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Subject: Science and Technology

  • Krutrim AI: India’s indigenous AI

    Why in the news?

    Krutrim AI is Ola’s homegrown AI assistant, designed to cater to the diverse needs and nuances of Indian consumers, bridging the gap between conventional AI and specific cultural contexts.

    Krutrim’s Capabilities

    • Multilingual Support: Krutrim boasts the ability to converse in English, Hindi, Tamil, Telugu, Malayalam, Marathi, Kannada, Bengali, Gujarati, and Hinglish, catering to the linguistic diversity of India.
    • Multi-Functionality: Users can leverage Krutrim for a range of tasks, including writing emails, seeking information, learning new skills, planning travel, discovering recipes, and more.

    Technology behind Krutrim AI

    • Sophisticated AI Model: Krutrim operates on a sophisticated AI model trained on vast datasets encompassing Indian languages, social contexts, and cultural references.
    • Natural Language Processing (NLP): Utilizes NLP to comprehend human language nuances, including colloquialisms and cultural contexts, enhancing user interactions.
    • Machine Learning (ML): ML algorithms enable Krutrim to learn from datasets, continuously improving responses and understanding user intent.
    • Deep Learning: Leverages Deep Learning to recognize patterns and analyze complex data, crucial for contextual responses and performance enhancement.

    Applications and Benefits for Users

    • Enhanced User Experience: Krutrim AI enhances user experiences across various sectors by offering culturally sensitive interactions, personalized learning in education, and automating administrative tasks.
    • Support for Content Creators: Content creators can leverage Krutrim for ideation and localization, making content more relatable and engaging.
    • Automating Repetitive Tasks: Krutrim’s capabilities extend to automating repetitive administrative tasks across industries, boosting efficiency and productivity.

    PYQ:

    2018: When the alarm of your smartphone rings in the morning, you wake up and tap it to stop the alarm which causes your geyser to be switched on automatically. The smart minor in your bathroom shows the day’s weather and also indicates the level of water in your overhead tank. After you take some groceries from your refrigerator for making breakfast, it recognises the shortage of stock in it and places an order for the supply of fresh grocery items. When you step out of your house and lock the door, all lights, fans, geysers and AC machines get switched off automatically. On your way to office, your car warns you about traffic congestion ahead and suggests an alternative route, and if you are late for a meeting, it sends a- message to your office accordingly.

    In the context of emerging communication technologies, which one of the following term” best applies to the above scenario?

    1. Border Gateway Protocol
    2. Internet of Things
    3. Internet Protocol
    4. Virtual Private Network

     

    Practice MCQ:

    Consider the following statements about the ‘Krutrim AI’:

    1. It is a homegrown AI assistant developed by the Centre for Development of Advanced Computing (C-DACs).
    2. It can converse in regional languages of India.

    Which of the given statements are correct?

    1. Only 1
    2. Only 2
    3. Both 1 and 2
    4. Neither 1 nor 2

  • On the resurgence of Mumps in Kerala

    Why in the news? 

    Mumps, an acute viral infection that historically affects children, has been spreading like wildfire in Kerala, for the past few months.

    Context:

    • Despite being a vaccine-preventable disease, mumps has never been a part of the Universal Immunisation Programme (UIP) because of the disease’s no-mortality profile and the perception that it has low public health significance.
    • According to the World Health Organization (WHO), vaccination strategies targeting mumps control should be closely integrated with existing measles elimination and rubella control.

    About: Mumps is an airborne viral disease primarily affecting children and adolescents. It manifests with symptoms like fever, headache, and painful swelling of the salivary glands, particularly the parotid glands on both sides of the face.

    Is it a cause for concern? 

    • Self-Limiting Disease: Mumps is described as a self-limiting disease, meaning it typically resolves on its own with rest and symptomatic management within about two weeks.
    • Underreporting: Due to approximately half of infected children developing classical symptoms and around 30% remaining asymptomatic, many cases of mumps go unreported. This suggests that reported cases are likely a significant underestimation of the actual prevalence in the community.
    • Public Health Perspective: Historically, measles has been prioritized in public health efforts due to its potential for severe morbidity and mortality, overshadowing the attention given to mumps.
    • Emerging Concerns: Despite being less prioritized, recent reports indicate a surge in mumps cases, including complications such as encephalitis, epilepsy, aseptic meningitis, and acute pancreatitis, particularly at Kozhikode Medical College hospital.
    • Impact on Reproductive Health: Mumps can affect the gonads (reproductive glands) in both males and females. In males, it poses the rare but significant risk of infertility or reduced sperm count in the long term.

    Why is the mumps vaccine not part of the national immunization schedule?

