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  • Kavli Prize, 2024 Announced

    Why in the News? 

    The winners of the 2024 Kavli Prize were announced, recognising achievements in astrophysics, neuroscience, and nanoscience.

    About Kavli Prize

    • The Kavli Prize celebrates outstanding achievements in astrophysics, neuroscience, and nanoscience.
    • It is established in honour of Norwegian-American businessman and philanthropist Fred Kavli (1927-2013).
    • Awarded biennially, the prize recognizes researchers whose work pushes the boundaries of human knowledge and enhances our understanding of the universe, the brain, and nanoscale phenomena.

    About Fred Kavli

    • Fred Kavli, born in Erejsford, Norway, immigrated to California in 1956 and quickly made a mark in the engineering field.
    • His entrepreneurial journey began in 1958 with the founding of Kavlico, a pioneering company known for its precision pressure sensors used across diverse industries, from aviation to consumer electronics.

    The Kavli Foundation:

    • In 2000, after selling Kavlico for $340 million, Fred Kavli established the Kavli Foundation.
    • This philanthropic organisation supports fundamental research aimed at improving global quality of life.
    • The foundation operates 20 institutes worldwide dedicated to astrophysics, neuroscience, nanoscience, and theoretical physics.

    Prize Structure and Prestige:

    1. Comparison with Nobel Prize: The Kavli Prize mirrors the Nobel Prize in its prestige and international recognition but differs by not limiting awards to achievements within the preceding year, allowing broader scope and longevity in selection criteria.
    2. Award Ceremony: Each Kavli Prize includes a $1 million cash award per field, a scroll, and a 7 cm diameter medal. The ceremony, held at the Oslo Concert Hall and attended by global scientific leaders, features a red-carpet event, emphasizing its significance in the scientific community.
    3. Selection Process:
    • Committees: Three international committees nominate and review candidates, providing a unanimous recommendation to the Norwegian Academy of Science and Letters.
    • Nominees: Nominees come from prestigious institutions worldwide, ensuring a diverse and comprehensive evaluation process.

    Winners of the 2024 Kavli Prize:

    Field Winners Contributions
    Astrophysics David Charbonneau (Harvard University), Sara Seager (Massachusetts Institute of Technology) Pioneering methods for detecting atomic species in planetary atmospheres and measuring their thermal infrared emission, are crucial for identifying molecular fingerprints in atmospheres of exoplanets.
    Nanoscience Robert Langer (MIT), Armand Paul Alivisatos (University of Chicago), Chad Mirkin (Northwestern University) Langer: Nano-engineering for controlled drug delivery systems.

    Alivisatos: Development of semiconductor quantum dots for bio-imaging.

    Mirkin: Concept of spherical nucleic acids (SNAs) for applications in gene regulation and immunotherapy.
    Neuroscience Nancy Kanwisher (MIT), Winrich Freiwald (Rockefeller University), Doris Tsao (University of California, Berkeley) Mapping brain functions related to facial recognition using neuroimaging and neuronal recording techniques, identifying brain centers and neural architectures involved in face processing.

     

    PYQ:

    [2021] The Nobel Prize in Physics of 2014 was jointly awarded to Akasaki, Amano and Nakamura for the invention of Blue LEDs in the 1990s. How has this invention impacted the everyday life of human beings?

    [2018] Discuss the work of ‘Bose-Einstein Statistics’ done by Prof. Satyendra Nath Bose and show how it revolutionized the field of Physics.

    [2008] Nobel Prize-winning scientist James D. Watson is known for his work in which area? (2008)

    (a) Metallurgy

    (b) Meteorology

    (c) Environmental protection

    (d) Genetics

  • Longitude Prize on Antimicrobial Resistance (AMR)

    Why in the News?

    Sysmex Astrego, a Sweden-based diagnostic company, won the £10 million Longitude Prize for developing a high-tech UTI (Urinary Tract Infection) test called the PA-100 AST System. 

    What is Antimicrobial Resistance?

    • Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi, and parasites change so that medicines no longer work against them.
    • This makes infections harder to treat and can lead to more severe illness and even death.
    • AMR can occur naturally through genetic changes or when one type of microorganism picks up resistance from another.
    • It can also occur randomly due to mutations or when resistant genes spread between different organisms.
    • The main reasons for AMR are antibiotics incorrectly or too often, not having access to clean water and good hygiene, not doing enough to prevent infections, and people not knowing how to use antibiotics properly.

    Global Impact of AMR

    • Global Threat: Antibiotic-resistant infections caused nearly 1.3 million deaths in 2019, with projections to exceed cancer-related deaths by 2050.
    • Economic Impact: The global economy faces potential losses of up to 4 trillion by 2030 and 100 trillion by 2050 due to the AMR crisis.

