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  • What are ‘Bio-Computers’ and what can they tell us about the human brain?

    bio-computer

    Central idea: Johns Hopkins University scientists have proposed creation of Bio-Computers’ using a new area of research called “organoid intelligence”.

    Background

    • JHU scientists will harness the processing power of the brain and help understand the biological basis of human cognition, learning, and neurological disorders.
    • Traditional methods of studying the human brain involve using rat brains, which are structurally and functionally different from human brains.

    Building brain organoids in the lab

    • Scientists are building 3D cultures of brain tissue in the lab, called brain organoids, using human stem cells.
    • Brain organoids capture many structural and functional features of a developing human brain and are being used to study human brain development and test drugs.
    • However, brain organoids developed in the lab lack sensory inputs and blood circulation, which limits their growth and sophistication.

    Transplanting brain organoids

    • Scientists have transplanted human brain organoid cultures into rat brains, where they formed connections with the rat brain and were functionally active.
    • However, human brain organoids are still nested in the rat-brain microenvironment, which limits their relevance to humans.

    What is the new “bio-computer”?

    • The JHU researchers’ scheme combines brain organoids with modern computing methods to create “bio-computers”.
    • Brain organoids will be grown inside flexible structures affixed with multiple electrodes to record the firing patterns of neurons and deliver electrical stimuli.
    • Machine-learning techniques will be used to analyze the response patterns of neurons and their effect on human behavior or biology.

    Opportunities for “bio-computers”

    • Brain organoids can be developed using stem cells from individuals with neurodegenerative diseases or cognitive disorders to reveal the biological basis of human cognition, learning, and memory.
    • “Bio-computers” could help decode the pathology of and develop drugs for neurodevelopmental and degenerative diseases such as Parkinson’s disease and microcephaly.

    Challenges for bio-computers

    • Brain organoids have a diameter of less than 1 mm and have fewer than 100,000 cells on average, limiting their computing capacity.
    • Researchers will have to develop microfluidic systems to transport oxygen and nutrients and remove waste products.
    • The hybrid systems will generate large amounts of data that will need to be stored and analyzed using “Big Data” infrastructure and advanced analytical techniques.
    • An ethics team is proposed to identify, discuss, and analyze ethical issues as they arise in the course of this work.

    Conclusion

    • Biocomputers will harness the processing power of the brain and help understand the biological basis of human cognition, learning, and various neurological disorders.
    • Scaling up brain organoids and developing microfluidic systems and analytical techniques are the key challenges.
    • Ethical issues arising from the development of biocomputers will be analyzed by an ethics team.

     

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  • SWAMIH investment fund and its affordable housing push

    swami

    The Special Window for Affordable and Mid-Income Housing (SWAMIH) Investment Fund I has raised Rs 15,530 crore so far.

    What is the SWAMIH investment fund?

    • The SWAMIH Investment Fund I is a social impact fund specifically formed for completing stressed and stalled residential projects.
    • The Fund is sponsored by the Ministry of Finance and is managed by SBICAP Ventures Ltd., a State Bank Group company.
    • The Fund is considered as the lender of last resort for distressed projects.

    Who are eligible for this fund?

    It considers-

    • First-time developers,
    • Established developers with troubled projects,
    • Developers with a poor track record of stalled projects,
    • Customer complaints and NPA accounts, and even
    • Projects where there are litigation issues.

    Significance of the funds

    • The Fund’s presence in a project often acts as a catalyst for better collections and sales primarily in projects that were delayed for years.
    • According to the Finance Ministry, SWAMIH Fund has one of the largest domestic real estate private equity teams focused only on funding and monitoring the completion of stressed housing projects.

    How many projects so far have been financed by the Fund?

    • SWAMIH has so far provided final approval to about 130 projects with sanctions worth over Rs 12,000 crore.
    • The Fund has completed 20,557 homes and aims to complete over 81,000 homes in the next three years across 30 tier 1 and 2 cities.
    • The Fund has been able to complete construction in 26 projects and generate returns for its investors.
    • It has also played a critical role in the growth of many ancillary industries in real estate and infrastructure sector having successfully unlocked liquidity of more than Rs. 35,000 crore.
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  • One Nation, One Challan Initiative

    challan

    The Gujarat Govt. informed High Court that it’s setting up virtual traffic courts under ‘One Nation One Challan’ initiative while hearing a PIL on the matter.

    What is the One Nation, One Challan initiative?

    • One Nation, One Challan is an initiative of the Ministry of Road Transport and Highways.
    • It aims to bring all related agencies, such as the traffic police and the Regional Transport Office (RTO), on one platform, to enable seamless collection of challans as well as data transfer.
    • The integrated system uses the CCTV network to detect traffic violations and retrieve the registration number of the offending vehicle from applications like VAHAN and SARATHI.
    • An e-Challan is then generated with the relevant penalty amount, and sent to the mobile number linked with the vehicle.

