixed structure, chemically stable, easy to replicate, patent-protected.
    • Cost Dynamics: Expensive while under patent; affordable generics post-expiry (e.g., Sovaldi dropped from $84,000 to $1,000).

    About Biologics & Biosimilars:

    • Biologics-
      • Overview: Large, complex drugs made from living cells or organisms.
      • Examples: Insulin (~5,800 daltons), Remicade (~150,000 daltons).
      • Nature: Slight structural variations possible; used for cancer, autoimmune diseases, hormone therapy.
    • Biosimilars-
      • Overview: Near-identical versions of biologics, made after patent expiry.
      • Not Generics: Due to complex cell-based production, they’re similar but not identical.
      • Use: Offer lower-cost alternatives to high-end biologics.

    Regulation and Reform:

    • Current Barriers: Biosimilars need costly trials (animal + clinical), unlike generics.
    • Global Moves: UK and USA are easing animal trial norms (organ-on-chip, human models).
    • India: Still follows older norms; waivers under review, but clinical trials still mandatory.

    Significance for India:

    • Access: Generic small molecules transformed Indian healthcare.
    • Opportunity: Affordable biosimilars can do the same for chronic and rare diseases.
    • Urgency: Regulatory reform is key to reduce costs, speed up access, and widen healthcare coverage.
    [UPSC 2020] What is the importance of using Pneumococcal Conjugate Vaccines in India?

    (1) These vaccines are effective against pneumonia as well as meningitis and sepsis. (2) Dependence on antibiotics that are not effective against drug-resistant bacteria can be reduced. (3) These vaccines have no side effects and cause no allergic reactions.

    Options: (a) 1 only (b) 1 and 2 only* (c) 1 and 3 only (d) 1, 2 and 3

     

  • Why the ICJ’s advisory opinion on climate change opens the window for a new, restorative vision of environmental law in India

    Why in the News?

    Recently, the International Court of Justice (ICJ) delivered a landmark advisory opinion on July 23, 2025, clarifying the legal obligations of states regarding climate change.

    Note: The International Court of Justice (ICJ) is the principal judicial organ of the United Nations. While advisory opinions are not formally binding, they hold persuasive (Convince other) legal weight and reflect the Court’s authoritative interpretation of international law.

    What does the ICJ say about saving nature and the climate?

    • Nature is a climate actor, not just a victim: ICJ recognizes ecosystems like forests, oceans, and coral reefs as active parts of the climate system. Eg: Forests absorb CO₂ and regulate rainfall.
    • Protecting nature is a legal climate duty: Countries have a responsibility to safeguard nature as part of their climate obligations. Eg: Wetlands must be preserved to manage floods and store carbon.
    • Ecological literacy is essential: Decision-makers must understand ecosystem roles in climate regulation. Eg: Mangrove destruction worsens storm impact and carbon release.
    • Biodiversity and climate are equal: Climate action must not come at the cost of biodiversity. Eg: Solar parks should not destroy grasslands or wildlife zones.
    • Global justice includes nature’s rights: The ICJ promotes a shift from human-centred to eco-centred justice. Eg: Legal personhood to rivers (like Ganga) aligns with this approach.

    How can India align the ICJ view with Articles 21 and 48A of the Constitution?

    • Recognize environmental rights as part of Right to Life (Article 21): Link clean air, water, and a healthy ecosystem to the fundamental right to life. Eg: Supreme Court’s recognition of the right to a healthy environment in the Subhash Kumar case.
    • Implement Directive Principle on environment (Article 48A): Strengthen policies to protect and improve forests, rivers, and biodiversity. Eg: Initiatives like Namami Gange align with this duty.

    What are the roles of Tribals in India’s climate plans?

    The roles of tribals in India’s climate plans are crucial because they are deeply connected with nature and are key to conservation and climate resilience.

