💥Join UPSC 2027,2028 Mentorship (August Batch) + XFactor Notes & Microthemes PDF

Subject: Science and Technology

  • ecDNA Challenges Law of Genetics

    Why in the News?

    A recent study published in theNature’ has shown that Extrachromosomal DNA (ecDNA) is present in approximately 50% of cancer types, playing a significant role in tumor evolution and genetic heterogeneity.

    What is ecDNA?

    Details ecDNA stands for extrachromosomal DNA, which is small, circular DNA found in the nucleus of cells, separate from regular chromosomes.
    • Forms when DNA breaks off from chromosomes, often due to damage or errors in cell division.
    • Can carry extra copies of oncogenes, which promote cancer growth.
    • Initially thought to be unimportant, recent studies show it plays a major role in cancer.
    How ecDNA Contributes to Cancer and Drug Resistance Helps Tumors Grow: ecDNA contains extra copies of oncogenes that help cancer cells grow faster and become more aggressive.
    Drug Resistance: The extra oncogenes make the cancer harder to treat with standard drugs by producing more harmful proteins.
    Faster Tumor Evolution: ecDNA allows cancer cells to evolve rapidly, making them more resistant to treatments like chemotherapy and enabling the tumor to grow even when drugs are used.

     

    How ecDNA Challenges Genetics Laws?

    • Mendel’s Law says that genes on different chromosomes are inherited independently, meaning they are passed on randomly to the next generation.
    • ecDNA breaks this rule by grouping genes together and passing them on as a cluster during cell division.
    • This allows cancer cells to inherit beneficial genes more easily and helps the tumor grow faster.
    • Unlike regular chromosomes, which are distributed randomly during cell division, ecDNA is passed on together as a package.
    • This process gives cancer cells an advantage by making sure they inherit helpful genetic combinations that support cancer growth and resistance to drugs.
  • What India’s AI Safety Institute could do?

    Why in the News?

    In October, the Ministry of Electronics and Information Technology (MeitY) held discussions with industry leaders and experts about establishing an AI Safety Institute as part of the IndiaAI Mission.

    What are the core objectives and focus areas for the AI Safety Institute?

    • Setting Standards for AI Safety: The AISI aims to develop frameworks, guidelines, and standards for safe AI deployment without acting as a regulatory body. This approach is designed to foster innovation while ensuring safety.
    • Enhancing Domestic Capacity: The institute will focus on building domestic capabilities in AI safety, leveraging India’s unique strengths and addressing local challenges related to AI deployment.
    • Promoting Multi-Stakeholder Collaboration: Engaging various stakeholders—including government bodies, industry players, academia, and civil society—is crucial for creating a comprehensive approach to AI safety that reflects diverse perspectives.
    • Risk Assessment and Mitigation: The AISI will develop tools for risk assessment and mitigation related to AI technologies, focusing on issues such as bias, discrimination, and social exclusion.
    • Global Engagement: By integrating into international networks like the Bletchley Process, the AISI will participate in global dialogues on AI safety, bringing forward the concerns of developing countries and contributing to a more inclusive governance framework.

    How should the organizational structure of the AISI be designed to ensure scalability and independence?

    • Independence from Regulatory Bodies: The AISI should operate independently from rulemaking and enforcement authorities to maintain its focus on research, testing, and standardization rather than regulatory compliance.
    • Collaboration with Academic Institutions: Establishing the AISI within academic institutions (e.g., IITs) can provide it with a degree of independence while tapping into existing research capabilities and expertise.
    • Scalable Framework: The organizational structure should be designed for scalability, allowing the institute to adapt to evolving technological landscapes and increasing demands for AI safety oversight.
    • Technical Research Focus: The AISI should prioritize technical research and development of indigenous AI safety tools that address India’s specific challenges while aligning with global standards.

