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Subject: Science and Technology

  • What is KAVACH Collision Avoidance System (CAS)?

    Why in the News?

    Indian Railways expects to launch Kavach CAS on Mumbai-Delhi-Kolkata routes by March 2025.

    About Kavach Train Collision Avoidance System (TCAS)

    Details
    Development
    • Development started in 2011 by Indian Railways and Research Designs & Standards Organisation (RDSO).
    • Key developer: B. Rajaram, known for the Skybus Metro system.
    • Field trials began in 2014, and final approval was granted in 2019.
    Safety Parameters Certified for Safety Integrity Level 4 (SIL-4) operations
    Working Mechanism
    • Components: Trackside RFID tags, onboard locomotive equipment, radio infrastructure.
    • Functionality: Real-time monitoring, driver alerts, and automatic braking to prevent collisions.
    • Data Inputs: Location, direction, time.
    • Event Recorders: Retain records for post-incident analysis.
    Collision Prevention
    • Alert Mechanism: Alerts the locomotive pilot if a ‘red signal’ is missed.
    • Automatic Braking: If speed exceeds 15 kmph after a red signal, Kavach applies brakes to halt the train.
    Issues
    • High Cost: ₹50 lakh per kilometer for deployment.
    • Low Coverage: Covers only 1,500 kilometers out of the total 68,000-kilometer rail network (as of November 2023).

    How does CAS work in ships and aircraft?

    Key Systems Functions
    Ships AIS (Automatic Identification System) Sends and receives data on location, speed, and direction between ships and land-based stations.
    LRIT (Long Range Identification and Tracking)
    • Requires ships to report location, time, and equipment every 6 hours to authorities.
    • Data shared with contracting governments and rescue operators via International LRIT Data Exchange.
    Aircraft Transponders Respond to radio-frequency pings to build a 3D view of surrounding air traffic.
    Alerts and Resolution Issues alert if another aircraft is within 48 seconds (traffic advisory) or 30 seconds (resolution) of a collision.
    Radar Altimeters and Obstacle Detection Monitors distance to the ground and alerts pilots about tall obstacles like towers.

     

    PYQ:

    [2015] With reference to bio-toilets used by the Indian Railways, consider the following statements:

    1. The decomposition of human waste in the biotoilets is initiated by a fungal inoculum.
    2. Ammonia and water vapour are the only end products in this decomposition which are released into the atmosphere.

    Which of the statements given above is/are correct?

    (a) 1 only
    (b) 2 only
    (c) Both 1 and 2
    (d) Neither 1 nor 2

  • August 23rd declared as National Space Day

    Why in the News?

    The Centre has officially declared August 23rd as “National Space Day” in honor of the Chandrayaan-3 Mission’s historic achievement.

    About the National Space Day:

    • It is set to be celebrated on August 23rd every year.
    • It marks the successful landing of the Chandrayaan-3 mission’s Vikram Lander and Pragyan Rover on the Moon.
    • Theme for 2024:
      • “Touching Lives while Touching the Moon: India’s Space Saga” highlights space exploration’s impact on society and technology.
    • Significance:
      • India became the fourth country to land on the Moon and the first to land near the Moon’s southern polar region.

    About Chandrayaan-3 Mission:

    Details
    Launch
    • India’s third lunar mission, second attempt at soft landing on the Moon.
    • Launched on July 14, 2023. Landed on August 23.
    Landing Site Near the Lunar South Pole (Coordinates: 69.373°S 32.319°E)
    Mission Objectives
    • Demonstrate safe and soft landing on the Moon.
    • Rover mobility on lunar surface.
    • Conduct in-situ scientific experiments.
    Components
    • Propulsion Module: Carries lander and rover to 100 km lunar orbit; includes SHAPE payload.
    • Lander Module (Vikram): Instruments: ChaSTE, ILSA, Langmuir Probe, Laser Retroreflector Array.
    • Rover Module (Pragyan): Instruments: APXS, LIBS.
    Major Findings
    • Lunar Surface Temperature: Recorded up to 70°C, higher than expected.
    • Elemental Composition: Sulphur, aluminum, calcium, iron, chromium, titanium, manganese, silicon, and oxygen confirmed.
    Landing Site Name Named by PM as ‘Shiv Shakti’ (Sanctioned by IAU as “Statio Shiv Shakti”).

