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GS Paper: GS3-16.Achievements of Indians in Science & Technology; Indigenization of Technology and Developing New Technology.

  • India using too many powerful antibiotics meant for specific infections: Study

    Why in the News?

    A study published in The Lancet Public Health finds that India overuses ‘Watch’ category antibiotics while underusing ‘Access’ and ‘Reserve’ category drugs under the World Health Organization (WHO)’s AWaRe (Access, Watch, Reserve) classification, raising concerns about the country’s antimicrobial resistance (AMR) trajectory.

    Key Highlights

    1. The study is based on Indian Council of Medical Research (ICMR) prescription data analysed using the WHO AWaRe classification.
    2. India shows disproportionate use of broad-spectrum ‘Watch’ category antibiotics, which carry a higher risk of antimicrobial resistance.
    3. ‘Access’ category antibiotics (first-line, lower resistance risk) and ‘Reserve’ category antibiotics (last-resort drugs) are comparatively underused.

    Back2Basics

    WHO AWaRe Classification (2017)

    1. Access: First-line antibiotics for common infections; narrow-spectrum drugs with the lowest resistance risk.
    2. Watch: Broad-spectrum antibiotics with higher resistance potential; should be prescribed selectively.
    3. Reserve: Last-resort antibiotics for treating multidrug-resistant infections; should be used only when all other options fail.

    Antimicrobial Resistance (AMR)

    • Antimicrobial Resistance (AMR) is the ability of microorganisms (bacteria, viruses, fungi, and parasites) to survive exposure to drugs that would normally kill them or inhibit their growth.
    • It is primarily driven by the overuse and misuse of antimicrobials in humans, animals, and agriculture.

    (2019) Which of the following are the reasons for the occurrence of multi-drug resistance in microbial pathogens in India?

    1. Genetic predisposition of some people
    2. Taking incorrect doses of antibiotics to cure diseases
    3. Using antibiotics in livestock farming
    4. Multiple chronic diseases in some people

    Select the correct answer using the code given below.

    (a) 1 and 2
    (b) 2 and 3 only
    (c) 1, 3 and 4
    (d) 2, 3 and 4

  • Commercialisation and Transfer of Government-Developed Technologies

    Why in News?

    The Government informed Parliament about the institutional framework, technology transfer mechanisms, and commercialization of technologies developed by public-funded research institutions such as the Council of Scientific and Industrial Research (CSIR), Department of Science and Technology (DST), Department of Biotechnology (DBT), and National Research Development Corporation (NRDC).

    National Research Development Corporation (NRDC)

    • NRDC is an autonomous organization under the Department of Scientific and Industrial Research (DSIR).
    • It is the nodal agency for technology transfer, licensing, commercialization, and Intellectual Property (IP) management.
    • Has licensed technologies to 5,100+ entrepreneurs and facilitated filing of 2,100+ Intellectual Properties (IPs).
    • Supports patenting, prototyping, pilot plants, feasibility studies, and export of indigenous technologies.

    Institutional Framework

    • Council of Scientific and Industrial Research (CSIR): Technology Transfer and Utilisation of Knowledgebase Guidelines.
    • Department of Biotechnology (DBT): Intellectual Property (IP) Guidelines, 2023, enabling institutions to own and license IP through exclusive or non-exclusive agreements.
    • Technology Development Board (TDB) under the Department of Science and Technology (DST): Provides financial assistance for commercialization of indigenous technologies.

    Startup & Industry Support

    • Biotechnology Industry Research Assistance Council (BIRAC) has established:
      • 7 Technology Transfer Offices (TTOs) under the National Biopharma Mission (NBM).
      • 94 biotechnology incubation/pre-incubation centres across 25 States and Union Territories (UTs).
    • Department of Science and Technology (DST) has established 22 Technology Enabling Centres (TECs) to connect researchers with industry.
    • Incubation centres at IITs and NRDC provide mentorship, testing facilities, funding support, and Technology Readiness Level (TRL) assessment.

