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Subject: Biotech and Medical Sciences

  • APOBEC (Apolipoprotein B mRNA Editing Catalytic Polypeptide)

    Why in the News?

    Since smallpox was eradicated in 1980, research on mpox has highlighted how the virus mutates, particularly through the APOBEC family of immune system proteins.

    About APOBEC

    • APOBEC (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like) is a family of proteins involved in regulating the genetic material of viruses and cells.
    • They are part of the human immune system and play a crucial role in protecting against viral infections by editing RNA and DNA.
    • APOBEC consists of several enzymes, with APOBEC1, APOBEC3 family members being the most well-known.
    • There are 11 identified members of the APOBEC family, primarily named APOBEC1, APOBEC2, and APOBEC3, with APOBEC3 being the most studied due to its antiviral properties.
    • It has a Zinc Finger Domain, which is essential for their enzymatic activity and ability to bind to DNA or RNA.
    • APOBEC proteins are found in various tissues and cells, but they are notably present in the immune cells such as T-cells, B-cells, and macrophages.
    • Role in Immune Defense:
      • APOBEC proteins contribute to the innate immune response by editing viral genomes, preventing the replication of viruses, and reducing the ability of viruses to establish infections.
      • They are known to be cytosine deaminases, which means they modify cytosine bases in nucleic acids to uracil, leading to mutations that can prevent successful viral replication.
      • APOBEC proteins target the genomes of several viruses, including retroviruses (like HIV), hepatitis B virus, and poxviruses (such as mpox and smallpox).

    Functions of APOBEC Proteins:

    • DNA Editing: APOBEC proteins can deaminate cytosine bases in single-stranded DNA, converting them into uracil, which can lead to mutations.
      • This introduces errors in the viral genome and inhibits replication.
    • RNA Editing: Some APOBEC proteins, like APOBEC1, are involved in editing mRNA. In the case of APOBEC1, it helps edit the mRNA of apolipoprotein B, which is crucial for lipid metabolism.
    • Antiviral Activity: APOBEC3 proteins, particularly APOBEC3G, inhibit the replication of HIV and other retroviruses by editing viral DNA during reverse transcription.
      • They also reduce the replication of poxviruses (such as mpox), making them crucial in controlling infections caused by these viruses.
    • Cytosine Deamination in Viral RNA: APOBEC proteins induce mutations in viral RNA, reducing the virus’s ability to efficiently replicate and spread. This helps prevent viral evolution and adaptation.
    • Inhibition of Viral Resistance: By causing mutations in viral genomes, APOBEC proteins prevent viruses from easily developing resistance to the immune system’s defenses.
    • Interaction with Other Immune Mechanisms: APOBEC proteins work in concert with other immune mechanisms, like interferons, to enhance antiviral responses and limit infections.

    PYQ:

    [2016]  In the context of the developments in Bioinformatics, the term ‘transcriptome’, sometimes seen in the news, refers to:

    (a) a range of enzymes used in genome editing

    (b) the full range of mRNA molecules expressed by an organism

    (c) the description of the mechanism of gene expression

    (d) a mechanism of genetic mutations taking place in cells

  • Caterpillar fungus

    Why in the News?

    Recent research by scientists at the University of Nottingham’s has found that a chemical produced by a fungus growing on caterpillars may slow cancer cell growth.

    What is Caterpillar fungus?

    • Cordyceps militaris, also known as caterpillar fungus, is a parasitic fungus that primarily infects caterpillars and other insects.
    • Found in the Himalayan region and parts of Asia, it is valued in traditional Asian medicine for its health benefits, including immune support, anti-inflammatory properties, and energy enhancement.
    • It is considered a delicacy in some Asian cultures and has long been used for its purported wellness effects.

    How it can slow down growth of cancer cells?

    • Researchers from the University of Nottingham’s School of Pharmacy have identified cordycepin, a compound produced by Cordyceps militaris, as potentially effective in slowing cancer cell growth.
    • Cordycepin works by interrupting overactive cell growth signals in cancer cells, which prevents rapid multiplication and allows for more targeted treatment.
    • This approach may be less harmful to healthy tissues compared to conventional cancer treatments, offering a promising direction for targeted cancer therapies.

