Coronavirus – Disease, Medical Sciences Involved & Preventive Measures

What is Hybrid Immunity?


From UPSC perspective, the following things are important :

Prelims level: Hybrid immunity

Mains level: Not Much

A study has shown that a combination of natural infection with a single dose of vaccine provides greater immunity than either natural infection without vaccination or full vaccination in individuals.

What is the new study?

  • People without prior infection but fully vaccinated with the Pfizer or AstraZeneca vaccine showed a decline in neutralising antibodies over a period of three to seven months.
  • But the decline was much less in vaccinated people with prior infection.
  • People with hybrid immunity had a higher and more durable neutralising antibody response.
  • The hybrid immunity offers stronger protection than just infection or full vaccination alone.

What is Hybrid Immunity?

  • It is natural immunity from an infection combined with the immunity provided by the vaccine.
  • The immunological advantage from hybrid immunity arises mostly from memory B cells.

What are memory B cells?

  • In immunology, a memory B cell (MBC) is a type of B lymphocyte that forms part of the adaptive immune system.
  • B lymphocytes are the cells of the immune system that make antibodies to invade pathogens like viruses.
  • They form memory cells that remember the same pathogen for faster antibody production in future infections.

How do they assist hybrid immunity?

  • While the bulk of antibodies after infection or vaccination decline after a short while, the memory B cells get triggered on subsequent infection or vaccination.
  • The memory B cells triggered by infection and those triggered by vaccination have different responses to viruses.
  • Infection and vaccination expose the spike protein to the immune system in vastly different ways.
  • After full vaccination, antibodies produced by natural infection continued to grow in potency and their breadth against variants for a year after infection.
  • Unlike after vaccination, the memory B cells formed after natural infection are more likely to make antibodies that block immune-evading variants.


UPSC 2022 countdown has begun! Get your personal guidance plan now! (Click here)

Get an IAS/IPS ranker as your 1: 1 personal mentor for UPSC 2024

Attend Now

Notify of
Inline Feedbacks
View all comments


Join us across Social Media platforms.

💥Mentorship New Batch Launch
💥Mentorship New Batch Launch