     

    PYQ:

    [2016] Consider the following statements:

    The Mangalyaan launched by ISRO

    1. is also called the Mars Orbiter Mission
    2. made India the second country to have a spacecraft orbit the Mars after USA
    3. made India the only country to be successful in making its spacecraft orbit the Mars in its very first attempt

    Which of the statements given above is/are correct?

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

  • Hidden dangers of irrational use of antibiotics on microbiome    

    Why in the news?

    While vital for treating infections, antibiotics can disrupt the microbiome by indiscriminately killing both harmful pathogens and beneficial gut bacteria, especially broad-spectrum types.

    Various roles played by Antibiotics (Applications):  

     

    Treatment of Infections

    Antibiotics are essential for treating bacterial infections, significantly reducing mortality rates associated with infectious diseases

    For example, penicillin and other antibiotics, the mortality rate from strep throat dropped dramatically from 1% to less than 0.1%.

    Preventing Disease Spread 

    Treating bacterial infections, antibiotics can prevent the spread of disease to other individuals

    For instance, during the 2009 H1N1 influenza pandemic, antibiotics were used to treat secondary bacterial pneumonia, which was a major cause of death.

    Reducing Complications

    Antibiotics can reduce the risk of serious complications from bacterial infections.

    For instance, In the case of urinary tract infections (UTIs), untreated infections can lead to kidney damage or life-threatening conditions like sepsis. However, with prompt antibiotic treatment, the risk of complications is greatly reduced

    Supporting Medical Procedures

    Antibiotics are used prophylactically to prevent infections before certain medical procedures

    For example in surgery

    Concerning Aspects of Antibiotic Use

    • Dysbiosis: The disruption of the microbiome, known as dysbiosis, can lead to severe health issues, including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). 
    • Increased Infection Risk: Antibiotics can reduce colonization resistance, which is the microbiome’s ability to prevent pathogenic microorganisms from establishing infections. This reduction increases the risk of infections by harmful bacteria, such as Clostridioides difficile.
    • Antimicrobial Resistance (AMR): Overuse of antibiotics contributes to the development of antimicrobial resistance, making it more challenging to treat infections. The global crisis of antibiotic resistance is exacerbated by the enrichment of antibiotic resistance genes within the gut microbiota due to antibiotic exposure.
    • Long-term Health Consequences: Repeated antibiotic use can prevent full recovery of the microbiome, leading to chronic health issues. Research shows that children who receive multiple courses of antibiotics are at higher risk for developing conditions like IBD later in life.
    • Impact on Other Organ Systems: Dysbiosis can affect various organ systems through gut-organ axes, influencing conditions such as mental health disorders (via the gut-brain axis), liver diseases (via the gut-liver axis), and skin conditions (via the gut-skin axis) due to altered immune responses and increased permeability.

    Government initiatives: 

    1. The Indian Council of Medical Research (ICMR) has initiated an antibiotic stewardship program (AMSP) on a pilot basis in 20 tertiary care hospitals across India to control the misuse and overuse of antibiotics in hospital wards and ICUs.
    2. ICMR collaborated with the Indian Council of Agriculture Research, Department of Animal Husbandry, Dairy and Fisheries, and the Drugs Controller General of India (DCGI) to ban the use of Colistin as a growth promoter in animal feed in poultry.
    3. The Government of India launched the National Action Plan on Antimicrobial Resistance (NAP-AMR) in April 2017, focusing on a One Health approach.

    Way forward: 

    • Antibiotic Stewardship Programs: Implement and promote antibiotic stewardship programs in healthcare settings to ensure antibiotics are prescribed only when necessary and with the appropriate dosage and duration.
    • Probiotic Supplementation: Encourage the use of probiotics alongside antibiotic treatments to help maintain a healthy microbiome and mitigate the risks of dysbiosis and related health issues.

