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Subject: Science and Technology

  • Lifting Off, Reaching a New Space Milestone

    Why in the News:

    Skyroot Aerospace’s Vikram-1 successfully reached orbit, becoming the first India based private company to independently develop and launch an orbital rocket. With this achievement, India joins the United States and China as the only countries where a private company has achieved an orbital launch, six years after opening the space sector to private participation.

    What does the Vikram-1 launch signify about India’s position in the global private space sector?

    1. Exclusive club: India becomes only the third country after the United States and China where a private company has independently developed and launched an orbital rocket.
    2. Policy milestone: The achievement follows the 2020 space sector reforms, later institutionalised through the Indian Space Policy, 2023, which enabled greater participation by private players.
    3. Expanding ecosystem: India now has around 400 space start ups working across the space value chain, including launch vehicles, satellites, space electronics, and downstream applications.
    4. Growth potential: India’s space sector is valued at around Rs 70,000 crore, with the government projecting four to five times growth over the next decade.

    Why does the launch matter specifically for Low Earth Orbit (LEO), and what does that free ISRO to do?

    1. Emerging commercial market: The rapid increase in small satellites weighing from a few kilograms to a few hundred kilograms has created a fast growing commercial launch market, beyond the capacity of any single national space agency.
      • Term: Low Earth Orbit (LEO): The region of space located approximately 160 km to 2,000 km above Earth’s surface, where most modern communication, Earth observation, and small satellite missions operate.
    2. Division of responsibilities: As private companies undertake commercial satellite launches, ISRO can increasingly focus on high value scientific and strategic missions such as Chandrayaan, Gaganyaan, and future deep space exploration programmes.

    Does private launch capability mean independence from ISRO, or a different kind of dependency?

    1. Continued role of ISRO: The development of Vikram-1 relied significantly on ISRO’s infrastructure, testing facilities, and ecosystem, demonstrating a public private partnership model rather than complete private independence.
    2. India’s distinct model: Unlike the United States, where companies such as SpaceX independently develop technologies before partnering with NASA, India’s private space sector is expected to remain closely linked with ISRO for the foreseeable future.
    3. Competitive advantage: Indian companies like Skyroot Aerospace are expected to compete globally by leveraging India’s strengths in cost effective engineering, frugal innovation, and efficient manufacturing.
    4. Commercial challenges: The failures of companies such as Vector Launch and Virgin Orbit highlight the high financial risks and competitive nature of the commercial launch industry.

    Conclusion:

    The successful launch of Vikram-1 marks a major milestone in India’s transition towards a vibrant private space ecosystem, demonstrating the impact of the 2020 space reforms and the Indian Space Policy, 2023. While the achievement reflects the growing capability of Indian private industry, it also underscores the continuing importance of ISRO’s institutional support. Going forward, the long term success of India’s private space sector will depend on its ability to build commercially sustainable business models, expand global launch services, and strengthen public private collaboration in an increasingly competitive global space economy.

  • India Approves First Dengue Vaccine (QDENGA)

    Why in News?

    India has approved its first dengue vaccine, QDENGA (TAK-003), developed by Takeda Biopharmaceuticals, after receiving market authorization from the Drug Controller General of India (DCGI).

    Key Highlights

    • First dengue vaccine approved in India.
    • Approved for individuals aged 4 to 60 years.
    • Type: Live attenuated tetravalent vaccine.
    • Protects against all four dengue virus serotypes (DENV-1, DENV-2, DENV-3, DENV-4).
    • Dosage: Two doses administered 3 months apart.
    • Can be given irrespective of previous dengue infection.
    • No pre-vaccination screening is required.

    Clinical Performance

    • Based on 19 Phase I, II and III clinical trials involving over 28,000 participants.
    • Phase III (TIDES) trial enrolled 20,000+ participants across eight dengue-endemic countries.
    • 80.2% efficacy against confirmed dengue (12 months after second dose).
    • 90.4% efficacy against dengue-related hospitalization (18 months).
    • Long-term studies showed sustained protection for up to 7 years.

