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Type: Prelims Only

  • Nobel and other Prizes

    Physiology Nobel for work on temperature and touch

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Nobel Price, Genes controling senses

    Mains level: Read the attached story

     

    U.S. scientists David Julius and Ardem Patapoutian have won the Nobel Medicine Prize for discoveries on receptors for temperature and touch.

    Who are the Laureates?

    • David Julius and Ardem Patapoutian, working independently in the United States, made a series of discoveries in the late 1990s and early 2000s.
    • They figured out the touch detectors in our body and the mechanism through which they communicate with the nervous system to identify and respond to a particular touch.

    What did they discover?

    • They discovered the molecular sensors in the human body that are sensitive to heat, and to mechanical pressure, and make us “feel” hot or cold, or the touch of a sharp object on our skin.
    • n 1997, Dr. Julius and his team published a paper in Nature detailing how capsaicin, or the chemical compound in chili peppers, causes the burning sensation.
    • They created a library of DNA fragments to understand the corresponding genes and finally discovered a new capsaicin receptor and named it TRPV1.
    • This discovery paved the way for the identification of many other temperature-sensing receptors.
    • They identified another new receptor called TRPM8, a receptor that is activated by cold. It is specifically expressed in a subset of pain-and-temperature-sensing neurons.
    • They identified a single gene PIEZO2, which when silenced made the cells insensitive to the poking. They named this new mechanosensitive ion channel Piezo1.

    How do they work?

    • The human ability to sense heat or cold and pressure is not very different from the working of the many detectors that we are familiar with.
    • When something hot, or cold, touches the body, the heat receptors enable the passage of some specific chemicals, like calcium ions, through the membrane of nerve cells.
    • It’s like a gate that opens up on a very specific request. The entry of the chemical inside the cell causes a small change in electrical voltage, which is picked up by the nervous system.
    • There is a whole spectrum of receptors that are sensitive to different ranges of temperature.
    • When there is more heat, more channels open up to allow the flow of ions, and the brain is able to perceive higher temperatures.

    Therapeutic implications

    • Breakthroughs in physiology have often resulted in an improvement in the ability to fight diseases and disorders. This one is no different.
    • There are receptors that make us feel pain. If these receptors can suppress, or made less effective, the person had felt less pain.
    • Chronic pain is present is a number of illnesses and disorders. Earlier, the experience of pain was a mystery.
    • But as we understand these receptors more and more, it is possible that we gain the ability to regulate them in such a way that the pain is minimized.

    [Note: We will compile all Nobel Prizes into a single post once all are awarded.]

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  • ISRO Missions and Discoveries

    IAO Hanle: A promising astronomical observatory

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: IAO Hanle

    Mains level: NA

    A new study shows that the Indian Astronomical Observatory (IAO) located in Hanle is one of the emerging sites for infrared and optical astronomy studies.

    About IAO Hanle

    • The IAO, located in Hanle at Mount Saraswati near Leh in Ladakh, has one of the world’s highest located sites for optical, infrared and gamma-ray telescopes.
    • It was established in 2001 and is operated by the Indian Institute of Astrophysics, Bangalore.
    • It is currently the ninth highest optical telescope in the world, situated at an elevation of 4,500 meters.

    Note: University of Tokyo Atacama Observatory (TAO) located in the Atacama desert of Chile is the highest at an elevation of 5,640 m.

    Major telescopes at Hanle include:

    1. Himalayan Chandra Telescope (An optical-infrared telescope named after India-born Nobel laureate Subrahmanyam Chandrasekhar)
    2. GROWTH-India Telescope (A robotic optical telescope)
    3. High Altitude Gamma Ray Telescope

    Distinct factors of IAO Hanle

    • IAO Hanle offers a clear view of space among all observatories globally.
    • This is due to its advantages of more clear nights, minimal light pollution, background aerosol concentration, extremely dry atmospheric condition and uninterrupted monsoon.
    • Hanle site is as dry as Atacama Desert in Chile and much drier than Devasthal and has around 270 clear nights in a year and is also one of the emerging sites for infrared and submillimetre optical astronomy.
    • This is because water vapor absorbs electromagnetic signals and reduces their strength.

     

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  • Festivals, Dances, Theatre, Literature, Art in News

    Langa-Manganiyar Folk Music

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Langa-Manganiyar

    Mains level: NA

    Considered the repository of the Thar region’s rich history and traditional knowledge, the ballads, folklore and songs of the Langa-Manganiyar artistes are being preserved through an initiative for documentation and digitisation.

