Why in the News?
Scientists at Stanford University discovered that TR1 cells play a dominant role in fighting malaria reinfections.
Understanding the Body’s Immune Response:
- What is the Immune System? It’s the body’s defence system that protects us from infections like malaria.
- First Defence: The skin and body surfaces block germs from entering.
- Innate Immunity: If germs get in, the innate immune system reacts fast, like an emergency response team.
- Adaptive Immunity: Then, the adaptive immune system kicks in, targeting germs specifically and remembering them for future protection.
- B-Cells and T-Cells:
- B-cells make antibodies to fight germs.
- T-cells attack infected cells and guide other immune cells.
- Helper T-Cells: A type called CD4+ T-cells helps organise the defence. Earlier, scientists thought TH1 cells were key in malaria, but a new study shows TR1 cells are more important, especially in repeat infections.
What are TR1 Cells?
- Role of TR1 Cells: These are special T-cells that help control the immune system and prevent overreaction.
- Major Response in Malaria: Though small in number, during malaria, TR1 cells become the main helper cells.
- Study in Uganda: In young children with repeated malaria, TR1 cells grew in number and improved the body’s ability to fight malaria without severe illness.
- Memory and Immunity: TR1 cells remember the malaria parasite and return stronger with each infection.
- Types of TR1 Cells:
- Naïve TR1 – not yet active.
- Effector TR1 – fighting infection.
- Memory TR1 – remembering past infections.
- Epigenetic Role: TR1 cells may respond by switching genes on or off, not by changing the genes themselves.
Key Findings of the Study:
- Research Team: Scientists from Stanford University studied people in Uganda over many months and years.
- Tracking Infections: They followed individuals through multiple malaria infections to see how immune cells behaved.
- Gene Scanning: A special technique was used to read the genes of each immune cell — like scanning a barcode.
- Findings: TR1 cells were accurate, long-lasting, and clearly connected to malaria (not other infections).
- Why it matters: This discovery can help in making better malaria vaccines, boosting long-term protection, and even improving treatments for other serious diseases.
| [UPSC 2025] With reference to monoclonal antibodies, consider the following:
I. They are man-made proteins. II. They stimulate the patient’s immune system to fight the specific disease. III. They are produced using animal cells only. Which of the statements given above are correct? Options: (a) I and II only (b) II and III only (c) I and III only (d) All the three * |
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