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Subject: Science and Technology

  • Candida auris

    Why in the News?

    An Indian led study has warned that Candida auris, a drug resistant fungal pathogen, is becoming more virulent and spreading globally, with high mortality rates even after treatment, raising serious public health concerns.

    About Candida auris

    • Candida auris is a multidrug resistant fungal pathogen.
    • It causes severe invasive infections, particularly in hospitalised and immunocompromised patients.
    • First identified in 2009.
    • Classified as an emerging global health threat due to frequent treatment failure and high fatality.

    Transmission

    • Spreads through direct contact with infected or colonised individuals, including asymptomatic carriers.
    • Transmitted via Contaminated surfaces, Medical equipment and Invasive devices like catheters and ventilators

    Prelims Pointers

    • Candida auris is a fungus, not a bacterium or virus
    • Primarily a hospital acquired infection
    • Difficult to detect due to sepsis like symptoms
    • Major concern due to antifungal resistance and high mortality
    [2019] Which of the following are the reasons for the occurrence of multi-drug resistance in microbial pathogens in India?Ā 

    1. Genetic predisposition of some peopleĀ 

    2. Taking incorrect doses of antibiotics to cure diseasesĀ 

    3. Using antibiotics in livestock farmingĀ 

    4. Multiple chronic diseases in some peopleĀ 

    Select the correct answer using the code given below:Ā 

    (a) 1 and 2 (b) 2 and 3 only (c) 1, 3 and 4 (d) 2, 3 and 4

  • PathGennie Software

    Why in the News?

    The Ministry of Science and Technology has announced the development of PathGennie, a new open-source computational software that can significantly speed up drug discovery by accurately simulating drug–protein unbinding, a crucial step in understanding drug efficacy and safety.

    What is PathGennie?

    • PathGennie is an open-source computational framework designed to simulate rare molecular events, especially the unbinding of drugs from protein targets.
    • It helps in predicting drug residence time, a key parameter that determines how long a drug remains effective inside the body.
    • It avoids artificial distortions commonly introduced in conventional simulation methods.

    Developed by

    • Scientists at the S. N. Bose National Centre for Basic Sciences, Kolkata.

    Aim of PathGennie

    • To overcome the limitations of traditional molecular dynamics simulations, which struggle to capture slow and rare molecular transitions.
    • To generate physically accurate pathways for drug–protein interactions.
    • To reduce computational time and cost without compromising accuracy.

    Applications

    • Predicts accurate drug unbinding pathways and residence times
      • Example: Imatinib with Abl kinase
    • Improves understanding of protein–ligand kinetics for better drug design
    • Applicable beyond drug discovery in: Chemical reactions, Catalysis, Phase transitions and Molecular self-assembly

    Prelims Pointers

    • PathGennie is open-source and computational in nature
    • Focuses on drug unbinding, not just binding
    • Helps estimate drug residence time, a key pharmacological parameter
    • Avoids artificial bias unlike conventional simulation techniques
    • Developed in India under the Ministry of Science and Technology
    [2022] Consider the following:Ā 

    1. Aarogya SetuĀ 

    2. CoWINĀ 

    3. DigiLockerĀ 

    4. DIKSHA.Ā 

    Which of the above are built on top of open-source digital platforms?Ā 

    (a) 1 and 2 only (b) 2, 3 and 4 only (c) 1, 3 and 4 only (d) 1, 2, 3 and 4

  • Copper

    Why in the News?

    Copper prices touched a record high of over USD 12,000 per tonne in 2025, driven by US tariff uncertainty, global supply disruptions and rapidly rising demand from AI infrastructure, clean energy systems and electric vehicles.