    Global Status

    • Approved in 43 countries.
    • WHO recommends its use in high dengue transmission settings.
    • Received WHO prequalification.
    • Included in the national immunization programmes of Brazil and public programmes in Argentina, Colombia, and Indonesia.

    About Dengue

    • Cause: Dengue virus (Flavivirus).
    • Vector: Female Aedes aegypti mosquito (also Aedes albopictus).
    • Transmission: Mosquito-borne (not spread directly from person to person).
    • Symptoms: High fever, severe headache, muscle and joint pain, skin rash, and bleeding in severe cases.
    • Severe Form: Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS).

    [2023] ‘Wolbachia method’ is sometimes talked about with reference to which one of the following?

    [A] Controlling the viral diseases spread by mosquitoes.

    [B] Converting crop residues into packing material.

    [C] Producing biodegradable plastics.

    [D] Producing biochar from thermo- chemical conversion of biomass

  • Making Sense of Embodied AI: The Next Frontier in Robotics

    Why in the News?

    On April 14, Boston Dynamics and Google DeepMind gave Spot, a robot dog long confined to scripted routines, an AI brain (Gemini Robotics-ER 1.6). This revived global interest in “embodied AI” as robots moved from labs into real-world settings such as the FIFA World Cup 2026 football field and America’s Got Talent. This has sharpened the debate over whether robotic intelligence is fundamentally a software problem or one rooted in the physical body itself.

    What does ’embodied AI’ actually mean, and why is intelligence not just software placed in a robot body?

    1. Definition: Embodied AI is a paradigm of artificial intelligence where algorithms are integrated into physical systems (such as humanoid robots, robotic arms, and autonomous vehicles) to perceive, learn from, and interact with the physical world through sensory motor control.
    2. Body as computation, not container: Researchers argue a robot’s body is not merely a delivery mechanism for intelligence but part of the computation itself. This claim is advanced by Rolf Pfeifer (Zurich) and Josh Bongard (Vermont) in How the Body Shapes the Way We Think.
    3. Subsumption architecture: Rodney Brooks showed in the late 1980s-90s that layered reflexes coupled directly to sensors and motors can produce robust real-time behaviour without any internal world-model. This challenged the dominant symbolic-AI paradigm of the time.
    4. Morphological computation: Physical body structure offloads work that would otherwise require a brain. A passive-dynamic walker descends a slope using only leg geometry, with no motors or control system.
    5. Adaptive material design: A soft, compliant robotic hand grips oddly shaped objects without an explicit shape model, because the material itself deforms and adapts.
    6. Common thread: Across Pfeifer’s lab, Brooks’s robots, and today’s humanoids, intelligence is distributed between brain, body, and environment, not confined to one part.

    Why does mastering the physical world remain far harder for AI than mastering language and images?

    1. Different learning problem: Unlike chatbots trained on text, images, and video, embodied AI must master gravity and balance across countless physical scenarios a robot may face.
    2. Simulation-to-real gap: Success in simulation rarely translates perfectly to the real world, since simulated environments cannot capture every physical contingency.
    3. Market-performance mismatch: The embodied AI market is projected to reach $23 billion by 2030, yet most humanoid robots still run only about 90 minutes on a charge.
    4. Lab-to-field performance drop: Policies that succeed 95% of the time in the lab drop to roughly 60% in the real world.
    5. Central bottleneck: The gap between demo and deployment remains the field’s unglamorous but defining problem.

    How does embodied AI differ from neuromorphic AI, despite both drawing on biology?

