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Subject: Science and Technology

  • What are Hydrothermal Vents?

    Why in the News?

    • Indian oceanographers have captured the first-ever image of an active hydrothermal vent located 4,500 metres below the surface of the Indian Ocean.
      • This discovery is part of India’s Deep Ocean Mission under the Ministry of Earth Sciences, with a total outlay of ₹4,000 crore.

    What are Hydrothermal Vents?

    • Hydrothermal vents are typically found near tectonic plates, where cold water (about 2°C) near the ocean floor mixes with magma, leading to superheated water (up to 370°C) that emerges through chimneys.
    • These vents release mineral-rich plumes, including metals like copper, zinc, gold, silver, platinum, iron, cobalt, and nickel, making them significant for mineral exploration.

    Mineral Potential of Hydrothermal Vents:

    • Hydrothermal vent deposits are rich in valuable minerals such as copper, zinc, gold, silver, and nickel, which are highly sought after for various industries.
    • These vents can remain active for periods ranging from a few hundred years to 30,000 years, making them long-lasting and crucial for mineral exploration.
    • Scientists at NCPOR, confirmed that the image showed an active vent chimney with black smokers, and signs of chemosynthetic organisms thriving in this extreme environment.
      • This discovery enhances India’s Deep Ocean Mission, particularly the Samudrayaan mission, which focuses on mineral exploration from inactive hydrothermal vents.

    About the Hydrothermal Exploration Programme by NCPOR:

    Details
    • A scientific initiative by the National Centre for Polar and Ocean Research (NCPOR) to explore hydrothermal vents in the Indian Ocean, focusing on the Central and Southwest Indian Ridges.
    • Aimed at mineral exploration and studying ecosystems around hydrothermal vents.
    Aims and Objectives
    • Locate and Study Hydrothermal Vents: Identify active vents with minerals like copper, zinc, gold, and nickel.
    • Mineral Exploration: Part of India’s Deep Ocean Mission, aiming at valuable mineral exploration such as cobalt and platinum.
    • Biodiversity Studies: Understand chemosynthetic organisms that thrive in extreme conditions of the vents.
    Key Features of the Programme
    • Geophysical Surveys: Conducted since 2012 to detect temperature anomalies and turbidity in the water columns for locating vent fields.
    • Use of Advanced Technology: Utilizes Automatic Underwater Vehicles (AUVs) and high-resolution imaging.
    • Collaborations: Partners with the National Institute of Ocean Technology (NIOT) for exploration in the Southern Indian Ocean.

     

    About the Deep Ocean Mission (DOM):

    • DOM is an ambitious initiative by the Ministry of Earth Sciences (MoES) approved in 2021 to develop technologies for deep-sea exploration.
    • Part of the 9 missions under the Prime Minister’s Science, Technology, and Innovation Advisory Council (PMSTIAC).

    Important updates in DOM:

    • Samudrayaan and Matsya6000:
      • Launched in 2021 under DOM, Samudrayaan is India’s flagship crewed expedition to reach a depth of 6,000 m in the Central Indian Ocean.
      • The mission will utilize Matsya6000, a deep-ocean submersible designed for a three-member crew.
        • Construction: Made from titanium alloy to endure pressures up to 6,000 bar.

    India’s Ocean Exploration Milestones:

    • 1981: Ocean studies began with a program on polymetallic nodules (PMN) initiated at CSIR-NIO, marked by the collection of the first nodule sample from the Arabian Sea aboard the research vessel Gaveshani.
    • 1987: India became the first country to receive Pioneer Investor status from the International Seabed Authority (ISA).
      • Allocated 1.5 lakh km² in the Central Indian Ocean Basin (CIOB) for nodule exploration, based on extensive surveys by CSIR-NIO.
    • 2002: India signed a contract with the ISA; after resource analysis, surrendered 50% of the allotted area, retaining 75,000 km².
    • Further studies narrowed the mining area to 18,000 km², identified as the First Generation Mine-site.

     

    PYQ:

    [2021] Consider the following statements:

    1. The Global Ocean Commission grants licences for seabed exploration and mining in international waters.
    2. India has received licences for seabed mineral exploration in international waters
    3. ‘Rare earth minerals’ are present on the seafloor in international waters.