    • Lack of Mortality: Mumps typically does not result in fatalities, further contributing to the belief that it may not warrant inclusion in routine vaccination schedules.
    • Underestimation of Public Health Significance: Despite arguments from organizations like the Indian Academy of Pediatrics (IAP) that mumps’ public health significance is underestimated, there has been insufficient evidence or data to prompt its inclusion in national immunization programs.
    • Poor Documentation and Lack of Studies: Limited documentation of clinical cases, complications, and follow-up data, as well as a scarcity of published studies on mumps, have hindered efforts to fully understand its impact and advocate for its vaccine inclusion.
    • Absence of Nationally Representative Data: The lack of nationally representative data on the incidence of mumps in India makes it challenging to assess its burden accurately and advocate for vaccine inclusion based on epidemiological evidence.
    • Limited Information on Long-Term Morbidity: While mumps is known to have some impact on reproductive organs, there is very little information available on its actual long-term morbidity profile, further complicating decisions regarding vaccine inclusion.

    How can the current outbreaks be controlled?

    • Public Awareness Campaigns: Launch comprehensive public awareness campaigns to educate the community about mumps, its symptoms, transmission, and the importance of isolation. Emphasize the significance of vaccination and maintaining good hygiene practices.
    • Improve Immunization Coverage: Strengthen efforts to improve general immunization coverage, especially targeting unimmunized children and adolescents. Ensure accessibility to vaccination services in all communities.
    • Strict Isolation Measures: Enforce strict isolation measures for mumps patients for the full three-week duration to limit disease transmission. Provide clear guidelines to healthcare facilities and schools on managing mumps cases and preventing spread.
    • School Closure: Consider temporary closure of schools during outbreaks to prevent further transmission, especially if a significant number of cases are reported among students. Use the summer break as an opportunity to break the chain of transmission.
    • Enhanced Surveillance and Reporting: Implement robust surveillance systems to promptly detect and report mumps cases. Ensure healthcare providers are vigilant in diagnosing and reporting suspected cases to public health authorities for timely intervention.
    • Contact Tracing and Monitoring: Conduct thorough contact tracing of individuals who have been in close contact with confirmed mumps cases. Monitor them for symptoms and enforce isolation measures if necessary to prevent secondary transmission.
    • Healthcare Provider Training: Provide training to healthcare providers on mumps diagnosis, management, and reporting protocols. Ensure they are equipped to identify and manage cases effectively.
    • Community Engagement: Engage with community leaders, schools, and parents to encourage cooperation with control measures. Encourage individuals to seek medical care promptly if they develop symptoms suggestive of mumps.

    Way Forward:

    • Assessment of Vaccine Effectiveness: Despite the lack of studies on the effectiveness of the mumps vaccine in India, global data suggests that two doses of the MMR vaccine can provide protection ranging from 70% to 95%, provided that coverage is high.
    • Integration with Measles and Rubella Control: The World Health Organization (WHO) recommends integrating mumps vaccination strategies with existing efforts for measles elimination and rubella control. This ensures a comprehensive approach to vaccine-preventable diseases.
    • Consideration of Regional Factors: Evaluate regional factors influencing vaccine effectiveness, disease burden, and immunization coverage. Tailor vaccination strategies accordingly to address the specific needs and challenges faced in Kerala.
    • Consultation with Experts and Stakeholders: Engage with public health experts, immunization specialists, and stakeholders to review the evidence, assess the impact of different vaccination strategies, and determine the most effective approach moving forward.
    • Monitoring and Surveillance: Strengthen monitoring and surveillance systems to track mumps cases, vaccine coverage, and vaccine effectiveness. This data will be crucial for evaluating the impact of vaccination strategies and making informed decisions.
    • Policy Decision: Based on the evidence and expert recommendations, make a policy decision regarding the inclusion of MMR vaccine in the Universal Immunization Programme. Consider factors such as vaccine availability, cost-effectiveness, and logistics.

    Conclusion: Addressing the resurgence of mumps in Kerala necessitates a comprehensive approach, including vaccination integration, public awareness, strict isolation measures, and policy review guided by expert consultation and regional considerations.

  • IAU approves ‘Statio Shiv Shakti’ as name for Chandrayaan-3 Landing Site

    What is the news?

    The International Astronomical Union (IAU) working group for Planetary System Nomenclature recently sanctioned the name ‘Statio Shiv Shakti’ for the landing site of Chandrayaan-3’s Vikram lander, marking a significant milestone in planetary nomenclature.

    About International Astronomical Union (IAU)

    • The IAU was founded on July 28, 1919, during the Constitutive Assembly held in Brussels, Belgium.
    • Its creation was prompted by the need for international collaboration in astronomy, especially after the devastation caused by World War I.
    • It aims for promoting and safeguarding astronomy in all its aspects through international cooperation.
    • IAU is now headquartered in Paris, France.