    Other observations and significance of the species

    • In addition to its traditional uses, Cordyceps militaris is significant for its role in ecological balance, helping control insect populations in forest ecosystems.
    • Advances in research have enabled large-scale studies on cordycepin’s effects, with future studies focusing on derivatives of cordycepin for potentially enhanced anti-cancer properties.
    • The fungus illustrates how natural compounds can contribute to sustainable medical practices, offering less toxic alternatives for disease treatment, especially in oncology.

    PYQ:

    [2019] Recently, there was a growing awareness in our country about the importance of Himalayan nettle (Girardinia diversifolia) because it is found to be a sustainable source of:

    (a) Anti-malarial drug

    (b) Biodiesel

    (c) Pulp for paper industry

    (d) Textile fibre

  • IDF working on new guidelines to treat Type 2 Diabetes

    Why in the News?

    • The International Diabetes Federation (IDF) is developing new Type 2 diabetes treatment guidelines in collaboration with a global expert panel.
      • These guidelines aim to integrate scientific evidence and clinical practice, adapted to the healthcare environment of specific countries.

    What is Type 2 Diabetes?

    • Type 2 Diabetes is a chronic condition where the body becomes resistant to insulin or doesn’t produce enough, leading to high blood sugar levels.
    • It is commonly linked to obesity, physical inactivity and poor diet.
    • Symptoms include increased thirst, frequent urination, fatigue, and blurred vision.
    • Treatment involves lifestyle changes like a healthy diet, regular exercise, and weight management.
      • Medications such as Metformin help regulate blood sugar levels, and in some cases, insulin therapy may be required.

    About International Diabetes Federation (IDF):

    Details
    About
    • Established in 1950; Brussels, Belgium;
    • Members: Over 230 national diabetes associations in 170 countries and territories.
    • Collaborations: Partners with global organizations like the World Health Organization (WHO), UNICEF, and others for global health initiatives.
    • Led by an elected President with the support of a Board of Directors from member countries.
    • Regional offices: Operates regional offices in Africa, Europe, North America, Asia, Latin America, and the Middle East.
    Aims and Objectives
    • To improve the care and lives of people with diabetes and promote its prevention worldwide.
    • Advocacy, research, education, and raising awareness to reduce the global burden of diabetes.
    Key Programs
    • World Diabetes Day (November 14)
    • Global Diabetes Atlas
    • Educational initiatives for healthcare professionals
    Diabetes Types Covered
    • Type 1 Diabetes: Primarily affects children and young adults, where the body’s immune system attacks the insulin-producing cells in the pancreas.
    • Type 2 Diabetes: The most common form, often linked to lifestyle factors and obesity. It involves insulin resistance and eventually pancreas dysfunction.
    • Gestational Diabetes: A type of diabetes that occurs during pregnancy and increases the risk of developing Type 2 diabetes later in life.
    • Other Forms: Covers genetic forms, latent autoimmune diabetes in adults (LADA), and MODY (Maturity Onset Diabetes of the Young).

  • How Röntgen accidentally discovered x-rays & changed the world

    Why in the News?

    On the evening of November 8, 1895, Wilhelm Conrad Röntgen was conducting experiments in his laboratory at the University of Würzburg in Germany when he made an unusual discovery.

     

    Did you know the Röntgen’s discovery story of X-rays?

    • While experimenting with cathode rays in a glass vacuum tube, Röntgen noticed a fluorescent screen glowing at a distance, despite being too far to be affected by the rays he was studying.
    • Intrigued by this unexpected glow, he wondered if this mysterious ray could penetrate organic materials, so he experimented by photographing his wife’s hand, capturing her bones and ring. This was the world’s first recorded X-ray image of the human body.
    • Röntgen documented his findings in an article titled “On a new kind of rays,” in 1895 which was published by introducing “X-rays” to the scientific community.

    How did Röntgen’s discovery transform Medical practices and Diagnostics?