    Mains PYQ: 

    Q Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved. (2014)

  • India to roll out BPaL Regimen for Drug-Resistant TB

    Why in the News?

    India is preparing to introduce the BPaL (bedaquiline, pretomanid, and linezolid) regimen for all patients with multi/extensively drug-resistant tuberculosis (M/XDR-TB).

    What is BPaL Regimen? 

    Details
    Purpose
    • Treatment for multi-drug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB).
    • Provides a potent, shorter, and more effective treatment option for patients resistant to standard TB drugs.
    Components of the regimen Bedaquiline (Bdq):

    • Targets ATP synthase enzyme in Mycobacterium tuberculosis, disrupting energy production.
    • Key drug in combating drug-resistant TB.
    Pretomanid (Pa):

    • Inhibits bacterial cell wall synthesis and kills bacteria under anaerobic conditions.
    • Enhances effectiveness when combined with other TB drugs.
    Linezolid (Lzd):

    • Inhibits protein synthesis, stopping bacterial growth.
    • Effective against MDR and XDR TB strains.

     

    Significance of BPaL Regimen

    • Studies and trials have shown that the BPaL regimen has higher success rates in treating MDR and XDR TB compared to older regimens.
    • It reduces treatment duration for MDR/XDR-TB from the traditional 18-24 months to 6 months approx.  
    • It is entirely oral with NO injectable, making it easier for patients to adhere to the treatment.
    • It reduces number of drugs patients need to take daily from up to 14 to just 3.

    PYQ:

    [2014] Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.

  • Why Silica Dust could become the ‘New Asbestos’ Health Risk?

    Why in the News?

    UK researchers suggest stricter daily silica dust exposure limits in industries could save 13,000 lives as per British Medical Journal Thorax.

    What is Silicosis?

    • Silicosis is a lung disease that results in the hardening of the lungs. It is caused by inhaling silica dust or crystals, commonly found in soil, sand, concrete, mortar, granite, and artificial stone.
    • Silicosis is a chronic disease that develops slowly, often after 10 to 20 years of exposure.
    • Silicosis can lead to other severe conditions, including lung cancer, tuberculosis, and chronic obstructive pulmonary disease (COPD).
    Note: Silicosis is a recognized disease under the Mines Act (1952) and the Factories Act (1948).

    Causes of Silicosis:

    • Workers in industries such as construction, mining, oil and gas extraction, kitchen engineering, dentistry, pottery, and sculpting are at high risk.
    • The cutting, drilling, or breaking down of materials containing silica releases fine dust into the air.

    As per National Programme on Elimination of Silicosis in India

    Remedies for Silicosis:

    Currently, there is no cure for silicosis, and treatment focuses on managing symptoms and preventing complications.

    Preventive measures:

    • Water Suppression Techniques: Using water or foam to suppress dust at the source.
    • Proper Ventilation: Ensuring adequate airflow in work environments to reduce dust accumulation.
    • Personal Protective Equipment (PPE): Providing workers with masks and respirators that filter out fine particles.
    • Regular Monitoring: Implementing regular health checks for workers and monitoring air quality in workplaces.

    Case study related to reducing Silica Dust Exposure

    • United States: Implemented stricter regulations on silica dust, resulting in a significant reduction in silicosis cases.
    • Australia: Banned the use of engineered stone due to its propensity to release high levels of silica dust when cut or drilled.

     

    PYQ:

    [2019] Why is there a great concern about the ‘microbeads’ that are released into environment?

    (a) They are considered harmful to marine ecosystems.

    (b) They are considered to cause skin cancer in children.

    (c) They are small enough to be absorbed by crop plants in irrigated fields.

    (d) They are often found to be used as food adulterants.

  • Trichophyton indotineae: A drug resistant fungal infections   

    Why in the News?