    Who are the Langa-Manganiyar?

    • The Langas and Manganiyars are hereditary communities of Muslim musicians residing mostly in western Rajasthan’s Jaisalmer and Barmer districts and in Pakistan’s Tharparkar and Sanghar districts in Sindh.
    • The music of the two marginalised communities, who were supported by wealthy landlords and merchants before Independence, forms a vital part of Thar desert’s cultural landscape.
    • The performances are in multiple languages and dialects including Marwari, Sindhi, Saraiki, Dhatti and Thareli.
    • The romantic tales revolving around legendary lovers such as Umar-Marvi, Heer-Ranjha, Sohni-Mahiwal, Moomal-Rana and Sorath-Rao Khangar have traditionally captivated audiences.

    Instruments used

    • The Langa’s main traditional instrument is the sindhi sarangi; Manganiyar’s is the kamaicha.
    • Both are bowed stringed instruments with skin membrane sounding boards and many sympathetic strings.
    • Both Langas and Manganiyars sing and play the dholak (double-headed barrel drum), the kartal(wooded clappers), the morchan (jaws harp), and the ubiquitous harmonium.

    Try answering this PYQ:

    Q. Consider the following pairs:

    Tradition: State

    1. Chapchar Kut: festival Mizoram
    2. Khongjom Parba ballad: Manipur
    3. Thang Ta dance: Sikkim

    Which of the pairs given above is/are correct?

    (a) 1 only

    (b) 1 and 2

    (c) 3 only

    (d) 2 and 3

     

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  • Historical and Archaeological Findings in News

    Chola inscriptions on qualifications for civic officials

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Kudavolai System

    Mains level: Chola Administration

    In the Kancheepuram district of Tamil Nadu, some Chola-era inscriptions on Kanthaleeswarar Temple bear testimony to the qualifications required for members of the village administrative council.

    Inscription details: Kudavolai System

    • The Kudavolai system was very vital and unique feature of administration of villages of Cholas.
    • In the system one representative is elected from each ward and every village had 30 wards.
    • The village administrative committee was called as variyam.
    • The election was unique as names of contestants were written on palm leaf and put in a pot.

    Taxation details

    • The rulers were considerate while taxing agricultural produce.
    • For areca nuts, only 50% tax would be collected for the first 10 years after cultivation. Farmers would pay full tax only after the trees started yielding fruits.
    • Similarly, 50% tax was imposed on banana crops until the yield.

    Though a tough one, but try answering this PYQ:

    Q.In the context of the history of India, consider the following pairs:

    Term: Description

    1. Eripatti: Land revenue from which was set apart for the maintenance of the village tank
    2. Taniyurs: Villages donated to a single Brahmin or a group of Brahmins
    3. Ghatikas: Colleges generally attached to the temples

    Which of the pairs given above is/are correctly matched?

    (a) 1 and 2

    (b) 3 only

    (c) 2 and 3

    (d) 1 and 3

     

    [wpdiscuz-feedback id=”ae2horatv9″ question=”Please leave a feedback on this” opened=”1″]Post your answers here.[/wpdiscuz-feedback]

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  • Goods and Services Tax (GST)

    GST collections hit 5-month high

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Revenue receipts

    Mains level: GST

    India’s gross Goods and Services Tax (GST) revenues crossed ₹1.17 lakh crore in September, hitting a five-month high.

    Take a look towards the share of GST in government earnings for the previous fiscal:

    UPSC can ask about the majority component of the Revenue Receipts of the govt. See how Corporate tax is nearing the GST revenues.

    Do you think it will surpass GST revenue when the economy is fully recovered?

    What is the news?

    • September’s revenues were 23% higher than a year ago and 27.3% more than collections in the pre-pandemic month of September 2019.
    • Revenues from import of goods were 30% higher while indirect tax collected on domestic transactions, including the import of services, were 20% higher in September, compared to the same month in 2020.
    • Among the major States, GST revenues grew 29% in Karnataka, 28% in Gujarat, followed by 22% in Maharashtra and 21% each in Tamil Nadu and Andhra Pradesh.
    • Telangana recorded a 25% surge in revenues, while Odisha saw a sharper 40% rise.

    Significance

    • This clearly indicates that the economy is recovering at a fast pace.
    • Coupled with economic growth, anti-evasion activities, especially action against fake billers have also been contributing to the enhanced GST collections.
    • It is expected that the positive trend in the revenues will continue and the second half of the year will post higher revenues.