    What strategies can be implemented to engage stakeholders and build partnerships for effective AI safety governance? (Way forward)

    • Building Strong Partnerships: The AISI should actively seek partnerships with key stakeholders in government, industry, academia, and civil society both nationally and internationally to foster collaboration on AI safety initiatives.
    • Engaging in Global Dialogues: Participation in international forums and dialogues on AI governance will help position India as a leader in global discussions on AI safety, allowing for knowledge exchange and shared best practices.
    • Community Involvement: Engaging local communities through outreach programs can raise awareness about AI risks and promote inclusive participation in shaping AI governance policies.
    • Establishing Voluntary Compliance Tools: Developing voluntary compliance toolkits can help industries adopt best practices in AI safety without imposing stringent regulatory requirements that could stifle innovation.
    • Continuous Feedback Mechanisms: Implementing mechanisms for continuous feedback from stakeholders will ensure that the AISI remains responsive to emerging challenges in AI technology and governance.

    Mains PYQ:

    Q  What are the main socio-economic implications arising out of the development of IT industries in major cities of India? (UPSC IAS/2021)

  • [pib] Asia-Oceania Meteorological Satellite Users’ Conference (AOMSUC-14)

    Why in the News?

    The 14th Asia-Oceania Meteorological Satellite Users’ Conference (AOMSUC-14) will take place from December 4-6, 2024, in New Delhi.

    About AOMSUC:

    Details
    What is it? • It is a conference focused on the use of meteorological satellite data for weather forecasting, climate monitoring, and disaster risk management.
    First AOMSUC was held in Beijing, China in 2010.• Held annually across various locations in the Asia-Oceania region, becoming a significant event for meteorological satellite applications.

    • Participants: WMO, NASA, ESA, JAXA, and other leading space organizations.

    Aims and Provisions Collaboration: Facilitate regional cooperation in the use of satellite data.
    Weather & Climate Monitoring: Improve forecasting and monitoring of climate patterns.
    Disaster Management: Enhance early warning systems for extreme weather events.
    Capacity Building: Provide training, workshops, and knowledge-sharing opportunities for local meteorologists and satellite data users.
    Data Sharing: Promote satellite data sharing across countries.
    Significance Regional Cooperation: Promotes stronger collaboration between Asia-Oceania countries, helping to address shared meteorological challenges.
    Improved Forecasting: Facilitates the improvement of satellite data usage for more accurate weather forecasts and better disaster risk reduction strategies.
  • [pib] National AYUSH Mission (NAM)

    Why in the News?

    • The National AYUSH Mission (NAM) is an important Centrally Sponsored Scheme aimed at promoting and developing the AYUSH systems of medicine across the country.
      • In addition to NAM, Central Sector Schemes like the AYURSWASTHYA Yojana and the AYURGYAN Scheme play a crucial role in advancing the mission’s objectives

    About AYURGYAN and AYURSWATHYA Scheme

    Details
    AYURSWASTHYA Yojana • Under the Ministry of AYUSH to promote AYUSH healthcare and education.
    • Has two key components:

    1. AYUSH and Public Health: Promotes AYUSH interventions for community health care.
    2. Upgradation of Facilities to Centre of Excellence: Improves standards of AYUSH medical units and establishes advanced centers in AYUSH and Allopathic institutions (both Govt. and Private).

    • Funding: Maximum assistance of ₹10 crore for Centre of Excellence upgrades for 3 years.

    AYURGYAN Scheme • Created by merging two schemes under one umbrella.
    • Focuses on promoting AYUSH education and research.
    • Aims to develop quality standards and expand AYUSH education and healthcare services across India.
    Training of healthcare professionals in AYUSH and supporting research initiatives to improve efficacy and standards of traditional medicine.