    Major Activities and Initiatives

    • General Assembly: The IAU holds a general assembly every three years in varying parts of the world at which professional astronomers meet to discuss research, new cooperative ventures, and similar matters of professional interest.
    • Astronomical Nomenclature: IAU standardizes the nomenclature of celestial bodies, features, and phenomena. It maintains several working groups dedicated to naming conventions for stars, planets, asteroids, and other objects.
    • Research and Collaboration: It promotes international cooperation in astronomical research and supports initiatives such as observational campaigns, data sharing, and joint projects.
    • Education and Outreach: It is actively involved in promoting astronomy education and public outreach efforts worldwide. It supports educational programs, workshops, and resources for students, teachers, and the general public.

    Membership

    1. IAU membership spans 92 countries. Out of those countries, 85 are National Members.
    2. India is represented by the Astronomical Society of India (ASI).
    3. Its members are professional astronomers from all over the world, at the D. level and beyond, who are active in professional research, education, and outreach in astronomy.

    IAU Nomenclature  Criteria

     

    • Rule 4: It emphasizes the international nature of solar system nomenclature and encourages equitable representation of names from diverse ethnic groups, countries, and genders.
    • Rule 9: The IAU adheres to Rule 9, prohibiting names with political, military, or religious connotations, except for historical political figures prior to the 19th century.
    • Rule 11: It emphasizes that names should be unique within the context of celestial nomenclature to prevent confusion.

    About Statio Shiv Shakti’

    • Prime Minister announced the name ‘Shiv Shakti’ for the Chandrayaan-3 landing site in August, 2023, reflecting the significance of Indian mythology and cultural heritage.
    • It is located at the co-ordinates 69.373°S 32.319°E and lies between the lunar craters Manzinus C and Simpelius N.
    • The name ‘Shiv Shakti’ symbolizes the masculine-feminine duality of nature, embodying strength and resolution, with a profound connection to India’s diverse cultural landscape.

    PM previously named the Chandrayaan-2 crash site ‘Tiranga point’, while former President A.P.J. Abdul Kalam suggested ‘Jawahar Point’ for the Chandrayaan-1 impact probe landing site, reflecting a tradition of honoring national figures and symbols.

     

    PYQ:

    2021: Which one of the following is a reason why astronomical distances are measured in light-years?​

    1. Distances among stellar bodies do not change.​
    2. Gravity of stellar bodies does not change.​
    3. Light always travels in straight line.​
    4. Speed of light is always same.​

     

    Practice MCQ:

    Consider the following statements about International Astronomical Union (IAU):

    1. It aims for promoting and safeguarding astronomy in all its aspects through international cooperation.
    2. India is represented by the ISRO in the IAU.

    Which of the given statements are correct?

    1. Only 1
    2. Only 2
    3. Both 1 and 2
    4. Neither 1 nor 2

  • Clinical Trials for MTBVAC Tuberculosis Vaccine in India

    What is the news?

    • Bharat Biotech, in collaboration with Spanish biopharmaceutical company Biofabri, has initiated clinical trials for the Mycobacterium Tuberculosis Vaccine (MTBVAC) in India, marking a significant milestone in TB vaccine development.
    • The only currently available TB vaccine, the Bacillus Calmette-Guérin vaccine (BCG), was developed 100 years ago and is less effective.

    About MTBVAC

    • MTBVAC is a unique TB vaccine based on a genetically modified form of Mycobacterium tuberculosis, containing all antigens present in human-infecting strains, unlike the BCG vaccine.
    • It is developed in the laboratory of the University of Zaragoza with contributions from Dr. Brigitte Gicquel of the Pasteur Institute, Paris.
    • MTBVAC is designed to offer superior and potentially longer-lasting protection compared to the BCG vaccine, particularly for newborns and in preventing TB in adults and adolescents.

    Objectives of Clinical Trials in India

    • Safety and Immunogenicity: The ongoing trials in India aim to evaluate the safety and immunogenicity of MTBVAC, with plans for a pivotal Phase 3 trial in 2025.
    • Population Significance: Studying the vaccine’s efficacy in India, with its high TB burden, is crucial for advancing TB vaccine research and addressing the global TB epidemic.

    What is Tuberculosis?

    • Tuberculosis is an infection caused by Mycobacterium tuberculosis.
    • Robert Koch discovered Mycobacterium tuberculosis which causes TB, and his discovery opened the way towards diagnosing and curing this disease.
    • It can practically affect any organ of the body.
    • The most common ones are lungs, pleura (lining around the lungs), lymph nodes, intestines, spine, and brain.

    Transmission:

    It is an airborne infection that spreads through close contact with the infected, especially in densely populated spaces with poor ventilation.

    Symptoms:

    Common symptoms of active lung TB are cough with sputum and blood at times, chest pains, weakness, weight loss, fever and night sweats.