    Issues underlying

    • Though GST revenues are picking up pace after the impact of the Covid-19 pandemic, revenue buoyancy under GST is being seen as a concern.
    • This is especially after the legally mandated compensation to states for revenue shortfall from the GST implementation comes to an end in June 2022.

    Back2Basics: Goods and Services Tax

    • The GST is a value-added tax levied on most goods and services sold for domestic consumption.
    • It was launched into operation on the midnight of 1st July 2017.
    • It subsumed almost all domestic indirect taxes (petroleum, alcoholic beverages, and stamp duty are the major exceptions) under one head.
    • The GST is paid by consumers, but it is remitted to the government by the businesses selling the goods and services.
    • GST is levied at four rates viz. 5%, 12%, 18% and 28%. The schedule or list of items that would fall under these multiple slabs is worked out by the GST council.

    Types

    • The GST to be levied by the Centre is called Central GST (CGST) and that to be levied by the States is called State GST (SGST).
    • Import of goods or services would be treated as inter-state supplies and would be subject to Integrated Goods & Services Tax (IGST) in addition to the applicable customs duties.

    The GST Council

    • It is a constitutional body (Article 279A) for making recommendations to the Union and State Government on issues related to GST.
    • The GST Council is chaired by the Union Finance Minister and other members are the Union State Minister of Revenue or Finance and Ministers in charge of Finance or Taxation of all the States.
    • It is considered as a federal body where both the centre and the states get due representation.
  • Innovations in Biotechnology and Medical Sciences

    What is Computer Tomography?

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Computer Tomography (CT) and its working

    Mains level: NA

    The first computed tomography image – a CT scan – of the human brain was made 50 years ago, on Oct. 1, 1971.

    A few months back, almost all of us have heard about the High-resolution computed tomography (HRCT) scan being conducted on our relatives for diagnosing the damage of lungs caused due to the Wuhan Virus.

    About Computer Tomography (CT)

    • A CT scan is a medical imaging technique used in radiology to get detailed images of the body noninvasively for diagnostic purposes.
    • The multiple X-ray measurements taken from different angles are then processed on a computer using reconstruction algorithms to produce tomographic (cross-sectional) images (virtual “slices”) of a body.

    How does it work?

    • They use a narrow X-ray beam that circles around one part of your body. This provides a series of images from many different angles.
    • A computer uses this information to create a cross-sectional picture. Like one piece in a loaf of bread, this two-dimensional (2D) scan shows a “slice” of the inside of your body.
    • This process is repeated to produce a number of slices.
    • The computer stacks these scans one on top of the other to create a detailed image of your organs, bones, or blood vessels.
    • For example, a surgeon may use this type of scan to look at all sides of a tumor to prepare for an operation.

    Its development

    • Since its development in the 1970s, CT has proven to be a versatile imaging technique.
    • While CT is most prominently used in diagnostic medicine, it also may be used to form images of non-living objects.
    • The 1979 Nobel Prize in Physiology or Medicine was awarded jointly to South African-American physicist Allan M. Cormack and British electrical engineer Godfrey N. Hounsfield “for the development of computer-assisted tomography”.

    Threats

    • CT scans use X-rays, which produce ionizing radiation.
    • Such radiation may damage your DNA and lead to cancer.
    • The risk increases with every CT scan we get.
    • Ionizing radiation may be more harmful in children.

     

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  • Air Pollution

    Probe shows use of toxic material in firecrackers: Supreme Court

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Air pollutants in crackers, Green Crackers

    Mains level: Air pollution due to firecrackers

    The Supreme Court has said a preliminary enquiry by the CBI into the firecracker industry, including in Tamil Nadu, revealed rampant violation of its ban on use of toxic ingredients like Barium and its salts.

    Air Pollution created by firecrackers

    • Firing crackers increase the concentration of dust and pollutants in the air.
    • After firing, the fine dust particles get settled on the surrounding surfaces which are packed with chemicals like copper, zinc, sodium, lead, magnesium, cadmium and pollutants like oxides of sulphur and nitrogen.
    • These invisible yet harmful particles affect the environment and in turn, put our health at stake.

    Harmful elements used

    • Copper: Irritates the respiratory tract.
    • Cadmium: Leads to anemia by reducing the capacity of blood to carry oxygen.
    • Zinc: Can cause metal fume fever and induces vomiting.
    • Lead: Harms the nervous system.
    • Magnesium: Metal fume fever is caused by Magnesium fumes.
    • Sodium: It is a highly reactive element and caused burns when it is combined with moisture.