    • Traditional Ecological Knowledge: Tribals have deep understanding of local ecosystems, useful for conservation and climate adaptation. Eg: Bhil tribes, Madhya Pradesh – traditional water harvesting for drought resilience.
    • Forest and Biodiversity Guardianship: Indigenous communities act as forest protectors and biodiversity custodians, aiding carbon sequestration. Eg: Dongria Kondh, Odisha – protect Niyamgiri Hills’ biodiversity.
    • Sustainable Livelihood Practices: Tribes follow low-carbon, eco-friendly practices, supporting climate goals. Eg: Apatani tribe, Arunachal Pradesh – eco-friendly wet rice farming (growing rice in flooded fields).
    • Community-Based Climate Adaptation: Local innovation enables faster climate resilience and resource management. Eg: Women in Kutch, Gujarat – build check dams for water security.
    • Effective Implementation of Climate Schemes: Grassroots involvement improves policy success, ensures inclusive development. Eg: Van Dhan Yojana – empowers tribal collectives for sustainable forest use.

    Which laws should India improve to better protect nature and fight climate change?

    • Strengthen Environmental Impact Assessment (EIA): Make public consultations more transparent and science-based. Eg: Dilution in EIA 2020 draft faced criticism for reducing oversight on polluting projects.
    • Amend Forest Conservation Act (FCA): Ensure tribal rights and ecological value are protected during land diversion. Eg: FCA 2023 allowed exemptions for some forest lands, risking biodiversity loss.
    • Update Air (Prevention and Control of Pollution) Act, 1981: Include stricter penalties and real-time monitoring for industrial emissions. Eg: Delhi’s recurring smog highlights the law’s limited deterrence.

    Way forward:

    • Empower Local Communities: Recognize and support tribal and grassroots climate efforts through legal rights, funding, and capacity building.
    • Mainstream Climate in Policy Planning: Integrate climate adaptation and mitigation into urban planning, agriculture, and infrastructure development.
    • Promote Green Finance and Innovation: Incentivize clean technologies, nature-based solutions, and public-private partnerships for sustainable development.

    Mains PYQ:

    [UPSC 2023] The most significant achievement of modern law in India in the constitutionalization of environmental problems by the Supreme Court. Discuss this statement with the help of relevant case laws.

    Linkage: The article highlights that India’s Supreme Court has interpreted Article 21 (right to life) to include the right to a healthy environment, and the ICJ’s opinion internationalizes this idea, providing a strong basis for India’s legal framework to embrace a restorative vision.

  • What is Darwin Tree of Life (DToL) Project?

    Why in the News?

    Researchers in Britain & Ireland are aiming to sequence all animals, fungi and plants under the Darwin Tree of Life (DToL) Project.

    About Darwin Tree of Life (DToL) Project:

    • Objective: To sequence the genomes of all ~70,000 known eukaryotic species (whose cells contain a nucleus and other membrane-bound organelles) found in Britain and Ireland.
    • Initiated: In 2019 as a UK–Ireland contribution to the Earth BioGenome Project.
    • Geographic Focus: Great Britain and Ireland, chosen for their well-documented and accessible biodiversity.

    Key Features:

    • Phases:
      • Pilot Phase (2019–2022): Focused on collecting 8,000 species; targeted 2,000 genome assemblies.
      • As of 2025: ~8,000 species collected; over 2,000 genomes sequenced.
    • Approach:
      • Systematic specimen collection and species verification.
      • High-quality genome sequencing using advanced tools and curated pipelines.
    • Public Access: All genome data is released openly via the DToL portal and public archives.
    • Scientific Significance:
      • Enhances understanding of evolution, adaptation, and species relationships.
      • Supports conservation efforts amid growing biodiversity threats.
    • Applications: Informs conservation biology, medicine, agriculture, and climate adaptation.
    [UPSC 2011] At present, scientists can determine the arrangement or relative positions of genes or DNA sequences on a chromosome. How does this knowledge benefit us?

