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Subject: Science and Technology

  • ISRO has a problem: many rockets, but too few satellites to launch 

    Why in the News? 

    After the ambitious Next Generation Launch Vehicle (NGLV) was finalized in June 2024, ISRO Chairman S. Somanath stated its launch capability exceeded demand threefold, highlighting a need for robust domestic market demand for launch vehicles.

    What is the present scenario of Satellites in India?   

    • India operates a diverse fleet of satellites with applications in Communications, Remote Sensing, Positioning, Navigation and Timing (PNT), Meteorology, Disaster Management, Space-based internet, Scientific missions, and Experimental missions.
    • India currently has four main launch vehicles: the Small Satellite Launch Vehicle (SSLV), the Polar Satellite Launch Vehicle (PSLV), the Geosynchronous Satellite Launch Vehicle (GSLV), and the Launch Vehicle Mark-III (LVM-3), capable of launching satellites up to four tonnes to geosynchronous orbit.
    • For satellites weighing more than four tonnes, India relies on foreign launch vehicles, such as Europe’s Ariane V and SpaceX’s Falcon 9, to meet its heavy payload requirements.
    • India has been actively involved in significant space missions like Chandrayaan 3 (a lunar mission) and Aditya L1 (a mission to study the Sun), showcasing its growing capabilities in space exploration.

    Existing Demand-Driven Model in India – Before and After       

    • Before (Supply-Driven Model)
        • The Indian Space Research Organisation (ISRO) primarily built and launched satellites based on its assessments and planned missions without waiting for specific customer demands.
        • After launching satellites, ISRO would then look for customers who needed the services provided by the satellites, which sometimes led to underutilization or delayed utilization of satellite capabilities.
        • The space sector was heavily government-controlled, with limited involvement and investment from private players
        • There was less emphasis on educating potential customers about the benefits and applications of space-based services, leading to lower demand from various sectors.
    • After 2020 (Demand-Driven Model)
      • The Space sector reforms 2019-2020 encouraged greater private sector participation, fostering innovation, competition, and commercialization in the Indian space industry.
      • Satellites are now built and launched based on confirmed customer demands, ensuring that each satellite has a predefined purpose and user base before it is sent into space.
      • The market demand for satellite services is validated and secured before the construction and launch phases, leading to better alignment of resources and higher utilization rates.

    Major Three Limitations Associated at Present Time:

    • Limited Launch Vehicle Capability: Currently, the Indian launch vehicles have restricted payload capacities, necessitating multiple launches for larger missions, increasing costs and complexity.
    • Demand-Supply Mismatch: Transitioning from a supply-driven to a demand-driven model faces challenges, including the need to educate potential customers and create a robust private sector ecosystem.
    • Economic and Technological Constraints: High costs of developing and maintaining launch vehicles and satellites, coupled with the early stages of implementing cost-effective reusable technologies, and insufficient infrastructure and investment.

    Way forward: 

    • Enhance Launch Vehicle Capacity: Invest in research and development to upgrade existing launch vehicles like GSLV and LVM-3 to increase payload capacity, reducing dependence on foreign launch providers.
    • Strengthen Market Engagement and Education: Expand outreach programs to educate potential customers across sectors about the benefits and applications of satellite-based services.
    • Promote Private Sector Participation: Facilitate a conducive regulatory environment to attract private investments and foster innovation in satellite manufacturing and launch services.

    Mains PYQ: 

    Q India has achieved remarkable successes in unmanned space missions including the Chandrayaan and Mars Orbiter Mission, but has not ventured into manned space missions. What are the main obstacles to launching a manned space mission, both in terms of technology and logistics? Examine critically. (UPSC IAS/2017)

  • Tirzepatide: the Weight-loss Drug nearing Approval in India

    Why in the News?

    • India’s apex drug regulator Central Drug Standard Control Organisation (CDSCO) gave preliminary approval to the drug Tirzepatide.
      • Tirzepatide is known to have assisted in weight control treatment among diabetic patients.

    About Central Drugs Standard Control Organisation (CDSCO): 

    • CDSCO is India’s national regulatory body for cosmetics, pharmaceuticals and medical devices.
    • It serves a similar function to the Food and Drug Administration (FDA) of the US or the European Medicines Agency of the European Union.
    • The Indian government has announced its plan to bring all medical devices, including implants and contraceptives under a review of the CDSCO.
    • Within the CDSCO, the Drug Controller General of India (DCGI) regulates pharmaceutical and medical devices and is positioned within the Ministry of Health and Family Welfare.
    • The DCGI is advised by the Drug Technical Advisory Board (DTAB) and the Drug Consultative Committee (DCC).