    Why is the issue in news now?

    Ans. Barium content

    • A chemical analysis of the samples of finished and semi-finished firecrackers and raw materials taken from the manufacturers showed Barium content.
    • The court stated that loose quantities of Barium were purchased from the market.
    • Also, firecracker covers did not show the manufacture or expiry dates.

    Issues with Barium

    • Barium nitrate, which emits green flames when a cracker is lit, is a metal oxide that increases both air and noise pollution.
    • There is is no clarity on whether barium nitrate can actually be used or not.

    Alternatives: Green Crackers

    • The new CSIR-NEERI formulation for green crackers has NO barium nitrate — one of the key ingredients of traditional firecrackers.
    • These crackers have been named “safe water releaser (SWAS)”, “safe minimal aluminium (SAFAL)” and “safe thermite cracker (STAR)”.
    • The three crackers release water vapour or air as a dust suppressant and diluent for gaseous emissions.
    • These products can only be manufactured by those who have signed a non-disclosure agreement (NDA) with CSIR-NEERI.
    • The green crackers are sold with a unique logo on the box, and will also have a QR code with production and emission details.

     

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  • US policy wise : Visa, Free Trade and WTO

    What is H-1B Visa?

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Various visas mentioned

    Mains level: NA

    The need for H-1B visas will continue to exist till the ‘talent challenge’ is tackled globally, even though the information technology industry has successfully adopted the work-from-home model amid pandemic-related travel restrictions.

    Various US Visa Programs

    1) H-1B visa

    What is it: The H-1B visa category covers individuals who “work in a speciality occupation, engage in cooperative research and development projects administered by the US Department of Defense or are fashion models that have national or international acclaim and recognition.”

    Who’s covered: The H-1B is most well known as a visa for skilled tech workers, but other industries, like health care and the media, also use these visas.

    2) H-2B visa

    What it is: According to USCIS, the H-2B program allows US employers or agents “to bring foreign nationals to the United States to fill temporary non-agricultural jobs.”

    Who’s covered: They generally apply to seasonal workers in industries like landscaping, forestry, hospitality and construction.

    3) J-1 visa

    What it is: The J-1 visa is an exchange visitor visa for individuals approved to participate in work-and-study-based exchange visitor programs in the United States.

    Who’s covered:
    The impacted people include interns, trainees, teachers, camp counsellors, au pairs and participants in summer work travel programs.

    4) L-1 visa

    What it is: The L1 Visa is reserved for managerial or executive professionals transferring to the US from within the same company, or a subsidiary of it. The L1 Visa can also be used for a foreign company opening up US operations.

    Who’s covered: Within the L1 Visa, there are two subsidiary types of visas

    • L1A visa for managers and executives.
    • L1B visa for those with specialized knowledge.

     

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  • Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

    Antimalarial drug resistance in India

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Malaria and it vaccines

    Mains level: Non-communicable diseases burden on India

    In recent years there is increasing evidence for the failure of artemisinin-based combination therapy for falciparum malaria either alone or with partner drugs.

    What is Malaria?

    • Malaria is caused by the bite of the female Anopheles mosquito if the mosquito itself is infected with a malarial parasite.
    • There are five kinds of malarial parasites — Plasmodium falciparum, Plasmodium vivax (the commonest ones), Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi.
    • Therefore, to say that someone has contracted the Plasmodium ovale type of malaria means that the person has been infected by that particular parasite.

    Burden of Malaria in India

    • In 2018, the National Vector-borne Disease Control Programme (NVBDCP) estimated that approximately 5 lakh people suffered from malaria.
    • 63% of the cases were of Plasmodium falciparum.
    • The recent World Malaria Report 2020 said cases in India dropped from about 20 million in 2000 to about 5.6 million in 2019.

    Treatment of Malaria

    • Malaria is treated with prescription drugs to kill the parasite. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug.
    • In most malaria-endemic countries including India, Artemisinin-based antimalarial drugs are the first-line choice for malaria treatment.
    • This is especially against Plasmodium falciparum parasite which is responsible for almost all malaria-related deaths in the world.

    Why in news now?

    • There are reports of artemisinin resistance in East Africa and is a matter of great concern as this is the only drug that has saved several lives across the globe.
    • In India, after the failure of chloroquine to treat P. falciparum malaria successfully, artemisinin-based combination therapy was initially introduced in 2008.
    • Currently, several combinations of artemisinin derivatives are registered in India.