    Which of the statements given above are correct?

    (a) 1 and 2 only
    (b) 2 and 3 only
    (c) 1 and 3 only
    (d) 1, 2 and 3

  • Japan, India startups collaborate to tackle space debris

    Why in the News?

    space startups from Japan and India announced a joint agreement to explore the use of laser-equipped satellites for removing debris from orbit, addressing the growing issue of orbital congestion.

    What is Space Debris?

    • Space debris, often referred to as space junk, consists of non-functional spacecraft, spent rocket stages, and fragments from collisions or disintegration of satellites.
    • These objects orbit the Earth at high speeds, posing significant risks to operational satellites and manned missions.

    What are laser-equipped satellites for removing debris from orbit?

    • Laser-equipped satellites utilize focused laser beams to target and vaporize small parts of space debris, effectively stopping its rotation and making it easier for servicing spacecraft to rendezvous with and de-orbit defunct satellites. T
    • Companies like Japan’s Orbital Lasers and India’s InspeCity are collaborating to explore business opportunities for these laser systems.
    • They plan to demonstrate this technology in space, with potential deployment on satellites after meeting regulatory requirements in their respective countries, indicating a growing interest in international partnerships to tackle the issue of space debris.

    What are the concerns related to space debris?

    • Collision Risks: The increasing amount of space debris raises the likelihood of collisions with active satellites and spacecraft, which can lead to further debris generation in a cascading effect known as the Kessler Syndrome.
    • Operational Challenges: Space debris complicates satellite operations and can disrupt services such as telecommunications, weather forecasting, and global positioning systems.
    • Environmental Impact: The accumulation of debris in low Earth orbit (LEO) threatens the sustainability of space activities and could hinder future space exploration efforts.

    What are the initiatives to tackle space debris globally?

    • International Collaboration: Organizations like the United Nations have called for urgent action to track and manage space debris, emphasizing the need for global cooperation.
    • Technological Innovations: Companies like Orbital Lasers are exploring innovative solutions such as using laser-equipped satellites to de-orbit defunct satellites and mitigate debris by vaporizing parts of their surfaces.
    • Regulatory Frameworks: Various countries are developing regulations to ensure responsible satellite launches and operations, including guidelines for end-of-life satellite disposal to minimize future debris creation.

    What are the measures should be taken by Satellite? (Way forward)

    • Tracking and Monitoring: Satellites use onboard systems and ground-based tracking data to monitor the position of space debris and predict potential collision risks.
    • Avoidance Maneuvers: Satellites perform preemptive orbital adjustments or “collision avoidance manoeuvres” to shift their trajectory away from debris.
    • Shielding and Resilience: Some satellites are equipped with protective shielding to withstand minor debris impacts, minimizing potential damage in low-risk scenarios.

    Mains PYQ:

    Q What is India’s plan to have its own space station and how will it benefit our space programme? (UPSC IAS/2019)

  • IRIS² Program

    Why in the News?

    The European Union has signed a contract for IRIS², a network of 290 satellites aimed at improving resilience, connectivity, and security.

    About IRIS²:

    Details
    • IRIS² stands for Infrastructure for Resilience, Interconnectivity, and Security by Satellite.
    • It consists of a 290-satellite constellation, including 264 satellites in Low Earth Orbit (LEO) and 18 in Medium Earth Orbit (MEO).
    • Collaboration between European Union and SpaceRISE.
    • First satellite launch planned for 2029.

    Key Features of IRIS²:

    • Deployment of 264 satellites in LEO and 18 in MEO.
    • Provide secure, high-speed broadband connectivity, particularly in underserved regions.
    • Focus on Europe for secure satellite internet services.
    Project Funding and Implementation
    • 12-year concession for IRIS² is funded by the EU, ESA, and private firms like SES, Eutelsat, and Airbus.
    • Total cost: €10.6 billion (~$11 billion).
    Applications of IRIS²
    • Governmental Use: Border surveillance, crisis management, infrastructure security, and defense.
    • Civilian Use: Broadband access, smart energy, transportation, and remote healthcare.

