Innovations in Biotechnology and Medical Sciences

Novel Microscope observes Molecular Motion

Why in the News?

Over a century after Einstein explained Brownian motion, California Institute of Technology (Caltech) scientists have created a powerful microscope that shows molecules moving in real time at an extremely tiny scale.

Novel Microscope observes Molecular Motion

What is Brownian Motion?

  • Definition: Random movement of tiny particles in a fluid due to constant collisions with surrounding molecules.
  • Significance: Validated the existence of atoms and molecules; explained by Albert Einstein in 1905.
  • Particle Behavior: Smaller particles move faster and more erratically; larger ones move slower.

About Caltech Microscope:  

  • Resolution: Angstrom-level (1 Å = 0.0000000001 m).
  • Speed: Captures hundreds of billions of frames per second.
  • Advantage: Wide-field, single-shot imaging with no sample damage.
  • How It Works?
    • Setup: Fluorescent molecules in water illuminated by ultrafast lasers.
    • Light Capture: Scattered light directed via Digital Micromirror Device.
    • Streak Imaging: Light converted to electron patterns revealing molecular size.
    • Reading Size: Faster changes = smaller molecules; slower = larger.
[UPSC 2000] Which one of the following can be used to confirm whether drinking water contains a gamma emitting isotope or not?

Options: (a) Microscope (b) Lead plate (c) Scintillation counter* (d) Spectrophotometer

 

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