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  • [pib] India’s First Indigenous Tumour Antigen SPAG9

    The National Institute of Immunology (NII) has received a trademark for India’s First Indigenous Tumor Antigen SPAG9.

    About SPAG9

    • India’s first indigenous tumor antigen SPAG9 was discovered by Dr Anil Suri in 1998 who is heading the Cancer Research Program at NII.
    • In a recent development, the SPAG9 antigen has received the trademark ASPAGNII-TM.
    • Currently, ASPAGNIITM is being used in dendritic cell (DC) based immunotherapy in cervical, ovarian cancer and will also be used in breast cancer.

    What is immunotherapy?

    • Immunotherapy is a new approach that exploits the body’s inner capability to put up a fight against cancer.
    • With this approach, either the immune system is given a boost, or the T cells are “trained’’ to identify recalcitrant cancer cells and kill them.
    • In this personalized intervention, those patients expressing SPAG9 protein can be treated with DC-based vaccine approach.
    • In DC-based vaccine, patient’s cells called monocytes from their blood are collected and modified into what are called dendritic cells.
    • These dendritic cells are primed with ASPAGNIITM and are injected back to the patient to help the ‘fighter’ cells, or T-cells, in the body to kill the cancer cells.

    Why need such therapy?

    • DC-based immunotherapy is safe, affordable and can promote antitumor immune responses and prolonged survival of cancer patients.
    • The ASPAGNIITM is a true example of translational cancer research and the Atmanirbhar Bharat spirit.
    • This will be a real morale boost in affordable, personalized, and indigenous products for cancer treatment.

    Answer this PYQ in the comment box:

    Q.‘RNA Interference (RNAi)’ technology has gained popularity in the last few years. why?

    1. It is used in developing gene silencing therapies
    2. It can be used in developing therapies for the treatment of cancer
    3. It can be used to developer hormone replacement therapies
    4. It can be used to produce crop plants that are resistant to viral pathogens

    Select the correct answer using the code given below.

    a) 1, 2 and 4

    b) 2 and 3

    c) 1 and 3

    d) 1 and 4 only

    The burden of cancer in India

    • Cancer kills 8.51 lakh people in India every year (International Agency for Research on Cancer, 2020).
    • As per World Health Organization (WHO), one in 10 Indians will develop cancer during their lifetime, and one in 15 will die of cancer.

  • US investigation into India’s Digital Services Tax (DST)

    The US government has announced the further suspension of punitive tariffs for six months on India, Austria, Italy, Spain, Turkey, and the UK while it continues to resolve the DST investigation amid the ongoing multilateral negotiations at the OECD and the G20.

    Do you remember?

    GAFA tax—named after Google, Apple, Facebook, Amazon—is a proposed digital tax to be levied on large technology and internet companies.

    What are the Digital Services Taxes in India?

    • The NDA government had moved an amendment in the Finance Bill 2020-21 imposing a 2 percent digital service tax on trade and services by non-resident e-commerce operators with a turnover of over Rs 2 crore.
    • The new levy has expanded the ambit of the equalization levy for non-resident e-commerce operators involved in the supply of services, including the online sale of goods and provision of services.
    • E-commerce operators are obligated to pay the tax at the end of each quarter.
    • Estimates by the USTR indicate that the value of the DST payable by US-based company groups to India will be up to approximately $55 million per year.

    Also read:

    What are Digital Services Taxes?

    What is the story?

    • The US is focused on finding a multilateral solution to a range of key issues related to international taxation, including our concerns with digital services taxes.
    • It is trying to reaching a consensus on international tax issues through the OECD and G20 processes.

    Investigation regarding DST

    • The US has conducted a year-long investigation into digital services taxes imposed by countries, stating that they are against tech companies like Apple, Amazon, Google, and Facebook.
    • It had determined that the digital services taxes adopted by Austria, India, Italy, Spain, Turkey, and the UK has discriminated against US digital companies and were inconsistent with principles of international taxation, and burdened US companies.

    What’s the case against India?

    • In the case of India, the USTR’s proposed course of action includes additional tariffs of up to 25 percent ad valorem on an aggregate level of trade.
    • Around 26 categories of goods are in the preliminary list of products that would be subject to the additional tariffs.
    • This includes shrimps, basmati rice, cigarette paper, cultured pearls, semi-precious stones, silver powder and silver articles of jewelry, gold mixed link necklaces, and neck chains, and certain furniture of bentwood.