     

    World’s Largest Earth Observation Programs: Take a look

    • Copernicus Program (EU): Launched in 2014, the Copernicus Program is a European Union initiative with satellites like Sentinel to monitor land, ocean, and atmosphere, enhancing environmental management and disaster response.
    • NASA Earth Observing System (EOS): Initiated in 1997, NASA’s EOS provides comprehensive Earth observation data from satellites like Terra and Aqua, focused on understanding Earth’s environment, climate change, and atmospheric composition.
    • Global Earth Observation System of Systems (GEOSS): Founded in 2005, GEOSS connects Earth observation systems globally to provide data on climate, water resources, biodiversity, and natural disasters, involving over 100 organizations.
    • Landsat Program (USA): Launched in 1972 by NASA and USGS, Landsat is the longest-running satellite program offering continuous Earth surface monitoring, focusing on land cover, land use, and environmental changes.

    Note: 

    In September, 2024, ISRO launched the Earth Observation Satellite EOS-08 under the SSLV-D3/EOS-08 mission from the Satish Dhawan Space Centre, Sriharikota, with the satellite operating in a circular Low Earth Orbit at an altitude of 475 km and a mission life of 1 year.

  • Making affordable generics more reliable

    Why in the News?

    India’s decentralised drug regulation system dominated by State Drug Regulatory Authorities causes inconsistent quality standards. Strengthening oversight is essential to ensure generics are as affordable and effective as branded drugs.

    How Reliable Are Generic Medicines?

    • Bioequivalence to Innovators: Generic medicines are bioequivalent to brand-name drugs, meaning they have the same active ingredient and are intended to work the same way.
    • Affordability and Accessibility: Generics significantly lower healthcare costs, making treatment more accessible, especially for low-income populations.
    • Challenges in Quality: Despite their potential, the reliability of generics has been questioned due to variability in therapeutic outcomes, often caused by differences in excipients, manufacturing processes, and bioequivalence thresholds.

    What are the main quality concerns associated with it?

    • Efficacy and Bioavailability: Studies have shown that while generics are bioequivalent to branded drugs, they may not always achieve the same therapeutic levels.
      • For example, a study on itraconazole showed that only 29% of patients using generic versions achieved the right drug levels in their body within two weeks, compared to 73% of patients using the original branded drug.
    • Manufacturing Variability: The manufacturing processes for generics can differ significantly from those of branded drugs. Variations in excipients (binders, fillers) and production methods can lead to differences in tablet hardness, dissolution rates, and overall drug stability. This variability can result in inconsistent therapeutic outcomes.
    • Regulatory Oversight: India’s decentralized drug regulation system contributes to inconsistent quality standards across states.
      • The Central Drugs Standard Control Organisation (CDSCO) has limited authority over State Drug Regulatory Authorities (SDRAs), leading to regulatory arbitrage where manufacturers exploit weaker oversight. Moreover, the lack of stringent enforcement of stability testing further jeopardizes the quality of generics available in the market.

    What regulatory reforms are needed?  

    • Centralisation of Drug Regulation: A comprehensive overhaul of India’s drug regulation system is necessary. Centralising oversight under the CDSCO would help enforce consistent quality standards across all states and reduce the risk of substandard drugs entering the market.
    • Enhanced Stability Testing Protocols: Uniform stability testing protocols should be established to ensure that all generics maintain their quality under various climatic conditions. This would involve periodic reassessment of approved generics to uphold their efficacy over time.
    • Stricter Impurity Standards: Aligning India’s Pharmacopoeia with international standards regarding permissible impurity levels would improve the overall quality of generic medicines available in the market.

    How can patient and healthcare provider perceptions of generics be improved? (Way forward)

    To enhance patient and healthcare provider confidence in generic medicines, several strategies can be employed:

    • Public Awareness Campaigns: Educating patients about the efficacy and safety of generics compared to branded drugs can help dispel misconceptions that higher-priced medications are superior.
    • Incentives for Healthcare Providers: Offering incentives for prescribing generics can encourage healthcare professionals to recommend these cost-effective alternatives more frequently.
    • Strengthening Quality Assurance: Implementing stronger regulatory frameworks and ensuring compliance with quality standards can build trust among both patients and providers regarding the reliability of generics.

    Mains PYQ:

    Q Why is there so much activity in the field of biotechnology in our country? How has this activity benefitted the field of biopharma? (UPSC IAS/2018)

  • Firefly Sparkle Galaxy

    Why in the News?

