Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

India nears milestone with first indigenous Dengue Vaccine


From UPSC perspective, the following things are important :

Prelims level: Dengue

Mains level: Not Much


Central Idea: Serum Institute of India and Panacea Biotec have applied to the ICMR’s call for Expression of Interest for collaborative Phase-III clinical trials for an indigenous dengue vaccine.

What is Dengue?

Transmission Primarily transmitted through the bite of infected Aedes mosquitoes
Virus and Serotypes Dengue virus belonging to the Flaviviridae family

Four distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4

Symptoms High fever, severe headache, joint and muscle pain, rash, pain behind the eyes, mild bleeding
Severe Dengue Progression to severe dengue can cause plasma leakage, bleeding, organ impairment
Geographic Distribution Endemic in more than 100 countries, particularly in tropical and subtropical regions
Incidence and Global Impact 100-400 million dengue infections occur annually globally, affecting healthcare systems and economies
Vector and Breeding Sites Aedes aegypti mosquito breeds in stagnant water containers found near human dwellings
Treatment No specific antiviral treatment available; supportive care, rest, fluid intake, symptom management
Prevention and Control Reduce mosquito breeding sites, proper water storage, cleaning of water containers, use of insecticides


Dengue Virus Disease and Global Impact

  • Dengue virus disease causes significant morbidity and mortality worldwide, with 2 to 2.5 lakh (200,000 to 250,000) cases reported annually in India.
  • The global incidence of dengue has increased dramatically, with over half of the world’s population at risk.
  • The World Health Organization (WHO) has identified dengue as one of the top ten global health threats in 2019.
  • Currently, there is no specific treatment for dengue, highlighting the urgent need for effective vaccines.

Desirable Characteristics of a Dengue Vaccine

The ICMR highlights the desirable characteristics of a dengue vaccine, including a-

  • Favorable safety profile
  • Protection against all four serotypes of dengue
  • Reduced risk of severe disease and death
  • Induction of a sustained immune response and
  • Effectiveness regardless of previous sero-status and age


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