    Characteristics of Copper

    Chemical Characteristics

    • Symbol: Cu
    • Atomic weight: 63.546 amu
    • High resistance to corrosion and oxidation
    • Forms important alloys
      • Brass: Copper plus Zinc
      • Bronze: Copper plus Tin

    Physical Characteristics

    • Excellent electrical and thermal conductivity
    • Highly ductile and malleable, suitable for wiring and shaping
    • Reddish brown in colour, among the few naturally coloured metals

    Unique Properties

    • 100 percent recyclable without loss of quality
    • Antimicrobial in nature, useful in healthcare settings
    • Improves energy efficiency and lowers COā‚‚ emissions over product life cycles

    Applications of Copper

    Energy and Power Sector

    • Power transmission lines and grids
    • Transformers and substations
    • Renewable energy systems like solar and wind
    • Battery energy storage systems

    Electric Vehicles

    • EVs use more than twice the copper of conventional vehicles
    • Used in motors, batteries, inverters and charging infrastructure

    Digital and AI Infrastructure

    • Data centres and hyperscale AI facilities
    • Power transmission and cooling systems

    Construction and Manufacturing

    • Plumbing and roofing
    • Industrial machinery
    • Electronics and electrical appliances

    Defence and Healthcare

    • Defence electronics and ammunition
    • Antimicrobial medical surfaces and equipment

    India and Copper

    • India has recognised copper as a critical mineral under its resource strategy
    • Over 90 percent dependence on imported copper concentrate
    • Domestic demand expected to rise sharply due to EVs, renewable energy and digital infrastructure expansion

    Major Copper Producing Countries

    • Chile, Peru, Democratic Republic of the Congo, China and the United States

    Prelims Pointers

    • Copper is a critical mineral for energy transition and digital economy
    • EVs and AI driven data centres are major demand drivers
    • Copper is fully recyclable and antimicrobial
    • India is heavily import dependent for copper concentrat
    [2021] Why is there a concern about copper smelting plants?Ā 

    1. They may release lethal quantities of carbon monoxide into the environment.Ā 

    2. The copper slag can cause the leaching of some heavy metals into the environment.Ā 

    3. They may release sulphur dioxide as a pollutant.Ā 

    Select the correct answer using the code given below:Ā 

    (a) 1 and 2 only (b) 2 and 3 only (c) 1 and 3 only (d) 1, 2, and 3

  • [1st January 2026] The Hindu OpED: India’s space programme, a people’s space journey

    [UPSC 2016] Discuss India’s achievements in the field of Space Science and Technology. How has the application of this technology helped India in its socio-economic development?

    Linkage: The article illustrates India’s progression from landmark space missions to a citizen-centric space ecosystem supporting disaster management, agriculture, infrastructure, and governance.

    Mentor’s Comment

    India’s space programme has entered a decisive phase of transformation, from a state-led scientific endeavour to a people-centric strategic ecosystem. The article captures this transition by mapping India’s journey from symbolic achievements to institutional depth, private participation, and societal integration. It highlights how space has become a tool for governance, economy, national confidence, and global leadership, rather than remaining a niche scientific pursuit.

    Introduction

    India’s space programme is in focus following a series of firsts and institutional shifts that redefine its purpose and scale. From the Prime Minister’s articulation of Amrit Kaal goals to the operationalisation of the Indian Space Policy 2025, the sector is no longer limited to launches and missions. It now underpins disaster management, governance delivery, startup ecosystems, education, and international collaboration. The transformation is significant because it marks India’s shift from a mission-centric model to a citizen-facing, market-enabled, and globally integrated space ecosystem, an evolution rarely achieved by developing economies.

    How did India’s space journey evolve from inspiration to infrastructure?

    1. Foundational Vision: Established scientific self-reliance through indigenous launch vehicles and satellites, creating strategic autonomy in space access.
    2. Mass Participation: Chandrayaan missions generated nationwide engagement, embedding scientific ambition within public consciousness.
    3. Technological Maturity: Achieved precision landing, rover operations, and in-orbit docking, reflecting systemic depth beyond symbolic success.
    4. Societal Integration: Transitioned space assets from elite scientific use to everyday governance and citizen services.

    What milestones redefined India’s credibility as a space power?

