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GS Paper: GS3

  • 2-DG: DRDO’s new oral drug for Covid-19

    Defence Minister has released the first batch of the indigenously developed anti-Covid-19 drug, 2-deoxy-D-glucose or ‘2-DG’.

    What is the news?

    • The Drugs Controller General of India (DCGI) had cleared the formulation on May 1 for emergency use as an adjunct therapy in moderate to severe Covid-19 patients.

    What is 2-DG?

    • 2-DG has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, a lab of the DRDO in collaboration with Hyderabad-based pharma company Dr Reddy’s Laboratories (DRL).
    • The 2-DG anti-Covid drug is expected to reduce dependence on medical oxygen in Covid-19 infected patients.
    • The pseudo glucose molecule in the drug stops the virus in the tracts.
    • Hence, it has been prescribed for Coronavirus infected patients requiring critical medical oxygen.

    How does it work?

    • Clinical trial data show that the molecule helps in faster recovery of patients hospitalized with Covid-19, and reduces their dependence on supplemental oxygen.
    • The drug accumulates in virus-infected cells, and prevents the growth of the virus by stopping viral synthesis and energy production.
    • Its selective accumulation in virally-infected cells makes this drug unique.

    Advantages

    • 2-DG being a generic molecule and an analogue of glucose, it can be easily produced and made available in large quantities.
    • The drug is available in powder form in a sachet, and can be taken orally after dissolving in water.

  • RBI should return to its dharma of taming inflation

    The article highlights the need for the RBI to focus on inflation instead of pursuing elusive growth.

    Is inflation at a level to be concerned about?

    • Due to the devastation caused by the pandemic, MPC kept its stance to ‘look through’ the sustained rise in prices through much of last year.
    • The release of the consumer-price inflation number for April 2021 (4.3%) might seem to validate their decision.
    • But there are many reasons why the MPC should be concerned.
    • To start with, the April print carries little validity since the base for comparison (April 2020) has been rubbished by RBI in the past on the grounds that it relates to the first month of the lockdown.

    Inflation comes down but after causing devastation

    • Through a combination of the base effect (high level of inflation in the previous comparable period), belated but inevitable monetary policy action and a fall in demand that more than offsets the disruption in supply, inflation will come down.
    • However, before inflation comes down, it brings untold misery to the public at large.
    •  In a country where close to 20% of the population lives below the poverty line and food is a major item of their consumption basket, any rise in inflation, especially food inflation, hurts the poor disproportionately.
    • Add to that the distress caused by job losses on account of the pandemic, and this time round, the pain is likely to be magnified many times over.

    What is causing inflation?

    • Monetary policy acts with long and indeterminate lags.
    • Far from spurring credit offtake through low interest rates excess liquidity has spilled over into price pressures in India.
    • Wholesale price inflation at 7.4% (March 2021) was the highest in 8 years, while it would be naïve to take any solace from the latest consumer price index number.
    • The RBI needs to be appreciated for doing its bit to keep the wheels of our economy moving during the pandemic.
    • However, its failure to shift gear in the face of mounting evidence of inflation cannot be neglected.
    • When inflation was breaching the upper end of RBI’s target band for months on end, the message should have been clear.

    US recovery and its impact on Indian economy

    • Globally, commodity prices are already on the rise.
    • Not without reason, it would seem, as borne out by 12 May’s inflation print of 4.2%, America’s highest in 12 years
    • Part of the reason is the excessive easing of US monetary and fiscal policies.
    • Rising US inflation has huge implications for countries like India that are at the receiving end of US policies.
    • As the US economy recovers, the dollar strengthens and US interest rates rise, the rupee is bound to weaken in response, adding to inflationary pressures here.

    Consider the question “What are the factors stoking inflation in the pandemic? How far the monetary policies pursued by the central bank is responsible for it?”

    Conclusion

    When the MPC meets next in early June, it must re-order its priorities. Instead of chasing elusive growth, it must revert to its swadharma, own dharma, and focus instead on inflation.

  • Native Indian turtles face U.S. slider threat across Northeast

    About red-eared slider

    • The red-eared slider (Trachemys scripta elegans) derives its name from red stripes around the part where its ears would be and from its ability to slide quickly off any surface into the water.
    • Native to the U.S. and northern Mexico, this turtle is an extremely popular pet due to its small size, easy maintenance, and relatively low cost.