    Treatment Facilities in India:

    • DOTS (Directly Observed Treatment, Short-Course) regimen: It is the recommended treatment approach for TB by the WHO. Patients receive a combination of four antibiotics: isoniazid, rifampicin, pyrazinamide, and ethambutol. These drugs are usually administered daily for the first two months of treatment, followed by a continuation phase with isoniazid and rifampicin for an additional four to seven months.
    • Nikshay Poshan Yojana (2018): It was launched to support every Tuberculosis (TB) Patient by providing a Direct Benefit Transfer (DBT) of Rs 500 per month for nutritional needs.

    Issues in TB Treatment: Drug Resistance

    Drug resistance emerges when anti-TB medicines are used inappropriately, through incorrect prescription by health care providers, poor quality drugs, and patients stopping treatment prematurely.

    1. Multidrug-resistant tuberculosis (MDR-TB): Itis a form of TB caused by bacteria that do not respond to isoniazid and rifampicin, the 2 most powerful, first-line anti-TB drugs. MDR-TB is treatable and curable by using second-line drugs such as
    2. Extensively drug-resistant TB (XDR-TB): Itis a more serious form of MDR-TB caused by bacteria that do not respond to the most effective second-line anti-TB drugs, often leaving patients without any further treatment options.

     

    PYQ:

    2014: Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.

     

    Practice MCQ:

    With reference to the Tuberculosis (TB), consider the following statements:

    1. TB is an infection caused by Mycobacterium tuberculosis.
    2. It only targets Lungs.
    3. Nikshay Poshan Yojana aims for TB support is essentially a Direct Benefit Transfer (DBT).

    How many of the given statements is/are correct?

    1. One
    2. Two
    3. Three
    4. None

  • [pib] Project ANAGRANINF

    What is the news?

    • The Technology Development Board (TDB) has allocated a grant of ₹75 Lakhs for the project “ANAGRANINF – Development of a Novel Class of Antibiotics against Gram-Negative Bacterial-Infections,” totalling ₹1.5 crores.

    What is Project ANAGRANINF?

    • Project ANAGRANINF is titled “Development of a Novel Class of Antibiotics Against Gram-Negative Bacterial-Infections.”
    • It is a collaborative initiative involving M/s Peptris Technologies Pvt. Ltd. and the Foundation for Neglected Disease Research (FNDR) in India, along with ABAC THERAPEUTICS SL from Spain.
    • The primary objective of the project is-
    1. To develop a novel antibiotic capable of inhibiting the FabI enzyme and
    2. Combating critical gram-negative pathogens.
    • Project ANAGRANINF aims to produce a series of compounds with enhanced efficacy against gram-negative bacterial infections.
    • The project aims to identify a candidate molecule that meets WHO’s innovation criteria, ensuring a new chemical structure, no cross-resistance with existing antibiotic classes, and a novel mechanism of action.

    About the Candidate Molecule ‘MMV1578564’

    The selected hit molecule from the project, MMV1578564, has exhibited promising activity against gram-negative pathogens, providing a foundation for further research and development efforts.

    Back2Basics:

    1. Gram-Negative Bacteria:
      • Gram-negative bacteria have a thin peptidoglycan layer in their cell wall, which is located between the outer and inner membranes.
      • They stain pink or red when subjected to the Gram staining technique.
      • Gram-negative bacteria are generally more resistant to antibiotics due to the presence of an outer membrane that acts as a barrier against certain antibiotics.
      • Examples of gram-negative bacteria include Escherichia coli (E. coli), Salmonella spp., Pseudomonas aeruginosa, and Neisseria gonorrhoeae.
      • They are known to cause infections like pneumonia, bloodstream infections, wound infections, and meningitis in healthcare settings
    2. Gram-Positive Bacteria:
      • Gram-positive bacteria have a thick layer of peptidoglycan in their cell wall, which retains the crystal violet stain used in the Gram staining technique.
      • They appear purple or blue under a microscope after staining.
      • Gram-positive bacteria are generally more susceptible to antibiotics because their thick peptidoglycan layer allows antibiotics to penetrate more easily.
      • Examples of gram-positive bacteria include Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, and Clostridium difficile.
      • Some examples of diseases caused by Gram-positive bacteria include anthrax, diphtheria, enterococcal infections, erysipelothricosis, and listeriosis.These bacteria can cause a range of infections from food poisoning to serious respiratory diseases and may require specific antibiotics for treatment.

     

    PYQ:

    2021: Consider the following:​

    1. Bacteria​
    2. Fungi​
    3. Virus​

    Which of the above can be cultured in artificial/synthetic medium?​

    1. 1 and 2 only ​
    2. 2 and 3 only​
    3. 1 and 3 only ​
    4. 1, 2 and 3​

     

    Practice MCQ:

    The recently launched Project ‘ANAGRANINF’ deals with:

    1. Agricultural Grant
    2. Artificial Intelligence
    3. Antibiotics Development
    4. None of these

  • ISRO successfully conducts ‘Pushpak’ Reusable Landing Vehicle Landing

    What is the news?