    1. Chandrayaan-1: Confirmed presence of water molecules on the Moon, reshaping lunar science understanding.
    2. Chandrayaan-2: Delivered high-resolution lunar data despite partial mission failure, reinforcing learning-based innovation.
    3. Chandrayaan-3: Achieved first-ever soft landing near the lunar south pole, placing India among elite lunar explorers.
    4. Gaganyaan Preparations: Advanced human spaceflight readiness through crew module recovery and test vehicle missions.
    5. Aditya-L1 and SPADEX: Expanded capabilities into solar observation and in-orbit docking for future space stations.

    Why is the space sector being reframed as a national development tool?

    1. Disaster Management: Enables early warning systems, damage assessment, and real-time coordination.
    2. Agriculture and Fisheries: Supports crop estimation, drought monitoring, and marine resource advisories.
    3. Infrastructure and Transport: Enhances railway safety, urban planning, and power grid monitoring.
    4. Democratisation of Access: Positions space-derived data as a public good accessible to citizens and states.

    How is policy reform reshaping India’s space ecosystem?

    1. Indian Space Policy 2025: Institutionalises private sector participation across launch, satellite, and downstream services.
    2. Commercial Scaling: Facilitates startups in satellite manufacturing, launch vehicles, and data analytics.
    3. Economic Expansion: Increased sector valuation from ₹5,615 crore (2013-14) to ₹24,116 crore (2025-26).
    4. Employment Creation: Generates high-skill jobs across aerospace, AI, robotics, and materials science.

    What role do youth, education, and innovation play in this transition?

    1. Capacity Building: Engages over 60,000 students annually through Olympiads and space challenges.
    2. Innovation Platforms: Hackathons and competitions integrate academia with applied research.
    3. Startup Ecosystem: Over 350 startups contribute to satellite systems, launch services, and applications.
    4. Future Workforce: Strengthens STEM education pipeline aligned with emerging space technologies.

    How does India project leadership in global space governance?

    1. Climate Monitoring: Deploys satellites like G-20 Climate Satellite for global environmental observation.
    2. Data Sharing: Collaborates with NASA, ISRO, CNES, and ESA on Earth observation and planetary missions.
    3. Normative Leadership: Advances cooperative space use rooted in Vasudhaiva Kutumbakam.
    4. South-South Outreach: Provides satellite services and training to developing nations.

    Conclusion

    India’s space programme has evolved from a symbol of scientific aspiration into a core pillar of national development and strategic capability. By integrating space technology with governance delivery, economic expansion, private innovation, and global cooperation, India has repositioned space as a public good rather than an elite scientific pursuit. The transition towards human spaceflight, indigenous space infrastructure, and citizen-centric applications reflects a mature ecosystem aligned with the vision of Amrit Kaal. Sustained policy support, institutional coordination, and inclusive access will determine whether this transformation consolidates India’s role as a leading space power serving both national and global interests.

  • Pinaka Long Range Guided Rocket Maiden Flight Test

    Why in the News?

    India successfully conducted the maiden flight test of the Pinaka Long Range Guided Rocket off the Odisha coast. The rocket hit the target with textbook precision at its maximum range of 120 km.

    What is Pinaka LRGR

    • Long range guided rocket ammunition of the Pinaka multi barrel rocket system
      • Evolved from Pinaka Mark II
      • Designed for precision strikes at extended ranges

    Developed by

    • Armament Research and Development Establishment
      • High Energy Materials Research Laboratory
      • Research Centre Imarat
      • Defence Research and Development Laboratory
      • Under Defence Research and Development Organisation

    Key Features

    • Range: Up to 120 km
      • Guidance: Navigation, guidance and control kit for high accuracy
      • In flight manoeuvrability: Executed planned trajectory changes
      • Launcher compatibility: Fired from in service Pinaka launcher
      • Firepower: MBRL can fire 12 rockets in a salvo

    Operational Advantages

    • High accuracy reduces collateral damage
      • Quick reaction time and high rate of fire
      • Effective in low intensity conflict scenarios
      • Multiple Pinaka variants can be launched from the same platform
    [2023] Consider the following statements:Ā 