    Mandate and Responsibilities:

    • Drug Approval: CDSCO is responsible for the approval of new drugs and clinical trials.
    • Standards Enforcement: Ensures standards of drugs and medical devices through various acts such as the Drugs and Cosmetics Act, 1940.
    • Import and Export: Regulates the import and export of drugs and medical devices in India.
    • Licensing Authority: Issues licenses for the manufacture, sale, and distribution of drugs in India.
    • Surveillance: Conducts drug quality surveillance and monitors adverse drug reactions.

     

    Diabetes Drug for Weight Loss

    • In 2017, the US Food and Drug Administration (FDA) approved a drug called Ozempic for managing type 2 diabetes.
    • The active ingredient, semaglutide, was later noted for causing weight loss, which led to its off-label use for treating obesity.
    • This usage became popular on social media, influencing further developments.

    What is Tirzepatide?

    • Tirzepatide is the main component of Eli Lilly’s drugs, Mounjaro and Zepbound.
    • It’s important to note here that Mounjaro is the brand name for diabetes, while Zepbound is for weight loss.

    How does it work?

    There is a dual action involving two hormones:

    (1) Regulation of glucagon-like peptide-1 (GLP-1): 

    • GLP-1 is a hormone that regulates appetite and calorie intake through effects on the brain and digestive tract.
    • Both semaglutide and tirzepatide function as polypeptides that enhance the body’s levels of GLP-1.
    • The higher levels of GLP-1 trigger satiety, the feeling of fullness, reducing the desire to eat.

    (2) Regulation of Glucose-dependent Insulinotropic polypeptide (GIP):

    • Unlike semaglutide, tripeptide also increases levels of GIP, the other hormone involved.

    Promising Global Trials

    • Global clinical trials for tirzepatide (Zepbound) have shown significant results, with the highest dosage leading to an average weight loss of 20.9% over 72 weeks.
    • The approval in India is due on further post-marketing surveillance (Phase IV trials) to monitor the drug’s side effects and its effectiveness across India’s diverse population.

    Long-term side effects:

    • Cardiovascular risks like increased heart rate and potential blood pressure elevation.
    • Gastrointestinal effects include nausea, vomiting, diarrhoea, and constipation. Endocrine concerns involve thyroid C-cell tumours in MEN syndrome patients.
    • Other issues include kidney problems, eye complications, mental health impacts, and long-term risks like pancreatic enzyme elevation and gallbladder problems.

    Why under-consideration in India?

    • India has the world’s second-highest number of people with type 2 diabetes and high obesity rates.
    • A study in Lancet in 2023 estimated that 101 million people in India — 11.4 per cent of the country’s population — are living with diabetes.
    • As per the World Obesity Federation Atlas, around 11 per cent of Indian adults will be obese by 2034.

  • ICAR launches ‘One scientist, One product’ Scheme 

    Why in the News?

    • The Indian Council of Agricultural Research (ICAR) is set to launch its ‘One Scientist-One Product’ program. This initiative aims to enhance research in agriculture and animal husbandry.

    About the Indian Council of Agricultural Research (ICAR)

    • ICAR is an autonomous organisation under the Department of Agricultural Research and Education (DARE), Ministry of Agriculture and Farmers Welfare.
    • It is headquartered in New Delhi.
    • ICAR was formerly known as the Imperial Council of Agricultural Research.
    • It was established in 1929 as a registered society under the Societies Registration Act, 1860 on the basis of the report of the Royal Commission on Agriculture.

    Functions of ICAR:

    • Its primary mandate is to coordinate agricultural education and research in India and provide leadership in agriculture and allied sectors.
    • It is the apex body for coordinating, guiding and managing research and education in agriculture including horticulture, fisheries and animal sciences in the entire country.

    Structure and Organization:

    • ICAR operates under the Department of Agricultural Research and Education (DARE), Ministry of Agriculture and Farmers Welfare, Government of India.
    • It consists of a network of research institutes, national bureaus, project directorates, and agricultural universities across the country.
    • The council is governed by a Governing Body and an Executive Committee, which oversee its functioning and activities.
    • ICAR confers prestigious awards, such as: the Rafi Ahmed Kidwai Award, the Borlaug Award, and the Hari Om Ashram Trust Award, to recognize excellence in agricultural research and education.