    • Revolution in Diagnostic Medicine: Physicians rapidly adopted X-rays, which allowed them to view the human body without surgery. This was transformative for diagnostics, especially in orthopedics and internal medicine.
    • Surgical Advancements: By February 1896, British physician Major John Hall-Edwards had successfully used X-rays to guide the surgery. Within months, armies began using X-ray technology to locate bullet wounds and diagnose fractures, marking the beginning of its use in trauma care.

    What are the long-term implications of Röntgen’s discovery on Public health and Safety?

    • Development of Radiology: this discovery led to the birth of radiology, with subsequent advancements leading to CT, MRI, ultrasound, and other imaging technologies that are essential in modern medicine.
    • Radiation Safety and Awareness: Initially, x-rays were used liberally, even for non-medical purposes (such as in shoe stores to fit footwear), with little awareness of potential harm. It wasn’t until early reports of radiation burns and later research in the early 20th century that the health risks of radiation exposure were acknowledged, prompting the development of safety protocols.
    • Ongoing Safety Protocols: Today, radiation safety is central to radiology practices. Equipment advancements and regulatory standards have minimized exposure risks, making x-rays safe for patients and medical personnel while ensuring their continued benefits.
    • Public Health and Preventive Care: The ability to detect diseases, fractures, and other internal injuries without invasive procedures has been crucial for preventive care, enabling early detection and treatment. This has significantly impacted patient survival rates and quality of care, solidifying diagnostic imaging as a pillar of modern public health.

    Issues related to X-ray machines in Rural areas:

    • Limited X-ray Equipment: Rural Community Health Centres (CHCs) in India often need more X-ray machines, with only 68% of available units functioning, primarily due to high operational costs and shortages of technicians.
    • Maintenance and Operational Delays: Even when X-ray machines are present, many remain non-functional due to installation delays and insufficient maintenance, as imaging services are not prioritized in CHC guidelines.
    • Access and Specialist Shortages: Rural patients face long travel distances to access imaging services, further limited by a concentration of radiologists in urban areas, reducing timely access to diagnostic interpretation.

    Way forward: 

    • Strengthen Infrastructure and Access: Increase the availability and functionality of X-ray machines in rural areas by improving equipment maintenance, investing in portable and mobile X-ray units to bring diagnostic services directly to underserved populations.
      • For example, Teleradiology enables remote interpretation of images, improving access to diagnostic services.
    • Telemedicine and Remote Diagnostics: Expand telemedicine platforms like ‘XraySetu’, enabling healthcare workers in rural areas to share X-ray images for remote analysis by radiologists, improving diagnostic capabilities without requiring patients to travel long distances.

    Mains PYQ:

    Q Appropriate local community level healthcare intervention is a prerequisite to achieve ‘Health for All’ in India. Explain. (UPSC IAS/2018)

  • How Vitamin D deficiency can trigger autoimmune conditions?

    Why in the News?

    Recent research conducted by scientists at McGill University has shed light on the critical role of vitamin D in maintaining thymus health and its implications for immune function.

    About Autoimmune Conditions:

    • Autoimmune conditions refer to disorders where the immune system mistakenly attacks the body’s own healthy tissues, viewing them as foreign.
    • Vitamin D plays a role in regulating immune responses and promoting immune tolerance—the body’s ability to avoid attacking its own cells.
    • It influences T-cells (a type of immune cell) to recognize and tolerate the body’s own tissues rather than attacking them.
    • The thymus gland trains T-cells to avoid attacking healthy cells. A deficiency in Vitamin D may cause the thymus to age prematurely, reducing its ability to regulate T-cells properly.
      • Vitamin D affects certain genetic pathways related to immune function.
      • Variations in the vitamin D receptor (VDR) gene may also predispose some individuals to autoimmune diseases, and these individuals might be more sensitive to Vitamin D levels.

    What is Vitamin D?