    1. Ballistic missiles are jet-propelled at subsonic speeds throughout their flights, while cruise missiles are rocket-powered only in the initial phase of flight.Ā 

    2. Agni-V is a medium-range supersonic cruise missile, while BrahMos is a solid-fuelled intercontinental ballistic missile.Ā 

    Which of the statements given above is/are correct?Ā 

    (a) 1 only (b) 2 only (c) Both 1 and 2 (d) Neither 1 nor 2

  • AI that you can hold in your hand, and that holds your hand

    Introduction

    Artificial Intelligence is undergoing a qualitative transformation, from a background computational tool to an active intermediary between humans and the digital world. The AI’s most significant impact is not automation alone, but the rewiring of the internet itself, including how users search, read, decide, and act. As AI becomes embedded in devices, browsers, and daily routines, it is redefining control over data, attention, and economic value in the digital ecosystem.

    Why in the News

    The year 2025 marks a decisive shift in the evolution of artificial intelligence, where AI began directly mediating how users access knowledge on the internet, rather than merely assisting search or productivity. For the first time, AI-powered browsers, devices, and assistants are challenging Google’s long-standing dominance as the internet’s gateway, particularly in emerging markets. This transition represents a sharp break from the earlier search-engine-centric model, as users increasingly receive direct, conversational answers instead of links, disrupting established advertising-based business models. While promised efficiency gains remain uneven, the scale and speed of adoption signal a structural transformation in how information is produced, accessed, and monetised globally.

    How is AI transforming the way people access the internet?

    1. Direct answer delivery: Enables users to receive summarised responses instead of navigating multiple websites, reducing dependence on traditional search links.
    2. Conversational interfaces: Facilitates follow-up questions and contextual clarification, mimicking human interaction rather than keyword searches.
    3. Behavioural shift: Alters user engagement patterns, weakening click-through-rate-based content discovery.
    4. Structural impact: Reconfigures how knowledge is consumed, prioritising synthesis over exploration.

    Why does this shift challenge Google’s dominance?

    1. Search disintermediation: Reduces the need for users to visit Google-indexed websites for answers.
    2. Advertising disruption: Weakens the ad-based revenue model built on page views and link navigation.
    3. Market vulnerability in developing countries: Creates entry points for AI platforms to act as alternative gateways to the internet.
    4. Competitive uncertainty: Introduces a new model where value lies in response quality rather than ranking authority.

    What role do AI-powered devices play in this transition?

    1. Device-level integration: Embeds AI deeply within smartphones and laptops rather than as standalone applications.
    2. Personal assistant evolution: Transforms AI into a system-level interface managing messages, emails, and summaries.
    3. User retention strategy: Ensures constant interaction by making AI central to everyday tasks.
    4. Platform competition: Encourages operating-system-driven AI ecosystems rather than app-based usage.

    How are AI browsers reshaping the architecture of the internet?

    1. AI-first browsers: Prioritise AI responses over traditional webpage navigation.
    2. Content extraction: Pulls information directly from websites without redirecting users.
    3. Publisher impact: Undermines traffic-dependent digital media and independent content creators.
    4. Information centralisation: Concentrates interpretive power in AI systems rather than distributed sources.

    What new forms of interaction are emerging between humans and technology?

    1. Non-visual interfaces: Expands interaction through voice, audio, and ambient computing.
    2. Background operation: Enables AI to function passively while continuously supporting user decisions.
    3. Contextual memory: Allows AI systems to recall conversations, preferences, and behavioural cues.
    4. Human-like assistance: Reduces cognitive load by suggesting next steps instead of presenting raw information.

    Why is ā€œagent orchestrationā€ significant for the future of AI?

    1. Multi-agent coordination: Enables AI to manage multiple tasks and systems simultaneously.
    2. Decision autonomy: Allows AI to execute complex workflows without continuous human input.
    3. Enterprise efficiency: Enhances productivity in organisations managing large data volumes.
    4. Economic projection: Signals rapid market expansion of autonomous AI services by 2026.