    Why does India need DST?

    • The agenda to reform international tax law so that digital companies are taxed where economic activities are carried is still a work in progress.
    • Due to this, countries are worried that they might cede their right to tax incomes. Therefore, many countries have either proposed or implemented a digital services tax.
    • The proliferation of digital service taxes (DSTs) is a symptom of the changing international economic order.
    • Countries such as India which provides large markets for digital corporations seek a greater right to tax incomes.
    • The taxation of the digitalized economy turned out to be a relatively contentious issue because there is a huge asymmetry in digital service providers and consumers.

  • DAVINCI+ and VERITAS missions for exploration of Venus

    NASA has selected two missions to the planet Venus, Earth’s nearest neighbor. The missions are called DAVINCI+ and VERITAS.

    DAVINCI+ and VERITAS

    (1) DAVINCI+

    • DAVINCI+ is short for ‘Deep Atmosphere Venus Investigation of Noble gases, Chemistry, and Imaging’ and is the first US-led mission to the planet’s atmosphere since 1978.
    • It will try to understand Venus’ composition to see how the planet formed and evolved.
    • This mission also consists of a decent sphere that will pass through the planet’s thick atmosphere and make observations and take measurements of noble gases and other elements.
    • Significantly, this mission will also try to return the first high-resolution photographs of a geological feature that is unique to Venus.
    • This feature, which is called “tesserae” may be comparable to Earth’s continents.
    • The presence of tesseraes may suggest that Venus has tectonic plates like Earth.

    (2) VERITAS

    • The second mission called VERITAS is short for ‘Venus Emissivity, Radio Science, InSAR, Topography, and Spectroscopy’.
    • It will map the planet’s surface to determine its geologic history and understand the reasons why it developed so differently from Earth.
    • VERITAS will orbit Venus with a radar that will help to create a 3D reconstruction of its topography which might be able to tell scientists if processes such as plate tectonics and volcanism are still active there.
    • This mission will also map the emissions from Venus’s surface that may help in determining the type of rocks that exist on Venus–a piece of information that is not exactly known yet.
    • It will also determine if active volcanoes are releasing water vapor into the atmosphere.

    Why study Venus?

    • The results from DAVINCI+ are expected to reshape the understanding of terrestrial planet formation in the solar system and beyond.
    • Taken together, both missions are expected to tell scientists more about the planet’s thick cloud cover and the volcanoes on its surface.
    • Further, scientists speculate about the existence of life on Venus in its distant past and the possibility that life may exist in the top layers of its clouds where temperatures are less extreme.

    Have humans visited Venus?

    • Because of the planet’s harsh environment, no humans have visited it and even the spacecraft that have been sent to the planet have not survived for a very long time.
    • Venus’ high surface temperatures overheat electronics in spacecraft in a short time, so it seems unlikely that a person could survive for long on the Venusian surface.
    • So far, spacecraft from several nations have visited the planet.
    • The first such spacecraft was the Soviet Union’s Venera series (the spacecraft, however, could not survive for long because of the planet’s harsh conditions).
    • It was followed by NASA’s Magellan Mission that studied Venus from 1990-1994. As of now, Japan’s Akatsuki mission is studying the planet from Orbit.

    Back2Basics: Venus

    • For those on Earth, Venus is the second-brightest object in the sky after the moon.
    • It appears bright because of its thick cloud cover that reflects and scatters light.
    • Surface temperatures on Venus can go up to 471 degrees Celsius, which is hot enough to melt lead, NASA notes. Surface temperatures on Venus can go up to 471 degrees Celsius, which is hot enough to melt lead, NASA notes.

    Some unknown facts

    • While Venus, which is the second closest planet to the Sun, is called the Earth’s twin because of their similar sizes, the two planets have significant differences between them.
    • For one, the planet’s thick atmosphere traps heat and is the reason that it is the hottest planet in the solar system, despite coming after Mercury, the closest planet to the Sun.
    • Further, Venus moves forward on its orbit around the Sun but spins backwards around its axis slowly.
    • This means on Venus the Sun rises in the west and sets in the East.
    • One day on Venus is equivalent to 243 Earth days because of its backward spinning, opposite to that of the Earth’s and most other planets.
    • Venus also does not have a moon and no rings.

  • China’s EAST Tokamak Device

    China’s Experimental Advanced Superconducting Tokamak (EAST), which mimics the energy generation process of the sun, set a new record.

