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Subject: Biotech and Medical Sciences

  • Geroscience: the Science related to Ageing

    Why in the news?

    • Dr. Daniel Belsky from Columbia University introduced the concept of “Geroscience” and develops a blood test, termed “gerozyme,” to measure aging pace by studying DNA methylation.
    • Various research groups explore drugs like Metformin and Rapamycin to target aging and enhance immunity in the elderly.

    What is Geroscience?

    • Geroscience refers to the interdisciplinary field focused on understanding the biological mechanisms of ageing and age-related diseases.
    • It involves studying various factors, including DNA methylation, enzyme activity (such as the gerozyme), socio-economic influences, and lifestyle interventions like nutrition, exercise, and music therapy.
    • It aims to develop strategies, such as drug interventions targeting specific ageing-related processes, to promote healthy ageing and combat age-related conditions like dementia.

    What is DNA Methylation?

    • DNA Methylation is a process in which methyl groups (CH3) are added to the DNA molecule.
    • This modification typically occurs at cytosine bases within the DNA sequence, often in the context of CpG dinucleotides (where cytosine is followed by guanine).
    • DNA methylation plays a crucial role in regulating gene expression and maintaining genome stability.
    • It can affect various cellular processes, including embryonic development, X-chromosome inactivation, genomic imprinting, and silencing of repetitive DNA elements.
    • Aberrant DNA methylation patterns have been implicated in various diseases, including cancer and neurological disorders.

    Drug Interventions in Geroscience

    • Metformin and TORC1 inhibitors show promise in targeting aging and improving immune response in seniors.
    • Research proposes rapamycin’s potential in extending longevity and combating age-related diseases.

    Impact of Socio-Economic Factors in Ageing

    • Dr. Belsky’s research reveals the influence of socioeconomic status on DNA methylation levels, highlighting the role of disadvantage in ageing.
    • Columbia Aging Centre emphasizes the role of a balanced diet in supporting brain health and reducing inflammation.
    • Healthline.com advocates for proteins, healthy fats, and antioxidant-rich foods to promote healthy ageing, crucial for India’s ageing population.

    PYQ:

    [2011] At present, scientists can determine the arrangement or relative positions of genes or DNA sequences on a chromosome. How does this knowledge benefit us?

    1. It is possible to know the pedigree of livestock.
    2. It is possible to understand the causes of all human diseases.
    3. It is possible to develop disease-resistant animal breeds.

    Which of the statements given above is/are correct?

    (a) 1 and 2 only

    (b) 2 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

  • Crafted in Indian labs, NexCAR19 takes India to next level in Cancer Care

    Why in the News? 

    • President Droupadi Murmu launched India’s first indigenously-developed CAR T-cell therapy, hailing it as a major breakthrough against cancer.
    • This therapy was developed by the Indian Institute of Technology (IIT) Bombay and the Tata Memorial Centre, and it is known as ‘NexCAR19 CAR T-cell therapy’.

    BACK2BASICS:

    What is CAR T cell thearpy? 

    CAR T-cell therapy is a type of immunotherapy that involves modifying a patient’s T cells, a type of white blood cell that plays a crucial role in the immune system, to recognize and attack cancer cells. This therapy is designed to target specific proteins found on the surface of cancer cells, such as CD19, which is commonly found on B cells.

    How are CAR-T cells made?

    Significance of CAR T Thearpy:

    • Promising results:  This therapy has shown promising results in treating some types of blood cancers, including certain kinds of lymphoma, pediatric leukemia, and adult leukemia.  It has shown with approximately 70% of patients responding to the treatment.
    • Less time for treatment: CAR T-cell therapies are generally a single infusion with less than 2 weeks of inpatient care, while stem cell transplants and chemotherapy treatment regimens can take months to complete

    Limitiations of CAR-T Therapy:

