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Subject: Science and Technology

  • Understanding the Ct value in a Covid-19 test

    Recently, the Maharashtra government sought clarity from the Indian Council of Medical Research (ICMR) on the threshold Ct value to treat a person Covid-negative.

    What is Ct value

    • Short for cycle threshold, Ct is a value that emerges during RT-PCR tests.
    • In an RT-PCR test, RNA is extracted from the swab collected from the patient.
    • It is then converted into DNA, which is then amplified.
    • Amplification refers to the process of creating multiple copies of the genetic material — in this case, DNA.
    • Amplification takes place through a series of cycles — one copy becomes two, two becomes four, and so on.
    • Put simply, the Ct value refers to the number of cycles after which the virus can be detected.
    • The lower the Ct value, the higher the viral load — because the virus has been spotted after fewer cycles.

    Why Ct value is important

    • According to the ICMR, a patient is considered Covid-positive if the Ct value is below 35.
    • If the benchmark were to be lowered to 24 — the value mentioned in Maharashtra’s letter — it would mean that Ct values in the range 25-34 would not be considered positive.
    • A benchmark of 35, therefore, means that more patients would be considered positive than we would get if the benchmark were 24.
    • The ICMR has said lowering Ct threshold parameter may lead to missing several infectious persons.

    Does Ct score indicate the severity of disease

    • A small study published in the Indian Journal of Medical Microbiology in January this year found that there was no correlation between Ct values and severity of disease or mortality in patients with Covid-19 disease.
    • It found that the time since the onset of symptoms has a stronger relationship with Ct values as compared to the severity of the disease.
    • The Ct value tells us about the viral load in the throat and not in the lungs.
    • The Ct value does not correlate with severity – only with infectivity.
  • Brucellosis: Preventive measures launched

    Health and Animal Husbandry teams have launched preventive measures and initiated an epidemiological investigation, after one case of brucellosis, was confirmed in a prisoner.

    • The infection is passed on to humans through the ingestion of unpasteurized milk and milk products or contact with animal secretions.

    Brucellosis:

    • Brucellosis is a bacterial disease that mainly infects cattle, swine, goats, sheep and dogs.
    • Humans can get infected if they come in direct contact with infected animals or by eating or drinking contaminated animal products or by inhaling airborne agents.
    • According to the WHO, most cases of the disease are caused by ingesting unpasteurised milk or cheese from infected goats or sheep.

    Symptoms:

    • Fever, sweats, malaise, anorexia, headache and muscle pain
    • While some signs and symptoms can last for long periods of time, others may never go away.
    • These include recurrent fevers, arthritis, swelling of the testicles and scrotum area, swelling of the heart, neurologic symptoms, chronic fatigue, depression and swelling of the liver or spleen.
    • Human to human transmission of the virus is rare.
  • [pib] Drone use permission for feasibility study of Covid-19 vaccine delivery

    Conditional drone use exemption for vaccine delivery

    • Ministry of Civil Aviation (MoCA) and Directorate General of Civil Aviation (DGCA) have granted conditional exemption to the Indian Council of Medical Research (ICMR).
    • The exemption is granted for conducting feasibility study of Covid-19 vaccine delivery using drones in collaboration with IIT Kanpur.
    • The permission exemption is valid for a period of one year or until further orders.

    Entities using drone on conditional drone use exemption basis

    • Conditional drone use exemption has been granted to the below entities for said purposes:
    • Nagar Nigam of Dehradun, Haldwani, Haridwar & Rudrapur for preparation of GIS based property database & electronic tax register.
    • West Central Railway, (WCR) Kota for train accident site & maintaining safety & security of the railway assets.
    • West Central Railway, (WCR) Katni for train accident site & maintaining safety & security of the railway assets.
    • Vedanta Ltd. (Cairn Oil & Gas) also received the conditional drone usage exemption for data acquisition for asset inspecting & mapping.
  • Plasmid

    • Scientists have developed a Covid-19 vaccine that could offer protection against not only existing and future strains of the SARS-CoV-2 coronavirus.
    • The vaccine costs $1 a dose. It uses the plasmid of E-coli bacteria to produce the vaccine.
    • A plasmid is a small, extrachromosomal DNA molecule within a cell that is physically separated from chromosomal DNA and can replicate independently.