    Conclusion

    Artificial Intelligence is no longer a peripheral tool but a central intermediary shaping how knowledge is accessed, processed, and acted upon. As AI restructures the internet from a link-based to an answer-based ecosystem, it creates efficiency gains alongside new challenges of competition, accountability, and data governance. The policy response must therefore balance innovation with safeguards to ensure transparency, fair competition, and equitable access to information in the digital age.

    PYQ Relevance

    [UPSC 2023] How can Artificial Intelligence (AI) help clinical diagnosis? Do you perceive any threat to privacy of the individual in the use of AI in healthcare?

    Linkage: The PYQ evaluates AI as a decision-support system and examines privacy risks arising from data-driven interventions. The article links by showing AI’s expansion as an intermediary across sectors, raising similar concerns of data control, accountability, and user trust.

  • Frequency Comb

    Ā Why in the News?

    • Frequency combs are highlighted as key modern tools used in atomic clock calibration and other precision measurements.

    What is a Frequency Comb

    • A special type of laser light
    • Its spectrum looks like the teeth of a comb
    • Connects the radio frequency domain (below ~100 GHz) with the optical domain (above ~200 THz)
    • Acts as a precise bridge between microwave and optical frequencies

    Key Characteristics

    • Emits many evenly spaced frequencies, not a single colour
    • Frequency spacing is extremely regular
    • Exhibits very high stability and precision
    • Enables coherent phase connection across wide frequency ranges
    • Compact and highly reliable measurement tool

    Why It Is Important

    • Allows comparison of an unknown light frequency with a stable reference
    • Achieves extraordinary measurement accuracy
    • Revolutionised precision metrology and optical physics

    Applications of Frequency Combs

    • Calibration of atomic clocks
    • Measurement of gravitational redshift effects on light
    • Detection of exoplanets using precise stellar spectroscopy
    • High speed and ultra precise spectroscopy
    • Fundamental physics experiments and precision navigation

    Prelims Takeaway

    • Frequency comb equals laser with evenly spaced frequencies
    • Acts as a frequency ruler for light
    • Essential for atomic clocks, astrophysics, spectroscopy, and precision measurements
    The term ā€˜Goldilocks Zone’ is often seen in the news in the context of (2015)

    (a) the limits of habitable zone above the surface of the EarthĀ 

    (b) regions inside the Earth where shale gas is availableĀ 

    (c) search for the Earth-like planets in outer spaceĀ 

    (d) search for meteorites containing precious metals

  • Industrial Hemp

    Why in the News?

    • The Chief Minister of Himachal Pradesh has initiated a policy push to legalise and regulate industrial hemp cultivation.

    What is Industrial Hemp

    • Scientific name: Cannabis sativa L.
    • Belongs to the Cannabis genus and Cannabaceae family
    • Herbaceous, dioecious plant
    • Botanically related to marijuana but very different in use and effects
    • THC content less than 0.3%
    • High fiber content and negligible psychoactive effect

    Industrial Hemp vs Marijuana

    • Marijuana: High tetrahydrocannabinol (THC) and psychoactive
    • Industrial hemp: Extremely low THC, used for industrial and commercial purposes

    Key Characteristics

    • Fast growing crop
    • Environment friendly
    • Requires relatively less water and pesticides
    • Suitable for diversified agro industrial value chains

    Applications of Industrial Hemp

    • Fibre and textiles: Cloth, upholstery, ropes
    • Industrial uses: Auto parts, paper, packaging
    • Energy: Biofuel production from stalk
    • Construction: Building materials like hempcrete
    • Seeds and oil: Food products and animal feed. Oil for cosmetics, lotions and personal care products

    Policy Significance

    • Opens avenues for farmer income diversification
    • Boosts green economy and sustainable industries
    • Potential for employment generation in hill states