    • The ISRO has conducted the Pushpak Reusable Landing Vehicle (RLV) LEX 02 landing experiment at the Aeronautical Test Range in Chitradurga. It was lifted by an Indian Air Force Chinook helicopter and released from an altitude of 4.5 km.
    • This experiment marks a significant milestone in ISRO’s pursuit of reusable space technology.

    About Pushpak Reusable Landing Vehicle (RLV)

    • The Pushpak RLV is a winged vehicle, equipped with aerodynamic surfaces that enable controlled flight during re-entry into the Earth’s atmosphere.
    • The RLV is designed to autonomously land on a designated runway after completing its mission in space, thereby demonstrating India’s capability in autonomous space vehicle landing.
    • It is equipped with sophisticated navigation, control, and landing gear systems that allow it to autonomously navigate and land on a predefined runway.

    Key Features

    1. The RLV is a space plane with a low lift-to-drag ratio, requiring an approach at high glide angles that necessitates landing at high velocities of 350 km/h.
    2. This design allows it to transport payloads to Low Earth orbits and return to Earth for future use.

    Future Prospects

    • Iterative Testing: ISRO conducts a series of experiments, such as the RLV LEX 02 landing experiment, to test and validate the performance of the RLV in various scenarios.
    • Orbital Re-entry Missions: The successful demonstration of the Pushpak RLV’s capabilities paves the way for future orbital re-entry missions, where reusable vehicles can be deployed for various scientific and commercial purposes.

    PYQ:

    2018: With reference to India’s satellite launch vehicles, consider the following statements:

    1. PSLVs launch the satellites useful for Earth resources monitoring whereas GSLVs are designed mainly to launch communication satellites.
    2. Satellites launched by PSLV appear to remain permanently fixed in the same position in the sky, as viewed from a particular location on Earth.
    3. GSLV Mk III is a four-stage launch l vehicle with the first and third stages l using solid rocket motors; and the second and fourth stages using liquid rocket engines.

    Which of the statements given above is/are correct?

    1. 1 only
    2. 2 and 3
    3. 1 and 2
    4. 3 only

     

    Practice MCQ:

    Consider the following statements about the ‘Pushpak’ Reusable Landing Vehicle (RLV):

    1. It is a winged vehicle.
    2. It can transport payloads to Low Earth orbits and return to Earth with the help of a parachute.

    Which of the given statements are correct?

    1. Only 1
    2. Only 2
    3. Both 1 and 2
    4. Neither 1 nor 2

  • Patent (Amendment) Rules, 2024: Key Highlights

    In the news-

    • The Patent (Amendment) Rules, 2024 were recently published in the Gazette of India, making crucial changes in the Indian patent regime.

    Context:

     

    2023 emerged as a landmark year for intellectual property rights (IPR) in India, reflecting the nation’s commitment to innovation and creativity.

     

    • 1 Lakh Patents filed: The Indian Patent Office has achieved a significant milestone this year by granting over 1 lakh patents in a year for the first time.
    • Sector-wise Breakdown: The highest number of patents, 47,993, were granted in the electrical and related field of invention, followed by mechanical (37,714), chemical sciences (12,028) and Biotech (3,576) categories.

    Key Amendments Introduced:

    • Revised Timeline for Request for Examination: The period for submitting a Request for Examination (RFE) in a patent application has been shortened from 48 months to 31 months from the earliest priority date.
    • Streamlined Applications: Patent applicants now need to furnish details of corresponding applications solely twice using Form 3.
    • Introduction of ‘Certificate of Inventorship’: This new provision acknowledges the contributions of inventors to patented innovations.
    • Reduction in Advance Renewal Fees: A discount of 10% on renewal fees is offered if paid electronically in advance for a minimum of four years.
    • Decreased Frequency of Patent Working Statements: The requirement to file statements of working patents has been reduced from annually to once every three financial years.
    • Enhanced Authority of Controller: The Controller is now empowered to extend specified periods and excuse delays for up to six months.
    • Amendments to Opposition Procedures: Adjustments have been made to the time frames for submitting recommendations by an Opposition Board and the response period for applicants in both pre-grant and post-grant opposition procedures.

    What are Patents?

    • A patent is a legal right granted by a government to an inventor or assignee, giving them exclusive rights to an invention for a limited period.
    • It provides the inventor with the right to exclude others from making, using, selling, or importing the patented invention without their permission.
    • In essence, a patent acts as a form of intellectual property protection for inventions, allowing inventors to control and commercialize their creations.
    • Patents are territorial rights. In general, the exclusive rights are only applicable in the country or region in which a patent has been filed and granted.

    Indian Patent Regime: A Backgrounder

    • Indian patents are governed by the Indian Patent Act of 1970.
    • India has gradually aligned itself with international regimes pertaining to intellectual property rights.
    • In 1995, India became a party to the Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement following its membership to the World Trade Organisation on January 1, 1995.
    • An interesting point is that the original Indian Patents Act did NOT grant patent protection to pharmaceutical products to ensure that medicines were available at a low price.
    • Patent protection of pharmaceuticals were re-introduced after the 2005 amendment to comply with TRIPS.