    1. Different questions: Embodied AI asks where intelligence lives, treating cognition as distributed across brain and body; neuromorphic AI asks how the processor itself is built.
    2. Hardware-agnostic: Embodied AI is largely indifferent to processor type; a robot’s “brain” can run on an ordinary GPU cluster.
    3. Spiking neural networks (SNNs): Neuromorphic AI most commonly uses SNNs, where each neuron fires only once incoming signals cross a threshold, suiting time-sensitive tasks like motion sensing.
    4. Power efficiency: Neuromorphic chips consume energy only when neurons are actively spiking, making them notably power-efficient.
    5. Convergence in practice: A growing body of research on “embodied neuromorphic intelligence” places spiking, event-driven chips inside physical robots specifically for their low power draw and fast response.

    How can co-designing body and brain through evolutionary computation address the body-task mismatch?

    1. The design question: If bodies perform computation, the right approach is to design the body for the task, rather than bolting an AI model onto whatever frame engineers have already built.
    2. Jin’s argument: Yaochu Jin, Alexander von Humboldt Professor at Bielefeld University, holds that neural control and physical form must be developed together, not designed separately and combined.
    3. Biological parallel: This mirrors how biological organisms grow nervous systems and bodies in tandem, shaped by continuous environmental feedback.
    4. Research focus: Jin’s work centres on co-evolving nervous systems and morphology, and on how environmental feedback shapes an organism’s sensory distribution.
    5. Practical payoff: Evolutionary computation lets simulated robot populations compete and replicate based on task performance before any physical prototype is built, addressing the costly, slow problem of manually re-engineering hardware whenever a task changes.

    Why is embodied AI a systems challenge that no single breakthrough can resolve?

    1. Persistent sim-to-real gap: Policies trained cheaply in simulation, run millions of times over, still degrade sharply once deployed on real hardware.
    2. Speed-reflex mismatch: Reasoning models are often too slow for robot limbs that must react in milliseconds, forcing a split between heavy “thinking” done off-device and lighter reflexive control on the robot itself.
    3. Hardware fragility: Short battery runtimes and vulnerable components undercut otherwise successful pilots.
    4. Data scarcity: Embodied systems lack an internet-scale training corpus. The Open X-Embodiment dataset and Generalist AI’s GEN-0 are early attempts to build one, but real-world deployment needs at least tens of millions of hours of training data.
    5. A systems problem, not just a software one: Safe deployment depends on sensors, hardware robustness, operational design limits, human interaction, cybersecurity, and organisational processes, not algorithms alone. Regulators must define evidentiary standards for deploying learning-enabled robots.
    6. Form factor as evidence: Boston Dynamics’ Atlas adapting to uneven turf at the FIFA World Cup 2026, and China’s Unitree G1 robots performing alongside professional dancer Wu Yufei on America’s Got Talent Season 21, show gains coming as much from redesigned quadruped and avian-inspired forms as from smarter software.

    Conclusion

    Embodied AI reframes robotic intelligence as something distributed across brain, body, and environment, not a software layer simply installed onto hardware. Progress is bottlenecked not by algorithmic sophistication but by physical constraints, the simulation-to-real gap, data scarcity, actuation-speed mismatches, and bodies poorly matched to their tasks. Closing this gap requires treating embodied AI as a systems-engineering and regulatory challenge, including the evolutionary co-design of body and brain, rather than a problem that better software alone can solve.

    PYQ Relevance

    [UPSC 2015] What are the areas of prohibitive labour that can be sustainably managed by robots ? Discuss the initiatives that can propel research in premier research institutes for substantive and gainful innovation.

    Linkage: The PYQ asks what areas of prohibitive labour can be sustainably managed by robots, and what initiatives can propel research in premier institutes for gainful innovation. It connects to the article’s broader theme of advancing robotics research.

  • Electronic Gold Receipts: A New Way to Own Gold

    Why in the News?

    The National Stock Exchange (NSE) introduced Electronic Gold Receipts (EGRs) in May 2026, a new exchange-traded segment for buying and selling gold electronically. The launch extends a SEBI-led regulatory push, begun in 2021, to move gold ownership from informal physical custody into standardised market infrastructure.

    What Explains the Shift from Physical Gold Custody to Exchange-Based Receipts?