    • Vitamin D is a fat-soluble vitamin crucial for the body’s ability to absorb calcium, magnesium, and phosphate, which are essential for bone health.
    • It supports muscle movement, nerve function, and immune system responses. Due to its synthesis in the skin upon exposure to sunlight, it is often called the ‘sunshine vitamin’.
    • The body naturally produces Vitamin D when skin is exposed to ultraviolet B (UVB) rays from sunlight.
    • Sources of Vitamin D:
      • Fish: Salmon, mackerel, tuna, and sardines are rich in Vitamin D.
      • Cod liver oil: A concentrated source, providing 400–1,000 IU per teaspoon.
      • Mushrooms: Varieties like portobello contain Vitamin D if exposed to UV light.
      • Fortified Foods: Milk, yogurt, orange juice, and cereals often have added Vitamin D.
      • Egg yolks: Contain a small amount of Vitamin D.
      • Common forms include Vitamin D2 (ergocalciferol) and Vitamin D3 (cholecalciferol), especially useful in autumn and winter when sunlight exposure is limited.

    Significance of Vitamin D

    • Bone Health: Essential for calcium absorption, which strengthens bones and prevents osteoporosis.
    • Muscle and Nerve Function: Supports muscle contractions and nerve signaling between the brain and body.
    • Immune System: Enhances immune defenses, helping to fight off infections by viruses and bacteria.
    • Brain Health: May play a role in maintaining cognitive health, especially with aging.
    • Inflammation and Pain: Helps regulate the body’s response to inflammation and pain.
    • Blood Pressure: Linked to regulating blood pressure; deficiency is associated with hypertension.

    Impacts of Vitamin D Deficiency

    • Increases the risk of rickets in children (softening of bones) and osteoporosis in adults.
    • Low levels of Vitamin D are linked to autoimmune conditions like rheumatoid arthritis, lupus, and multiple sclerosis.
    • Recent studies indicate that Vitamin D deficiency can accelerate thymus aging, leading to immune dysfunction and a higher risk of autoimmune diseases.
    • Deficiency has been associated with cancer, cardiovascular disease, diabetes, depression, and chronic pain.
    • Can include fatigue, muscle weakness, bone pain, and depression.
    • In severe cases, deficiency may cause impaired bone growth and fracture susceptibility.

    PYQ:

    [2011] Regular intake of fresh fruits and vegetables is recommended in the diet since they are a good source of antioxidants. How do antioxidants help a person maintain health and promote longevity?

    (a) They activate the enzymes necessary for vitamin synthesis in the body and help prevent vitamin deficiency.

    (b) They prevent excessive oxidation of carbohydrates, fats and proteins in the body and help avoid unnecessary wastage of energy.

    (c) They neutralize the free radicals produced in the body during metabolism.

    (d) They activate certain genes in the cells of the body and help delay the ageing process.

  • Assessing India’s Tuberculosis burden

    Why in the News?

    The Global Tuberculosis Report 2024 presented by WHO indicates that India recorded the highest burden of tuberculosis (TB) in 2023.

    Current Scope of Tuberculosis in India

    • High Burden: According to the Global Tuberculosis Report 2024, India accounts for 26% of all tuberculosis (TB) cases worldwide, making it the country with the highest TB burden. The report indicates that over 55.9% of global TB cases are concentrated in five countries: India, Indonesia, China, the Philippines, and Pakistan.
    • Mortality Rates: Although TB deaths in India have decreased from 580,000 in 2010 to 320,000 in 2023, the country still accounted for 26% of global TB deaths among people with and without HIV in 2023.
    • Incidence Trends: The incidence of TB has decreased from 275.7 cases per 100,000 population in 2010 to 194.9 cases in 2023. However, there has been a notable increase in notified TB relapse cases, reaching the highest level since 2010.
    • Risk Factors: Individuals with nutritional deficiencies, diabetes, and smoking habits are at the highest risk of contracting TB. The prevalence of TB infection among individuals aged 15 and older is reported at 31.4%, according to the National TB Prevalence Survey conducted from 2019-2021.
    • Preventive Treatment Uptake: The number of people receiving preventive treatment has been rising, indicating an increased focus on preventing TB progression among high-risk populations.