    Artemisinin-based combination therapy failure in India

    • In 2019, a report from Eastern India indicated the presence of two mutations in P. falciparum cases treated with artemisinin that linked to its presence of resistance.
    • Again in 2021, artemisinin-based combination therapy failure was reported from Central India where the partner drug SP showed triple mutations with artemisinin wild type.
    • This means the failure of artemisinin-based combination therapy may not be solely linked to artemisinin. Here it is needed to change the partner drug as has been done in NE states in 2013.

    History of drug resistance

    • In the 1950s chloroquine resistance came to light.
    • Both chloroquine and pyrimethamine resistance originated from Southeast Asia following their migration to India and then on to Africa with disastrous consequences.
    • Similarly, artemisinin resistance developed from the six Southeast Asian countries and migrated to other continents, as is reported in India and Africa.
    • It would not be out of context that artemisinin is following the same path as has been seen with chloroquine.
    • Now, the time has come to carry out Molecular Malaria Surveillance to find out the drug-resistant variants so that corrective measures can be undertaken in time to avert any consequences.
    • Some experts even advocate using triple artemisinin-based combination therapies where the partner drug is less effective.

    Try this PYQ:

    Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria.

    Why is it difficult to develop an effective malaria vaccine?

    (a) Malaria is caused by several species of Plasmodium

    (b) Man does not develop immunity to malaria during natural infection

    (c) Vaccines can be developed only against bacteria

    (d) Man is only an intermediate host and not the definitive host

     

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  • Capital Markets: Challenges and Developments

    What are Electronic Gold Receipts?

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Electronic Gold Receipts

    Mains level: NA

    The board of the Securities and Exchange Board of India (SEBI) has approved the framework for a gold exchange as well as for vault managers. This approval paves the way for gold exchanges to be set up for trading in ‘Electronic Gold Receipt’ (EGR).

    What is EGR?

    • SEBI’s concept paper proposes issuing an electronic gold receipt in exchange pf physical gold (similar to equity shares), deposited with a vault manager (like a depositary participant) and this receipt can then be traded.
    • The government wants India’s outsized influence in the physical market for gold to be visible in the financial market for gold as well.

    Why need EGRs?

    • EGI is a way of getting people to not hoard gold, by creating an exchange that provides transparent pricing and liquidity (to cash or back to gold).
    • India is a net importer of gold. We are price takers and not price setters. The whole idea is to move from being price takers to be price setters.
    • Price discovery at the exchanges will thus lead to transparency in gold pricing.
    • The gold exchanges would provide transparent price discovery, investment liquidity and assurance in the quality of gold.

    What is the SEBI regulation?

    • SEBI has also proposed a regulatory framework for setting up a gold exchange.
    • Existing stock exchanges will be allowed to provide the platform for trading of EGRs.
    • The denomination for trading of EGR and conversion of EGR into gold will be decided by the stock exchange with the approval of SEBI.
    • The clearing corporation will settle the trades executed on the stock exchanges by way of transferring EGRs and funds to the buyer and seller, respectively.

    How will EGR work?

    • EGR holders, at their discretion, can withdraw the underlying gold from the vaults after surrendering the EGRs.
    • SEBI-accredited vault managers will be responsible for the storage and safekeeping of gold deposits, creation of EGRs, withdrawal of gold, grievance redressal and periodic reconciliation of physical gold with the records of depository.
    • The vault manager will have a networth of at least ₹50 crore.

    Back2Basics: Securities and Exchange Board of India (SEBI)

    • The SEBI is the regulatory body for securities and commodity market in India under the jurisdiction of Ministry of Finance Government of India.
    • It was established on 12 April 1988 and given Statutory Powers on 30 January 1992 through the SEBI Act, 1992.

    Jurisdiction of SEBI

    • SEBI has to be responsive to the needs of three groups, which constitute the market:
    1. Issuers of securities
    2. Investors
    3. Market intermediaries

    SEBI has three powers rolled into one body: quasi-legislative, quasi-judicial and quasi-executive.

    • It drafts regulations in its legislative capacity, it conducts investigation and enforcement action in its executive function and it passes rulings and orders in its judicial capacity.
    • Though this makes it very powerful, there is an appeal process to create accountability.
    • There is a Securities Appellate Tribunal which is a three-member tribunal and is currently headed by Justice Tarun Agarwala, former Chief Justice of the Meghalaya High Court.
    • A second appeal lies directly to the Supreme Court.

     

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