    Significant feats achieved by ICAR:

    • Bio-fortified Coverage: In 2023-24, approximately 16 million hectares are cultivated with bio-fortified crop varieties.
    • Crops Mentioned: This includes wheat, rice, pearl millet, lentil, and mustard.
    • Climate Resilience: The deployment of climate-resilient technologies has boosted production, even in abnormal years.
    • Variety Release: From 2014-15 to 2023-24, ICAR has released 2,593 high-yielding varieties, including 2,177 climate-resilient and 150 bio-fortified varieties.

    What is the “One Scientist One Product” Scheme?

    • The “One Scientist One Product” initiative is a strategic research plan launched by the Indian Council of Agricultural Research (ICAR).
    • It aims to enhance agricultural productivity by assigning specific research targets to individual scientists within the organization in the next 5 years.

    Key Objectives of the Scheme:

    • Target-Oriented Research: Each scientist is given a specific target to develop a product. For example- seed variety, technology, research paper, or a conceptual model.
    • Avoiding Duplication: The initiative ensures that efforts are not duplicated by carefully mapping and assigning unique research targets to each scientist.
    • Regular Monitoring: Progress will be monitored every three months at the official level and twice a year by the researchers themselves.

    Implementation Details:

    • All 5,521 scientists of ICAR have been registered under this scheme.
    • At the beginning of each year, scientists must identify and inform about the product they aim to develop.
    • While the focus is on individual contributions, there will be instances where a product will be developed by a group of scientists.

    Long-Term Goals:

    • Product Development: The initiative is part of a broader plan to release 100 new seed varieties across various crops within the government’s 100-day plan.
    • Climate-Resilient Crops: A significant target is to increase the area under climate-resilient paddy seeds to 25% of the total kharif acreage, up from the current 15%.

    Announcement of New Crop Varieties

    • Event Details: ICAR will announce the release of 323 new crop varieties during a function in Delhi. The new releases include cereals, oilseeds, forage crops, and sugarcane.
    • Variety Breakdown: Among these, there are 289 climate-resilient varieties and 27 bio-fortified varieties.
    • Upcoming Initiatives: ICAR aims to develop 100 new seed varieties and 100 farm technologies within 100 days as part of a national 100-day action plan.

    Progress in Bio-fortification and Climate Resilience

    • ICAR reports significant progress in the adoption of bio-fortified crop varieties, with a total area of 16 million hectares under these varieties.
    • The organization emphasizes the success of its climate-resilient technologies, noting enhanced production even during years with abnormal weather conditions.

    PYQ:

    [2018] With reference to the Genetically Modified mustard (GM mustard) developed in India, consider the following statements:

    1. GM mustard has the genes of a soil bacterium that give the plant the property of pest-resistance to a wide variety of pests.
    2. GM mustard has the genes that allow the plant cross-pollination and hybridization.
    3. GM mustard has been developed jointly by the IARI and Punjab Agricultural University.

    Which of the statements given above is/are correct?

    (a) 1 and 3 only

    (b) 2 only

    (c) 2 and 3 only

    (d) 1, 2 and 3

  • 100 years of Electroencephalography (EEG)

    Why in the News?

    This year marks the 100th anniversary of the first human electroencephalography (EEG) by German physiologist Hans Berger.

    Historical Development of EEG

    • The development of EEG started with Richard Caton in 1875, who first noticed electrical signals in the brains of animals.
    • His work was expanded by Adolf Beck and later by Vladimir Pravdich-Neminsky, who recorded the first EEG of a dog.
    • Hans Berger was the first to record these signals from a human brain in 1924.

    What is EEG?

    • EEG stands for electroencephalography. “Electro” means electricity, “encephalo” refers to the brain, and “graphy” means recording.
    • It tracks the electrical activity in the brain that happens when neurons, the brain’s cells, move tiny charged particles. 
    • This helps doctors tell if the brain is working normally or not.
    • Doctors use EEG to diagnose epilepsy, check how deep a person is under anesthesia, study sleep patterns, and even confirm if a person has passed away.

    Understanding Volume Conduction

    • Volume conduction explains how the brain’s electrical signals move through different layers like skin and bone to reach the electrodes on the scalp.
    • The signals that electrodes pick up need to be cleaned up from any distortions caused by these layers or other noises before doctors can read them accurately.

    How does an EEG Test Works?

    • Neurons interact with their surroundings and sometimes push ions around.
    • This movement creates waves of electrical activity.
    • Electrodes on the head detect these waves and measure how strong they are, which is then recorded as an EEG.
    • Setting up an EEG involves putting gel on the head and placing electrodes accurately, which can be affected by things like having thick hair.