    What did the Gujarat govt inform?

    • In Gujarat, the initiative is operational in three commissionerate areas of Ahmedabad, Rajkot and Surat since January this year and implementation at Vadodara is underway.

    How does the integration help?

    • Prior to the integration, details of vehicle ownership from a different state could not be accessed through the CCTV network for penalization.
    • Integration of all states’ RTO data and traffic police data with the support of NIC servers allows access to vehicle registration and related data for violators from different states.
    • Challans will be sent directly to the mobile number registered with the vehicle.
    • NIC is set to launch its own application for e-Challan delivery.

    How do virtual traffic courts work?

    • Virtual courts are aimed at eliminating the presence of litigants in the court.
    • An accused can search their case on the virtual court’s website. Upon successful payment of the fine, the case will be shown as disposed of.
    • For now, one court is in the process of being designated as a virtual court for the whole of Gujarat.

     

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  • Assam’s Maidams meet UNESCO technical requirements for heritage centre

    maidam

    Assam’s pyramid-like structures known as moidams or maidams have met all the technical requirements of UNESCO’s World Heritage Centre.

    Charaideo Maidams

    • The Charaideo maidams represents the late medieval (13th-19th century CE) mound burial tradition of the Tai Ahom community in Assam.
    • The Ahoms preferred to place the departed family members at Charaideo where the first king Sukapha was laid to rest.
    • The historical chronicles inform that wives, attendants, pet animals and huge quantity of valuables were buried with the departed kings.
    • The Charaideo Maidams enshrine the mortal remains of the members of the Ahom royalty, who used to be buried with their paraphernalia.
    • After the 18th century, the Ahom rulers adopted the Hindu method of cremation and began entombing the cremated bones and ashes in a Maidam at Charaideo.
    • Out of 386 Maidams explored so far, 90 royal burials at Charaideo are the best preserved, representative of and the most complete examples of mound burial tradition of the Ahoms.

    Architecture details

    • Architecturally it comprises a massive underground vault with one or more chambers having domical superstructure.
    • It is covered by a heap of earthen mound and externally it appears a hemispherical mound.
    • At the top of the mound a small open pavilion chow-chali is provided.
    • An octagonal dwarf wall encloses whole maidam.

     

    Ahoms Dynasty

    • The Ahom, also known as the Tai-Ahom, are an ethnic group from Assam and Arunachal Pradesh in India.
    • This ethnic group is made up of interbred descendants of the Tai people, who first came to Assam’s Brahmaputra valley in 1228, and indigenous people who later joined them.
    • Sukaphaa, the Tai group’s leader, and his 9000 supporters founded the Ahom empire (1228–1826 CE), which ruled over part of modern-day Assam’s Brahmaputra Valley until 1826.
    • Charaideo, more than 400 km east of Guwahati, was the first capital of the Ahom dynasty founded by Chao Lung Sukaphaa in 1253.
    • The current Ahom people and culture are a mix of the ancient Tai people and culture, as well as indigenous Tibeto-Burman people and cultures that they assimilated in Assam.

     

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  • Foldscope: A new paper microscope

    fold

    Researchers from the Indian Institute of Science (IISc), Bengaluru, have developed a cheap paper microscope (foldscope) connected to a smartphone camera that could find wider application in a variety of research areas, and in some cases potentially replace more expensive equipment.

    What is Foldscope?

    • The Foldscope is a handheld microscope made mostly of paper that can be easily linked to a smartphone camera.
    • It has a magnification of around 140x and can identify objects just 2 micrometres wide.
    • It was first created by researchers at Stanford University in 2014.
    • IISc version of Foldscope costs around Rs 400, much cheaper than that of Stanford’s one.

    How is Foldscope comparable to electron microscope?

    • The researchers found that Foldscope could capture the roundness and aspect ratio of an object to within 5% of those imaged by a state-of-the-art instrument called a scanning electron microscope (SEM).
    • SEM costs more than Rs 50 lakh each.
    • Preparing a sample for study through a Foldscope takes less than an hour, whereas the same process for an SEM was “tedious and time-consuming”.

    Potential applications

    • Foldscopes can be used in pharmaceuticals (to inspect drug products), environmental science (to observe pollutants), and cosmetics (to observe powders and emulsions), among other fields.
    • They can also be used to study “soil particles’ morphology,” which can “help understand soil structure, nutrient availability, and plant growth” in agriculture.
    • It allows for in-field soil analysis and visualisation of soil structure per Indian Standard Soil Classification System which earlier required bulky microscopes with high resolution.
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  • Yellowstone NP celebrates its 151st anniversary

    yellow

    Yellowstone National Park, which celebrated its 151st anniversary earlier this week, is widely considered to be the first national park in the world.

