Why in the News?
AMR is rapidly becoming one of the greatest public health threats, contributing to 2.97 lakh deaths in India in 2019 alone, as reported by the Institute of Health Metrics and Evaluation.
What is Antimicrobial Resistance (AMR)?
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Why is it a growing concern globally?
- Rising Deaths Due to Resistant Infections: AMR causes infections that are harder to treat, leading to increased mortality. Eg, globally AMR contributed to 1.27 million deaths in 2019, and it is projected that by 2050, up to 10 million people could die annually due to resistant infections if no action is taken.
- Limited New Antibiotics Development: There has been a major decline in new antibiotic discovery over the past 30 years, leaving fewer effective treatment options. Eg, India’s development of Nafthromycin was the first new antibiotic in three decades, highlighting the global innovation gap.
- Widespread Misuse and Overuse of Antibiotics: Over-prescription and use of antibiotics in humans, livestock, and agriculture accelerate resistance. Eg, in India, antibiotics are often sold without prescriptions, promoting resistance and reducing drug effectiveness.
What is Nafthromycin?
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What is the role of Nafthromycin in fighting antimicrobial resistance (AMR)?
- Provides a New Effective Treatment Option: Nafthromycin is India’s first indigenously developed antibiotic in 30 years, offering a powerful new drug to treat infections like Community-Acquired Bacterial Pneumonia (CABP) with a 97% success rate. Eg: This helps overcome resistance to older antibiotics like azithromycin.
- Supports Antibiotic Stewardship by Reducing Overuse of Existing Drugs: By providing an effective alternative, Nafthromycin can reduce reliance on existing antibiotics that have become less effective due to resistance, helping slow down the spread of AMR.
Why is the misuse and overuse of antibiotics a major cause of AMR in India?
- Over-the-counter sales without prescription: Antibiotics are often sold without a prescription, leading to improper and unnecessary use. Eg: People buying antibiotics directly from pharmacies for viral infections like common cold, where antibiotics are ineffective.
- Use of antibiotics in livestock and agriculture: A large portion of antibiotics is used in animals to promote growth or prevent disease, which contributes to resistant bacteria spreading to humans. Eg: Use of colistin in poultry farming, which was recently banned in India to curb resistance.
- Self-medication and lack of awareness: Many people self-medicate with antibiotics or do not complete prescribed courses, promoting resistance.
What are the healthcare gaps in the treatment of AMR?
- Shortage of Trained Medical Personnel in AMR Management: There is limited awareness and training among healthcare providers on rational antibiotic use and infection control practices. Eg: A study by the Indian Council of Medical Research (ICMR) found that in community clinics in tier-2 cities, over 50% of doctors were unaware of the national treatment guidelines for infections.
- Lack of Diagnostic Infrastructure: Many primary and secondary healthcare centers in India lack adequate microbiology labs to accurately identify bacterial infections and their resistance profiles. Eg: In rural districts of Uttar Pradesh, absence of lab support leads doctors to prescribe broad-spectrum antibiotics blindly, increasing resistance risks.
What are the steps taken by the Indian Government?
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Way forward:
- Strengthen Regulation and Stewardship: Enforce strict controls on antibiotic sales and promote antimicrobial stewardship in hospitals and clinics.
- Invest in Surveillance and Public Awareness: Expand AMR surveillance networks and run sustained awareness campaigns to educate public and healthcare providers.
Mains PYQ:
[UPSC 2014] How do you explain the factors responsible for the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.
Linkage: The core issue of “drug-resistant diseases” which is Antibiotic Resistance (AMR). The article talking about the key factors for AMR, such as misuse and overuse of antibiotics across various sectors, including non-prescription sales in countries like India. It also discusses the need for monitoring and control mechanisms like responsible global stewardship, patient education, public awareness, innovation, regulation, and government leadership in stewardship.
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