    Back2Basics: National AYUSH Mission (NAM)

    Category Details
    Overview   Launched in September 2014 under the Ministry of Health and Family Welfare during the 12th Five Year Plan.
    • Aimed at promoting and strengthening traditional systems of medicine: AYUSH (Ayurveda, Yoga, Unani, Siddha, Homeopathy).
    Focuses on improving healthcare infrastructure in rural and remote areas, enhancing access to AYUSH services and promoting holistic health across India.
    Implementation and Structure • Initially implemented by the Department of AYUSH, now under the Ministry of AYUSH for nationwide execution.
    • Works in partnership with States and UTs to address healthcare gaps in underserved areas.
    Provisions under NAM Promotion of AYUSH Systems: Integrates AYUSH into the mainstream healthcare system, especially in rural and underserved areas.
    Support to State/UTs: Provides financial support for establishing AYUSH dispensaries, clinics, colleges and hospitals.
    Strengthening AYUSH Health Services: Financial assistance for expanding AYUSH services, especially in remote areas.
    Research & Development (R&D): Supports research for developing better treatments and standardizing practices in AYUSH.

    PYQ:

    [2019] How is the Government of India protecting traditional knowledge of medicine from patenting by pharmaceutical companies?

  • [pib] Schemes Implemented in Science and Technology

    Why in the News?

    The Ministry of Science and Technology, through its three key departments — Department of Science and Technology (DST), Department of Biotechnology (DBT), and Department of Scientific and Industrial Research (DSIR) — is implementing various schemes to bolster the Science, Technology, and Innovation (STI) ecosystem across India.

    Schemes Implemented Under the Department of Science and Technology (DST)

    Scheme   Objective Key Components
    Science and Technology (S&T) Institutional and Human Capacity Building (2015) Enhance human resource development and institutional capacity in science and technology. – Fellowships at various levels (undergraduate, postgraduate, doctoral, post-doctoral).
    – Establishment of sophisticated R&D facilities.
    – Capacity building for faculty.
    Research and Development (R&D) (2009) Support research in fundamental, applied, and translational sciences. – Collaborative research with universities, government, and private sectors.
    – International research cooperation.
    – Focus on diverse sectors like health, energy, and IT.
    Innovation, Technology Development, and Deployment (2016) Foster innovation and facilitate the development of new technologies for national development. – Technology incubation centers.
    – Technology transfer and commercialization.
    – Support for startups and entrepreneurs.
    National Mission on Interdisciplinary Cyber Physical Systems (NM-ICPS) (2017) Promote interdisciplinary research in Cyber Physical Systems (CPS) that integrate computational algorithms with physical processes. – Development of CPS technologies (e.g., IoT, smart cities, advanced manufacturing).
    – Setting up innovation centers and testbeds for CPS.
    National Quantum Mission (NQM) (2023) Advance quantum technologies for solving national challenges in energy, communications, and security. – Research in quantum computing, quantum communications, and quantum sensing.
    – Establishment of quantum technology hubs and research centers.

     

    Schemes Implemented Under the Department of Biotechnology (DBT)

    Scheme Objective Key Components
    Biotechnology Research Innovation and Entrepreneurship Development (Bio-RIDE) (2017) Foster innovation in biotechnology through research, industrial development, and entrepreneurship. Biotechnology R&D: Funding for research projects.
    Industrial & Entrepreneurship Development (I&ED): Support for biotech startups and industrial innovations.
    Biomanufacturing and Biofoundry: Development of manufacturing and biotechnological production systems.
  • Major Atmospheric Cherenkov Experiment (MACE) Telescope

    Why in the News?

    The Major Atmospheric Cherenkov Experiment (MACE) telescope was inaugurated on October 4th in Hanle, Ladakh.