    Reports about threat

    • Between August 2018 and June 2019, a team of herpetologists from NGO Help Earth published the finding in ‘Reptiles & Amphibians’, journal of the U.S.-based International Reptile Conservation Foundation in August 2020.
    • But the alarm was raised experts from Mizoram University’s Department of Zoology published another report in the same journal in April this year.

    How is it a threat?

    • They grow fast and virtually leaves nothing for the native species to eat.
    •  People who keep it as pets become sensitive about turtle conservation but endanger the local ecosystem, probably unknowingly, by releasing them in natural water bodies after they outgrow an aquarium, tank or pool at home.
    • Much like the Burmese python that went to the U.S. as a pet to damage the South Florida Everglades ecosystem, the red-eared slider has already affected States such as Karnataka and Gujarat, where it has been found in 33 natural water bodies.
    • Preventing this invasive species from overtaking the Brahmaputra and other river ecosystems in the Northeast is crucial because the Northeast is home to more than 72% of the turtle and tortoise species in the country, all of them very rare.

    Way forward

    • Although the red-eared slider is traded legally, the time has come for the government to come up with regulations against keeping invasive as pets.
    • There is a need to create awareness among pet traders for maintaining a database of red-eared slider buyers.
    • They can be contacted to hand over the turtles to the repository insulated from any wetland or natural water body.

  • Israel’s Iron Dome rocket defence system

    Context

    • Amid the Israel-Palestine conflict, the night sky over Israel has been ablaze with interceptor missiles from Iron Dome shooting down the incoming rockets in the sky.

    What is Iron Dome?

    • Iron Dome is a multi-mission system capable of intercepting rockets, artillery, mortars and Precision Guided Munitions as well as aircraft, helicopters and Unmanned Aerial Vehicles (UAV) over short ranges of up to 70 km.
    • It is an all-weather system and can engage multiple targets simultaneously and can be deployed over land and sea.
    • Iron Dome is jointly manufactured by Rafael Advanced Systems and has been in service with Israeli Air Force since 2011.
    • The radar system was developed by Elta.

    Working of Iron Dome

    • An Iron Dome battery consists of a battle management control unit, a detection and tracking radar and a firing unit of three vertical launchers, with 20 interceptor missiles each.
    • The interceptor missile uses a proximity fuse to detonate the target warhead in the air.
    • One of the system’s important advantages is its ability to identify the anticipated point of impact of the threatening rocket, to calculate whether it will fall in a built-up area or not, and to decide on this basis whether or not to engage it.
    • This prevents unnecessary interception of rockets that will fall in open areas and thus not cause damage, the paper states.
    • The system has intercepted thousands of rockets so far and, according to Rafael Advanced Systems, its success rate is over 90%.

    Limitations of the system

    • The system can see limitations when it is overwhelmed with a barrage of projectiles.
    • The system has a ‘saturation point’.
    • It is capable of engaging a certain number of targets at the same time, and no more.
    • One of the possible limitations is the system’s inability to cope with very short range threats as estimates put the Iron Dome’s minimum interception range at 5-7 kilometres.

     

  • Remittance received by India remain unaffected by pandemic

    What the World Bank report says

    • India received over USD 83 billion in remittances in 2020, according to a World Bank report.
    • In 2019, India had received USD 83.3 billion in remittances.
    • The report said India’s remittances fell by just 0.2 per cent in 2020.
    • Much of the decline was due to a 17 per cent drop in remittances from the United Arab Emirates, which offset resilient flows from the United States and other host countries.
    • The World Bank, in its latest Migration and Development Brief, said despite COVID-19, remittance flows remained resilient in 2020.

    Trend analysis

    • China, which received USD 59.5 billion in remittances in 2020 against USD 68.3 billion the previous year, is a distant second.
    • India and China are followed by Mexico (USD42.8 billion), the Philippines (USD34.9 billion), Egypt (USD29.6 billion), Pakistan (USD26 billion), France (USD24.4 billion) and Bangladesh (USD21 billion).
    • Remittance outflow was the maximum from the United States (USD68 billion), followed by UAE (USD43 billion), Saudi Arabia (USD34.5 billion), Switzerland (USD27.9 billion), Germany (USD22 billion), and China (USD18 billion).
    • The relatively strong performance of remittance flows during the COVID-19 crisis has also highlighted the importance of timely availability of data.
    • Given its growing significance as a source of external financing for low- and middle-income countries, there is a need for better collection of data on remittances, in terms of frequency, timely reporting, and granularity by corridor and channel.