    About the Longitude Prize

    • The Longitude Prize, valued at £8 million (₹85 crore), was recently awarded for its profound implications in combating antimicrobial resistance (AMR).
    • The prize launched in 2014, aims to revolutionize infection management globally.
    • Historical Context:  
      • Origins: Established in 1714 to solve the maritime longitude problem, demonstrating the critical need for accurate navigation.
      • Modern Application: The 21st-century Longitude Prize addresses pressing global challenges like AMR, incentivizing innovative solutions.
    • Goal of the Prize:
      •  Aims to replace current lab-based diagnostic methods with rapid tests that guide targeted antibiotic therapies, combating AMR effectively.

    About PA-100 AST System 

    • Technology Breakthrough: Developed by Sysmex Astrego, this system uses a phenotypic test that identifies UTI bacteria and performs antibiotic susceptibility testing in under 45 minutes.
    • Operation: A single-use cartridge processes less than half a milliliter of urine, using microfluidic traps and phase-contrast imaging in a shoe box-sized reader instrument.
    • Clinical Impact: Provides rapid “sensitive” or “resistant” results for antibiotics, aiding doctors in immediate, accurate treatment decisions at the point of care.

    Current Challenges in UTI Diagnosis

    • Limited Accuracy: Current options include urine dipstick tests for quick results but limited accuracy (50-60%) and lab cultures with 2-3 day turnaround times.
    • Impact on Treatment: Delayed diagnosis often leads to empirical antibiotic use, contributing to antibiotic resistance worldwide.

    Significance for India

    • Healthcare Burden: In India, millions seek treatment for UTIs annually, impacting lives and healthcare systems significantly.
    • Potential: Rapid, accurate point-of-care tests could revolutionize UTI management globally, saving lives and reducing healthcare costs.

    PYQ:

    [2014] Can overuse and free availability of antibiotics without a Doctor’s prescription be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.

    [2019] Which of the following are the reasons for the occurrence of multi-drug resistance in microbial pathogens in India?

    1. Genetic predisposition of some people
    2. Taking incorrect doses of antibiotics to cure diseases
    3. Using antibiotics in livestock farming
    4. Multiple chronic diseases in some people

    Select the correct answer using the code given below.

    (a) 1 and 2
    (b) 2 and 3 only
    (c) 1, 3 and 4
    (d) 2, 3 and 4

  • Scientists back new Alzheimer’s drug: Benefits vs Risks

    Why in the News?

    Donanemab, a new Alzheimer’s disease therapy developed by Eli Lilly, has gained unanimous support from independent scientists advising the US Food and Drug Administration (FDA), moving it closer to clinical use.

    What is Donanemab?

    • Donanemab is a monoclonal antibody, which means it is a laboratory-produced molecule designed to function like antibodies in the immune system.
    • It is specifically developed for individuals in the early stages of Alzheimer’s disease, including those with mild cognitive impairment or mild dementia.

    How Does Donanemab Work?

    • It targets amyloid beta proteins in the brain. Amyloid beta plaques are one of the defining features of Alzheimer’s disease.
    • Mechanism of Action: The drug binds to amyloid beta plaques and promotes their removal from the brain. This action is intended to slow down the progression of Alzheimer’s disease by reducing the accumulation of these toxic plaques.

    How do the benefits of the drug stack up against its risks?

    • Target Population: The drug is intended for those in the early stages of Alzheimer’s disease (mild cognitive impairment or mild dementia).
    • Benefits: Significant clinically meaningful slowing of the disease, allowing patients to retain their functions for a longer time. Phase 3 study shows a 35.1% slowdown in cognitive decline in early Alzheimer’s patients over 76 weeks.
    • Risks: Main adverse effects include brain swelling (24%) and brain bleeds (19.7%), with most cases being asymptomatic.Three treatment-related deaths reported.Amyloid-related imaging abnormalities (ARIA) like brain bleeds and seizures were mostly non-serious and resolved after discontinuation of therapy.
    • Risk Management: The key risks can be mitigated through appropriate labeling and clinical monitoring. Further risks will be characterized through post-authorization studies.

    Why is a breakthrough of this kind important?

    • Rising Burden of Alzheimer’s: The global population is ageing, leading to an increased burden of diseases like Alzheimer’s. In India, 5.3 million people are currently living with dementia, expected to rise to 14 million by 2050.
    • Lack of Effective Treatments: There are limited options for disease-modifying treatments for Alzheimer’s. Innovations like donanemab are crucial for providing new hope and potential therapies.
    • Economic Considerations: While the drug is expensive, it offers the potential for several more years of quality life for patients.

    Why was the approval for the drug delayed?

    • Additional Data Requirements: The USFDA wanted to understand further the data relating to the therapy, especially regarding the limited dosing protocol used during trials.
    • Limited Dosing Protocol: During the trial, therapy was stopped in patients who achieved a certain level of amyloid beta plaque clearance, which is a distinguishing feature of donanemab compared to other therapies.
    • Previous Drug Approval Irregularities: Scrutiny increased after irregularities were found in the approval process of the first drug, aducanumab, which involved close collaboration between the regulator and the drugmaker and approval despite negative trial outcomes. The second drug, lecanemab, also had cautious optimism from doctors due to its demonstrated efficacy with fewer side effects.