    About MACE Telescope:

    Details
    Details and Working World’s highest imaging Cherenkov telescope, located in Hanle, Ladakh, at 4.3 km above sea level.
    • It has a 21-meter-wide mirror-dish, the largest in Asia.
    Developed by Bhabha Atomic Research Centre (BARC), Tata Institute of Fundamental Research (TIFR), Electronics Corporation of India Ltd. (ECIL), and Indian Institute of Astrophysics (IIA).
    Cherenkov radiation is captured using mirrors and analyzed with photomultiplier tubes (PMTs). Cherenkov radiation is the blue glow emitted when charged particles travel faster than light in a medium.
    • Equipped with a high-resolution camera and movable base.
    Aims and Objectives of MACE Detects high-energy gamma rays (greater than 20 giga-electron volts) emitted by cosmic phenomena.
    Detect Weakly Interacting Massive Particles (WIMPs) for dark matter research.
    Contribute to multi-messenger astronomy by complementing data from other telescopes.
    How Do Gamma Rays Work in DNA Mutation? Cause ionization, which can break chemical bonds in DNA, leading to mutations.
    Mutations may result in cancers or genetic disorders if not repaired.
    DNA damage from gamma rays can lead to chromosomal aberrations and contribute to carcinogenesis.

     

    PYQ:

    [2015] In the context of modern scientific research, consider the following statements about ‘IceCube’, a particle detector located at South Pole, which was recently in the news:

    1. It is the world’s largest neutrino detector, encompassing a cubic kilometre of ice.
    2. It is a powerful telescope to search for dark matter.
    3. It is buried deep in the ice.

    Which of the statements given above is/are correct?

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

  • [pib] India’s first modern Compressed Biogas (CBG) Plant

    Why in the News?

    PM Modi inaugurated the 100 TPD cattle dung-based Compressed Bio-Gas (CBG) plant in Gwalior.

    About the CBG Plant 

    • The plant is located in Laltipara, Gwalior, within the largest cowshed in the region, Adarsh Gaushala, which houses over 10,000 cattle.
      • It spans over 5 acres.
      • It is India’s first self-sufficient gaushala with a modern CBG plant, where cow dung and organic waste (such as vegetable and fruit waste from mandis and households) are processed into valuable biogas.
    • The project, developed at a cost of ₹31 crores, is a collaboration between Gwalior Municipal Corporation and the Indian Oil Corporation.

    Working features:

    • Bio CNG: The plant produces 2 tons of compressed Bio CNG daily from 100 tons of cattle dung, providing a cleaner, eco-friendly alternative to traditional fossil fuels.
    • Organic Manure: The plant also generates 10-15 tons of dry bio-manure daily, which is a valuable by-product for organic farming.
    • Windrow composting: The plant incorporates windrow composting, located adjacent to the main facility, which enhances organic waste processing.

     

    What is Compressed Biogas (CBG)?

    Details
    About
    • CBG is a renewable natural gas produced from the biochemical conversion of organic waste into methane.
    • It is chemically similar to CNG (compressed natural gas) and can be used as an alternative to fossil fuels in transportation, cooking, and power generation.
    Process of Making CBG
    1. Collection of Organic Waste: Organic waste such as agricultural residue, animal dung, food waste, and municipal solid waste is collected from farms, industries, and households.
    2. Anaerobic Digestion: Waste is placed in an airtight chamber, where microorganisms break it down without oxygen, producing biogas (methane, carbon dioxide, trace gases).
    3. Purification: The raw biogas undergoes purification through methods like pressure swing adsorption, water scrubbing, or membrane separation to remove impurities like CO₂, H₂S, and water, leaving pure methane.
    4. Compression: The purified methane is compressed to 200-250 bar pressure to form CBG, reducing volume for storage and transportation.
    5. Storage and Distribution: It is stored in high-pressure cylinders or tanks and transported to fuel stations or industries for various applications.
    Significance of CBG
    • Reduces fossil fuel dependence.
    • Mitigates landfill methane emissions.
    • CBG can replace CNG, reducing pollution.
    • Utilizes local organic waste.
    • Creates jobs, promotes organic farming, and provides eco-friendly fertilizers.
  • Democratising AI needs a radically different approach

    Why in the News?

    Policymakers globally are addressing Big Tech’s dominance in AI by investing in sovereign cloud infrastructure, open data platforms, and supporting start-ups, yet these measures may inadvertently reinforce Big Tech’s control.