    1. Definition: An EGR is an exchange-traded security representing ownership of physical gold of a specified purity, held in SEBI-regulated vaults and tradeable electronically through a demat account.
    2. Regulatory foundation laid in 2021: SEBI approved the framework for Gold Exchange and the SEBI (Vault Managers) Regulations, 2021 on September 28, 2021.
    3. Legal status as securities: The Centre notified EGRs as securities under the Securities Contracts (Regulation) Act, 1956 in December 2021.
    4. Risk framework added in 2022: SEBI issued a Comprehensive Risk Management Framework for EGRs on April 1, 2022, completing the regulatory base for EGR trading.
    5. First mover was BSE, not NSE: The Bombay Stock Exchange received SEBI’s final approval in September 2022 and launched EGR trading on October 24, 2022, starting with 995 and 999 purity products traded in multiples of 1 gram.

    How Do EGRs Function as a Market Instrument?

    1. Trading window: EGRs trade Monday to Friday, from 9 a.m. to 11:30 p.m., extended to 11:55 p.m. during the U.S. daylight saving period.
    2. Settlement cycle: EGRs follow a T+1 settlement cycle, with receipts credited to the buyer’s demat account the next trading day.
    3. Eligible participants: Retail investors, jewellers, bullion traders, refiners and institutional investors can all buy EGRs through registered stockbrokers.
    4. Dual account requirement: Both a trading account and a demat account are mandatory to buy and sell EGRs.
    5. Purity and denomination structure: EGRs are available in 999 (99.9% pure) and 995 (99.5% pure) standards, each offered in six denominations from 10 mg to 1 kg.

    What Advantages Does the EGR Structure Offer Over Traditional Gold Ownership?

    1. Transparent price discovery: Exchange trading ensures a uniform gold price across India at any given point in time, unlike fragmented physical jewellery market pricing.
    2. Removal of storage and purity risk: Gold backing an EGR is held in SEBI-regulated vaults, removing the investor’s need to store gold at home or verify its purity independently.
    3. Liquidity and settlement guarantee: EGRs can be bought and sold during market hours with an exchange-backed settlement guarantee.
    4. Flexible entry points: Denominations from 10 mg to 1 kg allow both first-time small investors and larger accumulators to participate.
    5. Portfolio diversification and fungibility: EGRs can be held as a financial asset within a broader investment portfolio while retaining the option of conversion to physical gold.

    Does the Promise of Seamless Convertibility Between Physical and Electronic Gold Hold Up in Practice?

    1. Layered transaction costs: Beyond the purchase cost, investors bear brokerage, demat (depository) charges and vault-storage charges for holding EGRs electronically.
    2. Additional costs on conversion: Investors opting for physical delivery must separately bear purity testing and transportation charges not applicable to those who stay electronic.
    3. Tax asymmetry: EGR trading itself attracts no GST, but converting an EGR into physical gold triggers 3% GST on the gold value, the same as buying physical gold directly.
    4. Practical implication: The cost structure rewards investors who remain within the electronic system and penalises the physical-conversion route, so electronic and physical gold are not fully interchangeable in cost terms even though they are interchangeable in form.

    Conclusion

    EGRs formalise India’s gold market by converting informal physical gold holding into a SEBI-regulated, exchange-traded financial instrument with transparent pricing and vaulted custody. The layered brokerage, storage and conversion charges, particularly the 3% GST triggered only on physical delivery, show that electronic and physical gold remain only partially fungible in cost terms. 

    PYQ Relevance

    [UPSC 2015] Craze for gold in Indians have led to a surge in import of gold in recent years and put pressure on balance of payments and external value of rupee. In view of this, examine the merits of Gold Monetization Scheme.

    Linkage: The PYQ discusses the Gold Monetization Scheme, introduced to channel idle household gold into the formal economy and ease pressure on India’s balance of payments. Both the PYQ and the article concern state efforts to formalise gold within the financial system.

  • Skyroot Aerospace’s Vikram-1 Success

    Why in News?