    Conclusion: Ensure rigorous and transparent review processes for new Alzheimer’s treatments, incorporating comprehensive data analysis and post-authorization studies to monitor long-term safety and efficacy.

    Mains PYQ:

    Q Stem cell therapy is gaining popularity in India to treat a wide variety of medical conditions including leukaemia, Thalassemia, damaged cornea and several burns. Describe briefly what stem cell therapy is and what advantages it has over other treatments? (UPSC IAS/2017)

  • Why heatwaves have not been included as a notified disaster in the Disaster Management Act?

    Why in the news?

    The current period of intense heat in several regions has once more sparked debates about the potential inclusion of heatwaves as officially recognized disasters under the Disaster Management (DM) Act of 2005.

    What are Notified Disasters?

    • According to the Disaster Management (DM) Act, 2005, a disaster is defined as a “catastrophe, mishap, calamity, or grave occurrence” arising from natural or man-made causes that result in substantial loss of life, destruction of property, or environmental damage and is beyond the coping capacity of the affected community.
    • Funds: The DM Act allows states to draw money from the National Disaster Response Fund (NDRF) and the State Disaster Response Fund (SDRF) for managing these disasters.
    • Current Notified Disasters: There are currently 12 categories of notified disasters: cyclones, drought, earthquake, fire, flood, tsunamis, hailstorms, landslides, avalanches, cloudbursts, pest attacks, and frost and cold waves.

    Why Heatwaves Were Not Included as Notified Disasters?

    • Common Occurrence: Heatwaves were historically considered regular events during summer months in many parts of India. They were not seen as exceptional or unusual disasters warranting specific disaster management provisions under the DM Act, 2005.
    • Perception of Predictability: Unlike sudden-onset disasters such as earthquakes or cyclones, heatwaves were perceived as relatively predictable and part of seasonal weather patterns. This perception led to a belief that they could be managed through general public awareness and local interventions rather than formal disaster response mechanisms.
    • Not fit in definition of Disaster: When the DM Act was formulated, disasters were defined as events that caused substantial loss of life, property, or environmental damage beyond the coping capacity of the affected community. At that time, the impacts of heatwaves were typically viewed as localized health issues rather than widespread disasters.
    • Lack of Urgency: There was a lack of urgency in recognizing heatwaves as disasters requiring national-level response frameworks. The focus of disaster management efforts initially leaned towards more acute and visible calamities like cyclones, floods, and earthquakes.

    Why is the Centre Not Adding Heatwaves as a Notified Disaster Now?

    • Financial Concerns: One of the primary concerns is the potential financial burden of declaring heat waves as a notified disaster. Under the current provisions, the government is obligated to provide monetary compensation for lives lost during notified disasters, which is set at Rs 4 lakh per victim.
    • The reluctance of Finance Commissions: Despite requests from various states, the 15th Finance Commission has not recommended adding heatwaves to the list of notified disasters. They argue that the existing categories adequately cover disaster response needs, and they have provided provisions for states to utilize a portion of the State Disaster Response Fund (SDRF) for local disasters like heatwaves.

    Conclusion: Engage with the Finance Commission and other relevant bodies to reassess the inclusion of heatwaves as a notified disaster. Highlight the evolving nature of heat waves, their increasing frequency, and the need for dedicated funding and support mechanisms.

    Mains PYQ: 

    Q Climate change’ is a global problem. How India will be affected by climate change? How Himalayan and coastal states of India will be affected by climate change?  (UPSC IAS/2017)

  • Lal Crater on Mars

    Why in the News?

    Back2Basics: International Astronomical Union (IAU)

    • The IAU was founded on July 28, 1919, during the Constitutive Assembly held in Brussels, Belgium.
    • Its creation was prompted by the need for international collaboration in astronomy, especially after the devastation caused by World War I.
    • It aims to promote and safeguard astronomy in all its aspects through international cooperation.
    • IAU is now headquartered in Paris, France.

    Major Activities and Initiatives

    • General Assembly: The IAU holds a general assembly every three years in varying parts of the world at which professional astronomers meet to discuss research, new cooperative ventures, and similar matters of professional interest.
    • Astronomical Nomenclature: IAU standardises the nomenclature of celestial bodies, features, and phenomena. It maintains several working groups dedicated to naming conventions for stars, planets, asteroids, and other objects.
    • Research and Collaboration: It promotes international cooperation in astronomical research and supports initiatives such as observational campaigns, data sharing, and joint projects.
    • Education and Outreach: It is actively involved in promoting astronomy education and public outreach efforts worldwide. It supports educational programs, workshops, and resources for students, teachers, and the general public.