    Strategies and Programs Implemented by Govt to Reduce TB Incidence

    • National Tuberculosis Elimination Program (NTEP): This program aims to eliminate TB by 2025 through various strategies including early diagnosis, treatment support, and preventive measures.
    • TB Preventive Therapy (TPT): The introduction of TPT marks a significant shift in TB care in India. It focuses on providing preventive treatment to individuals at high risk of developing active TB.
    • Project Axshya Plus: Launched with support from the Global Fund, this project implements comprehensive interventions such as contact tracing, testing for infection, and managing latent TB infections.
    • Increased Funding: Domestic funding for TB prevention and treatment increased by 38% in 2023 to $253 million, although international funding has declined during the same period.
    • Community Engagement Initiatives: Programs like the Pradhan Mantri TB Mukt Bharat Abhiyan encourage community involvement in supporting TB patients through initiatives like Ni-kshay Mitras.
    • Digital Health Initiatives: The NTEP leverages digital platforms for monitoring patient progress and ensuring adherence to treatment protocols through tools like the Nikshay portal.
    • Awareness Campaigns: Public health campaigns aim to reduce stigma associated with TB and educate communities about prevention and treatment options.

    Challenges India Faces in Eliminating Tuberculosis by 2025

    • Funding and Infrastructure Gaps: Despite increases in domestic funding, overall financial resources remain lower than pre-COVID levels, impacting program implementation and outreach efforts.
      • Inadequate healthcare infrastructure, particularly in rural areas, hampers access to timely diagnosis and treatment for many patients.
      •  The COVID-19 pandemic disrupted TB services significantly, leading to a backlog of undiagnosed cases and impacting ongoing treatment programs.
    • Stigma and Discrimination: Stigma associated with TB continues to deter individuals from seeking diagnosis and treatment, which can lead to delayed care and increased transmission rates.
      • Social determinants such as poverty, malnutrition, and living conditions contribute to higher susceptibility to TB among vulnerable populations.
    • Drug Resistance Issues: The rise of drug-resistant strains of TB poses significant challenges for effective treatment and control strategies.
    • Multi-sectoral Coordination Challenges: Effective elimination requires collaboration across various sectors (healthcare, education, social services), which can be challenging due to bureaucratic hurdles.

    Way forward: 

    • Strengthening Multi-Sectoral Coordination: There is a need to foster collaboration among healthcare, education, and social services to address the social determinants of TB.
    • Enhancing Accessibility and Outreach: Need to improve access to TB diagnosis and treatment in rural areas by investing in healthcare infrastructure, training local health workers, and implementing mobile health units.

    Mains PYQ: 

    Q Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved. (2014)

  • The Gompertz Model

    Why in the News?

    Indian researchers have developed a predictive model based on the Gompertz Model to estimate a newborn’s birth weight using routine pregnancy scans.

    What is the Gompertz Model?

    • It is a mathematical model developed by English mathematician Benjamin Gompertz in the early 19th century.
      • It was originally designed to model population growth in a constrained environment, such as a specific geographic region.
      • The model uses an S-shaped (sigmoid) curve to represent growth patterns that start slowly, accelerate, and then slow again as they approach a plateau.
    • Applications:
      • Biology: The Gompertz Model is used to study tumor growth and cell population dynamics, reflecting constrained growth in biological systems.
      • Epidemiology: Applied in predicting the spread of infectious diseases like COVID-19, capturing how transmission rates slow with interventions.
      • Ecology: Useful for modelling species population growth in habitats with limited resources, aiding conservation and ecosystem management.
      • Healthcare: Recently adapted to predict foetal birth weight, helping identify potential risks associated with low or high birth weight.
      • Aging Research: Employed to analyze mortality rates and lifespan patterns, contributing to studies on aging and longevity.

    Recent Research and Significance

    • Recent research has applied the Gompertz Model in predicting foetal birth weight using routine scans, as shown by researchers from IISER Pune and IMSc Chennai, offering a non-invasive alternative for maternal health.
    • The model is used in tumor growth studies, allowing researchers to understand and predict cancer progression.
    • Its predictive accuracy under constrained conditions makes it useful for biological systems, including population growth and cell dynamics.
    • In healthcare, it supports early detection and intervention for conditions impacted by growth patterns, such as low or high birth weight risks.

  • Sleep Apnea contributes to Dementia in older adults

    Why in the News?

    A recent study from Michigan Medicine found that Obstructive Sleep Apnea (OSA), a common sleep disorder, increases the risk of dementia (loss of cognitive functioning) in adults, especially in women.

    What is Obstructive Sleep Apnea (OSA)?