    • They are most commonly found as small circular, double-stranded DNA molecules in bacteria; however, plasmids are sometimes present in archaea and eukaryotic organisms.
  • How & why of oxygen therapy

    How Covid-19 leads to shortness of breath?

    • Shortness of breath occurs because of the way Covid-19 affects the patient’s respiratory system.
    • When a person inhales, the tiny air sacs in the lungs — alveoli — expand to capture this oxygen, which is then transferred to blood vessels and transported through the rest of the body.
    • Respiratory epithelial cells line the respiratory tract.
    • Their primary function is to protect the airway tract from pathogens and infections, and also facilitate gas exchange.
    • And the SARS-CoV-2 coronavirus can infect these epithelial cells.
    • To fight such infection, the body’s immune system releases cells that trigger inflammation.
    • When this inflammatory immune response continues, it impedes the regular transfer of oxygen in the lungs.
    • Simultaneously, fluids too build up.
    • Both these factors combined make it difficult to breathe.
    •  Low levels of oxygen triggered by Covid-19 are inflammatory markers, which include elevated white blood cell counts and neutrophil counts.

    Does a patient always show Covid symptoms when their oxygen levels drop?

    • No.
    • According to the FAQs on Covid-19 from AIIMS e-ICUS, sudden deaths have been reported at presentation to the emergency department, as well as in hospital.
    • AIIMS has said that the reasons that have been proposed include a sudden cardiac event, preceding “silent hypoxia” that went unnoticed, or due to a thrombotic complication such as pulmonary thromboembolism.
    • In silent hypoxia, patients have extremely low blood oxygen levels, yet do not show signs of breathlessness.
  • What is the Whitest Paint?

    Engineers in the US have created what they are calling the whitest paint yet.

    What is the whitest paint?

    • The researchers created an ultra-white paint pushing the limits of how white paint can be.
    • This older formulation was made of calcium carbonate, while the new one is made up of barium sulphate, which makes it more white.
    • The newer paint is whiter and keeps the surface areas it is painted on cooler than the formulation before this could.
    • If this new paint was used to cover a roof area of 1,000 square feet, it may be able to get a cooling power of 10 kilowatts.
    • Most ovens use up about 2.3 kilowatts to run for an hour and a 3 ton 12 Seasonal Energy Efficiency Ratio (SEER) air conditioner uses up about 3 kilowatts to run for an hour.

    The researchers have claimed that this paint may be the closest equivalent to the blackest black paint called “Vantablack” which is able to absorb up to 99.9 per cent of visible light.

    What determines if a colour absorbs or reflects light?

    • To understand how this works one needs to note that whenever an object is seen by the eye, it is either because of sunlight or the artificial light in the room.
    • This light is made up of seven different colours (Violet, Indigo, Blue, Green, Yellow, Orange and Red or VIBGYOR).
    • Specifically, light is made up of wavelengths of different colours.
    • If an individual is looking at a sofa that is green, this is because the fabric or material it is made up of is able to absorb all the colours except green.
    • This means that the molecules of the fabric reflect the green coloured wavelengths, which is what the eye sees.
    • Therefore, the colour of any object or thing is determined by the wavelength the molecules are not able to absorb.

    Try this PYQ:

    Q.Rainbow is produced when sunlight falls on drops of rain. Which of the following physical phenomena are responsible for this?

    1. Dispersion
    2. Refraction
    3. Internal reflection

    Select the correct answer using the codes given below:

    a) 1 and 2 only

    b) 2 and 3 only

    c) 1 and 3 only

    d) 1, 2 and 3

    What determines which wavelength of light will be reflected and absorbed?

    • This is dependent on how electrons are arranged in an atom (the building block of life, an atom is made up of electrons, protons and neutrons.
    • These three particles make up everything in the known universe from mountains, planets, humans to pizza and cake).
    • In contrast, if an object is black, it is because it has absorbed all the wavelengths and therefore no light is reflected from them.
    • This is the reason that darker objects, as a result absorbing all wavelengths tend to heat up faster (during absorption the light energy is converted into heat energy).