    Membership

    1. IAU membership spans 92 countries. Out of those countries, 85 are National Members.
    2. India is represented by the Astronomical Society of India (ASI).
    3. Its members are professional astronomers from all over the world, at the D. level and beyond, who are active in professional research, education, and outreach in astronomy.

    Crater Names and Significance

    • Lal Crater: Named after Prof. Devendra Lal, former director of PRL, this 65 km wide crater is positioned at -20.98° and 209.34°.
    • Mursan Crater: Named after a town in Uttar Pradesh, India, this ~10 km wide crater is situated on the eastern side of the Lal crater’s rim.
    • Hilsa Crater: Named after a town in Bihar, India, this ~10 km wide crater is positioned on the western side of the Lal crater’s rim.

    Scientific Importance of Lal Crater

    • Lava Coverage: The entire Lal crater area, located in the Tharsis volcanic region on Mars, is covered with lava.
    • Evidence of Water: Geophysical evidence, including a 45-meter thick sedimentary deposit, suggests the presence of water in the subsurface of the Lal crater. This finding supports the theory that Mars once had water flowing on its surface.
    • Infilling Process: Mursan and Hilsa craters, positioned on either side of the Lal crater, offer insights into the infilling process of the Lal crater. Their presence indicates that infilling occurred episodically over time.

    India’s 2nd Quest for Mars

    • The ISRO is expected to launch Mangalyaan-2, or Mars Orbiter Mission 2 (MOM 2), in 2025.
    • The mission will last one year and is aimed at studying the Red Planet.
    • The successor to Mangalyaan-1, or Mars Orbiter Mission 1 (MOM 1), Mangalyaan-2 will consist of only one orbiter and will be launched atop a GSLV Mark III rocket from Satish Dhawan Space Centre.

    Other missions to Mars

    • ExoMars rover (2022): European Space Agency’s mission to explore Mars.
    • Tianwen-1 (2021): China’s Mars Mission aims to explore and study the Martian surface.
    • UAE’s Hope Mars Mission (2021): UAE’s first interplanetary mission focused on studying the Martian atmosphere.
    • NASA’s Mars Insight (2018): A lander designed to study the interior of Mars.
    • NASA’s Curiosity (2012) and Perseverance (2020): Rovers exploring the Martian surface.
    • NASA’s Mars Reconnaissance Orbiter (2005), Mars Odyssey (2001), and MAVEN (2013): Orbiters studying Mars from space.
    • Mars 2 and Mars 3 (1971): Soviet Union’s missions to Mars, which included orbiter and lander components.

     

    PYQ:

    [2016] The Mangalyaan launched by ISRO

    1. is also called the Mars Orbiter Mission.
    2. made India the second country to have a spacecraft orbit the Mars after USA
    3. made India the only country to be successful in making its spacecraft orbit Mars in its very first attempt.

    Which of the statements given above is/are correct?

    (a) 1 only
    (b) 2 and 3 only
    (c) 1 and 3 only
    (d) 1, 2 and 3

  • India is the World’s Second Largest emitter of Nitrous Oxide

    Why in the News?

    • India ranks as the world’s second-largest contributor (after China) to nitrous oxide (N2O), a potent greenhouse gas (GHG), accounting for approximately 11% of global man-made emissions in 2020 as per data published in the journal Earth System Science Data.
      • The top five country emitters by volume of anthropogenic N2O emissions in 2020 were China (16.7%), India (10.9%), the United States (5.7%), Brazil (5.3%), and Russia (4.6%).

    About Nitrous Oxide

    • Nitrous oxide (N2O), a colourless and odourless gas, is a potent greenhouse gas, 300 times more powerful than CO2. Despite its small atmospheric fraction, it ranks third in concentration after CO2 and methane (CH4). It’s a crucial target for environmental research and efforts to mitigate climate change impacts.

    Sources of Emission:

    1. Natural Sources: N2O is naturally produced in processes such as microbial nitrogen cycling in soil and water bodies, volcanic activity, and biomass burning.
    2. Anthropogenic Activities: Human activities significantly contribute to N2O emissions, with the primary sources being:
    • Agricultural practices, including the use of nitrogen-based fertilizers and animal manure.
    • Industrial processes such as combustion of fossil fuels and wastewater treatment.
    • Combustion of biomass and waste.
    • Use of nitrous oxide in medical and dental procedures (as a sedative) and in food packaging.

    Impact on Climate Change:

    • Greenhouse Gas: N2O is a potent greenhouse gas with a global warming potential (GWP) much higher than that of carbon dioxide (CO2).
    • Ozone Depletion: In addition to its role in climate change, N2O also contributes to ozone depletion in the stratosphere, further exacerbating environmental concerns.

    Environmental and Health Effects:

    • Environmental Pollution: N2O emissions can lead to pollution of soil, water bodies, and air, affecting ecosystems and human health.
    • Health Risks: While N2O is relatively non-toxic at ambient levels, prolonged exposure or high concentrations can pose health risks, including respiratory issues and neurological effects.