    What EEG Can and Can’t Show?

    • Strengths: EEG is very good at catching fast changes in the brain’s electrical activity, which is helpful for immediate observations.
    • Limitations: It mainly detects signals from the surface of the brain and is better at picking up signals from certain types of cell parts than others.
      • Pinpointing exactly where the brain an activity started can be difficult.

    Cost and Accessibility

    • EEG is simple and affordable compared to other methods like MRI.
    • It’s portable, doesn’t use large equipment, and is safe.

    PYQ:

    [2015] With reference to ‘Near Field Communication (NFC) Technology’, which of the following statements is/are correct?

    1. It is a contactless communication technology that uses electromagnetic radio fields.

    2. NFC is designed for use by devices which can be at a distance of even a metre from each other.

    3. NFC can use encryption when sending sensitive information.

    Select the correct answer using the code given below:

    (a) 1 and 2 only

    (b) 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

  • India-based Neutrino Observatory

    Why in the News?

    • Takaaki Kajita, a Nobel laureate has supported India’s pursuit of a neutrino lab.
      • Despite numerous obstacles, Kajita believes that the India-based Neutrino Observatory (INO) project, which would rank as one of the largest basic science projects in the country, is still worth pursuing.

    Who is Takaaki Kajita?

    • Takaaki Kajita is a Japanese physicist who was awarded the 2015 Nobel Prize in Physics for discovering the oscillations of neutrinos from one flavour to another, which proved that those subatomic particles have mass.
    • He shared the prize with Canadian physicist Arthur B. McDonald.16 May 2024

    About India-based Neutrino Observatory (INO):

    Details
    Location INO Peak near Theni, Tamil Nadu, India
    Objective Study atmospheric neutrinos and provide precise measurements of neutrino mixing parameters
    Project Scope One of the largest experimental particle physics projects in India
    Initial Completion Date Originally planned for 2015
    Key Equipment
    • Iron Calorimeter (ICAL) Detector, designed to probe Earth matter effects on neutrino propagation and determine neutrino oscillation parameters.
    • 50,000 tonnes, the world’s largest magnet, four times larger than CERN’s CMS detector magnet
    Research Goals
    • Neutrino Oscillation Parameters: Unambiguous and precise determination using atmospheric neutrinos.
    • Matter Effects: Study through electric charge identification to determine the sign of mass differences.
    • CP Violation: Investigate charge-conjugation and parity violations in the leptonic sector.
    • CPT Violation: Possible studies of charge-conjugation, parity, and time-reversal violations.
    • Kolar Events: Study possible identification of very-high-energy neutrinos and multi-muon events in Kolar Gold Fields.
    Historical Discussions Initial discussions in 1989, formal collaboration in 2001, and MoU signed in 2002
    Current Status Construction stalled as of July 2021 due to local opposition and environmental concerns; ongoing legal and governmental deliberations

     

    What is Neutrinos?

    Neutrinos, often referred to as “ghost particles,” are subatomic particles with nearly zero mass and no electric charge.

    Other issues in space:

    Last week, ISRO Chairman S Somanath expressed the possibility of engaging with the asteroid Apophis during its close approach to Earth at a distance of 32,000 km in 2029.

    What is Apophis?

    • Apophis is classified as a near-Earth asteroid (NEA), specifically a Potentially Hazardous Asteroid (PHA) due to its size and proximity to Earth’s orbit.
    • Apophis is approximately 335 meters (1,100 feet) in diameter, making it one of the larger near-Earth asteroids.
    • Discovered in 2004, Apophis initially posed a 2.7% chance of colliding with Earth, raising alarms due to its size (about 450 m wide).
    • Subsequent observations ruled out immediate collision risks in 2029, 2036, and 2068, but it will pass close to Earth in 2029 at 32,000 km.

     

    PYQ:

    [2010] India-based Neutrino Observatory is included by the planning commission as a mega-science project under the 11th Five-year plan. In this context, consider the following statements:

    1. Neutrinos are chargeless elementary particles that travel close to the speed of light.
    2. Neutrinos are created in nuclear reactions of beta decay.
    3. Neutrinos have a negligible, but non-zero mass.
    4. Trillions of Neutrinos pass through the human body every second.

    Which of the statements given above are correct?

    (a) 1 and 3 only

    (b) 1, 2 and 3 only

    (c) 2, 3 and 4

    (d) 1, 2, 3 and 4

  • ISRO’s plans to venture into planetary defence 

    Why in the news? 