    • Risks of CAR-T Therapy: The efficacy of CAR-T therapy varies from person to person, and it is too early to declare it a complete cure. While it has shown remarkable progress in challenging cases, its effectiveness is not universal.
    • High Cost Therapy: NexCAR19 is priced at a fraction of its US counterpart, it remains relatively high for many Indians, ranging from ₹40 to 45 lakh.
    • It’s Side Effects includes:
      • Cytokine Release Syndrome (CRS): CRS is the most common side effect of CAR-T therapy, triggering an ‘Inflammatory Response’ that leads to immune system hyperactivity.
      • Neurotoxicity: Although not observed in early-stage clinical trials, neurotoxicity is a common side effect of CAR-T therapy that can manifest as confusion, seizures, or difficulty speaking or walking.
      • Infections and Blood Cell Counts: Patients undergoing CAR-T therapy may experience infections and low blood cell counts as anticipated side effects.

    Conclusion: India’s is moving towards heralding a breakthrough in Cancer Care Therapy. Despite cost challenges, Government efforts are aimed to enhance accessibility and better outputs in Healthcare Sector.

  • Health Sector can’t ignore Telemedicine’s Green Gains, study shows

    Why in the news? 

    Recently a study by researchers at the L.V. Prasad Eye Institute (LVPEI), Hyderabad, has found that around 70-80% of people who visit an Eye Hospital can benefit from teleconsultations because their problems aren’t serious enough to require attention at a hospital.

    Key points as report:

    • Telemedicine in High-Income Countries: Studies in high-income countries have shown that telemedicine is both patient- and environment-friendly for delivering healthcare services.
    • Carbon Emissions from the Healthcare Sector: According to the International Comparison of Healthcare Carbon Footprints analysis, India’s healthcare sector emitted 74 million tonnes of carbon dioxide in 2014, around 3% of India’s total emissions of the gas that year.
    • Carbon Neutrality in Healthcare: The healthcare sector should aim for carbon neutrality to mitigate its environmental impact. Teleophthalmology is cited as an efficient and effective tool to help achieve this goal, as demonstrated by the lead author’s remarks.

    The teleophthalmology process:

    What are Telemedicine’s Green Gains?

    • Reduced Carbon Footprint: Teleophthalmology significantly reduces the need for patients, especially those from rural areas, to travel long distances to access healthcare services. This leads to a substantial reduction in carbon dioxide emissions, contributing to environmental sustainability.
    • Economic Gains: Teleophthalmology results in significant cost savings for both patients and healthcare systems. Patients save money on travel expenses
    • Easy Accessibility: Teleophthalmology improves access to eye care services, especially for individuals living in remote or rural areas where access to healthcare facilities is limited. It allows patients to receive timely consultations without the need for extensive travel.
    • Targeted Care Gains: Teleophthalmology is particularly beneficial for patients with minor eye problems like mild refractive errors or regular preventive eye check-ups. It enables healthcare providers to target specific demographics and deliver personalized care more effectively.

    Conclusion: The recent study highlights teleophthalmology’s potential in reducing carbon emissions and improving accessibility to eye care, emphasizing its role in achieving carbon neutrality and delivering cost-effective, targeted healthcare services, particularly for minor eye issues.

  • NexCAR19: India’s First Indigenous CAR T- Cell Therapy for Cancer

    Why in the news?

    • President Droupadi Murmu has unveiled ‘NexCAR19’ India’s first indigenously-developed CAR T-cell therapy for cancer treatment.

    What is CAR-T Cell Therapy?

    What is it?
    • CAR-T cell therapy stands for Chimeric Antigen Receptor T cell therapy.
    • It is a type of cancer immunotherapy that uses the patient’s own T cells, genetically modified in a laboratory to enhance their ability to locate and destroy cancer cells.
    How does it work?
    • T cells are white blood cells responsible for identifying and fighting illness and infection.
    • Each T cell has a receptor that can recognize antigens (proteins or molecules recognized by the immune system).
    • Cancer cells may have antigens that the immune system does not recognize as abnormal, allowing cancer to evade the immune response.
    • CAR-T cells are genetically engineered in the lab to express a new receptor that can bind to cancer cells and effectively kill them.
    Therapy Process The process involves several steps, including:

    1. Collecting T Cells: Blood is drawn from the patient’s arm, and T cells are separated from the blood using an apheresis machine.