    B2BASICS

    Remittances

    • Remittances are usually understood as financial or in-kind transfers made by migrants to friends and relatives back in communities of origin.
    • These are basically sum of two main components – Personal Transfers in cash or in kind between resident and non-resident households and Compensation of Employees, which refers to the income of workers who work in another country for a limited period of time.
    • Remittances help in stimulating economic development in recipient countries, but this can also make such countries over-reliant on them.

    Remittance and the Indian Economy

    Benefits

    • Increased inward remittance is a boon for the economy at both macro and micro levels.
    • At the macro level, remittances contribute to maintaining stable foreign reserves.
    • Remittances help Indian Rupee hold its value against the US dollar and forms a significant part of the GDP.
    • On a micro level, remittances have shown a positive impact on healthcare, entrepreneurship, education, and overall economic development of the recipient families.

    Issues

    An increase in outward remittances however, raises an alarm. It causes the rupee to weaken against the dollar, which in return impacts the businesses exposed to foreign exchange, and the economy overall.

  • Risk of mucormycosis in Covid-19 patients

    About mucormycosis

    • Mucormycosis is a fungal infection that has a high mortality rate of 50 per cent.
    • An increasing number of Covid-19 patients have been developing this infection while still at the hospital or after discharge.
    • The disease often manifests in the skin and also affects the lungs and the brain.
    • Some of the common symptoms include sinusitis, blackish nasal discharge, facial pain, headaches, and pain around the eyes.

    Who is at risk

    • Patients who have been hospitalised for Covid-19 and particularly those who require oxygen therapy during Covid-19 illness are at a much higher risk of mucormycosis.
    • However, there are some cases of mucormycosis in patients with asymptomatic Covid-19 infection.
    • Before the pandemic, patients with uncontrolled diabetes were at a higher risk of mucormycosis.
    • The risk of mucormycosis rises for these patients for two reasons.
    • First is that Covid-19 further impairs their immune system.
    • Second, they are given corticosteroids for their treatment it leads to a rise in their blood sugar level thus increasing their risk of mucormycosis.

    Treatment

    • Today, we have a number of drugs and anti-fungal medicines that can treat mucormycosis.
    • These are given by IV or taken orally.
    • Surgery is needed to remove the affected dead tissues along with antifungal therapy.

  • National Programme on Advanced Chemistry Cell Battery Storage

    About the scheme

    • The Cabinet, chaired by Prime Minister has approved the proposal of Department of Heavy Industry for implementation of the Production Linked Incentive (PLI) Scheme ‘National Programme on Advanced Chemistry Cell (ACC) Battery Storage’.
    • Each selected ACC battery Storage manufacturer would have to commit to set-up an ACC manufacturing facility of minimum five (5) GWh capacity and ensure a minimum 60% domestic value addition at the Project level within five years.
    • Furthermore, the beneficiary firms have to achieve a domestic value addition of at least 25% and incur the mandatory investment Rs.225 crore /GWh within 2 Years (at the Mother Unit Level) and raise it to 60% domestic value addition within 5 Years, either at Mother Unit, in-case of an Integrated Unit, or at the Project Level, in-case of “Hub & Spoke” structure.
    • The scheme will help in achieving manufacturing capacity of Fifty (50) Giga Watt Hour (GWh) of ACC and 5 GWh of “Niche” ACC with an outlay of Rs.18,100 crore.

    About ACC

    • ACCs are the new generation of advanced storage technologies that can store electric energy either as electrochemical or as chemical energy and convert it back to electric energy as and when required.

    Benefits of the scheme

    • Setup a cumulative 50 GWh of ACC manufacturing facilities in India under the Programme.
    • Direct investment of around Rs.45,000 crore in ACC Battery storage manufacturing projects.
    • Facilitate demand creation for battery storage in India.
    • Facilitate Make-ln-lndia: Greater emphasis upon domestic value-capture and therefore reduction in import dependence.
    • Net savings of Indian Rs. 2,00,000 crore to Rs.2,50,000 crore on account of oil import bill reduction during the period of this Programme due to EV adoption as ACCs manufactured under the Programme is expected to accelerate EV adoption.
    • The manufacturing of ACCs will facilitate demand for EVs, which are proven to be significantly less polluting.
    • As India pursues an ambitious renewable energy agenda, the ACC program will be a key contributing factor to reduce India’s Green House Gas (GHG) emissions which will be in line with India’s commitment to combat climate change.
    • Import substitution of around Rs.20,000 crore every year.
    • The impetus to Research & Development to achieve higher specific energy density and cycles in ACC.
    • Promote newer and niche cell technologies.