    Global Nitrous Oxide Emissions

    • Atmospheric Concentration: The concentration of atmospheric N2O reached 336 parts per billion in 2022, about 25% above pre-industrial levels.
    • Next to Carbon Emissions: In comparison, the concentration of carbon dioxide was 417 parts per million in 2022.
    • Persistent Lifespan: Once emitted, N2O stays in the atmosphere for longer than the average human lifespan (117 years), making its climate and ozone impacts long-lived.
    • Contribution to Climate Change: These emissions are responsible for 6.4% of the effective radiative forcing of greenhouse gases and have added about 0.1°C to current global warming.
    • Impact of Nitrogen Fertilizers: N2O emissions from human activities have increased by 40% in the past four decades, with agricultural production using nitrogen fertilizers and animal manure contributing 74% of total anthropogenic N2O emissions in the last decade.

    Call for Action and Future Outlook

    • Scientists warn that anthropogenic N2O emissions must decline by at least 20% relative to 2019 levels by 2050 to align with net-zero emission pathways consistent with the Paris Agreement.
    • Nitrogen fertilizers, which are heavily subsidized in India, contribute significantly to N2O emissions. Urgent reforms are needed to promote alternative production systems and mitigate emissions.

    India’s Policy Initiatives to Curb Nitrogen Pollution

    • Nutrient-Based Subsidy (NBS) (2010): This policy encourages the adoption of controlled-release fertilizers to enhance nutrient management efficiency.
    • Soil Health Cards (2015): Provided to farmers, these cards offer insights into soil nutrient levels and tailored fertilizer recommendations, promoting balanced nutrient application.
    • Bharat Stage (BS VI) Emission Standards (2016): These stringent regulations for vehicles and industries aim to reduce the emission of nitrogen oxides and particulate matter, thereby mitigating air and water pollution.
    • Nano Urea (2021): Marketed by the Indian Farmers Fertiliser Cooperative Limited (IFFCO), Nano Urea is a patented fertilizer approved for commercial use, designed to curb excessive and indiscriminate conventional urea use while boosting crop yields.

    PYQ:

    [2016] Why does the Government of India promote the use of ‘Neem-coated Urea’ in agriculture?

    (a) Release of Neem oil in the soil increases nitrogen fixation by the soil microorganisms

    (b) Neem coating slows down the rate of dissolution of urea in the soil

    (c) Nitrous oxide, which is a greenhouse gas, is not at all released into the atmosphere by crop fields

    (d) It is a combination of a weedicide and a fertilizer for particular crops

  • N332-GT5 and eOD-GT8: Advancements in HIV Vaccine Development

    Why in the News?

    Researchers at the Duke Human Vaccine Institute have successfully induced broadly neutralising antibodies (bNAbs) against HIV (human immunodeficiency virus) through vaccination for the first time.

    About HIV/AIDS:

    • Emergence: The first cases of AIDS (Acquired Immunodeficiency Syndrome) were reported in the early 1980s, primarily among gay men in the United States.
    • Discovery of HIV: In 1983-1984, scientists identified HIV (Human Immunodeficiency Virus) as the cause of AIDS.
    • Global Spread: HIV/AIDS quickly became a global pandemic, affecting millions of people worldwide.

    Causes:

    • HIV is transmitted through contact with certain body fluids of an infected person, including blood, semen, vaginal fluids, and breast milk.
    • Common modes of HIV transmission include unprotected sexual intercourse, sharing needles or syringes, and from mother to child during pregnancy, childbirth, or breastfeeding.

    Symptoms:

    • Acute HIV Infection: Many people experience flu-like symptoms, such as fever, headache, fatigue, and swollen lymph nodes, within 2-4 weeks after infection.
    • Asymptomatic Stage: After the initial symptoms subside, HIV often enters a latent stage where individuals may not experience any symptoms for years.
    • Progression to AIDS: Without treatment, HIV gradually weakens the immune system, leading to the development of opportunistic infections and cancers. This advanced stage is known as AIDS and is characterized by severe immune deficiency.

    Vaccines Development:

    • Challenges: Developing an HIV vaccine has been challenging due to the virus’s ability to mutate rapidly and evade the immune system.
    • Vaccine Candidates: Numerous vaccine candidates have been tested over the years, but none have yet been successful in providing robust protection against HIV infection.
    • Hope for the Future: Despite setbacks, advances in vaccine development, such as the identification of promising candidates like N332-GT5 and eOD-GT8, offer hope for eventually achieving an effective HIV vaccine.

    How B cells and mRNA play distinct roles in the context of HIV infection?

    1.    B cells (B lymphocytes):

    • B cells are a type of white blood cell crucial for the immune response.
    • In HIV infection, B cells participate in the adaptive immune response by producing antibodies specific to HIV antigens.
    • These antibodies can neutralize HIV particles, tag infected cells for destruction by other immune cells, and contribute to the immune memory against HIV.