    The increase in drug-resistant fungal infections, especially Trichophyton indotineae, is becoming a major health problem in India.

    What Is Trichophyton Indotineae?

    • Trichophyton indotineae is a dermatophyte commonly known as ringworm or jock itch.
    • First identified in India, this fungus has now spread to several countries worldwide.
    • It belongs to genotype VIII within the T. mentagrophytes/T. interdigitale species complex, found in regions including Australia and Oman.

    Factors causing its spread 

    • Patients often present with persistent, treatment-resistant rashes that can be mistaken for eczema or other skin conditions.
    • Misdiagnosis leads to the use of ineffective treatments, prolonging patient suffering and allowing the infection to worsen.
    • Trichophyton indotineae has shown resistance to terbinafine due to genetic mutations, with growing resistance to itraconazole also a concern.
    • The unregulated sale of steroid-containing combination creams further complicates treatment efforts.

    Treatments available

    • Alternative to terbinafine and Itraconazole are available but often come with significant side effects, requiring close monitoring by healthcare providers.
    • Integrating comprehensive skin care regimens can enhance treatment efficacy, including maintaining skin hydration and using barrier creams.

    PYQ:

    [2014] Lichens, which are capable of initiating ecological succession even on a bare rock, are actually a symbiotic association of:

    (a) algae and bacteria

    (b) algae and fungi

    (c) bacteria and fungi

    (d) fungi and mosses

  • The hormone Oestrogen

    Why in the News?

    • “Osteoporosis” is a condition where bones become weak and brittle, with over 10 million cases annually in India.
      • It predominantly affects ageing women due to decreased oestrogen levels post-menopause.
    A recent study in Nature by researchers at the Universities of California uncovered a brain-derived hormone, CCN3, which increases bone mass in postpartum lactating mothers.

     

    What is Oestrogen?

      • Oestrogen is a primary female sex hormone essential for reproductive and sexual development.
      • It regulates the menstrual cycle and is crucial for the development of secondary sexual characteristics like breast development. 
      • Oestrogen also plays a vital role in maintaining bone density and cardiovascular health.
    • It is produced mainly in the ovaries but also in smaller amounts by the adrenal glands and fat tissue. 
    • The hormone influences various tissues, including the brain, heart, skin, and bones.
    • Imbalances in oestrogen levels can lead to various health issues, such as osteoporosis and cardiovascular disease.

    Role of Oestrogen in Bone Growth

    • Oestrogen is crucial for bone growth and formation, acting as a manager signaling the bone construction crew.
    • During breastfeeding, oestrogen production drops to focus on milk production, which should weaken bones.
    • Contrary to expectations, mothers’ bones become stronger to meet their babies’ high calcium demands.

    How does the ‘Hidden’ Hormone Keep Mice Mothers’ Bones Healthy?

    • During breastfeeding, the body suppresses oestrogen production to focus on milk production, which should weaken bones.
    • Despite low oestrogen, mothers’ bones strengthen.
    Researchers found that KISS1 neurons in the hypothalamus (a part of the brain) release the CCN3 hormone, which helps maintain and even increase bone mineralisation.

    Experimental Findings:

    • In experiments with genetically modified mice, those lacking the oestrogen receptor alpha still maintained healthy bones due to CCN3.
    • When CCN3 was introduced to skeletal stem cells, it significantly increased bone formation, showing its potential to strengthen bones independently of oestrogen.

    PYQ:

    [2019] ‘RNA interference (RNAi)’ technology has gained popularity in the last few years. Why?

    1. It is used in developing gene silencing therapies.
    2. It can be used in developing therapies for the treatment of cancer.
    3. It can be used to develop hormone replacement therapies.
    4. It can be used to produce crop plants that are resistant to virtual pathogens.

    Select the correct answer using the code given below.

    (a) 1, 2 and 4

    (b) 2 and 3

    (c) 1 and 3

    (d) 1 and 4 only

  • Inaugural Rashtriya Vigyan Puraskar, 2024 announced 

    Why in the News?

