Pharma Sector – Drug Pricing, NPPA, FDC, Generics, etc.

What is 2-deoxy-D-glucose (2-DG) and is it effective against Covid?


From UPSC perspective, the following things are important :

Prelims level: 2-DG

Mains level: Paper 3- Drug developed by DRDO approved for Covid treatment

About the drug

  • DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the Drug Controller General of India (DCGI).
  •  2-DG halts the spread of COVID-19 inside the body cells.
  • Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence.
  • In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints.
  • A significantly favourable trend (2.5 days difference) was seen in terms of the median time to achieving normalisation of specific vital signs parameters when compared to SoC.

How 2-DG reduces dependence on oxygen

  • The 2 DG drug, like glucose, spreads through the body, reaches the virus-infected cells and prevents virus growth by stopping viral synthesis and destroys the protein’s energy production.
  • The drug also works on virus infection spread into lungs which help us to decrease patients dependability on oxygen.


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