    2. Engineering T Cells: In a laboratory, the T cells are modified by adding a manufactured CAR, and they are allowed to multiply and grow.

    3. Infusing CAR-T Cells: Once enough CAR-T cells are prepared, they are injected back into the patient’s arm.

    • Chemotherapy may be recommended before CAR-T cell infusion to enhance treatment effectiveness.
    • The process can take place in an outpatient infusion center or a hospital setting.
    Cancers Treated
    • CAR-T cell therapy is effective against certain types of cancer, especially when other treatments are ineffective.
    • It is currently FDA-approved for treating haematological malignancies, including leukemia, lymphoma, and multiple myeloma.

     

    NexCAR19: India’s Indigenously Developed CAR-T Therapy

    • NexCAR19 is designed to target cancer cells carrying the CD19 protein, a marker on cancer cells, enhancing precision in treatment.
    • It has been developed jointly by IIT Bombay and the Tata Memorial Centre.
    • Initially approved for patients aged 15 and above with B-cell lymphomas who did not respond to standard treatments, leading to relapse or recurrence.

    Effectiveness and Unique Features

    • Approximately 70% of patients respond to NexCAR19 treatment, with some achieving complete remission.
    • Lab and animal studies indicate lower drug-related toxicities, including reduced neurotoxicity and Cytokine Release Syndrome (CRS).
    • Trials for paediatric patients are underway at Tata Memorial Hospital, ensuring broader applicability.

    Availability and Affordability

    • ImmunoACT is in the process of securing licenses and partnering with hospitals, including Tata Memorial, Nanavati, Fortis, and Jaslok, across multiple cities.
    • Initially priced at Rs 30-40 lakh, ImmunoACT aims to eventually reduce the cost to Rs 10-20 lakh, making the therapy more accessible.

    PYQ:

    2017:

    Stem cell therapy is gaining popularity in India to treat a wide variety of medical conditions including leukaemia, Thalassemia, damaged cornea and several burns. Describe briefly what stem cell therapy is and what advantages it has over other treatments?

     

    Practice MCQ:

    With reference to the CAR-T Cell Therapy, consider the following statements:

    1.    T cells are Red Blood Cells responsible for identifying and fighting illness and infection.

    2.    Each T cell has a receptor that can recognize antigens (proteins or molecules recognized by the immune system).

    Which of the given statements is/are correct?

    (a) Only 1

    (b) Only 2

    (c) Both 1 and 2

    (d) Neither 1 nor 2

  • OptiDrop platform for studying Single Cells

    Why in the news?

    The Centre for Cellular and Molecular Platforms (C-CAMP) in Bengaluru has unveiled OptiDrop platform designed to simplify and significantly reduce the cost of studying single cells.

    About C-CAMP

    • C-CAMP Initiative was established in 2009 under the aegis of the Department of Biotechnology, Ministry of Science, Technology, and Earth Sciences.
    • It stands as India’s premier biosciences research and innovation hub.

    What is OptiDrop?

    • OptiDrop presents a cost-effective alternative to traditional flow cytometry methods, making single-cell analysis more accessible to a broader range of researchers and institutions.
    • OptiDrop simplifies single-cell analysis by encapsulating individual cells within droplets, facilitating easier manipulation and analysis compared to traditional methods.
    • Key features such as affordability, live data visualization, compact design, and closed-system architecture enhance its suitability for diverse clinical applications.
    Cytometry is the measurement of number and characteristics of cells. Variables that can be measured by cytometric methods include cell size, cell count, cell morphology (shape and structure), cell cycle phase, DNA content, and the existence or absence of specific proteins on the cell surface or in the cytoplasm.