    Commercialisation Performance (2023–2025)

    • CSIR: 707 technologies licensed/developed and 452 technologies commercialized/transferred.
    • DBT: 120 technologies licensed/developed and 18 technologies commercialized/transferred.
    • DST: 185 technologies licensed/developed and 36 technologies commercialized/transferred.

    Startup Creation

    • CSIR: Supported 148 startups, generating royalty income and employment for about 7,200 people.
    • DBT: Facilitated 34 startups in healthcare, agritech, diagnostics, and biomanufacturing.
    • NRDC: Supported 13 startups under the Technology Development, Validation and Commercialisation (TDVC) programme.

    [2017] With reference to the “National Intellectual Property Rights Policy” consider the following statements:

    1. It reiterates India’s commitment to Doha Development Agenda and the TRIPS agreement.
    2. Department of Industrial Policy and Promotion is the nodal agency for regulating Intellectual Property Rights in India.

    Which of the above statements is/are correct?
    a) Only 2
    b) Neither 1 nor 2
    c) Only 1
    d) Both 1 and 2

  • Borophene-Based Green Lubricant Can Help Save Energy

    Why in News?

    Scientists at the Institute of Advanced Study in Science and Technology (IASST), Guwahati, under the Department of Science and Technology (DST), have developed a borophene-enhanced castor oil lubricant that reduces friction and wear, improving energy efficiency. The research was published in ACS Applied Engineering Materials.

    What is Borophene?

    • A single-atom-thick (2D) allotrope of boron.
    • Possesses high strength, excellent electrical conductivity, and thermal stability.
    • Has applications in batteries, supercapacitors, sensors, fuel cells, and advanced lubricants.

    Key Findings

    • Adding 0.1 wt.% borophene to castor oil reduced friction by about 42%.
    • Improves load-bearing capacity and wear resistance.
    • Disperses uniformly in castor oil without chemical modification.

    How Does It Work?

    Borophene forms a tribofilm (a thin protective layer) on metal surfaces, reducing direct metal-to-metal contact, friction, and wear.

    Why is Castor Oil Used?

    • Renewable, biodegradable, and non-toxic.
    • Borophene enhances its performance, making it suitable as a sustainable alternative to petroleum-based lubricants.

    Significance

    • Reduces energy losses due to friction.
    • Increases machinery lifespan and efficiency.
    • Promotes eco-friendly lubricants for sustainable manufacturing.

    Prelims Facts

    • Borophene: Two-dimensional allotrope of boron.
    • Lubricant Base: Castor oil.
    • Friction Reduction: About 42%.
    • Protective Layer: Tribofilm.
    • Research Institute: IASST, Guwahati.
    • Ministry: Department of Science and Technology (DST).
  • India Approves First Dengue Vaccine (QDENGA)

    Why in News?

    India has approved its first dengue vaccine, QDENGA (TAK-003), developed by Takeda Biopharmaceuticals, after receiving market authorization from the Drug Controller General of India (DCGI).

    Key Highlights

    • First dengue vaccine approved in India.
    • Approved for individuals aged 4 to 60 years.
    • Type: Live attenuated tetravalent vaccine.
    • Protects against all four dengue virus serotypes (DENV-1, DENV-2, DENV-3, DENV-4).
    • Dosage: Two doses administered 3 months apart.
    • Can be given irrespective of previous dengue infection.
    • No pre-vaccination screening is required.

    Clinical Performance

    • Based on 19 Phase I, II and III clinical trials involving over 28,000 participants.
    • Phase III (TIDES) trial enrolled 20,000+ participants across eight dengue-endemic countries.
    • 80.2% efficacy against confirmed dengue (12 months after second dose).
    • 90.4% efficacy against dengue-related hospitalization (18 months).
    • Long-term studies showed sustained protection for up to 7 years.

    Global Status

    • Approved in 43 countries.
    • WHO recommends its use in high dengue transmission settings.
    • Received WHO prequalification.
    • Included in the national immunization programmes of Brazil and public programmes in Argentina, Colombia, and Indonesia.