    What is China’s ‘artificial sun’ EAST?

    • The Experimental Advanced Superconducting Tokamak (EAST) reactor is an advanced nuclear fusion experimental research device.
    • The purpose of the artificial sun is to replicate the process of nuclear fusion, which is the same reaction that powers the sun.
    • The EAST is one of three major domestic tokamaks that are presently being operated across the country.
    • Apart from the EAST, China is currently operating the HL-2A reactor as well as J-TEXT.
    • Since it first became operational in 2006, the EAST has set several records for the duration of confinement of exceedingly hot plasma.
    • The EAST project is part of the International Thermonuclear Experimental Reactor (ITER) facility, which will become the world’s largest nuclear fusion reactor when it becomes operational in 2035.
    • The project includes the contributions of several countries, including India, South Korea, Japan, Russia and the United States.

    How does the ‘artificial sun’ EAST work?

    • The EAST Tokamak device is designed to replicate the nuclear fusion process carried out by the sun and stars.
    • Nuclear fusion is a process through which high levels of energy are produced without generating large quantities of waste.
    • Previously, energy was produced through nuclear fission — a process in which the nucleus of a heavy atom was split into two or more nuclei of lighter atoms.

    Fission vs. Fusion

    • While fission is an easier process to carry out, it generates far more nuclear waste.
    • Unlike fission, fusion also does not emit greenhouse gases and is considered a safer process with a lower risk of accidents.
    • Once mastered, nuclear fusion could potentially provide unlimited clean energy and very low costs.

    But what is Fusion?

    • For nuclear fusion to occur, tremendous heat and pressure are applied on hydrogen atoms so that they fuse together. `
    • The nuclei of deuterium and tritium — both found in hydrogen — are made to fuse together to create a helium nucleus, a neutron along with a whole lot of energy.
    • Fuel is heated to temperatures of over 150 million degrees C so that it forms a hot plasma “soup” of subatomic particles.
    • With the help of a strong magnetic field, the plasma is kept away from the walls of the reactor to ensure it does not cool down and lose its potential to generate large amounts of energy.
    • The plasma is confined for long durations for fusion to take place.

    What is the latest record and why does it matter?

    • The EAST reactor set a new record on Friday when it achieved a plasma temperature of 216 million degrees Fahrenheit and also managed to run for 20 seconds at 288 million degrees Fahrenheit.
    • To put this in perspective, the sun’s core only reaches about 15 million degrees Celsius, which means the reactor was able to touch temperatures that are 10 times hotter than that.
    • The next goal for the scientists behind the experimental reactor is to maintain the high temperature for a long period of time. Previously, the EAST had reached a record temperature of 100 million degrees Celsius in 2018.

    China is not the only

    • But China is not the only country that has achieved high plasma temperatures.
    • In 2020, South Korea’s KSTAR reactor set a new record by maintaining a plasma temperature of over 100 million degrees Celsius for 20 seconds.

  • Monsoon onset over Kerala delayed: IMD

    • The monsoon’s arrival over Kerala has been delayed to June 3, according to an update by the India Meteorological Department (IMD).
    • Private weather forecast agency, Skymet, however, said that the monsoon had arrived.
    • This was because two of the three criteria — as defined by the IMD — had been met.
    • Currently, IMD’s own data indicated that except for the OLR, the other criteria were met. Thus, there is an element of subjectivity in arrival.

    What are those criterias defined by IMD?

    1. Rain-bearing westerlies being at a minimum depth and speed;
    2. At least 60% of the available 14 stations in Kerala and coastal Karnataka, reporting rainfall of 2.5 mm or more for two consecutive days after May 10;
    3. A certain degree of clouding, indicated by a parameter called ‘outgoing long wave radiation’ (OLR), being below 200 W/square meter.

    What is meant by ‘Outgoing Long Wave Radiation’ (OLR)?

    • Outgoing Long-wave Radiation (OLR) is electromagnetic radiation of wavelengths from 3–100 μm emitted from Earth and its atmosphere out to space in the form of thermal radiation.
    • It is also referred to as up-welling long-wave radiation and terrestrial long-wave flux, among others.
    • The flux of energy transported by outgoing long-wave radiation is measured in W/m.
    • In the Earth’s climate system, long-wave radiation involves processes of absorption, scattering, and emissions from atmospheric gases, aerosols, clouds and the surface.
    • Over 99% of outgoing long-wave radiation has wavelengths between 4 μm and 100 μm, in the thermal infrared part of the electromagnetic spectrum.

