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Subject: Biotech and Medical Sciences

  • Reverse Vaccinology and its benefits

    The Tamil Nadu Dr. MGR Medical University has developed a vaccine candidate against SARS-CoV-2 through ‘reverse vaccinology’.

    A definition based prelims question can be expected on Reverse Vaccinology. Ex. Which of the following statements best describes ‘Reverse Vaccinology’?

    Reverse Vaccinology

    • Reverse vaccinology is an improvement on vaccinology that employs applied bioinformatics.
    • The basic idea behind it is that an entire pathogenic genome can be screened using bioinformatics approaches to find genes.
    • Some traits that the genes are monitored for may indicate antigenicity.
    • Those genes are filtered for desirable attributes that would make good vaccine targets such as outer membrane proteins.
    • Once the candidates are identified, they are produced synthetically and are screened in animal models of the infection.
    • Since then, it has been used on several other bacterial vaccines.

    Benefits

    • Earlier researchers had to do a viral culture in the laboratory to develop a vaccine, and this was time-consuming.
    • The major advantage for reverse vaccinology is finding vaccine targets quickly and efficiently.
    • Traditional methods took decades to unravel pathogens and antigens, diseases and immunity
    • With ‘reverse vaccinology’ scientists know what molecules make the genomic sequence.

  • Anastomosis surgery for re-implantation

    The chopped off-hand of a Punjab Police officer has been successfully re-implanted after hours of surgery.

    Anastomosis is a general term in surgical sciences used to join amputated limbs or organs. The term has made headline due to its recent application. A piece of general information regarding novelties of medical sciences should be known to the aspirants.

    Anastomosis Surgery

    • A surgical Anastomosis is a surgical technique used to make a new connection between two body structures that carry fluid, such as blood vessels or bowel.
    • It involves conjoining various parts of the arm and the hand — bones, muscles, tendons, arteries, veins as well as nerves.
    • Both radial and ulnar arteries, accompanying nerves and the dorsal vein were anastomosed successfully, allowing for the hand to receive adequate circulation.
    • The bones are attached using K wires (used for orthopaedic surgery) which can be removed once the bones conjoin organically.

    In which cases is re-implantation possible?

    • When a surgeon makes that decision, the factors that he or she considers include how much time has elapsed since the injury.
    • The condition of the severed organ and the nature of the injury are also taken into account.

    Can a reattached hand get its function restored?

    • That is the goal of doing such surgery. The extent of restored function, however, can vary from case to case.
    • While a successful surgery can result in the good return of motor function, studies have shown that sensory recovery can often be poor.
    • Whether the blood circulation is optimum after surgery can only be observed within the next few days.
    • The patient also needs to attend regular physiotherapy sessions for total restoration of motor movement and sensation in his hand.

  • Covid-19: Software vendors focus on big data, AI despite fall in IT spending

    The article discusses how COVID-19 has prompted the software companies to focus on technologies that are still in demand. The IT companies have started to focus on ways to leverage the potential of AI and the Big data to deal with the pandemic.

    Impact on IT companies and how they are planning to cope with it?

    • Fall in spending: Spending on information technology (IT) globally is expected to shrink by 3-4% by the end of 2020.
    • Impact: That would have a severe impact on hardware and slowdown in the software and service businesses.
    • How companies are planning to deal with the situation? Software vendors such as IBM, SAP Software Solutions and Microsoft Corporation plan to make use of emerging technologies to become more relevant to their customers.
    • IBM has created an AI platform ‘Watson Assistant for Citizens’ on its public cloud.
    • The platform helps citizens understand and respond to common questions about covid-19, commonly known as the novel coronavirus.
    • While the ongoing pandemic is having a dreadful impact on companies at scale, matured ones are taking a pause and rethinking their analytics approach.
    • Using data analysis to prepare contingency plan: Data science teams are being called into action to crunch petabytes of data and build best business models on trusted data for decision-makers to quickly prepare contingency plans.
    • This is where we are seeing enterprises using AI, machine learning, and natural language processing to mine the data and build predictive or prescriptive models in IBM Cloud Pack for Data.

    UPSC could ask question connecting the use of IT and its potential to deal with the pandemics. And it could also be other way round you can cite the example of use of IT in the health sector.

    Adoption of the AI by various sectors

    • The government and public service agencies as well as healthcare and research companies urgently need AI solutions and analytics as they are in a race to find a treatment for the deadly disease.
    • Other industries with high end-user touch-points like banks, insurance, retail, etc. are also in urgent need to use AI/ML-driven analytics and cognitive technologies to automate their communications, streamline predictions, decision making, etc.