    James Webb Space Telescope (JWST) has identified a rare galaxy, Firefly Sparkle, offering a unique look into early galaxy formation.

    Firefly Sparkle Galaxy

    About Galaxy Firefly Sparkle:

    Details
    • Discovered by NASA’s James Webb Space Telescope (JWST), dating back to 600 million years after Big Bang.
      • It is one of the earliest low-mass galaxies discovered, providing rare insights into early galaxy formation.
    • It is named so because its star clusters shine brightly, resembling fireflies in JWST’s images.
    • It is part of a group of galaxies from the early universe, offering clues about how galaxies like the Milky Way may have formed.
    Features of the Galaxy
    • Mass equal to 10 million suns, making it a relatively low-mass galaxy.
    • Visible portion spans just 1,000 light-years, much smaller than the Milky Way’s 100,000 light-years.
    • Contains 10 distinct star clusters, each representing different stages of star formation.
      • Accompanied by 2 smaller galaxies, Firefly-Best Friend and Firefly-New Best Friend.
    • Elongated raindrop shape, indicating it is still forming.
    Observational Studies by JWST
    • Used gravitational lensing to magnify the galaxy’s light by 16-26 times, providing detailed observations.
    • JWST observed varied stages of star formation, with younger stars appearing blue and older stars red.
      • It is forming piece by piece, with each star cluster representing a phase of formation.
    • These observations help refine theories on galaxy formation and star cluster dynamics in the young universe.

     

    PYQ:

    [2022] Launched on 25th December, 2021, James Webb Space Telescope has been much in the news since then. What are its unique features which make it superior to its predecessor Space Telescopes? What are the key goals of this mission? What potential benefits does it hold for the human race?

    [2012] Which of the following is/are cited by the scientists as evidence/evidences for the continued expansion of universe?

    1. Detection of microwaves in space
    2. Observation of redshift phenomenon in space
    3. Movement of asteroids in space
    4. Occurrence of supernova explosions in space

    Select the correct answer using the codes given below:

    (a) 1 and 2
    (b) 2 only
    (c) 1, 3 and 4
    (d) None of the above can be cited as evidence

  • What is Disease X and why should the world prepare for it?

    Why in the News?

    The outbreak reported in the first week of December 2024 in the Democratic Republic of Congo, which has already claimed more than 400 lives and is yet to be classified, has sparked concerns that it might be an example of Disease X.

    What is Disease X?

    • Definition: Disease X is a hypothetical term coined by the World Health Organization (WHO) in 2018 to represent an unknown pathogen that could potentially cause a global epidemic or pandemic.
    • Conceptual Origin: The term was created in the aftermath of the Ebola epidemic (2014-2016) to emphasise the need for preparedness against unpredictable infectious diseases.
    • Nature of Disease X: It serves as a placeholder for both “known unknowns” (threats we are aware of but do not fully understand) and “unknown unknowns” (threats we are not yet aware of). This acknowledges the likelihood of future pandemics without specifying their characteristics.
    • Potential Pathogens: Disease X could originate from a variety of sources, including viruses, bacteria, parasites, fungi, helminths, or prions. Historical data indicates that about 70% of emerging infectious diseases have zoonotic origins, meaning they are transmitted from animals to humans.
    • Emerging Disease Patterns: The emergence of new diseases is often linked to ecological disruptions caused by human activities such as deforestation and urbanisation, which increase contact between humans and wildlife.

    Why is it Important to Prepare for Disease X?

    • Global Health Security: Preparing for Disease X is essential for protecting public health globally. The emergence of new pathogens can lead to widespread illness and mortality, as demonstrated by COVID-19.
    • Unpredictable Nature of Outbreaks: The unpredictable emergence of infectious diseases necessitates robust surveillance and rapid response systems. Being prepared helps mitigate the impact of unforeseen threats.
    • Increasing Frequency of Outbreaks: The frequency of novel outbreaks has significantly increased since the mid-20th century due to environmental changes, urbanization, and human encroachment on wildlife habitats.
    • Economic Impact: Pandemics can have devastating economic consequences, disrupting trade, travel, and healthcare systems. Preparedness can help minimize these impacts.