    About Dengue

    • Cause: Dengue virus (Flavivirus).
    • Vector: Female Aedes aegypti mosquito (also Aedes albopictus).
    • Transmission: Mosquito-borne (not spread directly from person to person).
    • Symptoms: High fever, severe headache, muscle and joint pain, skin rash, and bleeding in severe cases.
    • Severe Form: Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS).

    [2023] ‘Wolbachia method’ is sometimes talked about with reference to which one of the following?

    [A] Controlling the viral diseases spread by mosquitoes.

    [B] Converting crop residues into packing material.

    [C] Producing biodegradable plastics.

    [D] Producing biochar from thermo- chemical conversion of biomass

  • Ultrafast Organic Anodes for Next-Generation Rechargeable Batteries

    Why in News?

    Researchers from IACS and SNBNCBS have developed a porous organic anode material based on a Covalent Organic Framework (COF) that enables ultrafast charging lithium-ion batteries while maintaining high durability.

    Key Highlights

    • Developed by: Indian Association for the Cultivation of Science (IACS) and S. N. Bose National Centre for Basic Sciences (SNBNCBS) under DST.
    • Material Used: Covalent Organic Framework (COF) – a porous crystalline organic material.
    • Major Achievement: Battery reaches 80% charge in just over one minute.
    • Advantages:
      • Faster lithium-ion transport.
      • Higher energy storage capacity.
      • Long cycle life and improved durability.
      • Safer and low-cost organic battery electrodes.
    • Dual-Ion Capability: Can store both lithium ions and sodium ions, paving the way for affordable sodium-ion batteries.
    • Applications: Electric vehicles, smartphones, laptops, grid-scale renewable energy storage.

    What is a Covalent Organic Framework (COF)?

    • A highly porous, crystalline organic material made of light elements (C, H, O, N, B).
    • Features: High surface area. Tunable pore size. Lightweight and chemically stable. Enables rapid ion movement, making it ideal for battery electrodes.

    [2025] In the context of electric vehicle batteries, consider the following elements:
    I. Cobalt
    II. Graphite
    III. Lithium
    IV. Nickel
    How many of the above usually make up battery cathodes?

    [A] Only one

    [B] Only two

    [C] Only three

    [D] All the four

  • India’s First Hydrogen Fuel Cell Train

    Why in News?

    Indian Railways is set to launch India’s first Hydrogen Fuel Cell Trainset, marking a major step towards green and sustainable rail transportation.

    Key Highlights

    • First Hydrogen Fuel Cell Train in India.
    • Route: Jind–Sonipat section (Northern Railway), Haryana.
    • Train Configuration: 10 coaches
    • Passenger Capacity: Around 2,600 passengers (largest hydrogen passenger train globally in terms of capacity).
    • Operational Speed: 75 km/h
    • Design Speed: 110 km/h
    • Generates electricity onboard using hydrogen and oxygen, eliminating the need for overhead electric lines.
    • By-products: Only water vapour and heat (near-zero emissions at the point of use).

    How Does It Work?

    • Uses a Proton Exchange Membrane (PEM) Fuel Cell.
    • Hydrogen stored in cylinders reacts with oxygen from the atmosphere.
    • The electrochemical reaction generates electricity to power traction motors.
    • The train consists of: 2 Hydrogen Driving Power Cars (DPCs) and 8 Trailer Coaches (TCs)
    • Each DPC produces 1,200 kW (1,600 hp) of power.

    Hydrogen Refuelling Facility

    • Located at Jind, Haryana.
    • India’s largest railway hydrogen refuelling facility.
    • Hydrogen is Produced through electrolysis, Compressed to 500 bar, and Dispensed at 350 bar.
    • Stores nearly 3,000 kg of hydrogen.
    • Approved by the Petroleum and Explosives Safety Organisation (PESO).

    Safety Features

    • Hydrogen leak detectors.
    • Heat, flame and smoke detection systems.
    • Continuous ventilation.
    • Automatic hydrogen shut-off system.
    • Fire suppression systems.
    • Third-party safety assessment by TÜV SÜD (Germany).
    • Designed according to NFPA-2 and ISO 19880 standards.