    Yellowstone National Park

    • It is a large protected area located primarily in the U.S. state of Wyoming, although it also extends into Montana and Idaho.
    • It was established in 1872 and is widely considered to be the first national park in the world.
    • It spans an area of over 9,000 sq. km comprising lakes, canyons, rivers, iconic geothermal features such as the Old Faithful geyser, and mountain ranges.

    Some key features and attractions of Yellowstone National Park include:

    1. Geothermal features: Yellowstone is famous for its geothermal features, including geysers, hot springs, mud pots, and steam vents. The most famous of these is Old Faithful, a geyser that erupts on a regular schedule.
    2. Wildlife: Yellowstone is home to a diverse array of wildlife, including grizzly bears, wolves, bison, elk, and moose. Visitors can see these animals in their natural habitats throughout the park.
    3. Scenic drives: The park has several scenic drives, including the Grand Loop Road, which takes visitors to many of the park’s major attractions.
    4. Fishing: The park has many rivers and lakes that offer excellent fishing opportunities, including the Yellowstone River.

     

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  • What is the Expected Credit Loss (ECL) regime?

    The Reserve Bank of India is moving closer towards ring-fencing the banking system from credit losses as it proposes to move to provision on the principles of ‘expected losses’ from ‘incurred losses. ‘

    What is a Loan-Loss Provision?

    • The RBI defines a loan loss provision as an expense that banks set aside for defaulted loans.
    • Banks set aside a portion of the expected loan repayments from all loans in their portfolio to cover the losses either completely or partially.
    • In the event of a loss, instead of taking a loss in its cash flows, the bank can use its loan loss reserves to cover the loss.
    • The level of loan loss provision is determined based on the level expected to protect the safety and soundness of the bank.

    What is Expected Credit Loss (ECL) regime?

    • The Expected Credit Loss (ECL) regime is a new accounting standard that was introduced by the International Financial Reporting Standards (IFRS) in response to the global financial crisis of 2008.
    • The ECL regime requires banks and other financial institutions to estimate and report the expected losses from their loan portfolios over the lifetime of the loans.
    • Under the ECL regime, financial institutions must assess the credit risk associated with each loan and estimate the expected losses that will result from default or other credit events.
    • These expected losses must be recognized in the financial institution’s accounts and reported to investors and other stakeholders.
    • Under this practice, a bank is required to estimate expected credit losses based on forward-looking estimations rather than wait for credit losses to be actually incurred before making corresponding loss provisions.

    Benefits of the ECL regime

    • ECL will result in excess provisions as compared to a shortfall in provisions, as seen in the incurred loss approach.
    • It will further enhance the resilience of the banking system in line with globally accepted norms.

    Issues with this regime

    • It requires banks to provide for losses that have already occurred or been incurred.
    • The delay in recognizing loan losses resulted in banks having to make higher levels of provisions which affected the bank’s capital.
    • This affected banks’ resilience and posed systemic risks.
    • The delays in recognizing loan losses overstated the income generated by the banks, which, coupled with dividend payouts, impacted their capital base.

     

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  • In news: Anmol Jeevan Abhiyan

    A recent initiative called the ‘Anmol Jeevan Abhiyan’ (Precious Life Campaign) in Barmer, Rajasthan has motivated village panchayats and homeowners to add hand pumps and locked covers to tankas for improved structure.

    What are Tankas?

    anmol

    • The tankas with a huge water storage capacity are traditionally built adjacent to the residential units in western Rajasthan.
    • It is used for collecting rainwater and using it throughout the year for drinking and other household needs.
    • They were constructed in households under the Mahatma Gandhi National Rural Employment Guarantee Scheme (MGNREGS).

     

    Anmol Jeevan Abhiyan

    • The ‘Anmol Jeevan Abhiyan’ (Precious Life Campaign) has encouraged village panchayats and owners of houses to make the structural addition of hand pumps and locked covers on tankas.
    • The light-weight hand pumps made of fibre serve the dual purpose of preventing the accidents and suicides as well as drawing of water from the tank.
    • The campaign has been started jointly by the district administration, United Nations Children’s Fund (UNICEF) and Action Aid.
    • Among the 171 suicide cases reported last year, as many as 64 were those of women and a majority was those who had jumped into the water tanks.

    Benefits offered

    • Though the campaign has made an impact during the last three to four months, it cannot be measured in quantitative terms at present because of its continuity, even as the reports of suicides have gradually reduced.
    • The permanent closure of tankas with the metal cover having lock also ensured that no cattleheads or other animals fall into them tank.

     

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  • Proton Beam Therapy out of reach for many

    proton

    There is currently a demand-supply gap of proton beam therapy machines in India, leaving many cancer patients in a difficult situation.

    What is Proton Beam Therapy?