    What should be done to prevent this? ( Way forward) 

    • Advances in Science and Technology: Investments in research, genomic sequencing, artificial intelligence, and public health infrastructure enhance our ability to detect and respond to emerging diseases quickly.
    • International Cooperation: Global collaboration is crucial for effective outbreak response. Initiatives like the WHO’s priority pathogen list and proposed Pandemic Treaty aim to foster a unified approach to health emergencies.
    • Equitable Access to Resources: Ensuring equitable access to diagnostics, treatments, and vaccines across all countries is vital for effective pandemic response, particularly in low- and middle-income nations.

    Mains PYQ:

    Q COVID-19 pandemic has caused unprecedented devastation worldwide. However, technological advancements are being availed readily to win over the crisis. Give an account of how technology was sought to aid the management of the pandemic. (UPSC IAS/2020)

  • [pib] DAE-Homi Bhabha Chair Scheme

    Why in the News?

    The DAE—Homi Bhabha Chair for Distinguished Scientists/Professors was launched in 2021 by the Department of Atomic Energy (DAE).

    About DAE – Homi Bhabha Chair Scheme

    Details
    Aims and Objectives
    • To recognize outstanding contributions by scientists, including retired professionals, in atomic energy and related technologies.
    • Allow retired professionals to continue research aligned with the Department of Atomic Energy (DAE).
    • Focus on research in sensitive atomic energy technologies, benefiting strategic sectors.
    Provisions and Features
    • Honorarium: Rs. 200,000 per month (capped at last drawn salary).
    • Contingency Grant: Rs. 76,000 per year for secretarial assistance, telephone bills, etc.
    • Equipment and Book Allowance: Rs. 1,25,000 for equipment and Rs. 10,000 for books.
    • Transport Allowance: Fixed monthly transport allowance for those without an official vehicle.
    Structural Mandate and Implementation
    • Eligibility: Open to distinguished scientists, including retirees involved in critical atomic technologies.
    • Tenure: 1 to 5 years, decided by a Selection Committee.
    • Implementation: Administered by DAE, providing research support and necessary infrastructure.
    Present Challenges
    • Financial Constraints: Budget limitations can affect the scale of research.
    • Integration of New Technologies: Adapting to the fast-changing technological landscape poses challenges.
    • Coordination across Stakeholders: Bureaucratic delays and communication issues can arise.

     

    Who was Homi Bhabha?

    The DAE—Homi Bhabha Chair for Distinguished Scientists/Professors was launched in 2021 by the Department of Atomic Energy (DAE).

    • Homi Jehangir Bhabha (1909–1966) was a pioneering Indian physicist and the father of India’s nuclear programme.
    • He founded the Tata Institute of Fundamental Research (TIFR) in 1945 and the Atomic Energy Establishment, Trombay (later Bhabha Atomic Research Centre, BARC) in 1954.
    • Bhabha formulated India’s three-stage nuclear power programme in the 1950s and emphasized nuclear power for military and energy purposes.
    • He was the first Indian to receive the Adams Prize in 1942 and served as the President of the UN Conference on Peaceful Uses of Atomic Energy in 1955.
    • Bhabha activated Apsara, Asia’s first research reactor, at BARC in 1956, and was awarded the Padma Bhushan in 1954.

     

    PYQ:

    [2015] Indira Gandhi Peace Prize for Peace, Disarmament and Development for 2014 was given to which of the following?

    (a) Bhabha Atomic Research Centre

    (b) Indian Institute of Science

    (c) Indian Space Research Organization

    (d) Tata Institute of Fundamental Research

  • The significance of ANI versus OpenAI

    Why in the News?

    The lawsuit against OpenAI in India is poised to establish key precedents for defining the legal accountability of AI developers regarding the content generated by their platforms within the country.

    What are the core allegations made by ANI against OpenAI?

