Innovations in Sciences, IT, Computers, Robotics and Nanotechnology

Merging Brain Tissue with Electronics in Computing


From UPSC perspective, the following things are important :

Prelims level : Brain Tissues in Computers

Mains level : Read the attached story

Brain Tissue


  • Researchers have achieved a groundbreaking fusion of brain-like tissue with electronics, creating an ‘organoid neural network.’
  • This innovation marks a significant advancement in neuromorphic computing, directly incorporating brain tissue into computer systems.

Brainoware: Brain Tissues in Computers

  • Development Team: A collaborative effort by scientists from Indiana University, the University of Cincinnati, Cincinnati Children’s Hospital Medical Centre, and the University of Florida resulted in this breakthrough.
  • Publication: The study, published on December 11, signifies a convergence of tissue engineering, electrophysiology, and neural computation, expanding the horizons of scientific and engineering disciplines.

Context of Artificial Intelligence (AI)

  • AI’s Foundation: AI relies on artificial neural networks, silicon-based models of the human brain capable of processing vast datasets.
  • Memory and Processing Separation: Conventional AI hardware separates memory and processing units, leading to inefficiencies when transferring data between them.

Introducing Biological Neural Networks

  • Biocomputing Emergence: Scientists are exploring biological neural networks, composed of live brain cells, as an alternative. These networks can combine memory and data processing.
  • Energy Efficiency: Brain cells efficiently store memory and process data without physically segregating these functions.

Organoid Neural Networks

  • Biological Components: Brain organoids, three-dimensional aggregates of brain cells, were used to create an ‘organoid neural network.’
  • Formation: Human pluripotent stem cells were transformed into various brain cells, including neuron progenitor cells, early-stage neurons, mature neurons, and astrocytes.
  • Reservoir Computer: The network was integrated into a reservoir computer, comprising input, reservoir, and output layers.

Brainoware’s Capabilities

  • Predicting Mathematical Functions: Brainoware demonstrated its ability to predict complex mathematical functions like the Henon map.
  • Voice Recognition: The system could identify Japanese vowels pronounced by individuals with a 78% accuracy rate.
  • Efficiency: Brainoware achieved comparable accuracy to artificial neural networks with minimal training requirements.

Promising Insights and Limitations

  • Foundational Insights: The study provides crucial insights into learning mechanisms, neural development, and cognitive aspects of neurodegenerative diseases.
  • Challenges: Brainoware necessitates technical expertise and infrastructure. Organoids exhibit heterogeneous cell mixes and require optimization for uniformity.
  • Ethical Considerations: The fusion of organoids and AI raises ethical questions about consciousness and dignity.

Future Prospects

  • Optimizing Encoding Methods: Future research may focus on improving input encoding methods and maintaining uniformity in organoids for longer experiments.
  • Complex Computing Problems: Researchers aim to tackle more intricate computing challenges.
  • Ethical Discourse: Ethical debates surrounding organoid consciousness and dignity will continue to evolve.


  • The creation of Brainoware and the integration of brain organoids with computing systems represent a pioneering step towards more efficient and ethically-conscious AI systems.
  • This innovative approach may revolutionize computing paradigms while prompting profound ethical considerations.

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