  • [pib] NITI Aayog and Mastercard Release Report on financial inclusion

    About the report

    • NITI Aayog and Mastercardtoday released a report titled ‘Connected Commerce: Creating a Roadmap for a Digitally Inclusive Bharat’.
    • The report identifies challenges in accelerating digital financial inclusion in India and provides recommendations for making digital services accessible to its 1.3 billion citizens.
    • The report highlights key issues and opportunities, with inferences and recommendations on policy and capacity building across agriculture, small business (MSMEs), urban mobility and cybersecurity.
    • This report looks at some key sectors and areas that need digital disruptions to bring financial services to everyone.

    Key recommendations in the report include:

    • Strengthening the payment infrastructure to promote a level playing field for NBFCs and banks.
    • Digitizing registration and compliance processes and diversifying credit sources to enable growth opportunities for MSMEs.
    • Building information sharing systems, including a ‘fraud repository’, and ensuring that online digital commerce platforms carry warnings to alert consumers to the risk of frauds.
    • Enabling agricultural NBFCs to access low-cost capital and deploy a ‘phygital’ (physical + digital) model for achieving better long-term digital outcomes.
    • Digitizing land records will also provide a major boost to the sector.
    • To make city transit seamlessly accessible to all with minimal crowding and queues, leveraging existing smartphones andcontactless cards, and aim for an inclusive, interoperable, and fully open system such as that of the London ‘Tube’.

  • NASA’s OSIRIS-REx begins journey back from asteroid

    On May 11, NASA’s Origins, Spectral Interpretation, Resource Identification, Security, Regolith Explorer (OSIRIS-REx) spacecraft will depart asteroid Bennu, and start its two-year-long journey back to Earth.

    About OSIRIS-REx

    • OSIRIS-REx is NASA’s first mission to visit a near-Earth asteroid, survey its surface and collect a sample from it.
    • The mission was launched in 2016, it reached its target in 2018 and since then, the spacecraft has been trying to match the velocity of the asteroid using small rocket thrusters.
    • It also utilised this time to survey the surface and identify potential sites to take samples.
    • In October 2020, the spacecraft briefly touched asteroid Bennu, from where it collected samples of dust and pebbles. 
    • Once the surface was disturbed, the spacecraft’s robotic arm captured some samples.
    • The spacecraft’s engineers have also confirmed that shortly after the spacecraft made contact with the surface, it fired its thrusters and “safely backed away from Bennu”.

    About Bennu

    • Bennu is considered to be an ancient asteroid that has not gone through a lot of composition-altering change through billions of years, which means that below its surface lie chemicals and rocks from the birth of the solar system.
    • Around 20-40 percent of Bennu’s interior is empty space and scientists believe that it was formed in the first 10 million years of the solar system’s creation, implying that it is roughly 4.5 billion years old.
    • Bennu is a B-type asteroid, implying that it contains significant amounts of carbon and various other minerals.
    • Because of its high carbon content, the asteroid reflects about four percent of the light that hits it, which is very low when compared with a planet.
    • Bennu is named after an Egyptian deity.
    • The asteroid was discovered by a team from the NASA-funded Lincoln Near-Earth Asteroid Research team in 1999.

  • What is 2-deoxy-D-glucose (2-DG) and is it effective against Covid?

    About the drug

    • DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the Drug Controller General of India (DCGI).
    •  2-DG halts the spread of COVID-19 inside the body cells.
    • Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence.
    • In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints.
    • A significantly favourable trend (2.5 days difference) was seen in terms of the median time to achieving normalisation of specific vital signs parameters when compared to SoC.

    How 2-DG reduces dependence on oxygen

    • The 2 DG drug, like glucose, spreads through the body, reaches the virus-infected cells and prevents virus growth by stopping viral synthesis and destroys the protein’s energy production.
    • The drug also works on virus infection spread into lungs which help us to decrease patients dependability on oxygen.