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Subject: Science and Technology

  • Cancer Gene Mapping

     

    A series of new papers in the journal Nature has revealed the most comprehensive gene map ever of the genes causing cancer. It shows departures from normal behaviour i.e. mutations trigger a cascade of genetic misbehaviours that eventually lead to cancer.

    What is Mutation?

    • A mutation is a change that occurs in our DNA sequence, either due to mistakes when the DNA is copied or as the result of environmental factors such as UV light and pollution etc.
    • Structural variations mean deletion, amplification or reorganization of genomic segments that range in size from just a few bases to whole chromosomes.
    • Bases are the structural units of genes.
    • Over a lifetime our DNA can undergo changes or ‘mutations’ in the sequence of bases A, C, G and T.

    Why study cancer?

    • Cancer is known to be a disease of uncontrolled growth.
    • The growth process, like all other physiological processes, has genetic controls so that the growth is self-limiting. When one or more genes malfunction, the growth process can go out of hand.
    • Not just cancer, there are many other diseases with a genetic link in varying degrees.
    • Just a handful of “driver” mutations could explain the occurrence of a large number of cancers, the researchers said, raising hopes of a cancer cure being nearer than ever.

    How big is the cancer burden?

    • Cancer is the second most-frequent cause of death worldwide, killing more than 8 million people every year; incidence of cancer is expected to increase by more than 50% over the coming decades.
    • 1 in 10 Indians will develop cancer during their lifetime, and one in 15 Indians will die of cancer, according to the World Cancer Report by WHO.
    • The Northeastern states, UP, Rajasthan, West Bengal, Haryana, Gujarat, Kerala, Karnataka and Madhya Pradesh account for 44% of the cancer burden in India, says a recent analysis, published in The Lancet.

    Is the genetic link to cancer well established?

    • Yes, it is. One such association, for example, is of breast cancer with the BRCA 1 and BRCA 2 genes; the actress Angelina Jolie, who discovered that she carried the former gene, chose to undergo a preventive double mastectomy.
    • This is personalised therapeutics where, instead of traditional toxic medications like chemotherapy, drugs that specifically target the delinquent genetic mutation are already being used.
    • Such therapy, however, remains very expensive.

    What is the new study that has oncologists around the world excited?

    • It is a major international collaboration called the Pan-Cancer Analysis of Whole Genomes (PCAWG), in which researchers has published a series of papers after analysing some whole-cancer genomes and their matching normal tissues across 38 tumor types.
    • They concluded that on average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements.
    • This is the largest genome study ever of primary cancer.
    • Various kinds of cancers required to be studied separately because cancers of different parts of the body often behave very differently from one another; so much so that it is often said that cancer is not one disease but many.

    Breakthrough achievement of the study

    • The mutations identified by the team have been catalogued. Identification and cataloguing of the genes is a very crucial step and has taken science’s understanding of cancer and its genesis ahead by several leaps.
    • The catalogue, which is already available online, allows doctors and researchers from all over the world to look things up, consult and find information about the cancer of a given patient.
    • The study has discovered causes of previously unexplained cancers, pinpointed cancer-causing events and zeroed in on mechanisms of development, opening new vistas of personalized cancer treatment to strike at the root of the problem.
    • When it comes to drug development, however, the gene mapping is but a first step.

    The next step

    • The process of drug development will have to now kick in with pharmaceutical companies first identifying the compound(s) that target these gene mutations and then it being subjected to the rigours of clinical trials to prove its safety and efficacy.
    • That could take anything from a few decades to a few years to cover all the mutations identified.

  • [pib] SARAS Initiative

    Coal India’s flagship subsidiary NCL (Northern Coalfields Limited) has set up a centre named SARAS.

    SARAS Initiative

    • SARAS stands for Science and Applied Research Alliance and Support.
    • It aims to promote innovation, R&D and skill development along with improving company’s operational efficiency and utilize resources at optimum level.
    • SARAS will help and enable the company in Integration of Innovation and Research for enhancing coal production, productivity, and safety in mines.
    • Besides, the SARAS would also help establish centres of excellence to ensure technical support to R&D along with thrust on quality skill development and employment to local youths in and around company’s operational area.