    2.    mRNA (messenger RNA):

    • mRNA is a molecule that carries genetic information from DNA to the ribosomes, where proteins are synthesized.
    • In the context of HIV, mRNA is involved in the replication process of the virus.
    • HIV uses its RNA genome to produce viral mRNA, which directs the synthesis of viral proteins necessary for the assembly of new virus particles.
    • Understanding HIV mRNA is crucial for developing antiviral therapies that target viral replication, such as mRNA-based vaccines or mRNA inhibitors.

    N332-GT5 and eOD-GT8: The New Vaccines in Making

    • N332-GT5: This vaccine candidate targets a specific region on the surface of the HIV virus known as the N332 glycan site. By engaging B-cells that have the potential to produce bNAbs against this site, N332-GT5 aims to stimulate the immune system to generate a protective response against a wide range of HIV strains.
    • eOD-GT8: Similarly, eOD-GT8 is designed to target another region on the HIV virus, known as the eOD protein. By leveraging nanoparticles as carriers, eOD-GT8 aims to enhance the immune system’s ability to recognize and neutralize HIV, ultimately leading to the production of bNAbs.

    What are Broadly Neutralizing Antibodies (bNAbs)?

    • In the 1990s, scientists discovered that some HIV-infected individuals produced bNAbs, which neutralize many viral strains.
    • bNAbs target viral protein areas crucial for infectivity, making them less likely to change.
    • Despite their effectiveness, bNAbs take years to develop, by which time HIV has often evolved to escape them.

    Developing bNAb-Based Vaccines

    • The goal is to make the immune system produce bNAbs quickly in response to a vaccine.
    • Germline targeting involves three steps:
      1. Identify and engage B-cells capable of producing bNAbs.
      2. Use a booster to guide these cells to produce stronger bNAbs.
      3. Refine bNAbs to neutralize a wide range of HIV strains.

    PYQ:

    [2013] Which of the following diseases can be transmitted from one person to another through tattooing?

    1. Chikungunya

    2. Hepatitis B

    3. HIV-AIDS

    Select the correct answer using the codes given below.

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3
  • [12 June 2024] The Hindu Op-ed: India’s Looming Financial Crisis

    [12 June 2024] The Hindu Op-ed: India’s Looming Financial Crisis

    PYQ Relevance: 

    Q. The product diversification of financial institutions and insurance companies, resulting in overlapping of products and services strengthens the case for the merger of the two regulatory agencies, namely SEBI and IRDA. Justify. (UPSC IAS/2013)

    Q. Industrial growth rate has lagged behind in the overall growth of Gross-Domestic-Product (GDP) in the post-reform period” Give reasons. How far the recent changes in Industrial Policy are capable of increasing the industrial growth rate? (UPSC IAS/2017)

    Mentors’ comment: Rapid credit growth acts like a siren’s call, tempting economies with the allure of prosperity but ultimately steering them toward crises. Every financial boom is packaged as a tale of innovation and good fortune, yet each new narrative is merely a manufactured frenzy. This phenomenon, described by economist Robert Shiller as “irrational exuberance,” is a recurring theme in financial history. As economists Carmen Reinhart and Kenneth Rogoff detailed in their renowned account of financial folly, governments and market players tend to dismiss the lessons of past crises following credit booms, clinging to the belief that “this time is different.”

    Let’s learn.

    Why in the News?

    Rapid credit growth often promises prosperity but frequently leads to crises.These periods are seen as times of innovation and good fortune but often result in “irrational exuberance,” as economist Robert Shiller describes.

    A Lofty and Dangerous Narrative about the Indian economy 

    • Exaggerated Optimism About India’s Performance: Policymakers are excessively optimistic about India’s digital infrastructure as a catalyst for financial innovation and inclusion, promising growth and equality.
    • Enabling Poor Financial Practices: The narrative has facilitated a poorly regulated financial sector and led consumers to live beyond their means, generating a lending surge. Both international and domestic analysts have praised the surge, citing robust growth in bank lending and low levels of non-performing assets.
    • Misleading Applause: The IMF and National Council of Applied Economic Research have commended the increase in bank lending, particularly personal loans, interpreting it as a sign of bright prospects despite the struggles in industrial lending.
    • Ignored Fundamental Issues: The focus on credit growth detracts from addressing deep-rooted issues like job deficits and human capital deficits. The illusion of financial health is maintained as new loans pay off old ones, but this is unsustainable when lending slows.
    • Household Debt Boom: The rapid expansion of household lending, between 25% and 30% annually, is viewed as easy cash by lower- and middle-income households for various expenses, including lifestyle spending. This type of boom does not enhance productive capacity but increases domestic prices, making the country less competitive.
    • Economic Risks: Economists warn that higher household debt burdens lead to steeper crashes. Alongside the credit boom, factors like an overvalued stock market, weak corporate investment, anaemic consumer spending, an overvalued exchange rate, and dubious data reporting indicate a looming financial crisis.