    AI and Big data could be a game-changer across the various sectors, health being one of them. As among the buzzwords in technologie today UPSC could ask about AI and Big data.

    Covid-19 as an opportunity for the IT industry

    • The covid-19 crisis is an opportunity for IT vendors to build and improve on their capabilities on AI and big data.
    • Leveraging AI: They are also keeping an eye on emerging uses cases in AI for disease detection, tracking, and prevention.
    • Relatively smaller companies are also launching dedicated AI-based apps to assist people amid the covid-19 crisis.
    • Eka Software Solutions recently released ‘COVID-19 Risk Monitoring’, it help customers quickly gain visibility in supply chain risks by showing a company’s contract position across countries with reported cases of the virus.
    • Based on company data, the app instantly visualises contracts at risk and provides businesses with the ability to identify alternate suppliers to maintain business continuity.

    Conclusion

    As the epidemic is far from being tamed, various sectors are likely to feel the existential crisis and IT could be one of them. But they can also turn this crisis into an opportunity by leveraging the AI and Big data in tackling the epidemic at various levels.

  • What is Contact Tracing Technology?

    Global technology giants Apple and Google have announced that they are partnering on developing contact tracing technology to help governments and health authorities tackle the novel coronavirus pandemic.

    What did tech-giants announce?

    • Contact tracing is considered essential for bringing epidemics under control and is expected to help governments in relaxing lockdown orders.
    • The tech companies announced that they would build a comprehensive solution that includes application programming interfaces (APIs) and operating system-level technology to assist in enabling contact tracing.

    What is contact tracing?

    • The WHO defines contact tracing as the process of identifying, assessing, and managing people who have been exposed to a disease to prevent onward transmission.
    • Via contact tracing, people who have come into contact with a person carrying a disease are alerted and identified.

    Importance of contact tracing

    • Identifying people at the onset of symptoms and promptly isolating them reduces exposure to other persons, preventing subsequent EVD (Ebola Virus Disease) infections.
    • Additionally, prompt isolation and admission of the symptomatic person to a treatment facility decreases the delay to supportive treatment, which improves the likelihood of survival.

    How will the new technology by Google and Apple work?

    • Google and Apple are the developers of the Android and iOS platforms respectively, which together power most of the world’s smartphones.
    • Both companies will release application programming interfaces (APIs) that would enable interoperability between Android and iOS devices using apps from public health authorities.
    • The official apps will be available for users to download via their respective app stores, as per the press release.
    • When this step is realized, phone-based matching via official apps will help alert people if they have come in contact with someone diagnosed with COVID-19.

    Actual working

    • For this to work, COVID-19 patients would have to declare their status to the respective apps voluntarily.
    • Following this, all people whose Android/iOS smartphones were detected nearby such patients, would get notified.
    • This means the user will be notified even if he/she was around a stranger who has tested positive for the disease.

    Issues with contact tracing

    • Privacy, transparency, and consent are of utmost importance in this effort.
    • The tech giants should look forward to building this functionality in consultation with interested stakeholders.

    Note: How is our Aarogya Setu app different from the technology mentioned in the newscard?

  • Zoonotic Diseases: Medical Sciences Involved & Preventive Measures

  • Covid-19 Quarantine Alert System (CQAS)

    The Department of Telecommunications (DoT) has shared a Standard Operating Procedure (SOP) with all telecom service providers regarding the application called COVID-19 Quarantine Alert System (CQAS).

    • CQAS collects phone data, including the device’s location, on a common secured platform and alerts the local agencies in case of a violation by COVID patients under watch or in isolation.

    Quarantine Alert System (CQAS)

    • Developed By: The DoT and the Centre for Development of Telematics (C-DOT), in coordination with telecom service providers, have developed and tested the application.
    • Working: The CQAS prepares a list of mobile numbers, segregates them on the basis of telecom service providers, and the location data provided by the telecom companies are run on the application to create geo-fencing.
    • Geo-fencing is a location-based service in which an app or other software uses GPS, RFID, Wi-Fi or cellular data to trigger a pre-programmed action when a mobile device or RFID tag enters or exits a virtual boundary set up around a geographical location, known as a geofence.
    • Geo-fencing will only work if the quarantined person has a mobile phone from Airtel, Vodafone-Idea or Reliance Jio, as “BSNL/MTNL” do not support location-based services. BSNL and MTNL are government-owned.
    • The location information is received periodically over a secure network for the authorised cases with “due protection of the data received”.
    • The System triggers e-mails and SMS alerts to an authorised government agency if a person has jumped quarantine or escaped from isolation, based on the person’s mobile phone’s cell tower location. The “geo-fencing” is accurate by up to 300 m.