    1. It is possible to know the pedigree of livestock.

    2. It is possible to understand the causes of all human diseases.

    3. It is possible to develop disease-resistant animal breeds.

    Options: (a) 1 and 2 only (b) 2 only (c) 1 and 3 only* (d) 1, 2 and 3

     

  • [1st August 2025] The Hindu Op-ed: Why the world needs better green technologies

    PYQ Relevance:

    [UPSC 2024] The world is facing an acute shortage of clean and safe freshwater. What are the alternative technologies which can solve this crisis? Briefly discuss any three such technologies citing their key merits and demerits.

    Linkage: This question directly related to “alternative technologies” to address a critical global environmental and resource crisis (freshwater scarcity). This aligns with the broader theme that the world needs better and diverse green technologies to tackle urgent environmental problems and ensure resource self-sufficiency, as emphasized in the context of energy innovation.

     

    Mentor’s Comment: As the push for sustainable energy intensifies, concerns are rising over the efficiency limits of widely used silicon photovoltaics. With the growing need for green hydrogen and land constraints, experts are questioning whether next-gen solar technologies offer better solutions. India must invest in efficient, diverse, and scalable innovations to meet climate goals and ensure energy self-sufficiency.

    Today’s editorial analyses the concerns that are rising over the efficiency limits of widely used silicon photovoltaics. This topic is important for GS Paper III (Environment) in the UPSC mains exam.

    _

    Let’s learn!

    Why in the News?

    Recently, as the global need for clean energy has increased and countries aim to fulfill their climate promises, silicon solar panels have become the most popular choice, changing the look of places from city rooftops to large solar farms in villages.

    What limits silicon photovoltaics in meeting India’s climate goals?

    • Low Energy Efficiency: Silicon solar panels have an in-field efficiency of only 15–18%, meaning a significant portion of solar energy is not converted into electricity. Eg: In Rajasthan, more panels are required to meet energy demand, increasing cost and land use due to low conversion efficiency.
    • High Land Requirement: Due to their low efficiency, silicon panels need a larger surface area to generate the same output compared to newer technologies. Eg: The Rewa Solar Park in Madhya Pradesh covers over 1,500 hectares, reducing land availability for agriculture and conservation.
    • Slow Climate Impact: Despite growing solar capacity, CO₂ levels have risen from 350 ppm in 1990 to ~425 ppm in 2025, indicating renewables are not scaling fast enough. Eg: Even after installing 4.45 TWh of renewable energy by 2024, India remains behind on its climate targets.
    • Environmental Footprint of Manufacturing: The production of silicon panels involves high energy use and toxic chemicals, partially offsetting their green benefits. Eg: Most panels are imported from China, where coal-powered factories dominate, adding to indirect emissions.
    • Incompatibility with Advanced Applications: Silicon PVs are less suitable for high-efficiency applications like green hydrogen production, which needs more consistent, high-output energy. Eg: In pilot projects in Gujarat, using silicon panels reduces the overall efficiency of green hydrogen production due to energy losses.

    Why rethink electrolysis-based green hydrogen?

    • High Energy Consumption: Electrolysis requires more energy to produce green hydrogen than the energy hydrogen provides when used, making the process energy-inefficient. Eg: In India’s pilot projects in Ladakh, the high electricity input from solar panels results in low net energy gain, raising concerns about economic viability.
    • Storage and Transportation Challenges: Hydrogen has very low density, making it difficult and expensive to store and transport, often requiring high-pressure tanks or cryogenic conditions. Eg: In hydrogen mobility projects, such as those in Delhi, leakage and compression issues have hampered safe and cost-effective deployment.
    • Compounding Energy Losses in Conversion: Using green hydrogen to produce green ammonia or methanol, and then extracting hydrogen back, leads to multiple stages of energy loss. Eg: In proposed export hubs like Vizag, converting hydrogen to ammonia for shipping and then reconverting it abroad reduces overall energy efficiency.

    How do land and efficiency issues impact India’s solar push?