    Indigenous Development

    • Developed under Indian Railways.
    • Research Designs and Standards Organisation (RDSO) formulated technical specifications.
    • Medha Servo Drives integrated the train.
    • Integral Coach Factory (ICF) designed the train exterior.

    Global Significance

    • Countries operating or testing hydrogen trains include Germany, France, Italy, China, and Japan
    • India’s train is among the largest-capacity hydrogen-powered passenger trains and includes a complete hydrogen ecosystem from production to refuelling.

    Future Plans

    • Hydrogen technology is proposed for heritage railways, including the Kalka–Shimla Railway.
    • Supports the National Green Hydrogen Mission and India’s Net Zero goals

    [2026] Which of the following statements with regard to Green Hydrogen is/are correct ?
    1. It is decarbonized hydrogen obtained from natural gas reforming combined with carbon capture and storage (CCS).
    2. It is produced using electrolysis of water with electricity generated by renewable energy.
    3. National Green Hydrogen Mission of India aims for abatement of nearly 50 MMT of annual greenhouse gas emissions by 2030.
    Select the answer using the code given below :

    [A] 1 only

    [B] 2 and 3 only

    [C] 2 only

    [D] 1, 2 and 3

  • Gaganyaan: ISRO Successfully Tests Key Crew Module Systems

    Why in News?

    The Indian Space Research Organisation (ISRO) successfully conducted three major qualification tests of the Gaganyaan Crew Module to enhance astronaut safety during re-entry and recovery.

    Key Highlights

    • Crew Module Uprighting System (CMUS): Uses a stored cold gas inflation system to automatically restore the crew module to an upright position after sea splashdown, ensuring crew safety.
    • Crew Module Umbilical System (CSU-2): Successfully tested the separation of the Crew Module Umbilical-2 (CSU-2), which connects the Crew Module (CM) and Service Module (SM).
      • Enables clean separation before atmospheric re-entry while maintaining structural integrity.
    • Apex Cover Separation Test: Validated the structural integrity during separation of the apex cover, which protects the parachute system.
      • The cover separates before parachute deployment to ensure safe deceleration and landing.
      • Note: Parachute systems are deployed to slow descents through the atmosphere or space.

    About Gaganyaan Mission

    • India’s first indigenous human spaceflight mission.
    • Implemented by: Indian Space Research Organisation (ISRO).
    • Objective: Demonstrate India’s capability to send three astronauts to Low Earth Orbit (LEO) (about 400 km) for up to 3 days and safely return them to Earth.

    Significance

    • Strengthens astronaut safety during splashdown and re-entry.
    • Validates critical crew escape and recovery systems.
    • Advances India’s human spaceflight capability and future space exploration.

    [2025] Consider the following space missions:
    I. Axiom-4
    II. SpaDeX
    III. Gaganyaan
    How many of the space missions given above encourage and support microgravity research?

    [A] Only one

    [B] Only two

    [C] All the three

    [D] None

  • What India’s 12 ‘operationally deployed’ nuclear warheads mean

    Why in the News?

    SIPRI’s 2026 Yearbook classified 12 of India’s 190 nuclear warheads as operationally deployed for the first time. These are positioned with active military forces mated with delivery systems and ready for use.The classification has triggered concern over a possible shift in India’s No First Use (NFU) doctrine.

    Why does SIPRI’s “deployment” classification not indicate a shift in India’s nuclear doctrine?

    1. No change in launch policy: NFU commits India to not launching a pre-emptive strike; SIPRI’s report records no revision of this commitment.
    2. No threshold lowering: The report does not indicate any lowering of the threshold for nuclear employment.
    3. No change in political control: Civilian and political oversight mechanisms governing nuclear release remain unaltered.
    4. Expert confirmation: Warheads mated with delivery platforms make assured retaliation more credible, not less restrained.
    5. Reaffirmed commitment: India’s representatives reaffirmed NFU and non-use against non-nuclear-weapon states at the UN High-Level Meeting in September 2025.
    6. Internal calls for first-use rejected: Periodic domestic proposals for a conditional or hybrid first-use posture have not prevailed.