    Filing a Patent: Key Terms

    • Patentable Subject Matter: Under the Indian Patents Act, inventions related to products, processes, methods, and applications in all fields of technology are patentable, provided they are novel, involve an inventive step, and are capable of industrial application.
    • Patent Office: The Indian Patent Office, under the Department for Promotion of Industry and Internal Trade (DPIIT), administers the patent system in India. It operates through four branches located in Kolkata, Mumbai, Delhi, and Chennai, with the Controller General of Patents, Designs & Trade Marks overseeing patent-related matters.
    • 20-Year Validity: Patent protection is granted for a limited period, generally 20 years from the filing date of the application.

    Various Agreements

    India is also a signatory to several IPR-related conventions, including-

    1. Berne Convention (1886) The Berne Convention for the Protection of Literary and Artistic Works, established in 1886, is an international treaty governing copyright.
    2. Budapest Treaty (1977): It aims to facilitate the international recognition of patents relating to microorganisms by providing a centralized deposit system for the storage and distribution of biological materials.
    3. Paris Convention for the Protection of Industrial Property (1883): It aims to harmonize and standardize the protection of industrial property, including patents, trademarks, industrial designs, and trade secrets, among its member countries.
    4. Patent Cooperation Treaty (1970): It is an international treaty administered by the World Intellectual Property Organization (WIPO) to simplify the process of filing patent applications in multiple countries by providing a unified procedure for filing an international patent application.

    Back2Basics:

    Patents Copyright Trade Secrets
    Legal Basis Patents Act, 1970 Copyright Act, 1957 Common law, contracts
    Duration of Protection 20 years Author’s lifetime + 60 years Indefinite
    Nature of Protection Inventions, processes, methods Literary, artistic, musical works Confidential information
    Criteria for Protection Novelty, Inventiveness Originality, Fixation Confidentiality
    Registration Requirement Required Optional (automatic) None (advisable)
    Scope of Protection Technical aspects Expression of ideas Unauthorized use or disclosure
    Enforcement Mechanism Civil litigation Civil and criminal actions Civil litigation
    International Protection Patent protection can be sought internationally through the Patent Cooperation Treaty (PCT) and other international agreements Copyright protection is recognized internationally through the Berne Convention and other treaties Protection of trade secrets can vary internationally and may depend on the laws and regulations of individual countries
    Examples Inventions, software Books, music, software Formulas, processes

     

    PYQ:

     

    2013: Bringing out the circumstances in 2005 which forced an amendment to section 3(d) in Indian Patent Law, 1970, discuss how it has been utilized by the Supreme Court in its judgement in rejecting Novartis’ patent application for ‘Glivec’. Discuss briefly the pros and cons of the decision. (200 words)

    2014: In a globalized world, Intellectual Property Rights assume significance and are a source of litigation. Broadly distinguish between the terms—Copyrights, Patents and Trade Secrets.

  • Onward to Thorium

    Why in the News?

    Recently, at the start of March 2024, our 500-MWe Prototype Fast Breeder Reactor (PFBR) began fuel-loading, marking the successful completion of commissioning trials and rectification of a range of first-of-its-kind equipment in the fast breeder reactor technology.

    Context:

    • Homi Bhabha’s spirit of self-reliance has enabled the autonomous pursuit of ‘Thorium Goals’.
    • His proposed three-stage strategy aims to develop critical nuclear technologies, starting with modest uranium resources, and achieve a large-scale thorium-based energy program.
    • The largest contributor to the climate change-related existential threat we face has created an immediate demand for large-scale deployment of nuclear power plants.
    • BHAVINI, Indira Gandhi Centre for Atomic Research (IGCAR), and the Bhabha Atomic Research Centre (BARC) are responsible for building and operating the PFBR.

    What is the significance of thorium in making India energy self-sufficiency?

      • Meeting Energy Demand:
    • Boosting Domestic Market: 
        • Given the size of India’s population and its economy, its energy demands would lead to serious challenges to energy security.
        • For ‘Vikasit Bharat’, India needs around three-and-a-half times more energy, which can come only from nuclear energy, specifically thorium.
      • Reducing Imports:
        • India has been dependent on energy imports all along. Thorium presents us with a unique opportunity to become energy self-sufficient.
        • Renewable energy, including large hydropower projects, can, at best, meet current energy needs.
    • Building Global Perspective:
      • India’s long-term Energy security:
        • Looking towards India’s level of nuclear energy deployment will, the PFBR is expected to become operational, paving India into the second stage of its three-stage nuclear power programme.
        • It works as the gateway for meeting the country’s energy needs for a long time into the future, leveraging India’s vast thorium resources, which are the largest in the world.
      • Further, there is no other clean energy source available on the Indian landmass that can cope with India’s energy needs.