    About NCL

    • NCL accounts for 15 per cent of India’s coal production and 10 per cent of thermal power generation of the country is met by the coal produced by this Miniratna Company of Govt. of India.
    • The company produces more than 100 million tonnes of coal every year.
    • It has planned to produce 107 million tonnes of coal in the current fiscal.

  • Remdesivir: Under-trail vaccine against Coronavirus

    The Wuhan Institute of Virology at Wuhan, China has filed for a patent on Remdesivir, an antiviral experimental drug from the US which may help treat the novel coronavirus (nCoV-2019).

    Remdesivir

    • It is an experimental drug and has not yet been licensed or approved anywhere globally. It has not been demonstrated to be safe or effective for any use.
    • It is currently being developed for the treatment of Ebola virus infection.
    • Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
    • Chloroquine is a “widely used” anti-malarial and autoimmune disease medicine that has recently come to light as a potential antiviral drug.

    Can Remdesivir treat coronavirus?

    • Significantly, Remdesivir has demonstrated in vivo (experimentation using a whole living organism) and in vitro (activity performed in a controlled environment) activity in animal models against viral pathogens that cause MERS and SARS.
    • Even so, the use of the experimental drug has been allowed only as an emergency treatment, which can be administered in the absence of any other approved treatment options.
    • These two diseases are also caused by coronaviruses structurally similar to the nCoV-2019.
    • Additionally, limited clinical data is available from the emergency administration of Remdesivir in patients with Ebola.
    • Even so, it is yet to be seen if Remdesivir and chloroquine can be effective against the novel coronavirus in humans.

    How can the novel coronavirus infection be treated?

    • As of now, there is no known treatment for the novel coronavirus, and an appropriate antiviral drug is required for this.
    • Ideally, a vaccine against the infection can also prove to be effective, but such a development does not seem to be in the offing for at least three-four months.

  • Explained: Practice of Female Genital Mutilation (FGM)

     

    Every year, February 6 is observed as the International Day of Zero Tolerance for Female Genital Mutilation (FGM).  As per the WHO, globally, over 200 million girls alive today have suffered FGM in over 30 countries.

    Female Genital Mutilation

    • FGM is the name given to procedures that involve altering or injuring the female genitalia for non-medical or cultural reasons.
    • It is recognised internationally as a violation of human rights and the health and integrity of girls and women.
    • Most girls and women who have undergone FGM live in sub-Saharan Africa and the Arab States, but it is also practiced in some countries in Asia, Eastern Europe and Latin America.
    • According to the United Nations Population Fund (UNFPA), while the exact origins of the practice remain unclear, it seems to have predated Christianity and Islam.
    • It says that some Egyptian mummies display characteristics of FGM.
    • Significantly, the ancient Greek historian Herodotus has claimed that in the fifth century BC, the Phoenicians, the Hittites and the Ethiopians practised circumcision.

    Why is Female Genital Mutilation practiced?

    • Depending on the region, there can be various reasons why FGM is performed. The UNFPA has categorised the reasons into five categories —
    1. psycho-sexual reasons (when FGM is carried out as a way to control women’s sexuality, “which is sometimes said to be insatiable if parts of the genitalia, especially the clitoris, are not removed);
    2. sociological or cultural reasons (when FGM is seen as part of a girl’s initiation into womanhood and an intrinsic part of a community’s cultural heritage);
    3. hygiene and aesthetic reasons (this may be the reason for those communities that consider the external female genitalia as ugly and dirty);
    4. religious reasons (the UNFPA maintains that while FGM is not endorsed by Christianity or Islam, “supposed” religious doctrines may be used to justify the practice);
    5. socio-economic factors (in some communities FGM is a pre-requisite for marriage, especially in those communities where women are dependent on men economically).
    • Other reasons cited by the WHO include- an attempt to ensure women’s premarital virginity since FGM is believed to reduce libido,  and therefore believed to help her resist extramarital sexual acts.
    • FGM may also be associated with cultural ideals of feminity and modesty.