    So, what makes the paint so white?

    There are two features:

    1. One is the paint’s high concentration of a chemical compound called barium sulfate, which is also used to make photo paper and cosmetics white.
    2. The second feature is that the team has used different sized particles of this chemical compound, which means different sizes scatter different amounts of light.

    In this way, the varying size of particles of the compound makes sure that the paint can scatter more of the light spectrum from the sun.

  • Tiki Formation in Madhya Pradesh

    The Tiki Formation in Madhya Pradesh, a treasure trove of vertebrate fossils, has now yielded a new species and two genera of cynodonts, small rat-like animals that lived about 220 million years ago.

    Tiki Formation

    • The Tiki Formation is a Late Triassic geologic formation in Madhya Pradesh.
    • Dinosaur remains are among the fossils that have been recovered from the formation, although none have yet been referred to a specific genus.
    • Phytosaur remains attributable to the genus Volcanosuchus have also been found in the Tiki Formation.
    • The genera Tikiodon, Tikitherium and Tikisuchus and species Rewaconodon tikiensis, Hyperodapedon tikiensis and Parvodus tikiensis have been named after the Tiki Formation.

    Findings of the new study

    • The fossil teeth were studied for size, crown shape, structure of the cusps and compared with previously reported cynodonts.
    • Cynodonts are important in evolutionary studies as this group ultimately gave rise to the present-day mammals.
    • By studying their molar and premolar teeth, we see how they slowly evolved and modified.
    • Their crown shape shows that these animals are actually intermediate forms that are very near to the mammalian line of evolution.
    • Cynodonts and living mammals both belong to a group of egg-laying vertebrates (amniotes) called synapsids.
    • The close relationship of cynodonts with living mammals is seen in their bones.
  • The march towards an equitable data economy

    The article explains the data governance norms we need to adopt to secure better societal outcomes.

    Whatsapp privacy issue

    • New terms of service circulated by WhatsApp, caused a stir among the user.
    • It informed users that data about chats with business accounts would be shared with Facebook.
    • These policies seemed unfair to India as they were not applicable to the European Union (EU), given their strong data protection policies.

    Acceptable levels of data exchange

    • Default norms provide power to the tech platforms to collect, analyse and monetize data with complete control.
    • This undergirds business models that seem undesirable for society—with harms to privacy and free speech.
    • Global discussions about alternatives to the “exchange of data for free services” are becoming nuanced.

    3 Norms in the data governance

    1) Recognition of individual and collective rights related to data

    • It was generally accepted that extraction of data to access free services was a fair exchange with individuals.
    • Emergence of existential threats related to privacy and democracy have highlighted the role of guaranteeing human and civil rights.
    • There has been significant global progress through regulations on individual data rights.
    • A United Nations Conference on Trade and Development (UNCTAD) report claims that 128 of 194 countries have put in place legislations for data protection and privacy.
    • However, this protection is insufficient as it is centered on individuals and does not account for safety of groups.
    • The next wave of data governance ideas will seek to protect collective harms and build on the foundation of individual agency and control.

    2) Data sovereignty

    • One-size-fits all global norms of data governance are changing and being replaced by region-specific ideas.
    • Greater acceptance for “data sovereignty” assertions across India and Europe is a welcome shift towards crafting governance that is respectful of local nuances and inclusive of civic participation.
    • The EU general data protection regulation (GDPR) had created an early lighthouse example.
    • On the other hand, the US has adopted a light regulation approach—there is no comprehensive country-wide data protection law.
    • Closer home, India is finalizing the contours of a country-wide and cross-sector personal data protection bill, which reflects local norms.

    3) Value creation for all stakeholders

    • So far, data economy has operated in a completely unregulated space, creating a “winner takes all” market, with concentrated profits and little contribution to local taxes.
    • A healthy economy requires value creation for all stakeholders.
    • As tech platforms take up the profitable role of acting as the gateway to all information and social connections, they have a greater accountability and responsibility to contribute to the economy.
    • India’s digital tax through the 2% “equalization levy” is an attempt to make the tech giants pay for revenues earned in India.