    Last week, ISRO Chairman S Somanath expressed the possibility of engaging with the asteroid Apophis during its close approach to Earth at a distance of 32,000 km in 2029. However, the specific manner of ISRO’s involvement has not yet been determined.

    Space objects: 


    The asteroid Apophis may pose a threat:

    • Initial Concerns: Discovered in 2004, Apophis initially posed a 2.7% chance of colliding with Earth, raising alarms due to its size (about 450 m wide).
    • Revised Risk: Subsequent observations ruled out immediate collision risks in 2029, 2036, and 2068, but it will pass close to Earth in 2029 at 32,000 km.
    • Potential Impact: Its size could cause significant damage if it were to collide with Earth, though recent observations suggest no imminent danger.

    Other possible incoming threats from space:

    • Daily Encounters: Thousands of asteroids enter Earth’s atmosphere daily, most burning up due to friction, causing phenomena like fireballs.
    • Russian Example: In 2013, a 20-meter asteroid exploded above Russia, releasing significant energy and causing damage and injuries.
    • Detection Challenges: Some asteroids are detected only upon entering the atmosphere, especially those coming from the direction of the Sun, which can obscure detection.

    ISRO’s plan: From sci-fi to reality:

    • Planetary Defense Initiative: ISRO aims to develop capabilities in planetary defense, potentially participating in missions to study and potentially deflect asteroids.
    • Collaboration: Considering sending its own spacecraft or collaborating with other space agencies, like NASA, which has already redirected a spacecraft to study Apophis in 2029.
    • Evolution of ISRO: Reflects ISRO’s evolution as a space agency, transitioning from aspirations to reality in tackling global space objectives, demonstrating growing confidence and capabilities.

    Way forward: 

    • Form Partnerships: ISRO should actively seek partnerships with leading space agencies like NASA, ESA (European Space Agency), and others involved in asteroid detection and planetary defense.
    • Joint Missions: Collaborate on joint missions to study and potentially mitigate asteroid threats. This could include sharing resources, technology, and expertise to maximize effectiveness and minimize costs.

    Mains PYQ: 

    Q What is India’s plan to have its own space station and how will it benefit our space programme? (UPSC IAS/2019)

  • Why are dengue cases on the rise worldwide?     

    Why in the news?

    In recent weeks, there has been an increase in dengue cases, notably in Karnataka, with rising numbers also observed in Kerala and Tamil Nadu.

    What is the global situation of dengue?

    • Epidemiological Burden: In 2024, over 7.6 million cases of dengue were reported globally, with 3.4 million confirmed cases and significant numbers of severe cases and deaths. Dengue affects approximately half of the world’s population, with an estimated 100-400 million infections occurring annually.
    • Geographical Distribution: Dengue transmission occurs in 90 countries worldwide, predominantly in tropical and subtropical regions. The disease is endemic in more than 100 countries across WHO regions, including Africa, the Americas, the Eastern Mediterranean, South-East Asia, and the Western Pacific.

    Are urbanisation and climate change fuelling dengue spread in the world?

    Urbanization:

    • Increased Population Density: Urban areas provide optimal conditions for the Aedes aegypti mosquito due to the availability of breeding sites like stagnant water in containers, tires, and other urban infrastructure.
    • Expansion of Cities: Rapid urbanization leads to unplanned growth, inadequate waste management, and inadequate water supply, creating breeding grounds for mosquitoes.
    • Human Movement: Urbanization facilitates increased human mobility, enabling the spread of the dengue virus through infected individuals travelling between urban centers.

    Climate Change:

    • Temperature and Rainfall Patterns: Warmer temperatures and altered rainfall patterns associated with climate change create favourable conditions for mosquito breeding and survival.
    • Shifts in Geographic Distribution: Changing climate allows Aedes mosquitoes to expand their range to new regions previously unaffected by dengue, including temperate climates.
    • Extreme Weather Events: Increased frequency and intensity of extreme weather events like hurricanes and floods provide breeding opportunities for mosquitoes and facilitate virus transmission.

    Impact:

    • Health Impact: India accounts for an estimated 33 million clinically apparent dengue cases each year, contributing to a third of the global dengue burden
    • Economic Impact: A cost analysis study in southern India estimated the direct medical costs per hospitalized dengue patient at around ₹20,000 in 2017-18, with costs soaring to over ₹61,000 for complications requiring intensive care.
    • Impact on Individuals: Dengue can cause a wide spectrum of illness, from mild flu-like symptoms to severe complications like internal bleeding, organ impairment, and potentially death if not treated promptly.