    G Padmanabhan, the Chandrayaan-3 team, Annapurni Subramaniam, and 30 others have been chosen for the inaugural Rashtriya Vigyan Puraskar (RVP), India’s new national science awards established last year.

    What is Rashtriya Vigyan Puraskar?

    • The RVP comprises four awards:
    1. Vigyan Ratna for lifetime achievement.
    2. Vigyan Shri for scientists of all ages.
    3. Vigyan Yuva for scientists under 45 years.
    4. Vigyan Team for collaborative research work.
    • These awards were instituted last year, replacing all existing science awards, including the prestigious Shanti Swarup Bhatnagar Prize.
    • The Vigyan Yuva now serves as a replacement for the Bhatnagar Prize, which also recognized outstanding scientists below 45 years.

    Ceremony Details:

    • These awards shall be announced on the National Technology Day (11th May) every year.
    • The Award Ceremony for all categories of awards shall be held every year on the National Space Day on 23rd August.
    • The Hon’ble President of India / The Hon’ble Vice President of India may confer the Awards.

    Notable Awardees

    • G Padmanabhan: At 86, G Padmanabhan, a renowned biochemist known for his work on the malaria parasite, has been named a Vigyan Ratna, recognizing his lifetime achievement in science. Padmanabhan is a towering figure in Indian science and has been honored with the Padma Shri and Padma Bhushan.
    • Chandrayaan-3 Team: The team behind Chandrayaan-3, which successfully landed India’s first spacecraft on the Moon last year, has been awarded the Vigyan Team award for their collaborative research work.
    • Vigyan Yuva Puraskar Recipients:
      • Vivek Polshettiwar (Tata Institute of Fundamental Research, Mumbai): A chemist working on carbon capture technologies.
      • Urbasi Sinha (Raman Research Institute, Bengaluru): A leading expert in quantum research.
      • Roxy Mathew Koll (Indian Institute of Tropical Meteorology, Pune): A climate scientist.
    • Annapurni Subramaniam:
      • Among the 13 scientists selected for the Vigyan Shri award, Annapurni Subramaniam’s main research focuses on the formation and evolution of star clusters and galaxies.
    • Other Vigyan Shri Recipients:
      • Jayant Bhalchandra Udgaonkar: A biologist and former director of IISER Pune.
      • Naba Kumar Mondal: A particle physicist from Saha Institute of Nuclear Physics, Kolkata.

    PYQ:

    [2009] For outstanding contribution to which one of the following fields is Shanti Swarup Bhatnagar Prize given?

    (a) Literature

    (b) Performing Arts

    (c) Science

    (d) Social Service

  • The Physics of Pressure

    Why in the News?

    • Pressure is an indispensable part of life, often unnoticed but always present.
      • It’s the interaction of microscopic particles with the macroscopic world, creating phenomena like air pressure.

    What is Pressure?

    • Pressure is defined as the force exerted per unit area on a surface. 
    • For example, an apple weighing 100 g exerts a force of about 1 newton (N) on your hand and a pressure of approximately 500 Pa.
    • Atmospheric pressure is around 100,000 Pa, equivalent to the pressure exerted by about 200 apples on your hand.

    Everyday Examples of Pressure

    (1) Measuring Blood Pressure:

    • Blood pressure, measured in mm of mercury (mmHg), is an example of pressure in a different context.
    • Blood pressure is measured using a sphygmomanometer, which balances the pressure in an arm cuff with the pressure of the blood in the arteries.
    • The readings, such as 120/80 mmHg, represent the pressure during heartbeats (systolic) and between beats (diastolic).
    • Mercury, being 15 times heavier than water, allows for portable blood-pressure machines.

    (2) Pressure Cookers:

    • The whistle of a pressure cooker is a direct result of the increased pressure cooking the food efficiently.
    • The pressure cooker exemplifies the practical application of pressure in cooking, making it an indispensable kitchen tool.