    Economic cost of FGM

    • Beyond the immense psychological trauma it entails, FGM imposes large financial costs and loss of life.
    • In 2018, a study on FGM in India said that the practice was up to 75 per cent across the Bohra Muslim community.
    • The economic costs of treating health complications arising out of FGM amount to roughly $1.4 billion for 2018 for 27 countries where FGM is performed.
    • If the prevalence remains the same, the amount is expected to rise up to $2.3 billion by 2047.

    FGM in India

    • According to the aforementioned study, the reasons for FGM referred to as “Khafd” in India include continuing an old traditional practice, adhering to religious edicts, controlling women’s sexuality and abiding by the rules stated by the religious clergy.
    • It also states that the issue first rose to prominence in India because of two international legal cases on FGM against practising Bohras in Australia and the US.
    • In 2018, a bench of then CJI Dipak Misra referred a petition seeking a ban on FGM among Dawoodi Bohra girls to a five-judge Constitution Bench.
    • The Dawoodi Bohra community, on the other hand, maintained that the practice should be allowed since the Constitution grants religious freedom under Article 25.

    For detailed health risks associated with FGM, navigate to the page:

    Health hazards of FGM

  • Euthermia: the anomaly of human body temperature

     

    Euthermia refers to normal body temperature. The thermometer reading of 98.6°F has been a gold standard for a century and a half, ever since a German doctor laid it down as the “normal” body temperature.  A new research has found that body temperatures have, in fact, been declining over the last two centuries.

    Why we follow 98.6°F?

    • In 1851, Carl Reinhold August Wunderlich pioneered the use of the clinical thermometer.
    • It was a rod a foot long, which he would stick under the armpits of patients at the hospital attached with Leipzig University, and then wait for 15 minutes (some accounts say 20 minutes) for the temperature to register.
    • He took over a million measurements of 25,000 patients, and published his findings in a book in 1868, in which he concluded that the average human body temperature is 98.6°F.
    • Most modern scientists feel Wunderlich’s experiments were flawed, and his equipment inaccurate.
    • Another study concluded that the average human body temperature is closer to 98.2°F, and suggested that the 98.6°F benchmark be discarded.

    The body is cooler

    • The Stanford University the researchers confirmed some known trends — body temperature is higher in younger people, in women, in larger bodies and at later times of the day.
    • Additionally, they found that the bodies of men born in the early to mid-1990s is on average 1.06°F cooler than those of men born in the early 1800s.
    • And the body temperature of women born in the early to mid-1990s is on average 0.58°F lower than that of women born in the 1890s.
    • The calculations from the research correspond to a decrease in body temperature of 0.05°F every decade.

    Why there’s decrease in body temperature?

    • The researchers have proposed that the decrease in body temperature is the result of changes in the environment over the past 200 years, which have in turn driven physiological changes.
    • The decrease in average body temperature in the US, they said, could be explained by a reduction in metabolic rate, or the amount of energy being used.
    • The environment that we’re living in has changed, including the temperature in our homes, our contact with microorganisms and the food that we have access to.
    • Actually the human body is changing physiologically.

    So what’s the normal temperature?

    • The strong influences of age, time of day, and genders determine the healthy body temperature.

  • Velutheeyam Alloy

    A tri-metal sculpture of Jesus Christ( Healing Christ) in Thiruvalla, Kerala has entered the Universal Records Forum’s (URF) book of world records.

    Velutheeyam

    • The statue was sculpted with an alloy of zinc, copper, and velutheeyam (an alloy of tin and aluminium).
    • A URF team adjudged that the 368-cm tall statue, weighing 2,400 kg, is the largest one of its kind in the world.
    • It took 18 months for sculpting the statue.

  • [pib] Sophisticated Analytical & Technical Help Institutes (SATHI) Scheme

    The Department of Science & Technology has launched a unique scheme called “Sophisticated Analytical & Technical Help Institutes(SATHI)”.

    SATHI 

    • SATHI aims to address the need for building shared, professionally managed and strong S&T infrastructure in the country which is readily accessible to academia, start-ups, manufacturing, industry and R&D labs etc.
    • These Centres are expected to house major analytical instruments to provide common services of high-end analytical testing, thus avoiding duplication and reduced dependency on foreign sources.
    • These would be operated with a transparent, open access policy.
    • DST has already set up three such centres in the country, one each at IIT Kharagpur, IIT Delhi and BHU.