    Future Scope:

    • Transitioning to Better Fuel:
        • A high-assay, low-enriched uranium (LEU) and thorium fuel capable of delivering a seven-times larger fuel burn-up in the PHWR design is needed.
        • ANEEL fuel has been designed and will be available shortly. The ANEEL fuel concept could also bring the Advanced Heavy Water Reactor (AHWR300-LEU), a fully developed design immune to any severe accident-related anxiety, to reality.
    • Concurrent fuel Recycling Processes:
        • A Fast Reactor Fuel Cycle Facility (FRFCF) that would work alongside the PFBR is coming up.
        • Once a sizeable inventory of uranium-233 accumulates, we must bring in reactors specifically designed for thorium and the related fuel-cycle facilities, constituting the third stage of our nuclear power program.
    • Advancement in Fast Reactor Technology:
        • The rapid deployment of PHWRs based on imported uranium allows for the advancement of thorium utilization in PHWRs, facilitating the deployment of third-stage thorium reactor systems, reducing spent fuel inventory, and proliferation resistance, and enhancing safety and economy.
        • The fast reactor systems with faster growth based on inherently better breeding performance are needed.
        • More reactors on the PFBR model must be constructed to consolidate sodium-cooled fast reactor technology, a key feature of the second stage of the nuclear program.
    • High-temperature reactor:
      • Thorium utilization can be improved in high-temperature reactors to produce low-cost hydrogen with minimal carbon footprint.
      • Direct hydrogen production without electricity would make hydrogen production cheaper and less dependent on hydrogen electrolyzers.

    Conclusion: The beginning of fuel-loading in PFBR is a significant step that must be celebrated to motivate our scientists and prepare them for the bigger tasks ahead. Sustained encouragement backed up by a demanding but conducive framework around them is the need of the hour. One must move on the thorium path, though it has no parallel anywhere else in the world.

     

    Mains PYQ:

    1. With growing energy needs should India keep on expanding its nuclear energy programme? Discuss the facts and fears associated with nuclear energy. (UPSC 2018)
    2. Give an account of the growth and development of nuclear science and technology in India. What is the advantage of a fast breeder reactor program in India? (UPSC 2017)

  • Changing cancer nomenclature can improve treatment outcomes: doctors 

    Why in the news? 

    Physicians have expressed the necessity to categorize Cancers based on their genetic characteristics.

    Context:

    • An updated classification system could aid patients in comprehending the reasoning behind their treatment.
    • While two individuals may share the same type of cancer, their therapies could vary due to differences in the biological mechanisms driving their tumors.

    What motivates the need for change?

    •  Not limited to cancers of a single organ: With technological improvements, doctors are also able to find which genetic mutations are responsible for a tumor in many cases and target them with drugs.
      • All cancers from the same organ don’t always share the same mutations, and these mutations aren’t limited to cancers of a single organ
    • Access life-saving drugs sooner: This development in precision oncology requires cancers to be classified based on their molecular and genetic characteristics rather than the organ in which they originate, a team of researchers from France has written in a paper.
      • This way, according to them, cancer patients can also access life-saving drugs sooner. Oncologists spend a lot of time testing new drugs in clinical trials in a sequential manner, leading to “delay in treatment access”.

    Has sequential testing caused delays? 

      • A 2012 clinical trial conducted in the U.S. explored the efficacy of the drug nivolumab across various cancer types, including melanoma and kidney cancer. Nivolumab targets a specific protein receptor found in certain tumors, and it showed promising results by alleviating symptoms in individuals with tumors expressing this protein
    • Challenges Due to Traditional Organ-Based Classification-
      • Hindered by the traditional classification-Despite promising outcomes, the next logical step of testing nivolumab in individuals with tumors expressing the protein, regardless of cancer origin, was hindered by the traditional classification of cancers based on their organ of origin (e.g., breast, kidney, lung).
      • Multiple trials needed: As a consequence, researchers were compelled to conduct separate trials for each type of cancer, leading to significant delays in drug accessibility for patients with tumors expressing the targeted protein.
      • Time taking trails: Each trial requires substantial time and resources, from recruitment to data analysis, prolonging the process of drug approval and availability for specific cancer subtypes.