    Way forward: 

    • Enhance Urban Infrastructure: Improve urban planning to include effective waste management, regular clearing of stagnant water sources, and sustainable water supply systems to reduce mosquito breeding grounds.
    • Public Awareness Campaigns: Launch comprehensive public awareness campaigns focusing on urban populations to promote community involvement in mosquito control measures and encourage responsible waste disposal practices.

    Mains PYQ: 

    Q Public health system has limitation in providing universal health coverage. Do you think that private sector can help in bridging the gap? What other viable alternatives do you suggest? (UPSC IAS/2015)

  • Breaking the taboo around men’s reproductive health  

    Why in the news? 

    Following World Population Day (July 11), amidst discussions on global population dynamics, it is essential to highlight a topic often overlooked in conversations about reproductive health: male infertility.

    World Health Organization (WHO) Global Perspective on infertility:

    • Prevalence: WHO estimates that 60 million to 80 million couples worldwide experience infertility.
    • Male vs. Female Infertility: Globally, male infertility accounts for approximately 50% of all infertility cases.

    Issues Specific to India:

    • Data Deficiency: Unlike global estimates, specific prevalence data for infertility in India are outdated (from ICMR guidelines in 2005) and not comprehensive.
    • Male Infertility: In India, male infertility constitutes a significant portion of all infertility cases, estimated to be around 50%, mirroring global trends.
    • Contributing Factors: Unique challenges in India include environmental pollution, pesticide exposure in agriculture, lifestyle changes including late marriages and stress, which contribute to rising infertility rates.
    • Access to Treatment: Disparities in access to advanced infertility treatments exist, with urban areas having better access compared to rural regions.
    • Cultural and Social Stigma: Infertility remains stigmatized in Indian society, affecting mental health and social well-being of affected couples, and hindering open discussions and seeking timely medical help.

    What are the actual causes of infertility?   

    • Male Factors: Low sperm count (oligospermia) or poor sperm motility (asthenozoospermia). Anatomical issues such as blocked sperm ducts or varicocele. Hormonal imbalances, genetic factors, and environmental influences like exposure to toxins.
    • Female Factors: Ovulation disorders, including hormonal imbalances like PCOS. Structural issues like blocked fallopian tubes or uterine abnormalities. Endometriosis, is a condition where tissue similar to the lining of the uterus grows outside the uterus.
    • Shared Factors: Age-related decline in fertility. Lifestyle factors such as smoking, excessive alcohol consumption, and obesity. Medical conditions like cancer and its treatments, autoimmune disorders, and certain medications affecting fertility.

    Treatment options

    • Semen Analysis: Essential for diagnosing male infertility, conducted after a period of sexual abstinence.
    • Medical Consultation: Vital to identify underlying causes, whether physical (e.g., blocked sperm flow, anatomical issues) or genetic.
    • Corrective Surgeries: Address issues like blocked sperm ducts, undescended testicles, or anatomical abnormalities affecting sperm production and flow.

    Assisted Reproductive Technologies (ART):

    • Intra Cytoplasmic Sperm Injection (ICSI): Effective for cases of severe male infertility where sperm count is extremely low.
    • Intrauterine Insemination (IUI): Suitable when sperm motility is good but count is low, facilitating fertilization within the uterus.
    • In vitro Fertilisation (IVF): Used when both sperm count and motility are low, involving fertilization outside the body before implantation.
    • Donor Sperm Insemination or Adoption: Options for couples where male infertility is irreparable, providing alternative paths to parenthood.

    Way forward: 

    • Enhanced Data Collection and Research: Update and expand prevalence data on infertility in India through national surveys and research initiatives. This should include both urban and rural populations to understand regional disparities.
    • Public Awareness and Support Programs: Launch nationwide campaigns to raise awareness about infertility as a medical condition, debunk myths, and reduce stigma.

    Mains PYQ: 

    Q In order to enhance the prospects of social development, sound and adequate health care policies are needed particularly in the fields of geriatric and maternal health care. Discuss. (UPSC IAS/2020)

  • [pib] 25th PM-STIAC Meeting

    Why in the News?

    The 25th Prime Minister’s Science, Technology & Innovation Advisory Council (PM-STIAC) meeting was recently held at Vigyan Bhawan Annexe in New Delhi.