    The Technology Development Board (TDB) under the Department of Science & Technology (DST) congratulated Skyroot Aerospace on the successful Vikram-1 mission, highlighting its early recognition through the National Technology Start-up Award 2022.

    Key Highlights

    • Vikram-1 became India’s first successful private orbital launch vehicle, marking a major milestone for the private space sector.
    • Skyroot Aerospace received the National Technology Start-up Award 2022 from TDB-DST.
    • The award recognised Skyroot’s indigenous:
      • Cryogenic propulsion
      • Liquid propulsion
      • Solid propulsion technologies
    • Skyroot has also submitted a proposal under the Research, Development and Innovation (RDI) Fund, currently under TDB’s consideration.

    About Technology Development Board (TDB)

    • Established: 1996.
    • Statutory body under the Department of Science & Technology (DST).
    • Functions under the Technology Development Board Act, 1995.
    • Objective: Promote development and commercialization of indigenous technologies.
    • Supports innovation through financial assistance (equity, loans, grants) to industries and start-ups.

    Prelims Value Addition

    National Technology Start-up Award

    • Instituted by the Technology Development Board (TDB).
    • Presented annually on National Technology Day (11 May).
    • Recognises start-ups developing innovative indigenous technologies with high commercialization potential.

    [2026] Consider the following statements with regard to involvement of private entities in India’s space programme :
    1. The Indian National Space Promotion and Authorisation Centre (IN-SPACe) is an autonomous agency formed to facilitate participation of private entities.
    2. Agnikul Cosmos launched the world’s first flight using 3D-printed rocket engine.
    3. Skyroot Aerospace has developed liquid fuel for GSLV.
    Which of the statements given above is/are correct?

    [A] 1 only

    [B] 2 and 3 only

    [C] 1 and 2 only

    [D] 1, 2 and 3

  • International Biology Olympiad (IBO) 2026

    Why in News?

    India won 1 Gold and 3 Silver medals at the 37th International Biology Olympiad (IBO) 2026, held in Vilnius, Lithuania.

    Key Highlights

    • Host: Vilnius, Lithuania.
    • Participants: 307 students from 78 countries.
    • India’s Performance: 1 Gold and 3 Silver medals.
    • India’s Overall IBO Medal Tally: 17 Gold, 69 Silver, 17 Bronze, and 1 Honourable Mention
    • This was India’s 26th participation in the IBO.

    About the International Biology Olympiad (IBO)

    • International Biology Olympiad (IBO) is an annual global biology competition for secondary school students.
    • Established: 1990.
    • Hosted by a different country every year.
    • Includes theoretical and practical examinations.
    • Covers Cell & Molecular Biology, Genetics, Evolution, Plant & Animal Biology, Ecology, and Biosystematics.

    Prelims Value Addition

    Homi Bhabha Centre for Science Education (HBCSE)

    • HBCSE is a constituent institution of the Tata Institute of Fundamental Research (TIFR).
    • It coordinates India’s Science Olympiad Programme and prepares Indian teams for international Olympiads.

    [2026] X’, born in the UK, was conferred the Nobel Prize in 2025. He was a professor in an American university when this prize was announced. Identify X’:

    [A] Michel H. Devoret

    [B] Richard Robson

    [C] John Clarke

    [D] Joel Mokyr

  • Ultrafast Organic Anodes for Next-Generation Rechargeable Batteries

    Why in News?

    Researchers from IACS and SNBNCBS have developed a porous organic anode material based on a Covalent Organic Framework (COF) that enables ultrafast charging lithium-ion batteries while maintaining high durability.