    Significance of categorizing cancers based on their genetic characteristics-

    • Faster drug development and availability: By targeting specific genetic mutations rather than specific cancer types, clinical trials for drugs can encompass all cancer types with those mutations. This approach potentially expedites the trial process, leading to faster drug development and availability.
    • Reduces confusion among the patient: The revamped classification system not only accelerates clinical trial timelines but also enhances patient understanding of treatment rationale. Patients often receive different therapies for the same cancer due to diverse underlying biological mechanisms. Aligning cancer names with biological mechanisms reduces confusion and helps patients comprehend the reasoning behind their treatment plans.
    • Personalized treatment: Physicians, including Dr. Jobanputra, emphasize the importance of educating patients about the molecular characteristics of their cancers. As the approach to cancer treatment becomes more personalized, understanding these molecular aspects becomes crucial as they directly impact prognosis and treatment costs.
    • Reducing the timing in trial-naming cancers based on their biological characteristics rather than their anatomical origin can significantly reduce the time required to conduct clinical trials. This shift eliminates the need for separate trials for each cancer type defined by organ of origin, streamlining the research process

    Challenges in Implementing the Proposed Cancer Classification Change:

    • Limited Access to Genetic Testing: The accessibility and affordability of genetic testing are major hurdles, particularly in regions like India where many patients cannot afford these tests.
      • Without widespread access to such tests, implementing a classification system based on molecular alterations becomes impractical.
    • Financial Barriers to Genetic Testing: The cost of genetic testing in Indian labs and abroad is prohibitively high for many patients, further exacerbating the issue of limited access.
      • Addressing these financial barriers is crucial for ensuring equitable access to precision oncology.
    • Lack of Patients in Clinical Trials: Clinical trials based on molecular signatures require a significant number of patients with each type of cancer to produce meaningful results.
      • Without adequate representation across cancer types, there is a risk of generalizing results, limiting the effectiveness of precision oncology approaches.
    • Time-taking Process: Transitioning to a new diagnostic nomenclature based on molecular alterations will likely occur gradually and require careful implementation.
      • While the proposed change has the potential to improve drug accessibility, its full realization will take time and concerted effort to overcome various challenges.

    Conclusion: Categorizing cancers based on genetic characteristics can streamline treatment, improve drug accessibility, and enhance patient understanding. However, challenges like limited access to genetic testing and lack of patient representation in trials must be addressed.

  • Many elections, AI’s dark dimension

    Why in the news? 

    With a series of elections to be held across the world in 2024, the potential of AI to disrupt democracies cannot be dismissed.

    • The rapid development of Generative Artificial Intelligence (GAI) and its potential evolution into Artificial General Intelligence (AGI) could have significant implications for elections.

    AI and the Electoral landscape in India (Possible opportunities and Concerns):

    Opportunities: 

    • Campaign Strategy Revolution: AI tools like sentiment analysis and chatbots optimize campaign strategies, making them more efficient and cost-effective.
    • Disinformation Campaigns: AI facilitates can also be used against targeted disinformation campaigns, spreading fake news tailored to specific demographics or regions.
    • Technological Advancements: Rapid developments in AI technologies simulate real-world interactions and have the potential to influence electoral dynamics significantly.
    • Micro-Targeting Voters: AI enables precise targeting based on data like demographics and online behaviour, enhancing campaign effectiveness.
    • Influence through Personalization: Tailored messages resonate better with voters, potentially swaying opinions.

    Concerns

    • Quality and Quantity of Misinformation: In the upcoming 2024 elections, AI-driven disinformation campaigns are expected to overwhelm voters with vast quantities of incorrect information, including hyper-realistic Deep Fakes and micro-targeted content.
    • Challenges to Democracy: The disruptive potential of AI in influencing electoral behaviour necessitates the implementation of robust checks and balances to prevent AI-driven manipulation and ensure the integrity of democratic processes.
    • Deep Fake Concerns: There are fears of AI-powered “Deep Fake Elections,” where AI-generated content manipulates and confuses voters. This phenomenon may exploit existing societal attitudes, such as the reported support for authoritarianism in India.
    • Propaganda Techniques: AI facilitates the development of sophisticated propaganda techniques, aiming to mislead and manipulate voters. As elections progress, newer methods emerge, potentially leading to the proliferation of Deep Fake content.
    • Disinformation Amplification: AI technology amplifies the spread of falsehoods and misinformation, posing a significant threat to democracies by confusing and misleading the electorate on an unprecedented scale.

    What are ways to tackle AI ‘determinism’? (Way Forward):

    • Mitigate voter mistrust: AI-deployed tactics may erode trust in democratic institutions and processes, highlighting the need for measures to counter AI determinism and mitigate voter mistrust.
    • Checks and Balances: While acknowledging AI’s considerable potential, it is imperative to implement checks and balances to mitigate its harmful effects and safeguard against AI’s unpredictable behavior.
    • Inconsistencies in AI Models: Public scrutiny over inaccuracies associated with AI models, such as those observed with Google, underscores the inherent dangers of relying solely on AI for decision-making without adequate validation and oversight.
    • Existential Threats: Beyond biases in design and development, AI systems pose existential threats, including adversarial capabilities like poisoning, backdooring, and evasion, which undermine the reliability and effectiveness of AI solutions.
    • Mitigating Adversarial Capabilities: Current concepts and ideas for mitigating adversarial capabilities in AI systems are insufficient, requiring further research and development to address the inherent vulnerabilities and risks associated with AI technology.