    Highlights of the 25th PM-STIAC Meet

    • The meeting was aimed to discuss robust policy formulation for effective Carbon Capture, Utilization, and Storage (CCUS) in India.
    • Focus was on India’s carbon market, carbon credit scheme, and strategies to achieve a 45% reduction in emission intensity by 2030 and Net Zero by 2070.

    About PM-STIAC

    Details
    Objective Provide advice on STI policies and oversee implementation of the government’s STI vision
    Establishment 2018
    Chairperson Principal Scientific Adviser (PSA) to the Government of India
    Composition Eminent scientists, technologists, and innovators from various fields
    Key Roles and Functions
    • Policy Advice
    • Inter-Ministerial Coordination
    • Project Oversight
    • Innovation Ecosystem Promotion
    • Global Collaboration
    • Public Engagement
    • Policy and Program Development
    Major Initiatives and Missions
      1. NM-ICPS: Cyber-Physical Systems Innovation Hubs
      2. Quantum Frontier Mission: Quantum Technologies
      3. AI Mission: AI for Inclusive Growth
      4. Electric Mobility Mission: Promote EVs
      5. Waste to Wealth Mission: Sustainable Waste Management
      6. Health and Well-being Mission: Improve Healthcare Delivery
      7. AGNIi: Accelerating Growth of New India’s Innovations
    • Deep Ocean Exploration

    What is Carbon Capture, Utilization, and Storage (CCUS)?

    Carbon Capture, Utilization, and Storage (CCUS) is a technology aimed at reducing carbon dioxide (CO₂) emissions from industrial processes and power generation.

    It involves three main steps:

    1. Capture:
      • CO₂ is separated and captured from industrial emissions or directly from the air.
      • Capture technologies include pre-combustion, post-combustion, and oxy-fuel combustion.
    2. Utilization:
      • Captured CO₂ is converted into useful products such as chemicals, fuels, and building materials.
      • Utilization helps in creating economic value from CO₂ and can support the development of a circular carbon economy.
    3. Storage:
      • CO₂ is transported and stored in geological formations such as depleted oil and gas fields, deep saline aquifers, or basalt formations.
      • This prevents CO₂ from entering the atmosphere, thereby mitigating climate change.

    Significance:

    • Climate Change Mitigation: Reduces greenhouse gas emissions, helping to meet climate targets.
    • Energy Transition: Supports the transition to low-carbon energy systems.
    • Economic Benefits: Generates new economic opportunities through the creation of new markets for CO₂-derived products.

    Policy Initiatives for CCUS in India

    • National Hydrogen Energy Mission (2021):
      • Launched in 2021, the mission aims to promote the production and use of green hydrogen, with CCUS being a crucial component for producing blue hydrogen from natural gas.
    • Department of Science and Technology (DST) Initiatives:
      • DST has funded various research projects focusing on developing CCUS technologies since the early 2000s.
      • Projects include capturing CO₂ from industrial sources and converting it into valuable products like methanol and synthetic fuels.
    • National Carbon Capture, Utilization & Storage Policy Framework and Its Deployment Mechanism (2020):
      • Established in 2020, the framework aims to create a roadmap for deploying CCUS technologies across various sectors.
      • It focuses on enhancing research, development, and demonstration (RD&D) activities and creating enabling regulatory and policy environments.
    • Industry Collaborations:
      • Collaborations with industries such as Oil and Natural Gas Corporation (ONGC) and Bharat Petroleum Corporation Limited (BPCL) for pilot projects on CCUS.
      • Public-private partnerships to foster innovation and scale up CCUS technologies have been ongoing since the 2010s.
    • International Collaborations (CSLF, 2003):
      • India joined the Carbon Sequestration Leadership Forum (CSLF) in 2003, which promotes international collaboration on CCUS technology development.
      • Collaborations with countries like the United States and the United Kingdom for knowledge sharing and technical support.
    • Green Energy Corridors (2015):
      • Integration of CCUS with renewable energy initiatives to ensure a sustainable and low-carbon energy mix.
      • Established in 2015, this initiative supports developing infrastructure for transporting and storing captured CO₂.

    PYQ:

    [2020] Which one of the following statements best describes the term ‘Social Cost of Carbon’?

    (a) It is a measure, in monetary value, of the long-term damage done by a tonne of CO2 emissions in a given year.

    (b) Requirement of fossil fuels for a country to provide goods and services to its citizens, based on the burning of those fuels.

    (c) Efforts put in by a climate refugee to adapt to live-in a new place.

    (d) Contribution of an individual person to the carbon footprint on the planet Earth.