    Applications of OptiDrop

    • Expansive Utility: OptiDrop unlocks various downstream applications, including drug screening, environmental monitoring, immunotherapy, and single-cell genomics, revolutionizing research across multiple domains.
    • Advanced Research Capabilities: Researchers can leverage OptiDrop to study individual cell behavior during drug screenings, identify and monitor environmental contaminants, sort specialized cell populations, and explore genetic heterogeneity within cell populations.

    Benefits offered by OptiDrop

    • Accessible Technology: Unlike conventional cytometers, which can cost up to Rs 40 lakh or more, OptiDrop offers a cost-efficient solution likely priced around Rs 10 lakh, making it accessible to a broader range of research labs and institutions.
    • Affordable Scalability: OptiDrop’s affordable pricing and scalable design allow institutions of varying sizes to adopt the technology, democratizing access to cutting-edge single-cell analysis capabilities.
    • Long-Term Sustainability: By reducing the barrier to entry for single-cell analysis, OptiDrop paves the way for sustainable and impactful research initiatives, driving innovation and discovery in the life sciences.

    PYQ:

    2020:

    Which of the following statements are correct regarding the general difference between plant and animal-calls?

    1.    Plant cells have cellulose cell walls whilst animal cells do not.

    2.    Plant cells do not have plasma membrane unlike animal cells which do.

    3.    Mature plant cell has one large vacuole whilst animal cell has many small vacuoles.

    Select the correct answer using the code given below:

    (a) 1 and 2 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

     

    Practice MCQ:

    The OptiDrop equipment recently seen in news finds application in:

    (a) Cytometry

    (b) Astronomy

    (c) Geology

    (d) Radiometry

  • Hepatitis B: Everything you need to know

    Why in the news?

    • A recent study by Sir Ganga Ram Hospital, New Delhi, revealed alarming deficiencies in public knowledge (transmission, effects & vaccination) about Hepatitis B in India.
    • Despite the availability of a vaccine for over 30 years, HBV infection rates remain high in India, with prevalence estimates ranging from 2% to 8% and approximately 37 million carriers nationwide.

    About Hepatitis

    • Hepatitis is a medical condition characterized by inflammation of the liver.
    • It can be caused by various factors, including viral infections (hepatitis viruses), alcohol consumption, certain medications, toxins, autoimmune diseases, and metabolic disorders.
    Hepatitis A Hepatitis B Hepatitis C
    Causative Virus Hepatitis A Virus (HAV) Hepatitis B Virus (HBV) Hepatitis C Virus (HCV)
    Transmission Fecal-oral route (contaminated food/water) Blood and body fluids (unsafe sex, sharing needles) Blood-to-blood contact (sharing needles, transfusions)
    Vaccine Available Yes Yes Yes
    Chronic Infection No (usually acute) Yes (can become chronic) Yes (often becomes chronic)
    Symptoms Mild flu-like symptoms, jaundice Variable, from none to severe symptoms Often asymptomatic, but can lead to liver damage
    Chronic Complications None Cirrhosis, liver cancer Cirrhosis, liver cancer
    Preventable by Vaccine Yes Yes No
    Treatment Supportive care Antiviral medications Antiviral medications

     

    PYQ:

     

    Which one of the following statements is not correct? (2019)

    (a) Hepatitis B virus is transmitted much like HIV.

    (b) Hepatitis B, unlike Hepatitis C, does not have a vaccine.

    (c) Globally, the number of people infected with Hepatitis B and C viruses are several times more than those infected with HIV.

    (d) Some of those infected with Hepatitis B and C viruses do not show the symptoms for many years.

     

    Which of the following diseases can be transmitted from one person to another through tattooing? (2013)

    1.    Chikungunya

    2.    Hepatitis B

    3.    HIV-AIDS

    Select the correct answer using the codes given below.

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

     

    Practice MCQ:

     

    Consider the following statements regarding Hepatitis C virus:

    1.    It is spread mainly through contaminated water and food.

    2.    It primarily affects the functioning of respiratory system.

    Which of the statements given above is/are correct?