    Why does the stockpile-deployment distinction matter for assessing India’s posture?

    Possessing a warhead and deploying it as part of an operational deterrent are not the same condition. The distinction determines whether a count of warheads signals readiness or merely holdings.

    1. De-mated baseline: For most of its nuclear history, India stored warheads separately from delivery vehicles at a central site under strict oversight.
    2. Purpose of de-mating: This was meant to maximise safety, reduce accidental-use risk, and signal restraint internationally.
    3. Definition of deployment: Deployment pairs a warhead with a delivery system and positions it with operational forces in readiness.
    4. Readiness, not intent: A deployed weapon is configured for use if authorised; it is not a signal of imminent use.
    5. Speed differential: A de-mated weapon needs time to prepare and deploy; a mated weapon can be launched faster.
    6. Scale of the shift: SIPRI’s count reflects a small but significant fraction of India’s arsenal now held in operational readiness, not a wholesale change in posture.

    How does the sea-based deterrent resolve the central vulnerability in India’s NFU doctrine?

    NFU is a retaliation-only doctrine, so it stands or falls on whether the force can survive a first strike. Sea-basing closes the specific gap that land-based deployment cannot.

    1. Survivability requirement: NFU depends on enough of the arsenal surviving a first strike to deliver a retaliatory blow; without this, NFU becomes a liability rather than a doctrine.
    2. Land-based vulnerability: Land-based missiles sit at known, mappable locations and can be targeted in a disarming first strike.
    3. Sea-based advantage: A submerged submarine cannot be found, tracked, or destroyed in time, removing this vulnerability.
    4. Arihant-class platform: India’s Arihant-class submarines have steadily strengthened second-strike survivability, with additional platforms expected to further consolidate this leg of the triad.
    5. Operational milestone: Three operational SSBNs allow India to keep at least one submarine submerged and on patrol at all times.
    6. Supporting readiness measure: Increasing reliance on canisterised Agni-series missiles, which carry fuel sealed and ready, raises operational readiness without requiring further preparation before launch.

    What broader trend does India’s deployment milestone sit within, and why does it matter?

    1. Global reversal: SIPRI’s 2026 Yearbook records states increasingly relying on nuclear weapons as instruments of national power, reversing decades of gradual disarmament progress.
    2. Scale of global arsenals: Nine nuclear-armed states held an estimated 12,187 warheads as of January 2026.
    3. China’s pace: China’s arsenal has grown to approximately 620 warheads, expanding faster than any other nuclear power and now over three times Pakistan’s estimated stockpile.
    4. Dual-direction posture: India’s modernisation is increasingly focused on long-range systems capable of reaching China, while continuing to account for Pakistan.
    5. Weakening arms control: Arms-control agreements have weakened or collapsed even as competition intensifies in hypersonic delivery, AI-enabled decision support, missile defence, and anti-submarine warfare.
    6. Unresolved risk: The maturation of India’s second-strike capability strengthens deterrence bilaterally, but does nothing to address the rising risk of miscalculation across a destabilising global order.

    Conclusion

    SIPRI’s classification of 12 Indian warheads as operationally deployed documents the maturing of India’s sea-based second-strike capability, not a retreat from No First Use. This development, however, sits inside a global environment where arms-control frameworks are weakening and major powers are re-arming. The institutions designed to manage nuclear risk must adapt to this faster-fielding environment, or the credibility gained through India’s improved deterrent will be offset by a rising structural risk of miscalculation.

    PYQ Relevance

    [UPSC 2017] Give an account of the growth and development of nuclear science and technology in India. What is the advantage of fast breeder reactor programme in India?

    Linkage: Tests India’s strategic nuclear capabilities, indigenous nuclear development and the evolution of its deterrence architecture.The article explains how India’s maturing nuclear triad and operational deployment strengthen its credible minimum deterrence and second-strike capability without altering its No First Use doctrine.