    Use of Powers under the Indian Telegraph Act, 1885

    • The Centre is using powers under the Indian Telegraph Act to “fetch information” from telecom companies every 15 minutes to track COVID-19 cases across the country.
    • The States have been asked to seek the approval of their Home Secretaries under the provisions of Section 5(2) of the Indian Telegraph Act, 1885, for the specified mobile phone numbers to request the DoT to provide information by email or SMS in case of violation of “geo-fencing”.
    • Section 5(2) authorises State or Centre to access information of a user’s phone data in case of “occurrence of any public emergency or in the interest of the public safety.”

    Protection of Data

    • As per the SOP, the phone number should be deleted from the system after the period for which location monitoring required is over and the data would be deleted four weeks from thereon.
    • The data collected shall be used only for the purpose of Health Management in the context of COVID-19 and is strictly not for any other purposes. Any violation in this regard would attract penal provisions under the relevant laws.

    Centre for Development of Telematics

    • C-DOT was established in August 1984 as an autonomous Telecom R&D Centre of DoT.
    • It is a registered society under the Societies Registration Act, 1860.
    • It is a registered ‘public-funded research institution’ with the Department of Scientific and Industrial Research, Ministry of Science & Technology.

    Global Positioning System

    • The Global Positioning System is a Global Navigation Satellite System (GNSS), used to determine the ground position of an object.
    • It is a US-owned utility that provides users with Positioning, Navigation, and Timing (PNT) services.

    Radio-Frequency Identification

    • Radio-Frequency Identification (RFID) is the use of radio waves to read and capture information stored on a tag attached to an object.
    • A tag can be read from up to several feet away and does not need to be within the direct line-of-sight of the reader to be tracked.

    Wi-Fi

    • Wi-Fi is the name of a wireless networking technology that uses radio waves to provide wireless high-speed Internet and network connections.
    • WiFi network enables a connection between two or more devices wirelessly for data sharing purposes.

  • Sodium Hypochlorite as Coronavirus disinfectant

    In Uttar Pradesh, migrant workers travelling to their home states, or their belongings, were sprayed with a disinfectant, apparently to sanitise them.  The chemical in the spray was a sodium hypochlorite solution.

    Sodium hypochlorite

    • Sodium hypochlorite is commonly used as a bleaching agent, and also to sanitise swimming pools.
    • As a common bleaching agent, sodium hypochlorite is used for a variety of cleaning and disinfecting purposes.
    • It releases chlorine, which is a disinfectant. Large quantities of chlorine can be harmful.
    • The concentration of the chemical in the solution varies according to the purpose it is meant for.
    • A normal household bleach usually is a 2-10% sodium hypochlorite solution.
    • At a much lower 0.25-0.5%, this chemical is used to treat skin wounds like cuts or scrapes. An even weaker solution (0.05%) is sometimes used as a handwash.

    Note: The common bleaching powder is chemically referred to as Calcium hypochlorite and not Sodium hypochlorite.

    Is the chemical safe?

    • Sodium hypochlorite is corrosive and is meant largely to clean hard surfaces.
    • It is not recommended to be used on human beings, certainly not as a spray or shower. Even a 0.05% solution could be very harmful for the eyes.
    • A 1% solution can cause damage to the skin of anyone who comes in contact with it.
    • If it gets inside the body, it can cause serious harm to lungs.

    Does the chemical get rid of the novel coronavirus?

    • The WHO recommends homemade bleach solutions of about 2-10% concentration to clean hard surfaces to clear them of any presence of the novel coronavirus.
    • Cleaning hard surfaces with this solution can disinfect them not just from novel coronavirus but also help prevent flu, food born illnesses, and more.

  • Convalescent Plasma Therapy

    With no specific treatment available for novel coronavirus disease and a vaccine at least a year away, the US Food and Drug Administration (FDA) has approved use of blood plasma from recovered patients to treat severely critical COVID-19 patients.

    Convalescent Plasma Therapy

    • The therapy seeks to make use of the antibodies developed in the recovered patient against the coronavirus.
    • The whole blood or plasma from such people is taken, and the plasma is then injected in critically ill patients so that the antibodies are transferred and boost their fight against the virus.
    • A COVID-19 patient usually develops primary immunity against the virus in 10-14 days.
    • Therefore, if the plasma is injected at an early stage, it can possibly help fight the virus and prevent severe illness.

    How often has it been used in the past?

    • This therapy is no new wonder. It has been used several times.
    • The US used plasma of recovered patients to treat patients of Spanish flu (1918-1920).
    • In 2014, the WHO released guidelines to treat Ebola patients with convalescent whole blood and plasma.
    • In 2015, plasma was used for treating MERS patients.