    (a) Only 1

    (b) Only 2

    (c) Both 1 and 2

    (d) Neither 1 nor 2

  • Global Spread of H5N1 Bird Flu

    Why in the news?

    • Since 2020, the highly pathogenic H5N1 bird flu has been spreading globally, posing a significant threat to both birds and mammals.

    H5N1 Bird Flu: Details

    • H5N1 originated from a virus outbreak on a goose farm in China in 1996 and has since evolved into a highly pathogenic strain.
    • The virus quickly spread from Europe to Africa, Asia, North America, and South America, and most recently, it reached mainland Antarctica.
    • H5N1 is a subtype of the influenza A virus that causes severe respiratory disease in birds, known as avian influenza or “bird flu”.
    • Influenza A viruses are classified by subtypes based on the properties of their surface proteins, with H5N1 being one subtype.

    How widespread is it?

    • The virus has affected birds in over 80 countries, resulting in mass culling of poultry and wild birds.
    • Furthermore, it has now begun infecting mammals, including seals, sea lions, and marine mammals.
    • While humans rarely contract bird flu, those at risk are typically individuals who have extensive contact with infected birds at poultry farms.
    • Bird flu first broke out in Maharashtra in 2006.
    • The H5N1 virus led to the culling of millions of poultry so as to contain the virus. But it has resurfaced from time to time.

    Impact on Animals

    • Bird Species Affected: Numerous bird species, including Great Skuas and Barnacle Geese, have experienced significant mortality rates due to H5N1.
    • Endangered Species Threatened: Endangered birds like the California condors have been severely affected, with a notable percentage of the population succumbing to the virus.
    • Mammalian Casualties: H5N1 has crossed species barriers, infecting mammals such as foxes, pumas, skunks, and marine mammals like sea lions and dolphins.
    • Devastating Consequences: Mass mortalities of marine mammals, particularly elephant seals, have been reported, raising concerns about the long-term ecological impact.

    Factors behind Spread

    • Climate Change: Some scientists attribute the large-scale spread of bird flu to climate change, which alters bird behavior and facilitates the transmission of the virus.
    • Warmer Seas: Warmer sea temperatures have weakened marine mammal populations, making them more susceptible to disease outbreaks.

    PYQ:

     

    2015: H1N1 virus is sometimes mentioned in the news with reference to which one of the following diseases?

    (a) AIDS

    (b) Bird flu

    (c) Dengue

    (d) Swine flu

     

    Practice MCQ:

    How many of the given statements about H5N1 Virus is/are correct?

    1.    It is a type of influenza virus causing highly infectious, respiratory disease in birds.

    2.    It is highly contagious in humans.

    3.    Seals, sea lions, and other marine mammals are vulnerable to this Virus.

    Select the correct codes from below –

    (a) One

    (b) Two

    (c) Three

    (d) None

  • On the resurgence of Mumps in Kerala

    Why in the news? 

    Mumps, an acute viral infection that historically affects children, has been spreading like wildfire in Kerala, for the past few months.

    Context:

    • Despite being a vaccine-preventable disease, mumps has never been a part of the Universal Immunisation Programme (UIP) because of the disease’s no-mortality profile and the perception that it has low public health significance.
    • According to the World Health Organization (WHO), vaccination strategies targeting mumps control should be closely integrated with existing measles elimination and rubella control.

    About: Mumps is an airborne viral disease primarily affecting children and adolescents. It manifests with symptoms like fever, headache, and painful swelling of the salivary glands, particularly the parotid glands on both sides of the face.

    Is it a cause for concern? 