    Challenges related to the financial sector:

    • Fragmented Financial Sector: The Indian financial services industry is large and chaotic, with about 30 major providers (scheduled commercial banks and major NBFCs) and thousands of smaller, often dubious, players including fly-by-night NBFCs and fintechs.
    • Rogue Behavior and Scams: Major financial institutions have a history of rogue behavior, and the search for easy profits since economic liberalization in 1991 has led to numerous scams. Post-COVID-19, many financial service providers shifted their focus to household lending, often exploiting stagnant incomes.
    • Unsecured Lending: A significant and growing share of household loans (approaching a quarter) is unsecured, meaning they are not backed by collateral. The rapid increase in credit card debt exemplifies this trend, with the number of credit cards soaring from 20 million in 2011 to nearly 100 million by January 2024.
    • High-Risk Borrowers: Aggressive marketing of credit cards and loans to low-creditworthy individuals has built stress within both the borrower base and the financial system. The Reserve Bank of India has noted that the explosive growth of credit cards has attracted riskier, below-prime borrowers.
    • Debt Addiction and Financial Strain: Many households, lured by rewards and “no-interest EMIs,” are falling into debt traps, taking on more debt to repay existing dues, exacerbating their financial strain. The high household debt-service-to-income ratio (12%) is among the highest globally, comparable to pre-2008 crisis levels in the US and Spain.

    Solution (Way Forward)

    • Surgically Downsize the Financial Services Industry: The financial services industry needs to be resized to better align lending capacity with productive borrowing needs. This would involve reducing the number of financial providers and ensuring that loans are directed towards projects that enhance productivity.
    • Weaken the Rupee: A weaker rupee could help expand exports, providing a buffer against the economic downturn. By making Indian goods cheaper abroad, a weaker rupee could stimulate demand for exports.
    • Preventing Rapid Credit Growth: Historical evidence indicates that rapid credit growth combined with an overvalued exchange rate is dangerous. Measures should be taken to moderate credit growth to sustainable levels.
    • Shift in Policy Perspective: There is a need to move away from the current belief that finance alone can spur growth. Instead, policies should focus on sustainable growth supported by finance, aligning with Joan Robinson’s dictum that finance must follow growth.
    • Addressing Overvalued Exchange Rate: Policymakers need to reconsider their commitment to maintaining a strong exchange rate. A more flexible exchange rate policy could better reflect economic fundamentals and support external competitiveness.
    • Focus on Employment and Human Capital: The acute job shortage and regression of the workforce back to agriculture highlight the need for policies that generate employment and improve human capital. Investments in education, skills development, and public goods are essential.

  • 2025 to be International Year of Quantum Science and Technology

    Why in the News?

    • The United Nations has designated 2025 as the ‘International Year of Quantum Science and Technology’ to increase public awareness about the significance of quantum science and its applications.
      • This initiative, led by Mexico and supported by nearly 60 countries, aims to promote activities at all levels to highlight the importance of quantum science and technology worldwide.

    International Year of Quantum S&T

    • Growing Relevance: Quantum science and technologies, especially quantum computing, have gained prominence in public discourse due to their potential transformative impact on various fields.
    • Anniversary of Heisenberg’s Work: The proclamation coincides with the upcoming centenary of Werner Heisenberg’s groundbreaking paper on quantum mechanics, published in 1925.
    • Support from International Bodies: The proclamation has received endorsements from various international organisations, including the International Union of Pure and Applied Physics and the International Union of Pure and Applied Chemistry.

    What does one mean by Quantum?

    • “Quantum” refers to the smallest discrete unit of any physical quantity involved in an interaction according to quantum theory.
    • In classical physics, many properties, such as energy and momentum, are thought to be continuous and infinitely divisible.
    • However, in quantum mechanics, certain properties, like energy levels and the behaviour of particles, are quantised, meaning they can only exist in specific discrete amounts or levels.

    What is Quantum Theory?

    • Quantum theory is a fundamental theory in physics that provides a description of the physical properties of nature at the scale of atoms and subatomic particles.
    • Quantum mechanics differs from classical physics in that energy, momentum, and angular momentum.

    Development in Quantum Theory So Far

    • Planck’s assumption: In 1900, Planck made the assumption that energy was made of individual units or quanta.
    • Albert Einstein’s theory: In 1905, Albert Einstein theorized that not just the energy, but the radiation itself was quantized in the same manner.
    • Louis de Broglie theory: In 1924, Louis de Broglie proposed that there is no fundamental difference in the makeup and behaviour of energy and matter; on the atomic and subatomic level either may behave as if made of either particles or waves. This theory became known as the principle of wave-particle duality: elementary particles of both energy and matter behave, depending on the conditions, like either particles or waves (wave-particle duality).
    • Heisenberg proposed: In 1927, Werner Heisenberg proposed that precise, simultaneous measurement of two complementary values – such as the position and momentum of a subatomic particle – is impossible. Contrary to the principles of classical physics, their simultaneous measurement is inescapably flawed; the more precisely one value is measured, the more flawed will be the measurement of the other value. This theory became known as the uncertainty principle, which prompted Albert Einstein’s famous comment, “God does not play dice.”