    • Proton beam therapy is a type of radiation therapy — a treatment that uses high-energy beams to treat tumors.
    • Radiation therapy using X-rays has long been used to treat cancers and noncancerous (benign) tumors.
    • It uses protons rather than x-rays to treat cancer. At high energy, protons can destroy cancer cells.
    • It can also be combined with x-ray radiation therapy, surgery, chemotherapy, and/or immunotherapy.
    • Like x-ray radiation, proton therapy is a type of external-beam radiation therapy.

    How it works?

    proton

    • Fundamentally, all tissue cells are made up of molecules with atoms as their building blocks.
    • In the center of every atom is the nucleus. Orbiting the nucleus of the atom are negatively charged electrons.
    • When energized protons pass near orbiting electrons, the positive charge of the protons attracts the negatively charged electrons, pulling them out of their orbits. This is called ionization.
    • It changes the characteristics of the atom and consequentially the character of the molecule within which the atom resides.
    • Because of ionization, the radiation damages molecules within the cells, especially the DNA.
    • Damaging the DNA destroys specific cell functions, particularly the ability to divide or proliferate.
    • While both normal and cancerous cells go through this repair process, a cancer cell’s ability to repair molecular injury is frequently inferior.
    • As a result, cancer cells sustain more permanent damage and subsequent cell death than occurs in the normal cell population.

    Why in news?

    • There is currently a significant demand-supply gap of proton beam therapy machines in India, with only a few machines available in the country.
    • This has resulted in long wait times for patients who need the treatment, and many patients are forced to travel abroad to access the treatment, which can be prohibitively expensive.

    Various challenges

    • Huge demand: The demand for PBT machines is also increasing, as more and more patients are being diagnosed with cancer and are seeking the latest and most effective treatments available.
    • High cost: One of the major challenges in setting up PBT machines is the high cost involved, as the machines are complex and require a significant investment.
    • Shortage of personnel: In addition, there is a shortage of trained personnel who can operate and maintain the machines, which further limits their availability.

    Way Forward

    • The government and private sector need to invest more in setting up and maintaining the machines. This could include-
    1. Offering tax incentives and subsidies to private healthcare providers who invest in PBT machines
    2. Providing training and education to personnel who can operate and maintain the machines
    3. Setting up more public hospitals that offer proton beam therapy, which would help to make the treatment more accessible and affordable to patients who need it

     

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  • ISRO successful in key test for Chandrayaan-3 Mission

    chandrayaan

    The Indian Space Research Organisation (ISRO) has successfully conducted a crucial test for its upcoming Chandrayaan-3 mission.

    What was the test?

    • The test involved the high-thrust cryogenic engine, which will be used to power the rocket that carries the Chandrayaan-3 spacecraft.
    • The engine was tested for its endurance and performance under various conditions.

    About Chandrayaan-3 Mission

    • The Chandrayaan-3 mission is the third lunar exploration mission by the Indian Space Research Organisation.
    • The mission follows the successful Chandrayaan-1 and Chandrayaan-2 missions, which were launched in 2008 and 2019 respectively.
    • The Chandrayaan-3 mission is designed to further explore the Moon’s South Pole region and conduct various scientific experiments, including studying the lunar surface, mineralogy, and the presence of water.

    Significance of the recent test

    • With the successful test of the high-thrust cryogenic engine, ISRO is now one step closer to launching the Chandrayaan-3 mission.
    • The mission is expected to be a significant step forward in India’s space exploration efforts and will further our understanding of the Moon and its potential for future exploration and exploitation.

    Chandrayaan-2: A quick recap

    • Chandrayaan-2 consisted of an Orbiter, Lander and Rover, all equipped with scientific instruments to study the moon.
    • The Orbiter would watch the moon from a 100-km orbit, while the Lander and Rover modules were to be separated to make a soft landing on the moon’s surface.
    • ISRO had named the Lander module as Vikram, after Vikram Sarabhai, the pioneer of India’s space programme, and the Rover module as Pragyaan, which crash-landed.

    Inception of Chandrayaan 3

    • The subsequent failure of the Vikram lander led to the pursuit of another mission to demonstrate the landing capabilities needed for the Lunar Polar Exploration Mission proposed in partnership with Japan for 2024.

    Its design

    • The lander for Chandrayaan-3 will have only four throttle-able engines.
    • Unlike Vikram on Chandrayaan-2 which had five 800N engines with a fifth one being centrally mounted with a fixed thrust.
    • Additionally, the Chandrayaan-3 lander will be equipped with a Laser Doppler Velocimeter (LDV).

    Back2Basics: Chandrayaan-1 Mission

    • The Chandrayaan-1 mission was launched in October 2008 was ISRO’s first exploratory mission to the moon, in fact to any heavenly body in space.
    • The mission was designed to just orbit around the moon and make observations with the help of the instruments onboard.
    • The closest that the Chandrayaan-1 spacecraft came to the moon was in an orbit 100 km from its surface.

     

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