    • OSA is a sleep disorder where breathing repeatedly stops and starts during sleep due to blocked airways.
    • It is marked by episodes of disrupted or restricted breathing, leading to brief awakenings throughout the night.
    • Symptoms include loud snoring, gasping for air, morning headaches, and daytime drowsiness.
    • Risk Factors: Common in individuals who are overweight, have large tonsils or suffer from nasal congestion.
      • In India, approximately 10.4 lakh people are reported to suffer from OSA, as per government data.
      • Untreated OSA is associated with various health risks, including heart disease, diabetes, and cognitive decline.

    Recent Findings on OSA and Dementia Risk

    • A study from Michigan Medicine found a link between OSA and increased dementia risk, especially in older adults over 50.
      • Women with known or suspected OSA were found to have a higher likelihood of developing dementia compared to men, with dementia diagnoses increasing as women age.
    • Another study by NIMHANS focused on the link between stroke and OSA.
      • 105 stroke patients over the age of 50 were studied using polysomnography (PSG), which tracks brain waves and sleep breathing patterns.
      • Results showed that 88% of stroke patients had sleep apnea soon after their stroke, with 38% having severe OSA.

  • What is Chronic Wasting Disease (CWD)?

    What is Chronic Wasting Disease (CWD)?

    Why in the News?

    A case of Chronic Wasting Disease (CWD) was confirmed in the US.

    About Chronic Wasting Disease (CWD)

    • CWD is a fatal, transmissible disease that affects the brain and central nervous system of deer, elk, and moose.
    • First identified in 1967, CWD is a prion disease where normal proteins misfold, leading to symptoms that eventually cause death.
    • Transmission occurs through animal-to-animal contact or contamination of feed or water by infected saliva or bodily waste.
    • Environmental contamination can occur through soil exposure from infected carcasses or bodily fluids.
    • High-risk areas include places where deer and elk gather closely, like feeding or watering sites.
    • Species affected: CWD does not naturally infect cows, other livestock, or pets.
    • Although no strong evidence exists that it can spread to humans, officials advise against eating meat from infected animals.

    Symptoms of CWD:

    • Symptoms: Drastic weight loss, lack of coordination, drooling, listlessness, and excessive thirst. Infected animals may also show drooping ears and lose their fear of humans.
      • Prevention: To prevent the spread of CWD, avoid handling or eating sick animals, use synthetic lures, dispose of carcass waste in landfills, and report any sick or unusual deer to local wildlife authorities.

    PYQ:

    [2012] Vultures which used to be very common in Indian countryside some years ago are rarely seen nowadays. This is attributed to:

    (a) The destruction of their nesting sites by new invasive species

    (b) A drug used by cattle owners for treating their diseased cattle

    (c) Scarcity of food available to them

    (d) A widespread, persistent and fatal disease among them

  • How Tardigrades are able to resist high levels of radiation?

    Why in the News?

    • A team of researchers has discovered the genetic mechanisms that allow a newly identified tardigrades species—Hypsibius henanensis—to withstand high levels of radiation.

    About Tardigrades

    • Tardigrades, often called “water bears” or “moss piglets,” are tiny, water-dwelling microorganisms known for their remarkable ability to survive extreme conditions.
    • They can withstand environments that would be lethal for most life forms, including:
      • Extremely high and low temperatures (from near absolute zero to over 150°C),
      • High levels of radiation and vacuum conditions found in space,
      • Extreme dehydration (losing nearly all water in their bodies),
      • High pressures (up to six times that of the ocean’s deepest trenches).
    • This adaptability makes them a subject of interest for scientists, especially in understanding survival mechanisms in extreme conditions.

    How Tardigrades resist High Radiations?

    The researchers identified 2,801 genes involved in DNA repair. Three key factors contributing to radiation tolerance include:

    • DNA Repair Protein (TRID1): Enabled the species to repair double-strand DNA breaks due to radiation.
    • Gene Activation for Mitochondrial Proteins: Radiation exposure activated a gene that produced two proteins vital for mitochondrial synthesis and DNA repair.
    • Antioxidant Pigments (Betalains): These pigments neutralize harmful chemicals generated by radiation within cells.