    Consider the question “What should be norms of data governance we must adopt for achieving better societal outcomes?”

    Conclusion

    Formal adoption of regulations and setting up of enforcement institutions will lead to meaningful progress in the right direction.

  • Species in news: Azhdarchid Pterosaurs

    Azhdarchid pterosaurs, the giant reptiles that flew in the skies nearly 65 million years ago, had necks longer than that of a giraffe (i.e. more than 6fts).

    What are pterosaurs?

    • Pterosaurs are reptiles that are close cousins of dinosaurs, the first animals after insects to evolve powered flight.
    • Some pterosaurs were as large as an F-16 fighter jet, while others were as small as a paper aeroplane.
    • Pterosaurs went extinct about 65-66 million years ago (end of the Cretaceous period) and while they did not leave any of their descendants behind.
    • One reason for this is that few pterosaurs lived in places where fossils tend to form, because of which their bones are preserved poorly.

    Revise the geological timescale from your NCERT textbook.

    Azhdarchid pterosaurs

    • They are one type of pterosaur and one of the distinguishing characteristics about them is how big they were, especially their long necks.
    • Some of these pterosaurs were the largest animals to have flown in the sky, with wingspans greater than 30 feet.
    • The name azhdarchid, as per a blog on Scientific American comes from Azhdarcho, a Central Asian form named by Russian ornithologist and palaeontologist in 1984.

    What have the researchers found?

    • Researchers involved in this study were curious about how the reptile’s long neck functioned and how it was able to support the pterosaur’s body, allowing them to capture and eat heavy prey animals.
  • [pib] National Internet Exchange of India (NIXI)

    The Ministry of Electronics & Information Technology (MeitY) has inaugurated three path-breaking initiatives for the National Internet Exchange of India (NIXI).

    What is NIXI?

    National Internet Exchange of India (NIXI) is a not-for-profit organization (section 8 of the Companies Act 2013) working since 2003 for spreading the internet infrastructure to the citizens of India through the following activities:

    1. Internet Exchanges through which the internet data is exchanged amongst ISP’s, Data Centers and CDNs.
    2. .IN Registry, managing and operation of .IN country-code domain and .भारत IDN domain for India.
    3. IRINN, managing and operating Internet protocol (IPv4/IPv6).

    Which are the three new initiatives?

    (1) IPv6 Expert Panel (IP Guru) (https://nixi.in):

    • IP Guru is a group to extend support to all the Indian entities who are finding it technically challenging to migrate and adopt IPv6.
    • In addition to this, the IPv6 expert group will help in identifying & hiring an agency that will help end customer by providing necessary technical support to adopt IPv6.
    • This panel will guide all such Indian entities and help in increasing IPv6 adoption.

    Note: An Internet Protocol (IP) address is a numerical label assigned to each device connected to a computer network that uses the Internet Protocol for communication. An IP address serves two main functions: host or network interface identification and location addressing.

    (2) NIXI Academy (https://training.nixi.in):

    • NIXI Academy is created to educate technical/non-technical people in India to learn and relearn technologies like IPv6 which are normally not taught in Educational Institutes.
    • NIXI academy comprises an IPv6 training portal which is developed with the help of various technical experts in order to provide mass training to the community.
    • The easy-to-use platform helps network operators and educators understand networking best practices, principles and techniques; manage Internet resources better; and use appropriate Internet technologies more effectively.

    (3) NIXI-IP-INDEX (https://ipv6.nixi.in):

    • NIXI has developed an IPv6 index portal for the Internet community.
    • NIXI-IP-INDEX portal will showcase the IPv6 adoption rate in India and across the world.
    • It can be used to compare the IPv6 Indian adoption rate with other economies in the world.
    • NIXI will populate this portal with web adoption in IPv6, IPv6 traffic etc. in the coming days.
    • This portal will motivate organisations to adopt IPv6, provide inputs for planning by technical organisations and research by academicians.