Innovations in Biotechnology and Medical Sciences

Newfound ‘Obelisks’ join Viruses, Viroids as third unusual life form

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Obelisks, Viroids

Mains level: NA

Obelisks

In the news

  • Recently identified by scientists at Stanford University, obelisks represent a distinct class of virus-like entities residing within the human body.

What are Obelisks?

  • Novel Discoveries: Recently identified, obelisks represent a distinct class of virus-like entities residing within the human body.
  • Genetic Diversity: Comprising diverse RNA molecules, obelisks have pervaded both human and global microbiomes, yet remained unnoticed until now.
  • Distinctive Characteristics:
    1. Structural Symmetry: Named after the rod-like, highly symmetrical structures formed by their twisted RNA strands.
    2. Genetic Makeup: Obelisks boast compact genetic sequences of approximately 1,000 nucleotides, devoid of known similarities to other biological agents.
    3. Size Disparity: Significantly larger than conventional genetic molecules like plasmids, which are primarily composed of DNA.
  • Taxonomic Position: Positioned between viruses and viroids, obelisks constitute a unique class of organisms with intriguing properties.
  • Host Interaction: While the hosts of certain obelisks remain unidentified, bacterial associations are speculated, hinting at a broader ecological significance.
  • Spatial Distribution: Various types of obelisks inhabit diverse regions within the human body, highlighting their pervasive presence and potential physiological roles.

Understanding Viroids: Nature’s Tiny RNA Loops

  • Genetic Cousins: Viroids are compact loops of RNA, closely related to DNA, primarily infecting plant organisms.
  • Discovery: In 1971, Theodor Diener identified viroids during research on potato spindle tuber disease, revealing naked RNA entities devoid of protein coats or lipid layers.
  • Unique Features:
    1. Lack of Encapsulation: Unlike larger RNA viruses, viroids lack protective shells, relying solely on their RNA structure for stability.
    2. Genetic Composition: Viroid RNA does not encode protein-building instructions, contrasting with viruses that carry genetic blueprints for their replication machinery.
  • Host Interactions: Viroids exploit host enzymes for replication, highlighting their parasitic nature within plant cells.

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