    • Self-Limiting Disease: Mumps is described as a self-limiting disease, meaning it typically resolves on its own with rest and symptomatic management within about two weeks.
    • Underreporting: Due to approximately half of infected children developing classical symptoms and around 30% remaining asymptomatic, many cases of mumps go unreported. This suggests that reported cases are likely a significant underestimation of the actual prevalence in the community.
    • Public Health Perspective: Historically, measles has been prioritized in public health efforts due to its potential for severe morbidity and mortality, overshadowing the attention given to mumps.
    • Emerging Concerns: Despite being less prioritized, recent reports indicate a surge in mumps cases, including complications such as encephalitis, epilepsy, aseptic meningitis, and acute pancreatitis, particularly at Kozhikode Medical College hospital.
    • Impact on Reproductive Health: Mumps can affect the gonads (reproductive glands) in both males and females. In males, it poses the rare but significant risk of infertility or reduced sperm count in the long term.

    Why is the mumps vaccine not part of the national immunization schedule?

    • Lack of Mortality: Mumps typically does not result in fatalities, further contributing to the belief that it may not warrant inclusion in routine vaccination schedules.
    • Underestimation of Public Health Significance: Despite arguments from organizations like the Indian Academy of Pediatrics (IAP) that mumps’ public health significance is underestimated, there has been insufficient evidence or data to prompt its inclusion in national immunization programs.
    • Poor Documentation and Lack of Studies: Limited documentation of clinical cases, complications, and follow-up data, as well as a scarcity of published studies on mumps, have hindered efforts to fully understand its impact and advocate for its vaccine inclusion.
    • Absence of Nationally Representative Data: The lack of nationally representative data on the incidence of mumps in India makes it challenging to assess its burden accurately and advocate for vaccine inclusion based on epidemiological evidence.
    • Limited Information on Long-Term Morbidity: While mumps is known to have some impact on reproductive organs, there is very little information available on its actual long-term morbidity profile, further complicating decisions regarding vaccine inclusion.

    How can the current outbreaks be controlled?

    • Public Awareness Campaigns: Launch comprehensive public awareness campaigns to educate the community about mumps, its symptoms, transmission, and the importance of isolation. Emphasize the significance of vaccination and maintaining good hygiene practices.
    • Improve Immunization Coverage: Strengthen efforts to improve general immunization coverage, especially targeting unimmunized children and adolescents. Ensure accessibility to vaccination services in all communities.
    • Strict Isolation Measures: Enforce strict isolation measures for mumps patients for the full three-week duration to limit disease transmission. Provide clear guidelines to healthcare facilities and schools on managing mumps cases and preventing spread.
    • School Closure: Consider temporary closure of schools during outbreaks to prevent further transmission, especially if a significant number of cases are reported among students. Use the summer break as an opportunity to break the chain of transmission.
    • Enhanced Surveillance and Reporting: Implement robust surveillance systems to promptly detect and report mumps cases. Ensure healthcare providers are vigilant in diagnosing and reporting suspected cases to public health authorities for timely intervention.
    • Contact Tracing and Monitoring: Conduct thorough contact tracing of individuals who have been in close contact with confirmed mumps cases. Monitor them for symptoms and enforce isolation measures if necessary to prevent secondary transmission.
    • Healthcare Provider Training: Provide training to healthcare providers on mumps diagnosis, management, and reporting protocols. Ensure they are equipped to identify and manage cases effectively.
    • Community Engagement: Engage with community leaders, schools, and parents to encourage cooperation with control measures. Encourage individuals to seek medical care promptly if they develop symptoms suggestive of mumps.

    Way Forward:

    • Assessment of Vaccine Effectiveness: Despite the lack of studies on the effectiveness of the mumps vaccine in India, global data suggests that two doses of the MMR vaccine can provide protection ranging from 70% to 95%, provided that coverage is high.
    • Integration with Measles and Rubella Control: The World Health Organization (WHO) recommends integrating mumps vaccination strategies with existing efforts for measles elimination and rubella control. This ensures a comprehensive approach to vaccine-preventable diseases.
    • Consideration of Regional Factors: Evaluate regional factors influencing vaccine effectiveness, disease burden, and immunization coverage. Tailor vaccination strategies accordingly to address the specific needs and challenges faced in Kerala.
    • Consultation with Experts and Stakeholders: Engage with public health experts, immunization specialists, and stakeholders to review the evidence, assess the impact of different vaccination strategies, and determine the most effective approach moving forward.
    • Monitoring and Surveillance: Strengthen monitoring and surveillance systems to track mumps cases, vaccine coverage, and vaccine effectiveness. This data will be crucial for evaluating the impact of vaccination strategies and making informed decisions.
    • Policy Decision: Based on the evidence and expert recommendations, make a policy decision regarding the inclusion of MMR vaccine in the Universal Immunization Programme. Consider factors such as vaccine availability, cost-effectiveness, and logistics.

    Conclusion: Addressing the resurgence of mumps in Kerala necessitates a comprehensive approach, including vaccination integration, public awareness, strict isolation measures, and policy review guided by expert consultation and regional considerations.

  • Clinical Trials for MTBVAC Tuberculosis Vaccine in India

    What is the news?

    • Bharat Biotech, in collaboration with Spanish biopharmaceutical company Biofabri, has initiated clinical trials for the Mycobacterium Tuberculosis Vaccine (MTBVAC) in India, marking a significant milestone in TB vaccine development.
    • The only currently available TB vaccine, the Bacillus Calmette-Guérin vaccine (BCG), was developed 100 years ago and is less effective.

    About MTBVAC

    • MTBVAC is a unique TB vaccine based on a genetically modified form of Mycobacterium tuberculosis, containing all antigens present in human-infecting strains, unlike the BCG vaccine.
    • It is developed in the laboratory of the University of Zaragoza with contributions from Dr. Brigitte Gicquel of the Pasteur Institute, Paris.
    • MTBVAC is designed to offer superior and potentially longer-lasting protection compared to the BCG vaccine, particularly for newborns and in preventing TB in adults and adolescents.

    Objectives of Clinical Trials in India

    • Safety and Immunogenicity: The ongoing trials in India aim to evaluate the safety and immunogenicity of MTBVAC, with plans for a pivotal Phase 3 trial in 2025.
    • Population Significance: Studying the vaccine’s efficacy in India, with its high TB burden, is crucial for advancing TB vaccine research and addressing the global TB epidemic.

    What is Tuberculosis?

    • Tuberculosis is an infection caused by Mycobacterium tuberculosis.
    • Robert Koch discovered Mycobacterium tuberculosis which causes TB, and his discovery opened the way towards diagnosing and curing this disease.
    • It can practically affect any organ of the body.
    • The most common ones are lungs, pleura (lining around the lungs), lymph nodes, intestines, spine, and brain.

    Transmission:

    It is an airborne infection that spreads through close contact with the infected, especially in densely populated spaces with poor ventilation.

    Symptoms:

    Common symptoms of active lung TB are cough with sputum and blood at times, chest pains, weakness, weight loss, fever and night sweats.

    Treatment Facilities in India:

    • DOTS (Directly Observed Treatment, Short-Course) regimen: It is the recommended treatment approach for TB by the WHO. Patients receive a combination of four antibiotics: isoniazid, rifampicin, pyrazinamide, and ethambutol. These drugs are usually administered daily for the first two months of treatment, followed by a continuation phase with isoniazid and rifampicin for an additional four to seven months.
    • Nikshay Poshan Yojana (2018): It was launched to support every Tuberculosis (TB) Patient by providing a Direct Benefit Transfer (DBT) of Rs 500 per month for nutritional needs.

    Issues in TB Treatment: Drug Resistance

    Drug resistance emerges when anti-TB medicines are used inappropriately, through incorrect prescription by health care providers, poor quality drugs, and patients stopping treatment prematurely.