    • Unauthorized Use of Copyrighted Content: ANI alleges that OpenAI used its copyrighted news content to train its language models without obtaining the necessary permissions, constituting copyright infringement.
    • Verbatim Reproduction: ANI claims that ChatGPT generates responses that are either verbatim or substantially similar to its original articles, which violates copyright protections. They argue that this reproduction occurs without authorization.
    • False Attribution and Fabricated Information: ANI highlights instances where ChatGPT has attributed false statements or fabricated interviews to the agency, which they argue damages their reputation and risks spreading misinformation.
    • Ineffectiveness of Opt-Out Policy: ANI contends that OpenAI’s opt-out policy is ineffective because their content is still accessible through third-party websites, allowing OpenAI’s crawlers to scrape it despite ANI’s attempts to block access.
    • Request for Legal Restraints: ANI is seeking an interim injunction to prevent OpenAI from storing, using, or reproducing its work, as well as prohibiting access to its content through any means.

    How does this case reflect broader issues in AI and copyright law?

    • Liability of AI Platforms: The case presents an unresolved legal question regarding whether AI platforms can be held liable for copyright infringement when they use publicly available content for training purposes. This issue is not only pertinent in India but also resonates globally, as similar lawsuits have emerged in other jurisdictions.
    • Fair Use and Exceptions: The interpretation of fair use and the applicability of exceptions such as text and data mining (TDM) in the context of AI training remain ambiguous under Indian law. The court’s decision will be crucial in determining whether existing copyright frameworks can accommodate the unique characteristics of AI technologies.
    • Territoriality in Data Storage: OpenAI’s defence centres on the argument that it operates outside India, complicating the application of Indian copyright law. This raises broader concerns about data sovereignty and how traditional legal concepts apply to cloud-based services and distributed AI models.

    What implications does this case have for the future of AI development and media partnerships?

    • Setting Legal Precedents: The case may establish important legal precedents regarding the responsibilities of AI companies toward content creators, influencing how future disputes are resolved in India and potentially beyond.
    • Impact on Licensing Agreements: As seen with other publishers entering licensing agreements with AI firms, this case could encourage more formalised partnerships where media organisations negotiate terms for their content’s use in AI training, ensuring they receive compensation for their intellectual property.
    • Regulatory Framework Development: The lawsuit may prompt Indian lawmakers to consider new regulations addressing the use of copyrighted material by AI platforms, potentially leading to clearer guidelines that balance innovation with the rights of content creators.
    • Challenges for Smaller Publishers: While larger media organisations may have the resources to negotiate favourable terms with AI companies, smaller publishers could face difficulties without similar leverage. This disparity could affect diversity in media representation and innovation within the industry.

    Way forward: 

    • Establish a Balanced Regulatory Framework: Policymakers should develop clear guidelines addressing the use of copyrighted material by AI platforms, incorporating provisions for text and data mining (TDM) and fair use exceptions.
    • Promote Collaborative Licensing Models: Media organisations and AI firms should work towards formalised licensing agreements that outline terms for the use of copyrighted content in AI training.

    Mains PYQ:

    Q “The emergence of the Fourth Industrial Revolution (Digital Revolution) hasinitiated e-Governance as an integral part of government”. Discuss. (UPSC IAS/2020)

  • Deepening India’s steps as a key space-faring nation

    Why in the News?

    India has set ambitious objectives for its space programme over the next two decades, focusing on the development of powerful, reusable rockets like the Indian Space Research Organisation (ISRO)’s upcoming Next Generation Launch Vehicle (NGLV).

    What are the recent achievements of India’s space program?

    • Chandrayaan-3 Mission: India successfully achieved a soft landing near the lunar south pole with its Chandrayaan-3 mission, marking a historic milestone as the fourth country to do so. This mission demonstrated India’s growing technological capabilities in space exploration.
    • Aditya L1 Mission: Launched as India’s first space-based solar observatory, Aditya L1 aims to study the outer atmosphere of the Sun, contributing valuable data to solar science.
    • Gaganyaan Preparations: ISRO is actively working on the Gaganyaan mission, which aims to send Indian astronauts into orbit by 2025. This includes extensive testing of human-rated launch vehicles and crew escape systems.
    • Budget Increases: The Indian government allocated approximately $1.5 billion to the Department of Space for 2024-2025, reflecting a commitment to enhance space capabilities and infrastructure.

    How is India planning to expand its human spaceflight and exploration capabilities?