    Factors responsible for south-west monsoon formation:

    1. Intense heating of Tibetan plateau during summer months.
    2. Permanent high pressure cell in the South Indian Ocean (east to north-east of Madagascar in summer).

    Factors that influence the onset of south-west monsoons:

    1. Above points +
    2. Subtropical Jet Stream (STJ).
    3. Tropical Easterly Jet (African Easterly Jet).
    4. Inter Tropical Convergence Zone.

    Factors that influence the intensity of south-west monsoons:

    1. Strengths of Low pressure over Tibet and high pressure over southern Indian Ocean.
    2. Somali Jet (Findlater Jet).
    3. Somali Current (Findlater Current).
    4. Indian Ocean branch of Walker Cell.
    5. Indian Ocean Dipole.

    Factors responsible for north-east monsoon formation:

    1. Formation and strengthening of high pressure cells over Tibetan plateau and Siberian Plateau in winter.
    2. Westward migration and subsequent weakening of high pressure cell in the Southern Indian Ocean.
    3. Migration of ITCZ to the south of India.

  • IBF to cover Streaming Platforms

    The Indian Broadcasting Foundation (IBF), the apex body of broadcasters, is expanding its purview to cover digital streaming platforms and will be renamed the Indian Broadcasting and Digital Foundation (IBDF).

    Why such a move?

    • The move would bring broadcasters and OTT (over-the-top) platforms, which have seen a substantial jump in their viewership base after the pandemic, under one roof.
    • For this, the IBDF was in the process of forming a new wholly-owned subsidiary to handle all matters of digital media, an official statement said.
    • The IBDF would also form a self-regulatory body, the Digital Media Content Regulatory Council (DMCRC), for digital OTT platforms.

    Indian Broadcasting Foundation

    • The IBF is a unified representative body of television broadcasters in India.
    • The organization was founded in the year 1999. Over 250 Indian television channels are associated with it.
    • The organization is credited as the spokesman of the Indian Broadcasting Industry.
    • The IBF is the parent organization of the Broadcasting Content Complaints Council (BCCC) which was set up in the year 2011.
    • The BCCC examines content-related complaints relating to all non-news general entertainment channels in India.

    Note: The IBF has no statutory backing.

  • UAE’s Golden Visa Scheme

    A Bollywood actor has recently received a golden visa from the UAE government.

    What is the Golden Visa?

    • The Golden Visa system essentially offers long-term residency (5 and 10 years) to people belonging to the following groups: investors, entrepreneurs, individuals with outstanding talents the likes of researchers, medical professionals and those within the scientific and knowledge fields, and remarkable students.
    • The main benefit of the visa will be security.
    • The UAE government has made it clear that they are committed to providing expatriates, investors and essentially everyone looking to make the UAE their home an extra reason to feel secure about their future.

    Who are eligible to apply?

    • For the 10-year visa, investors having no less than AED (Dirham) 10 million worth of public investment, either in the form of an investment fund or a company, can apply.
    • However, at least 60 per cent of the total investment must not be in the form of real estate and the invested amount must not be loaned, or in case of assets, investors must assume full ownership.
    • The investor must be able to retain the investment for a minimum of three years as well.
    • The long-term visa can also include the holder’s spouse and children, as well as one executive director and one advisor.
    • In addition to the aforementioned, foreign nationals who are looking to set up their business in the UAE may also apply for permanent residency (5 years) through the Golden Business Visa scheme.

    Perks for the talent

    • Besides entrepreneurs, individuals with specialized talent can also apply for the visa. They include doctors, researchers, scientists, investors and artists.
    • These individuals may be granted a 10-year visa following accreditations granted by their respective departments and fields and the visa will also be extended to their spouses and children.
    • Exceptional high school and university students are eligible for a 5-year residency visa in the UAE.

  • Thomas Hickey’s 19th century painting on smallpox vaccination

    A 19th-century portrait of three women from Mysore has been going viral as “one of the most important scientific pictures in the history of medicine in India”.

    What did the portrait depict?