    1. Multidrug-resistant tuberculosis (MDR-TB): Itis a form of TB caused by bacteria that do not respond to isoniazid and rifampicin, the 2 most powerful, first-line anti-TB drugs. MDR-TB is treatable and curable by using second-line drugs such as
    2. Extensively drug-resistant TB (XDR-TB): Itis a more serious form of MDR-TB caused by bacteria that do not respond to the most effective second-line anti-TB drugs, often leaving patients without any further treatment options.

     

    PYQ:

    2014: Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.

     

    Practice MCQ:

    With reference to the Tuberculosis (TB), consider the following statements:

    1. TB is an infection caused by Mycobacterium tuberculosis.
    2. It only targets Lungs.
    3. Nikshay Poshan Yojana aims for TB support is essentially a Direct Benefit Transfer (DBT).

    How many of the given statements is/are correct?

    1. One
    2. Two
    3. Three
    4. None

  • [pib] Project ANAGRANINF

    What is the news?

    • The Technology Development Board (TDB) has allocated a grant of ₹75 Lakhs for the project “ANAGRANINF – Development of a Novel Class of Antibiotics against Gram-Negative Bacterial-Infections,” totalling ₹1.5 crores.

    What is Project ANAGRANINF?

    • Project ANAGRANINF is titled “Development of a Novel Class of Antibiotics Against Gram-Negative Bacterial-Infections.”
    • It is a collaborative initiative involving M/s Peptris Technologies Pvt. Ltd. and the Foundation for Neglected Disease Research (FNDR) in India, along with ABAC THERAPEUTICS SL from Spain.
    • The primary objective of the project is-
    1. To develop a novel antibiotic capable of inhibiting the FabI enzyme and
    2. Combating critical gram-negative pathogens.
    • Project ANAGRANINF aims to produce a series of compounds with enhanced efficacy against gram-negative bacterial infections.
    • The project aims to identify a candidate molecule that meets WHO’s innovation criteria, ensuring a new chemical structure, no cross-resistance with existing antibiotic classes, and a novel mechanism of action.

    About the Candidate Molecule ‘MMV1578564’

    The selected hit molecule from the project, MMV1578564, has exhibited promising activity against gram-negative pathogens, providing a foundation for further research and development efforts.

    Back2Basics:

    1. Gram-Negative Bacteria:
      • Gram-negative bacteria have a thin peptidoglycan layer in their cell wall, which is located between the outer and inner membranes.
      • They stain pink or red when subjected to the Gram staining technique.
      • Gram-negative bacteria are generally more resistant to antibiotics due to the presence of an outer membrane that acts as a barrier against certain antibiotics.
      • Examples of gram-negative bacteria include Escherichia coli (E. coli), Salmonella spp., Pseudomonas aeruginosa, and Neisseria gonorrhoeae.
      • They are known to cause infections like pneumonia, bloodstream infections, wound infections, and meningitis in healthcare settings
    2. Gram-Positive Bacteria:
      • Gram-positive bacteria have a thick layer of peptidoglycan in their cell wall, which retains the crystal violet stain used in the Gram staining technique.
      • They appear purple or blue under a microscope after staining.
      • Gram-positive bacteria are generally more susceptible to antibiotics because their thick peptidoglycan layer allows antibiotics to penetrate more easily.
      • Examples of gram-positive bacteria include Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, and Clostridium difficile.
      • Some examples of diseases caused by Gram-positive bacteria include anthrax, diphtheria, enterococcal infections, erysipelothricosis, and listeriosis.These bacteria can cause a range of infections from food poisoning to serious respiratory diseases and may require specific antibiotics for treatment.

     

    PYQ:

    2021: Consider the following:​

    1. Bacteria​
    2. Fungi​
    3. Virus​

    Which of the above can be cultured in artificial/synthetic medium?​

    1. 1 and 2 only ​
    2. 2 and 3 only​
    3. 1 and 3 only ​
    4. 1, 2 and 3​

     

    Practice MCQ:

    The recently launched Project ‘ANAGRANINF’ deals with:

    1. Agricultural Grant
    2. Artificial Intelligence
    3. Antibiotics Development
    4. None of these