    PYQ:

    [2021] In a pressure cooker, the temperature at which the food is cooked depends mainly upon which of the following?​

    1. Area of the hole in the lid​

    2. Temperature of the flame​

    3. Weight of the lid​

    Select the correct answer using the code given below.​

    (a) 1 and 2 only ​

    (b) 2 and 3 only​

    (c) 1 and 3 only ​

    (d) 1, 2 and 3​

  • What is ‘PrecivityAD2’ the new Alzheimer’s Blood Test?

    Why in the News?

    Researchers in Sweden have developed a new blood test, PrecivityAD2, which is about 90% accurate in identifying Alzheimer’s Disease (AD) in people experiencing cognitive symptoms.

    What is Alzheimer’s Disease (AD)?

    • Alzheimer’s disease is the most common type of dementia (loss of memory and cognitive abilities).
    • It is a progressive disease beginning with mild memory loss and possibly leading to loss of the ability to carry on a conversation and respond to the environment.
    • Alzheimer’s disease involves parts of the brain that control thought, memory, and language.
    • Brain cell connections and the cells themselves degenerate and die, eventually destroying memory and other important mental functions.
    • Memory loss and confusion are the main symptoms.
    • No cure exists, but medication and management strategies may temporarily improve symptoms.

    How PrecivityAD2 Test works?

    • The test measures a combination of two ratios within a blood sample:
    1. Plasma Phosphorylated-tau217 (p-tau217) to Not-Phosphorylated-tau21: The test measures the ratio of p-tau217 to non-phosphorylated tau21. Tau proteins are associated with the formation of neurofibrillary tangles in the brain, a hallmark of AD.
    2. Amyloid-beta (AB42 and AB40): The test also measures the ratio of two types of amyloid-beta proteins, AB42 and AB40. Amyloid plaques are another key pathological feature of AD.
    • Both tau and amyloid-beta proteins are considered pathological hallmarks of AD.

    Benefits of PrecivityAD2

    • Early Detection: PrecivityAD2 can diagnose AD at the early stage of mild cognitive impairment, enabling timely intervention and management.
    • Accurate Identification: With an accuracy rate of around 90%, the test provides reliable results, reducing the chances of misdiagnosis.
    • Non-Invasive: Unlike current diagnostic methods that involve complex PET scans or lumbar punctures, PrecivityAD2 requires only a simple blood draw.
    • Cost-Effective: The test is expected to be more affordable compared to expensive PET scans and cerebrospinal fluid analysis, making AD diagnosis more accessible.
    • Ease of Use: The blood test simplifies the diagnostic process, making it easier for primary care physicians to screen for AD.
    • Wider Reach: By reducing the complexity and cost of diagnosis, more patients can be tested, particularly in resource-limited settings.

    Significance of the Test

    • Standard of Care: PrecivityAD2 has the potential to become the standard first-line test for AD diagnosis, replacing more invasive and costly methods.
    • Support for Early Intervention: Early and accurate diagnosis allows for timely intervention, which is crucial for managing AD and improving patient outcomes.
    • Reduction in Misdiagnosis: The test’s high accuracy rate can help reduce the rates of misdiagnosis, particularly in primary care settings.

    Prevalence of Alzheimer’s Disease in India:

    • Alzheimer’s disease and dementia are significant public health concerns in India with a rapidly increasing prevalence rate.
    • According to CSIR-NIScPR, in 2019, there were 37 lakh active cases of Alzheimer’s disease and other dementias.
    • By 2050, dementia cases in India could exceed 11 crore as per projections from the Global Burden of Disease Study (GBDS).
    • The burden of non-communicable neurological disorders, including Alzheimer’s, more than doubled between 1990 and 2019.

    Feasibility for India:

    • In India, the current diagnostic tools for Alzheimer’s disease primarily include MRI and regular PET scans.
    • Advanced diagnostic tools like amyloid or Tau PET scans are not yet commercially available.
    • The introduction of PrecivityAD2 in India will require approval from the Drug Controller General of India (DCGI) and other relevant regulatory bodies.