    • Low Efficiency Increases Land Requirement: Silicon solar panels with 15–18% efficiency require larger surface areas to generate the same energy as advanced solar technologies. Eg: In Rajasthan’s Bhadla Solar Park, vast desert land is used to compensate for low panel efficiency, which limits deployment in land-constrained states.
    • Urbanisation Limits Land Availability: Rapid urban expansion and the need to conserve green zones reduce the availability of suitable land for large-scale solar projects. Eg: In Mumbai’s metropolitan region, limited open space has pushed the focus toward rooftop solar, which has its own technical and regulatory hurdles.
    • Hinders Achievement of Renewable Energy Targets: The inefficient land-to-energy ratio slows down the pace of solar capacity expansion, affecting progress toward India’s net-zero commitments. Eg: In Tamil Nadu, where land is both fertile and scarce, competing demands between agriculture and solar installations have delayed key solar proposals.

    What role can artificial photosynthesis play in renewable energy?

    • Direct Conversion of Sunlight into Fuel: Artificial photosynthesis (APS) mimics natural photosynthesis to convert sunlight, water, and CO₂directly into fuels like green methanol or hydrogen, offering a clean, efficient alternative to traditional energy-intensive processes.
    • Bypasses Inefficiencies in Current Technologies: APS has the potential to eliminate multiple energy-loss steps such as electrolysis, storage, and reconversion, thereby enhancing the overall energy efficiency of renewable fuel production systems.

    Why invest in next-gen renewable tech like RFNBO? (Way forward)

    • Enhances Energy Independence: Renewable Fuels of Non-Biological Origin (RFNBO) can reduce India’s heavy reliance on imported fossil fuels (currently ~85%), promoting energy self-sufficiency in a geopolitically volatile world.
    • Supports Diverse and Efficient Decarbonisation: RFNBO technologies enable the production of cleaner fuels like green hydrogen, ammonia, and methanol using renewable electricity, offering higher efficiency and adaptability for industrial and transport sectors.
    • Future-Proofing India’s Energy Strategy: Investing in RFNBO ensures India is aligned with global clean energy innovations, allowing it to meet net-zero targets and remain competitive in emerging green fuel markets.

  • IMF releases World Economic Outlook (WEO)

    Why in the News?

    The International Monetary Fund (IMF) has released the July 2025 update to its World Economic Outlook (WEO).

    IMF releases World Economic Outlook (WEO)

    About World Economic Outlook (WEO):

    • Published By: International Monetary Fund (IMF)
    • Frequency: Biannual (April, October) + updates in January and July
    • Purpose: Provides global forecasts on GDP, inflation, trade, and policy trends
    • Data Sources: IMF consultations with member nations and internal models
    • Audience: Governments, institutions, investors, researchers
    • July 2025 Update Title: “Global Economy: Tenuous Resilience amid Persistent Uncertainty”

    Key Highlights – July 2025 Update:

    • Global Growth Projections:
      • 2025: 3.0% (↑ from 2.8% in April)
      • 2026: 3.1% (↑ from 3.0%)
    • Despite multiple shocks—COVID-19, the Ukraine war, tariff increases—global growth continues.
      However, resilience remains fragile due to:

      • US–China tariff tensions and rising protectionism
      • Conflicts in Ukraine and the Middle East
      • High public debt in advanced economies is raising interest rates
    • Country Forecasts for 2025:  United States: 1.9%,  China: 4.8% (↑ from 4.0%),  Euro Area: 1.0%,  Germany: 0.1%,  United Kingdom: 1.2%,  Japan: 0.7%,  Russia: 0.9%,  Pakistan: 2.7%.

    India – The Bright Spot:

    • Growth Rate: 2023: 9.2%;  2024: 6.5%;  2025: 6.4% (strongest among major economies).
    • Drivers of Growth:
      • Robust domestic demand
      • Strong services and manufacturing output
      • Effective inflation and monetary policy management
    • Strategic Position:
      • Set to overtake several advanced economies in GDP size
      • Viewed globally as a “bright spot” amid persistent uncertainties
    [UPSC 2014] Which of the following organisations brings out the publication known as ‘World Economic Outlook?