    How is it done?

    • The process to infuse plasma in a patient can be completed quickly.
    • It only requires standard blood collection practices, and extraction of plasma.
    • If whole blood is donated (350-450 ml), a blood fractionation process is used to separate the plasma.
    • Otherwise, a special machine called aphaeresis machine can be used to extract the plasma directly from the donor.
    • While blood is indeed extracted from the donor, the aphaeresis machine separates and extracts the plasma using a plasma kit, and the remaining blood components are returned into the donor’s body.

    WHO’s guidelines

    • WHO guidelines in 2014 mandate a donor’s permission before extracting plasma.
    • Plasma from only recovered patients must be taken, and donation must be done from people not infected with HIV, hepatitis, syphilis, or any infectious disease.
    • If whole blood is collected, the plasma is separated by sedimentation or centrifugation, then injected in the patient.
    • If plasma needs to be collected again from the same person, it must be done after 12 weeks of the first donation for males and 16 weeks for females, the WHO guidelines state.

    How optimistic is the latest move?

    • COVID-19 does not have a specific treatment, only supportive care— including antiviral drugs, oxygen supply in mild cases and extracorporeal membrane oxygenation.
    • Plasma can be infused into two kinds of COVID-19 patients— those with a severe illness, or individuals at a higher risk of getting the virus.
    • However, that while plasma transfers immunity from one person to another, it is not known if it can save lives in COVID-19 infection.
    • The treatment could be effective for patients in the age group 40-60, but may be less effective for people aged beyond 60 years.

    Can it be done in India?

    • India has facilities for removing 500 ml of plasma from a donor using aphaeresis.
    • For this experimental therapy to be tried out, the Drug Controller General of India will first have to grant blood banks approval for removal of plasma from recovered COVID-19 patients.
    • The procedure is simple and can be done in India, but it is important to control the risk of infection during transfusion, and the patient’s acceptance is required.
    • It’s like a vaccine. It will engulf the virus and kill it. But it is easier said than done. We may need a series of approvals which India has never done before.

  • Indian Scientists’ Response to CoViD-19 (ISRC) Group

    Several Indian scientists have come together to form a Google group to address some of the concerns that the COVID-19 outbreak has thrown up.

    Indian Scientists’ Response to CoViD-19 (ISRC)

    • It is a voluntary group of scientists who regularly discuss the rapidly evolving situation with its dire need for science communication.
    • With nearly 200 members, the group has scientists from institutions such as the NCBS, the IISc, the TIFR, the IITs, the IISERs and many others.
    • The group aims to study existing and available data to bring out analyses that will support the Central, State and local governments in carrying out their tasks.

    Self-assigned tasks

    • Several working groups have been formed by scientists.
    • They include one on hoax busting to address disinformation spreading with respect to the coronavirus and one on science popularization to develop material that explains concepts such as home quarantine.
    • Other groups work on resources in Indian languages, mathematical models and apps.

    Why such a group?

    • The scientific community has realized their social and democratic responsibility in the current situation, both in terms of analysing the situation and reaching out to the public.

  • Serological test for COVID-19

    The ICMR invited bids for an estimated 10 lakh antibody kits (for serological tests) for the diagnosis of COVID-19.

    What are serological tests?

    • Viral infections are mainly identified by two kinds of tests– genetic and serological.
    • Genetic tests can identify infections that are active but cannot be used to detect past infections.
    • To trace how infections like the novel coronavirus have spread so far, it is important to detect people who contracted the disease in the past and have recovered.
    • This is what serological tests seek to determine.

    How are the two different?

    • The genetic test is conducted on a swab collected from the back of the throat, a liquid sample from the lower respiratory tract, or a simple saliva sample.
    • For SARS-COV-2, the virus’s RNA is first converted into DNA.
    • By a process called polymerase chain reaction (PCR), DNA fragments in the sample are copied exponentially — one is copied into two, the two are copied into four, and so on.
    • Unlike genetic tests, which look for RNA in swab samples, serological tests work on antibodies in blood samples. Hence, they are also called ‘antibody tests’.

    How serological tests work?

    • Antibodies, or protective proteins produced by the immune system to neutralize pathogens such as bacteria and viruses, are present in one’s bloodstream for a considerable period of time after the infection has gone.
    • To disable a pathogen, the antibody latches to a unique protein molecule on pathogen’s surface, called an antigen.
    • Serological tests use antigen molecules to detect the presence of antibodies relevant to the infection.
    • Generally, a blood sample is placed in a test tube that is lined with antigens on the inside. If the relevant antibodies are present, they latch on to the antigens.
    • Such tests are relatively inexpensive, and can display results within a few minutes.