    Objectives of the Scheme

    • SATHI will address the problems of accessibility, maintenance, redundancy and duplication of expensive equipment in the institutions.
    • This will also foster a strong culture of collaboration between institutions and across disciplines to take advantage of developments, innovations and expertise in diverse areas.

  • [pib] Classical Swine Fever (CSF) Cell Culture Vaccine

    Department of Agricultural Research and Education (DARE) released the Classical Swine Fever Vaccine (IVRI-CSF-BS) Technology developed by ICAR -Indian Veterinary Research Institute (IVRI).

    About the Vaccine

    • CSF is one of the most important diseases of pigs causing high mortality with annual loss of approx. Rs.4.299 billion.
    • A lapinized CSF vaccine (Weybridge strain, UK) is being used in India since 1964 for controlling the disease.
    • The vaccine is produced by sacrificing large numbers of rabbits for each batch.
    • In order to do away sacrificing of rabbits and increase the productivity, IVRI had earlier developed a cell culture CSF vaccine by adapting the lapinized vaccine virus in cell culture.
    • The vaccine virus has very high titre and lakhs of doses can be produced very easily in cell culture and country’s requirement can be easily fulfilled using this new vaccine.

  • [pib] National Mission on Quantum Technologies & Applications

    The Finance Minister in budget 2020 has announced a National Mission on Quantum Technologies & Applications (NM-QTA).

    What is Quantum Technology?

    • Quantum Technology is based on the principles of quantum theory, which explains the nature of energy and matter on the atomic and subatomic level.
    • It concerns the control and manipulation of quantum systems, with the goal of achieving information processing beyond the limits of the classical world.
    • Its principles will be used for engineering solutions to extremely complex problems in computing, communications, sensing, chemistry, cryptography, imaging and mechanics.
    • This key ability makes quantum computers extremely powerful compared to conventional computers when solving certain kinds of problems like finding prime factors of large numbers and searching large databases.

    What is Quantum Mechanics?

    • It is a fundamental theory in physics which describes nature at the smallest – including atomic and subatomic – scales.
    • At the scale of atoms and electrons, many of the equations of classical mechanics, which describe how things move at everyday sizes and speeds, cease to be useful.
    • In classical mechanics, objects exist in a specific place at a specific time.
    • However, in quantum mechanics, objects instead exist in a haze of probability; they have a certain chance of being at point A, another chance of being at point B and so on.

    About NM-QTA

    • The mission will function under the Department of Science & Technology (DST).
    • It will be able address the ever increasing technological requirements of the society, and take into account the international technology trends.
    • The mission will help prepare next generation skilled manpower, boost translational research and also encourage entrepreneurship and start-up ecosystem development.

    Why such mission?

    • Quantum technologies are rapidly developing globally with a huge disruptive potential.
    • The range of quantum technologies is expected to be one of the major technology disruptions that will change entire paradigm of computation, communication and encryption.
    • It is perceived that the countries who achieve an edge in this emerging field will have a greater advantage in garnering multifold economic growth and dominant leadership role.
    • It has become imperative both for government and industries to be prepared to develop these emerging and disruptive changes.
    • It will establish standards to be applied to all research and help stimulate a pipeline to support research and applications well into the future.

    Also read: https://www.civilsdaily.com/news/quantum-supremacy/

  • Archimedes Principle

    Recently, Archimedes Principle was used in Jharkhand to rescue baby elephant stuck in a well. The rescue team filled the well with water using motorized pipes, after which the struggling elephant floated to the top and was able to climb out through a ramp placed for it.

    What is the ‘Archimedes Principle’?

    • In physics, the Archimedes Principle refers to the law of buoyancy (the ability or tendency of something to float in water or other fluids).
    • According to the principle, when an object is completely or partially submerged in a fluid, whether gas or liquid, it is acted upon by an upward force (buoyancy) equal to the weight of the fluid it has displaced.
    • The force acting downward on the object is the weight of the object. The upward force is the one given by the Archimedes Principle.
    • The difference between the two forces is the net force acting on the object.
    • If the buoyant force is more than the weight, the object rises; if it is less, the object sinks.
    • If the net force is zero, the object remains in place, and neither rises nor sinks.