    How can we ensure that AI is implemented in a way that upholds democratic values?

    • It promotes Open Data Initiatives: While open data can enhance AI systems, it must be safeguarded against commercial capture by larger entities. Initiatives should focus on making data accessible and usable for smaller players without allowing Big Tech to monopolize it.
    • It invests in Public Compute Infrastructure: Establishing public computing resources can provide alternatives to private cloud services dominated by Big Tech. However, these resources must be competitive in terms of cost and functionality to be effective.
    • It fosters Smaller AI Models: Shifting focus from large-scale deep learning models to smaller, theory-driven AI models can democratize development. This approach emphasizes domain expertise and lived experiences over sheer data volume, which aligns better with democratic values.

    What role should public participation play?

    • Engagement in Policy Development: Involving diverse stakeholders, including community representatives and industry experts, can help create policies that reflect a broader range of interests and concerns regarding AI deployment.
    • Transparency and Accountability: Mechanisms should be established to ensure transparency in AI decision-making processes. Public oversight can help hold organizations accountable for their AI practices, particularly regarding data usage and algorithmic biases.
    • Community-Centric AI Solutions: Encouraging local communities to participate in the design and implementation of AI solutions can lead to more equitable outcomes. This involvement ensures that AI applications address specific community needs rather than serving corporate interests alone.

    What are the risks associated with technocratic governance?

    • Concentration of Power: The dominance of Big Tech can lead to a concentration of power where a few entities dictate the terms of AI development and deployment. This scenario risks sidelining smaller players and reducing diversity in innovation.
    • Surveillance and Privacy Concerns: The use of AI for surveillance by powerful corporations can threaten individual privacy rights. Policymakers must carefully consider the implications of deploying AI technologies that could exacerbate existing inequalities or infringe on civil liberties.
    • Erosion of Public Trust: If the public perceives that AI governance is primarily driven by technocratic elites without adequate input from citizens, trust in these systems may erode. This distrust can hinder the effective implementation of AI technologies that could otherwise benefit society.

    Way forward: 

    • Establish Inclusive AI Governance: Create multi-stakeholder frameworks involving governments, communities, and smaller players to ensure transparency, accountability, and equitable access to AI resources, safeguarding against monopolistic practices.
    • Prioritize Ethical, Small-Scale AI Development: Shift focus from large-scale deep learning models to theory-driven, domain-specific AI solutions that respect privacy, foster community involvement, and address localized needs, promoting democratic values in AI deployment.

    Mains PYQ:

    Q The emergence of the Fourth Industrial Revolution (Digital Revolution) hasinitiated e-Governance as an integral part of government”. Discuss. (UPSC IAS/2020)

  • [pib] India’s First Indigenous Antibiotic: Nafithromycin

    Why in the News?

    The Ministry of Science & Technology has launched Nafithromycin, India’s first indigenous antibiotic to combat drug-resistant infections.

    About Nafithromycin:

    Details
    About • It was developed with the support of the Biotechnology Industry Research Assistance Council (BIRAC), a unit under the Department of Biotechnology, to combat antimicrobial resistance (AMR).
    • It aims to treat Community-Acquired Bacterial Pneumonia (CABP) caused by drug-resistant bacteria.
    ( Awaiting final approval from CDSCO for manufacturing and public use.)
    Features   Developed over 14 years of clinical trials in the U.S., Europe, and India.
    10 times more effective than azithromycin. (3 doses to combat Drug-Resistant Pneumonia)
    Minimal side effects, no significant drug interactions, and food-independent.
    Significance   It targets both typical and atypical pathogens.
    • It addresses a global health issue, especially CABP, contributing to over 2 million deaths annually.
    • Offers a more effective, faster, and safer treatment for drug-resistant pneumonia.
    • Demonstrates successful public-private collaboration between the government and Wockhardt Pharmaceuticals.
    • A cost-effective solution for treating resistant infections in low-resource settings.