    Key Highlights

    • Developed by: Indian Association for the Cultivation of Science (IACS) and S. N. Bose National Centre for Basic Sciences (SNBNCBS) under DST.
    • Material Used: Covalent Organic Framework (COF) – a porous crystalline organic material.
    • Major Achievement: Battery reaches 80% charge in just over one minute.
    • Advantages:
      • Faster lithium-ion transport.
      • Higher energy storage capacity.
      • Long cycle life and improved durability.
      • Safer and low-cost organic battery electrodes.
    • Dual-Ion Capability: Can store both lithium ions and sodium ions, paving the way for affordable sodium-ion batteries.
    • Applications: Electric vehicles, smartphones, laptops, grid-scale renewable energy storage.

    What is a Covalent Organic Framework (COF)?

    • A highly porous, crystalline organic material made of light elements (C, H, O, N, B).
    • Features: High surface area. Tunable pore size. Lightweight and chemically stable. Enables rapid ion movement, making it ideal for battery electrodes.

    [2025] In the context of electric vehicle batteries, consider the following elements:
    I. Cobalt
    II. Graphite
    III. Lithium
    IV. Nickel
    How many of the above usually make up battery cathodes?

    [A] Only one

    [B] Only two

    [C] Only three

    [D] All the four

  • Magnetic Trees Help Researchers Unearth Hidden Flow in the Sun’s Upper Atmosphere

    Why in News?

    Scientists from ARIES (DST) and partner institutions have discovered that the Sun’s meridional plasma flow extends into the upper chromosphere, providing the first observational evidence supporting the “Magnetic Tree” hypothesis. The study was published in The Astrophysical Journal.

    Key Highlights

    • Meridional Flow: Slow movement of hot plasma from the Sun’s equator toward the poles, acting as a conveyor belt for magnetic fields and regulating the 11 year solar cycle.
    • Major Discovery: The poleward plasma flow continues up to 3,000 km above the Sun’s visible surface (upper chromosphere), linking the Sun’s surface with its upper atmosphere.
    • Magnetic Tree Hypothesis: Magnetic structures in the upper atmosphere remain connected to deeper layers, similar to branches connected to a tree’s trunk and roots.
    • Technique Used: Researchers analysed 27 years of radio observations from Japan’s Nobeyama Radioheliograph using a novel image correlation technique.
    • Flow Speed: Plasma moves toward the poles at 5 to 15 m/s, comparable to speeds in the Sun’s lower layers.
    • Solar Cycle Link: Flow patterns vary with the Sun’s 11 year solar cycle and differ between hemispheres depending on magnetic activity.
    • Space Weather Significance: Improves understanding of the solar dynamo, solar storms, and space weather affecting satellites, GPS, communication systems, and power grids.

    Key Terms

    • Chromosphere: Layer of the Sun’s atmosphere located above the photosphere and below the corona.
    • Solar Dynamo: Process by which plasma motion generates the Sun’s magnetic field.
    • Space Weather: Conditions caused by solar activity that influence Earth’s technological systems.

    [2022] If a major solar storm (solar flare) reaches the Earth, which of the following are the possible effects on the Earth?:
    1. GPS and navigation systems could fail.
    2. Tsunamis could occur at equatorial regions.
    3. Power grids could be damaged.
    4. Intense auroras could occur over much of the Earth.
    5. Forest fires could take place over much of the planet.
    6. Orbits of the satellites could be disturbed
    7. Shortwave radio communication of the aircraft flying over polar regions could be interrupted.
    Select the correct answer using the code given below;

    [A] 1, 2, 4 and 5 only

    [B] 2, 3, 5, 6 and 7 only

    [C] 1, 3, 4, 6 and 7 only

    [D] 1, 2, 3, 4, 5, 6 and

  • Engineering Biology Roadmap 2035

    Why in News?

    The Government launched the Roadmap: “Building India as a Leading Bioeconomy Powerhouse by 2035” and announced India’s first Engineering Biology undergraduate course to develop a future-ready biotechnology workforce.