    • Believed to be painted in 1805 by Irish-born artist Thomas Hickey, the oil on canvas was initially thought to be portraits of “dancing girls or courtesans”.
    • The painting depicted one of the first vaccine drives in India, with bejewelled women from the Wadiyar dynasty posing for Hickey.
    • The canvas was commissioned to promote participation in the smallpox vaccination programme and the women posing with the scars.

    What is smallpox?

    • Smallpox is an acute contagious disease caused by the variola virus, a member of the orthopoxvirus family.
    • It was one of the most devastating diseases known to humanity and caused millions of deaths before it was eradicated.
    • It is believed to have existed for at least 3000 years.

    How and when did the smallpox vaccine reach India?

    • The smallpox vaccine, discovered by Edward Jenner in 1796, was the first successful vaccine to be developed.
    • On June 14, 1802, Anna Dusthall, an Anglo-Indian toddler, was the first person in India to be successfully vaccinated against the virus that relied on the cowpox virus, “a mild cousin of smallpox” to trigger immunity.
    • The “vaccine vesicle” that came on the arm of the receiver was a source of lymphatic fluid or pus that would act as a vaccine, leading to an arm-to-arm immunisation chain.
    • The vaccine subsequently travelled to different parts of India, including Hyderabad, Cochin, Madras and Mysore.

    How was the drive carried out?

    • While the lymph was at times reportedly dried and sealed between glass plates to be transported, it often did not survive long journeys, due to which the British had to primarily rely on a human chain.
    • There was also opposition from the domestic population on the introduction of the cowpox virus and also because some believed the goddess of smallpox would be angered by the vaccination.
    • With Tipu Sultan defeated in Mysore, and the reinstatement of the Wadiyars, the East India Company was trying to strengthen its position in South India.
    • It protected the ex-pat population from an epidemic, making vaccination essential.
    • Queen Lakshmi Ammanni, who had lost her husband to smallpox, supported their cause and wanted to vaccine her population against the deadly virus.
    • The painting was supposed to encourage participation in the vaccination drive.

  • Mekedatu Project

    The National Green Tribunal (NGT), Southern Zone has appointed a joint committee to look into allegations of unauthorized construction activity taking place in Mekedatu, where the Karnataka government had proposed to construct a dam across the Cauvery River.

    What is the Mekedatu Project?

    • Mekedatu, meaning goat’s leap, is a deep gorge situated at the confluence of the rivers Cauvery and Arkavathi, about 100 km from Bengaluru, at the Kanakapura taluk in Karnataka’s Ramanagara district.
    • In 2013, then Karnataka announced the construction of a multi-purpose balancing reservoir project.
    • The project aimed to alleviate the drinking water problems of Bengaluru and Ramanagara district.
    • It was also expected to generate hydro-electricity to meet the power needs of the state.

    Issues with the project

    • Soon after the project was announced TN has objected over granting of permission or environmental clearance.
    • Explaining the potential for damage to the lower riparian state of TN, it said that the project was in violation of the final award of the Cauvery Water Disputes Tribunal.
    • It stated that the project will affect the natural flow of the river Cauvery considerably and will severely affect the irrigation in TN.

  • What is a Supermoon?

    The Moon will have the nearest approach to Earth on May 26, and therefore will appear to be the closest and largest Full Moon or “supermoon” of 2021.

    Tap here to read more about Solar and Lunar Eclipses

    What is a Supermoon?

    • A supermoon occurs when the Moon’s orbit is closest to the Earth at the same time that the Moon is full.
    • As the Moon orbits the Earth, there is a point of time when the distance between the two is the least (called the perigee when the average distance is about 360,000 km from the Earth).
    • Also, there is a point of time when the distance is the most (called the apogee when the distance is about 405,000 km from the Earth).
    • Now, when a full moon appears at the point when the distance between the Earth and the Moon is the least, not only does it appear to be brighter but it is also larger than a regular full moon.
    • According to NASA, the term supermoon was coined by astrologer Richard Nolle in 1979.
    • In a typical year, there may be two to four full supermoons and two to four new supermoons in a row.

    What is happening today?

    • Two celestial events will take place at the same time.
    • One is the supermoon and the other is a total lunar eclipse, which is when the Moon and Sun are on opposite sides of the Earth.
    • Because of the total lunar eclipse, the moon will also appear to be red.
    • This is because the Earth will block some of the light from the Sun from reaching the moon.
    • The Earth’s atmosphere filters the light, it will soften “the edge of our planet’s shadow” “giving the Moon a deep, rosy glow.”