    What is Entanglement?

    • Entanglement was another of several weird properties exhibited by these tiny particles.
    • Two particles, having ‘interacted’ with each other at some stage, were found to have got ‘entangled’ in a way that the behaviour of one produced an instantaneous reaction in the other even if the two were no longer connected in any way and were separated by very large distances.
    • The entanglement property opened up new technological possibilities first time that it was possible to ‘teleport’ the quantum states of a particle to another location without the particle moving anywhere and without a medium.

    What is Superposition?

    • It’s a phenomenon where, a particle exists simultaneously at multiple locations, known as superposition.
    • The chance of finding the particle at any given place was dictated by probabilistic calculations, and once it was found, or observed, at one location, it ceased to exist at all other places.

    What is Quantum Computing?

    • Quantum computing is a new and super powerful way of doing computer stuff.
    • Instead of using regular computer bits that are either 0 or 1, quantum computers use special bits called qubits that can be both 0 and 1 at the same time, thanks to a thing called “quantum superposition.”
    • This allows them to do lots of calculations all at once, making them really fast at solving certain types of problems.

    Back2Basics: National Quantum Mission (NQM)

    Details
    Mission Duration 2023-2031
    Implementing Authority Department of Science and Technology (DST) under the Ministry of Science & Technology
    India’s Position Seventh country to have a dedicated quantum mission after the US, Austria, Finland, France, Canada, and China
    Focus Areas
    • Intermediate-scale quantum computers with 50-100 physical qubits in 5 years and 50-1000 physical qubits in 8 years
    • Quantum computation, Quantum communication, Quantum Sensing & Metrology, Quantum Materials & Devices
    Development
    • High-sensitivity magnetometers for precision timing, communications, and navigation
    • Satellite-based secure quantum communications within India and with other countries
    • Design and synthesis of quantum materials like superconductors, novel semiconductor structures, and topological materials
    Thematic Hubs Establishment Four Thematic Hubs (T-Hubs) would be set up in top academic and National R&D institutes on the domains of Quantum Technology:

    1. Quantum computation
    2. Quantum communication
    3. Quantum Sensing & Metrology
    4. Quantum Materials & Devices

    PYQ:

    [2022] Which one of the following is the context in which the term “Qubit” is mentioned?

    (a) Cloud Services

    (b) Quantum Computing

    (c) Visible Light Communication Technologies

    (d) Wireless Communication Technologies

  • How SpaceX’s Starship can revolutionise space travel and exploration?

    Why in the News?

    • SpaceX’s Starship rocket completed its first fully successful test flight. This test flight brings SpaceX closer to its goal of creating a fully reusable rocket system, a development that could revolutionize space exploration and travel.

    What is Starship?

    • Starship is a two-stage heavy lift-off vehicle designed for crew and cargo transport to Earth orbit, the Moon, Mars, and beyond.
    • It stands nearly 120 meters tall, surpassing the Saturn V rocket.
    • The Super Heavy booster is powered by 33 Raptor engines, generating significant thrust, surpassing existing rocket systems like NASA’s Space Launch System (SLS).
    • Raptor engine fuel uses a mix of liquid oxygen and liquid methane, enabling efficient propulsion for the rocket.

    Cost Reduction and Efficiency with Starship

    • Starship can carry up to 150 tonnes of payload to low-Earth orbit.
    • It can be refuelled in space, thereby promising a significant reduction in the cost of space travel.
    • In-orbit refuelling allows Starship to operate like an aeroplane, reducing downtime between missions and maximizing efficiency.
    • Starship’s fully reusable design minimizes the need for costly hardware replacement, unlike traditional rocket systems.

    Scientific Benefits of Starship

    • Enhanced Payload Capability: Starship’s capacity for heavy payloads enables the launch of larger space telescopes and equipment for lunar and Martian missions.
    • Exploration Potential: Scientists can deploy larger and more sophisticated instruments, such as drilling rigs, to explore the Moon and Mars in unprecedented detail.
    • Sample Return Missions: Starship’s capability to return to Earth facilitates the retrieval of valuable samples from other planets, aiding in scientific research and understanding.

    PYQ:

    [2018] With reference to India’s satellite launch vehicles, consider the following statements:

    1. PSLVs launch satellites useful for Earth resources monitoring whereas GSLVs are designed mainly to launch communication satellites.
    2. Satellites launched by PSLV appear to remain permanently fixed in the same position in the sky, as viewed from a particular location on Earth.
    3. GSLV Mk III is a four-stage launch vehicle with the first and third stages using solid rocket motors, and the second and fourth stages using liquid rocket engines.

    Which of the statements given above is/are correct?

    (a) 1 only
    (b) 2 and 3
    (c) 1 and 2
    (d) 3 only