    Key Highlights

    • First Engineering Biology Graduation Course to be introduced in India.
    • Objective: Build a sovereign biotechnology ecosystem by integrating engineering, biology, medicine and AI.
    • IITs are preparing interdisciplinary programmes in collaboration with medical institutions.
    • Focus on AI-driven biology, synthetic biology and advanced biomanufacturing.
    • Bioeconomy Growth Fund: Proposed ₹50,000 crore to support innovation and commercialization.
    • Emphasis on industry-academia partnerships, talent development and indigenous biomanufacturing.

    What is Engineering Biology?

    • Engineering Biology is an interdisciplinary field that applies engineering principles to biological systems for designing and modifying organisms to develop useful products and technologies.

    Applications

    • Precision medicine and gene therapies, CAR-T cell therapy, Sustainable biofuels and bio-based chemicals, Climate-resilient agriculture, Alternative proteins and food systems, and Environmental remediation

    India’s Bioeconomy: Key Facts

    • Grew from ~USD 10 billion (2014) to ~USD 95 billion (2026).
    • Expected to reach USD 300 billion by 2030.
    • Roadmap targets USD 700 billion by 2035.
    • Over 11,000 biotechnology startups.
    • Nearly 100 bio-incubators.
    • Annual growth rate: 15 to 18%.
    • Contributes around 4.8% of GDP.

    Government Initiatives

    • BioE3 Policy (Biotechnology for Economy, Employment and Environment)
    • Promotion of AI-enabled biology and synthetic biology.
    • Strengthening bio-manufacturing and biotechnology innovation ecosystem.
    • Expansion of biotechnology education and skilled workforce.

    Prelims Facts

    • Synthetic Biology: Designing or modifying biological systems for useful applications.
    • Biomanufacturing: Using living organisms or biological processes to manufacture products.
    • CAR-T Cell Therapy: Personalized immunotherapy where a patient’s T cells are genetically modified to attack cancer cells.
    • DNA Vaccine: Uses genetically engineered DNA to trigger an immune response.

    [2025] With reference to monoclonal antibodies, often mentioned in news, consider the following statements:
    I. They are man-made proteins.
    II. They stimulate immunological function due to their ability to bind to specific antigens.
    III. They are used in treating viral infections like that of Nipah virus.
    Which of the statements given above are correct?

    [A] I and II only

    [B] II and III only

    [C] I and III only

    [D] 1, II and III

  • GLP-1 Drugs and Their Effects on Skin, Hair & Nails

    Why in News?

    Growing use of GLP-1 receptor agonists for obesity and Type 2 Diabetes Mellitus (T2DM) has highlighted their effects on skin, hair, and nails.

    What is GLP-1?

    • GLP-1: Glucagon-Like Peptide-1
    • An incretin hormone that stimulates insulin secretion, reduces glucagon release, slows gastric emptying, and Suppresses appetite, aiding weight loss.
    • Common Drugs: Semaglutide, Liraglutide, Dulaglutide, and Tirzepatide (dual GIP/GLP-1 agonist).
    • Emerging Role: Early studies suggest benefits in: Psoriasis and Hidradenitis Suppurativa (HS). However, GLP-1 drugs are not yet approved as standard dermatological treatments.

    Dermatological Effects

    • Skin: Facial fat loss (“Ozempic Face”), loose skin, pigmentation, fungal infections.
    • Hair: Temporary hair shedding (Telogen Effluvium) due to rapid weight loss or nutritional deficiencies.
    • Nails: Brittle, slow-growing or peeling nails linked to nutritional deficiencies.

    Prelims Facts

    • GLP-1: Glucagon-Like Peptide-1
    • T2DM: Type 2 Diabetes Mellitus
    • GIP: Glucose-Dependent Insulinotropic Polypeptide
    • HS: Hidradenitis Suppurativa
    • PCOS: Polycystic Ovary Syndrome
    • Telogen Effluvium: Temporary hair shedding triggered by physiological stress or rapid weight loss.

    [2024] Which one of the following is synthesised in human body that dilates blood vessels and increases blood flow

    [A] Nitric oxide

    [B] Nitrous oxide

    [C] Nitrogen dioxide

    [D] Nitrogen pentoxide