    Prelims Takeaway

    • Industrial hemp is legally distinct from narcotic cannabis due to very low THC
    • Multi sector utility crop with applications in textiles, construction, energy, food and cosmetics
    According to India’s National Policy on Biofuels, which of the following can be used as raw materials for the production of biofuels? (2020)

    1. CassavaĀ 

    2. Damaged wheat grainsĀ 

    3. Groundnut seedsĀ 

    4. Horse gramĀ 

    5. Rotten potatoesĀ 

    6. Sugar beetĀ 

    Select the correct answer using the code given below:Ā 

    (a) 1, 2, 5 and 6 only (b) 1, 3, 4 and 6 only (c) 2, 3, 4 and 5 only (d) 1, 2, 3, 4, 5 and 6

  • Titan

    Why in the News?

    Scientists have re examined data from NASA’s Cassini spacecraft and suggested that Saturn’s largest moon Titan may not have a global subsurface ocean, contrary to earlier studies.

    About Titan

    • Titan is the largest moon of Saturn
      • Second largest moon in the solar system, after Ganymede
      • Discovered in 1655 by Christiaan Huygens
      • Nearly 50 percent wider than Earth’s Moon
      • Only moon with a dense atmosphere
      • Atmosphere dominated by nitrogen with methane
      • Only body besides Earth with stable surface liquids
      • Presence of rivers, lakes, and seas
      • Liquids composed of methane and ethane

    Scientific Significance

    • Earlier models suggested a subsurface ocean
    • New findings indicate uncertainty in the existence or thickness of such an ocean
    • Important for understanding Titan’s internal structure
    • Affects assessment of potential habitability
    • Relevant for future planetary exploration missions

    Cassini Spacecraft

    • Cassini spacecraft was a joint mission of NASA, ESA, and ASI
    • Launched in 1997
    • First spacecraft to orbit Saturn
    • Studied Saturn, its rings, and moons
    • Carried the Huygens probe
    • Huygens landed on Titan in 2005
    • Provided first direct surface data from Titan
    Which of the following pairs is/are correctly matched? (2014)

    Spacecraft — Purpose:Ā 

    I. Cassini-Huygens: Orbiting the Venus and transmitting data to the Earth.Ā 

    II. Messenger: Mapping and investigating Mercury.Ā 

    III. Voyager 1 and 2: Exploring the outer solar system.Ā 

    Select the correct answer using the code given below:Ā 

    (a) 1 only (b) 2 and 3 only (c) 1 and 3 only (d) 1, 2 and 3 only

  • K 4 MissileĀ Ā 

    Why in the News?

    India successfully tested the K 4 submarine launched ballistic missile from INS Arighaat in the Bay of Bengal, strengthening its sea based nuclear deterrence.

    About K 4 Missile

    • Also known as Kalam 4 (K 4)
      • Nuclear capable intermediate range submarine launched ballistic missile (SLBM)
      • Designed mainly for deployment on Arihant class submarine
      • Indigenously developed by Defence Research and Development Organisation
    • Each Arihant class submarine can carry four K 4 missiles

    Key Features

    • Length about 12 metres
      • Weight around 17 tonnes
      • Two stage solid fuel propulsion system
      • Maximum range around 3,500 km
      • Payload capacity up to 2 tonnes, including nuclear warhead

    Prelims Pointers

    • K 4 is an SLBM, not a cruise missile
      • Operates from nuclear powered submarines
      • Uses NavIC for navigation support
      • Part of India’s indigenous strategic weapons programme
    Consider the following statements: (2023)

    1. Ballistic missiles are jet-propelled at subsonic speeds throughout their flights, while cruise missiles are rocket-powered only in the initial phase of flight.Ā 

    2. Agni-V is a medium-range supersonic cruise missile, while BrahMos is a solid-fuelled intercontinental ballistic missile.Ā 

    Which of the statements given above is/are correct?Ā 

    (a) 1 only (b) 2 only (c) Both 1 and 2 (d) Neither 1 nor 2