    • Gaganyaan Mission: This mission is pivotal for establishing India’s human spaceflight capabilities, with plans for multiple uncrewed test flights leading up to a manned mission. The first crewed flight is targeted for late 2024.
    • Lunar Exploration Goals: India plans to achieve a crewed lunar landing by 2040 and establish a lunar space station to facilitate ongoing research and exploration efforts on the Moon.
    • Bharatiya Antariksha Station: The establishment of India’s first space station in low Earth orbit is planned by 2035, serving as a platform for scientific research and technology testing.
    • Next Generation Launch Vehicle (NGLV): The development of the NGLV will enhance India’s heavy-lift capabilities, crucial for supporting human missions and larger payloads in future explorations.

    What role does international collaboration play in India’s space ambitions?

    • Commercial Partnerships: India has engaged in collaborations with international companies like SpaceX for satellite launches, showcasing an openness to leveraging foreign technology and expertise in its space endeavours.
    • Foreign Direct Investment (FDI): Recent reforms have opened up India’s space sector to increased foreign investment, fostering partnerships that can enhance technological capabilities and innovation within the domestic industry.
    • Collaborative Research and Development: By exploring foreign collaboration opportunities, Indian corporations can access advanced rocket technologies and expertise that may not currently exist within the country, accelerating development timelines for projects like reusable rockets.

    Way forward: 

    • Strengthen Private Sector Engagement: India should actively encourage partnerships with domestic and international private companies to accelerate the development of advanced space technologies, such as reusable rockets and heavy-lift vehicles, ensuring a competitive edge in global space exploration.
    • Expand International Collaborations: India should deepen its space collaborations with countries and space agencies globally, particularly in research, technology sharing, and joint missions, to leverage global expertise and enhance its own space capabilities.

    Mains PYQ:

    Q India has achieved remarkable successes in unmanned space missions including the Chandrayaan and Mars Orbiter Mission, but has not ventured into manned space mission. What are the main obstacles to launching a manned space mission, both in terms of technology and logistics? Examine critically. (UPSC IAS/2017)

  • [pib] CAR T-Cell Therapy

    Why in the News?

    The Department of Biotechnology (DBT) has been a key supporter of research projects focusing on CAR T-cell therapies for cancers.

    About CAR T-Cell Therapy:

    What is it?
    • Acronym  for Chimeric Antigen Receptor T–Cell Therapy;
    • Innovative  immunotherapy in which T-cells (a type of white blood cell) are genetically modified to express a receptor (CAR) that targets specific proteins on cancer cells.
    • T-cells are part of the immune system and help identify and eliminate infected or cancerous cells.
    Objective of the Therapy
    • To treat blood cancers, especially B Acute Lymphoblastic Leukemia (B-ALL) and Non-Hodgkin Lymphoma (B-NHL).
    • Aimed at patients whose disease relapsed or was resistant to conventional treatments (chemotherapy, radiation).
    • Specifically targets CD19, a protein found on the surface of B-cells, which includes cancerous B-cells.
    Implementation and Structural Mandate
    • Developed jointly by Indian Institute of Technology (IIT-Bombay) and Tata Memorial Center (TMC), Mumbai since 2015.
    • Approved by DCGI (Drug Controller General of India) in March 2021 for Phase 1 trials in children and adults with relapsed B-ALL and B-NHL.
    • Supported by academic grants from Department of Biotechnology and government agencies.
    • Trials were conducted at Tata Memorial Center (TMC), and other hospitals.
    Future Scope for Phase II
    • Phase 1 Trials: Conducted from 2021 to 2023 on children and adolescents with B-ALL and adults with B-NHL, with promising results matching international standards in terms of efficacy and safety.
    • Phase 2 Trials: Have been approved and are currently ongoing. These trials will expand on the efficacy and long-term safety of the therapy, including larger cohorts of patients.

    Future Scope: Holds the potential for expanding to other cancers, such as Multiple Myeloma, Glioblastoma, and Hepatocellular Carcinomas, based on continued research and results from Phase II trials.

     

    PYQ:

    [2022] Which one of the following statements best describes the role of B cells and T cells in the human body?

    (a) They protect the environmental allergens body.
    (b) They alleviate the body’s pain and inflammation.
    (c) They act as immuno-suppressants in the body.
    (d) They protect the body from diseases caused by pathogens.