     

    PYQ:

    [2019] Which of the following are the reasons for the occurrence of multi-drug resistance in microbial pathogens in India?

    1. Genetic predisposition of some people
    2. Taking incorrect doses of antibiotics to cure diseases
    3. Using antibiotics in livestock farming
    4. Multiple chronic diseases in some people

    Select the correct answer using the code given below.

    (a) 1 and 2
    (b) 2 and 3 only
    (c) 1, 3 and 4
    (d) 2, 3 and 4

  • Should packaged food content be labelled?

    Why in the News?

    A report by the Access to Nutrition Initiative (ATNi), a global non-profit, reveals that food and beverage companies generally sell less healthy products in low- and middle-income countries (LMICs) than in high-income countries (HICs).

    What does the report published by the Access to Nutrition Initiative state? 

    • Lower Health Ratings in LMICs: The report assessed 52,414 products from 30 of the world’s largest food and beverage manufacturers. It found that products sold in LMICs had an average Health Star Rating (HSR) of 1.8, whereas those in HICs averaged 2.3. This indicates that the portfolios of these companies are less healthy in poorer markets.
    • Healthier Product Sales: Only 30% of the assessed companies have a strategy to price their healthier products affordably for lower-income consumers. This lack of accessibility contributes to dietary issues in these regions.
    • Micronutrient Data Availability: The report highlighted that micronutrient data were available for a smaller proportion of products in LMICs compared to HICs, complicating efforts to address nutritional deficiencies.
    • Call for Action: The ATNi challenges companies to derive at least 50% of their sales from healthier products by 2030, a target that only a small fraction currently meets.

    How does a Health Star rating system work? 

      • The Health Star Rating (HSR) system is a front-of-pack labeling initiative that rates food products on a scale from 0.5 to 5 stars based on their nutritional profile.
    • The rating is calculated by assessing:
      • Risk Nutrients: Total energy, saturated fat, sugars, and sodium.
      • Positive Nutrients: Protein, fiber, fruits, vegetables, nuts, and legumes.
    • A score above 3.5 stars is considered healthier, while lower scores indicate less healthy options. This system allows consumers to easily compare similar products and make informed dietary choices.

    Why have non-communicable diseases become so common in India? 

    Non-communicable diseases have become increasingly prevalent in India due to several factors:

    • Dietary Shifts: There has been a significant increase in the consumption of highly processed foods that are high in sugars and fats, contributing to obesity and diabetes.
      • According to the Indian Council of Medical Research (ICMR), unhealthy diets account for over 56% of the total disease burden in India.
    • Affordability Issues: More than 50% of Indians cannot afford a healthy diet, exacerbating nutritional deficiencies alongside rising obesity rates.
    • Lifestyle Changes: Reduced physical activity and urbanization have also played roles in this epidemic, leading to a dual burden of undernutrition and obesity.

    Can front-of-pack labelling help?

    Front-of-pack labeling could significantly influence consumer behavior and public health outcomes:

    • Effectiveness of Warning Labels: Studies from countries like Chile and Mexico show that mandatory warning labels on sugary beverages have led to decreased consumption. This suggests that clear labeling can help consumers make healthier choices.
    • Need for Mandatory Policies: Activists argue that voluntary measures taken by companies have been insufficient. They advocate for mandatory regulations on front-of-pack labeling to effectively communicate nutritional information related to high sugar, fat, and sodium content.

    Conclusion: The Access to Nutrition Initiative report emphasizes the urgent need for healthier food portfolios in LMICs (Low- and Middle-Income Countries), equitable pricing, and front-of-pack labeling to combat non-communicable diseases. These steps align with SDG 3 (Good Health and Well-being), promoting healthier lives globally.

    Mains PYQ:

    Q Can the vicious cycle of gender inequality, poverty and malnutrition be broken through microfinancing of women SHGs? Explain with examples. (UPSC IAS/2021)