    Options: (a) The International Monetary Fund * (b)The United Nations Development Programme (c) The World Economic Forum (d) The World Bank

     

  • What are Skill Impact Bonds (SIB)?

    Why in the News?

    Skill Impact Bonds (SIB) were recently highlighted by the Skill Development Ministry.

    About the Skill Impact Bond:

    • Launched: November 2021
    • Nature: India’s first Development Impact Bond (DIB) focused on employment-linked skill development
    • Lead Agency: National Skill Development Corporation (NSDC), under the Ministry of Skill Development and Entrepreneurship
    • Collaborators: British Asian Trust, HSBC India, Michael & Susan Dell Foundation
    • Target: Train and place 50,000 youth over 4 years, with 62% women participation
    • How it Works:
      • Risk Investors: Provide upfront capital to training providers
      • Training Providers: Deliver skill training and ensure job placements
      • Outcome Funders: Repay investors only if job outcomes are achieved
      • Evaluators: Independently assess outcomes via CATI surveys and document verification

    Key Features:

    • Outcome-Focused Approach: Measures success by certification, placement, and 3-month retention, not just enrolment
    • Eligibility Criteria:
      • Age: 18–40 years; Education: Undergraduate or below
      • Status: Unemployed or earning below ₹15,000/month, or household income below ₹25,000/month
    • Sectoral Coverage: Retail, Healthcare, Apparel, Logistics, Information Technology & IT-enabled Services, Banking, Financial Services & Insurance.
    • Women-Focused Design: Ensures 62% female participation to bridge the gender employment gap
    [UPSC 2018] With reference to Pradhan Mantri Kaushal Vikas Yojana, consider the following statements:

    1. It is the flagship scheme of the Ministry of Labour and Employment.

    2. It, among other things, will also impart training in soft skills, entrepreneurship, financial and digital literacy.

    3. It aims to align the competencies of the unregulated workforce of the country to the National Skill Qualification Framework.

    Which of the statements given above is/are correct?

    Options: (a) 1 and 3 only (b) 2 only (c) 2 and 3 only* (d) 1, 2 and 3

     

  • [pib] Digital Payments Index (DPI)

    Why in the News?

    According to the Reserve Bank of India (RBI), digital payments registered a 12.6% year-on-year rise as of March 31, 2024, as measured by the RBI’s Digital Payments Index (DPI).

    About RBI’s Digital Payments Index (DPI):

    • Launched by: Reserve Bank of India (RBI) in January 2021
    • Purpose: Measures the extent of digital payment adoption across India
    • Base Period: March 2018 (Index value = 100)
    • Release Frequency: Semi-annually (with a 4-month lag)
    • Objective: Track usage, infrastructure, and growth in digital payments
    • Key Parameters (with Weightage): These evaluate infrastructure readiness, transaction volume, user adoption, and innovation.
      1. Payment Enablers – 25%
      2. Payment Infrastructure – Demand Side – 10%
      3. Payment Infrastructure – Supply Side – 15%
      4. Payment Performance – 45%
      5. Consumer Centricity – 5%

    Growth Highlight:

    • Growth Trends in RBI-DPI: DPI grew nearly 5 times from 100 in March 2018 to 493.22 in March 2025, reflecting India’s rapid digital payment adoption.
    • Nearly 5× increase from the base value in 7 years
    • Driven by rapid expansion of Unified Payments Interface (UPI), mobile wallets, and QR code infrastructure
    [UPSC 2024] Consider the following countries:

    I. United Arab Emirates II. France III. Germany IV. Singapore V. Bangladesh

    How many countries amongst the above are there other than India where international merchant payments are accepted under UPI?”

    Options: (a) Only two (b) Only three* (c) Only four (d) All the five

    Answer: (b) Only three (UAE, France, Singapore)