  • Indigenous HPV vaccine, the rhetoric and the reality

    Why in the news?

    Recent discourse suggests HPV vaccination prevents cervical cancer, but evidence linking HPV to cancer is inconclusive and most infected individuals don’t develop cancer, raising doubts about vaccine necessity.

    What is Cervical Cancer?

    Cervical cancer is a type of cancer that starts in the cells lining the cervix, which is the lower part of the uterus that connects to the vagina. It is usually a slow-growing cancer that may not have symptoms in its early stages.

    Present  trends of cervical cancer prevalence in India and the Globe                

    • Global Trends: Cervical cancer is the fourth most common cancer among women globally, with an estimated 604,000 new cases and 342,000 deaths reported in 2020. 
      • Mortality rates vary widely by region, with the highest rates observed in low- and middle-income countries due to limited access to screening and treatment.
    • Trends in India: In India, cervical cancer is the second most common cancer among women aged 15-44 years. It accounts for approximately 17% of all female cancer deaths in the country, with over 97,000 new cases reported annually.

     

    Recent debate – How does vaccination against HPV prevent cervical cancer and consequent death?                                                       

    • Efficacy Against HPV Infection and Cervical Cancer: HPV vaccines target high-risk HPV types, notably types 16 and 18, which are responsible for a significant proportion of cervical cancer cases worldwide. 
      • Clinical trials and real-world data consistently demonstrate the effectiveness of HPV vaccines in reducing HPV infection rates and preventing cervical cancer.
    • Public Health Impact and Benefits: Countries with high HPV vaccination coverage have observed significant declines in HPV infection rates and cervical cancer incidence among vaccinated populations. 
      • Vaccination programs aim to achieve herd immunity, thereby reducing overall transmission of HPV and protecting unvaccinated individuals.
    • Debate and Challenges: Debate surrounds the universal versus selective vaccination strategies, with considerations on cost-effectiveness, accessibility, and cultural acceptance.
      • Challenges include vaccine hesitancy, particularly in some regions, as well as affordability and logistical barriers to widespread vaccination coverage.

    Challenges Prevalent in Vaccine Manufacturing    

    • Complex Manufacturing Processes: Vaccine manufacturing involves complex biological processes and stringent quality control measures. 
      • Developing and scaling up production requires specialized facilities and skilled personnel, which can be costly and time-consuming to establish.
    • High Regulatory Standards: Vaccines are subject to rigorous regulatory scrutiny to ensure safety, efficacy, and consistency. 
      • Meeting regulatory requirements in multiple jurisdictions adds complexity and may delay the approval and market entry of new vaccines.
    • Supply Chain and Distribution: Maintaining a reliable supply chain for vaccine components and ensuring cold chain storage and distribution are critical challenges. 
      • This becomes even more pronounced in resource-constrained settings or during global health emergencies where demand surges.

    Its Impact on India                     

    • Delayed Access to Affordable Vaccines: India’s capability to produce vaccines at scale is hindered by stringent patent laws and complex regulatory requirements. 
      • This delays the availability of affordable vaccines domestically, impacting public health initiatives and access for vulnerable populations.
    • Economic and Health Implications: High costs associated with vaccine development and production limit affordability and accessibility, exacerbating healthcare inequalities. 
      • This affects India’s ability to address preventable diseases effectively, impacting public health outcomes and economic productivity.

    Unavailability of Competing Vaccines and Future Scope

    • Lack of Market Competition: Despite the expiration of earlier patents, there is a notable absence of competing HPV vaccines from domestic manufacturers in India. 
      • This limits options for consumers and healthcare providers, potentially leading to higher prices and reduced accessibility, particularly in the private market.
    • Potential for Future Development: Several Indian biotech companies had announced plans to develop HPV vaccines, indicating a future scope for competition and potentially lower prices. 
      • However, these initiatives have not materialized into market-ready products, highlighting challenges in vaccine development and commercialization in India’s regulatory and economic environment.

    Way forward: 

    • Promote Research and Development Incentives: Encourage and support Indian biotech companies through research grants, tax incentives, and streamlined regulatory pathways for HPV vaccine development.  
    • Enhance Public-Private Partnerships: Foster collaborations between government entities, academic institutions, and private-sector vaccine manufacturers to improve vaccine accessibility and affordability. 

    Mains PYQ: 

    Q What are the research and developmental achievements in applied biotechnology? How will these achievements help to uplift the poorer sections of the society? (UPSC IAS/2021)