Why in the News?
A mysterious illness in Jammu & Kashmir has caused 17 deaths, with doctors suspecting organophosphate poisoning from pesticides as the possible cause.
What are Organophosphates?
- Organophosphates (OPs) are a class of chemical compounds primarily used as pesticides and insecticides in agriculture.
- They work by disrupting the nervous system by inhibiting the enzyme acetylcholinesterase (AChE), leading to excessive nerve stimulation.
- It is commonly used in agriculture, household pest control, and chemical warfare agents (e.g., nerve gases like Sarin).
- It is found in pesticides such as malathion, chlorpyrifos, and diazinon.
- Effects of OP poisoning:
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- Acute Symptoms: Excessive sweating, nausea, vomiting, diarrhea, muscle twitching, breathing difficulty, seizures, and coma.
- Chronic Effects: Neurological disorders, memory loss, muscle weakness, and reproductive toxicity.
Treatment for Organophosphate Poisoning
- Organophosphate poisoning requires immediate medical attention to prevent fatal complications.
- Decontamination: Remove contaminated clothing, wash exposed skin, and use activated charcoal if ingested.
- Medical Treatment:
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- Atropine: Blocks excess nerve stimulation.
- Pralidoxime (2-PAM): Restores enzyme function.
- Oxygen therapy and ventilator support if needed.
- Supportive Care: IV fluids, anti-seizure medications, and hospitalization in severe cases.
