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Subject: Science and Technology

  • Uncontrolled Re-entries of Satellites

    satellite

    Many dignitaries have signed an open letter published by the Outer Space Institute (OSI) calling for both national and multilateral efforts to restrict uncontrolled re-entries of Satellites back to earth.

    About Open Space Institute (OSI)

    • OSI is a conservation organization that seeks to preserve scenic, natural and historic landscapes for public enjoyment, conserve habitats while sustaining community character, and help protect the environment.
    • It uses policy initiatives and ground-level activism to help accomplish its goals.

    What are the stages of a rocket launch?

    • Rockets have multiple stages.
    • Once a stage has increased the rocket’s altitude and velocity by a certain amount, the rocket sheds it.
    • Some rockets jettison all their larger stages before reaching the destination orbit; a smaller engine then moves the payload to its final orbit.
    • Others carry the payload to the orbit, then perform a deorbit manoeuvre to begin their descent.
    • In both cases, rocket stages come back down — in controlled or uncontrolled ways.

    What is an uncontrolled re-entry?

    • It is the phenomenon of rocket parts falling back to earth in unguided fashion once their missions are complete.
    • In an uncontrolled re-entry, the rocket stage simply falls.
    • Its path down is determined by its shape, angle of descent, air currents and other characteristics.
    • It will also disintegrate as it falls.

    How many satellites are there in space?

    • The Soviet Union launched the first artificial satellite in 1957.
    • Today, there are more than 6,000 satellites in orbit, most of them in low-earth (100-2,000 km) and geostationary (35,786 km) orbits, placed there in more than 5,000 launches.
    • The number of rocket launches have been surging with the advent of reusable rocket stages.

    Why is this hazardous?

    • As the smaller pieces fan out, the potential radius of impact will increase on the ground.
    • Some pieces burn up entirely while others don’t.
    • But because of the speed at which they’re travelling, debris can be deadly.
    • If re-entering stages still hold fuel, atmospheric and terrestrial chemical contamination is another risk.

    Why are we discussing this?

    • The OSI letter cited examples of parts of a Russian rocket in 2018 and China’s Long March 5B rockets in 2020 and 2022 striking parts of Indonesia, Peru, India and Ivory Coast, among others.
    • Many news reports have focused on Chinese transgressions of late, but historically, the US has been the worst offender.
    • Parts of a SpaceX Falcon 9 that fell down in Indonesia in 2016 included two “refrigerator-sized fuel tanks”.

     

    Damage control mechanism for uncontrolled re-entry

    • There is no international binding agreement to ensure rocket stages always perform controlled re-entries nor on the technologies with which to do so.
    • The Liability Convention, 1972 requires countries to pay for damages, not prevent them.
    • These technologies include wing-like attachments, de-orbiting brakes, and extra fuel on the re-entering body, and design changes that minimise debris formation.

     

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  • [pib] Vainu Bappu Observatory

    vainu

    The several stellar discoveries of the 40-inch telescope at the Vainu Bappu Observatory in Kavalur, Tamil Nadu, were highlighted at the celebration of its 50 years of its operation.

    Vainu Bappu Observatory

    • The Vainu Bappu Observatory is an astronomical observatory owned and operated by the Indian Institute of Astrophysics.
    • It is located at Kavalur in the Javadi Hills, near Vaniyambadi in Tirupathur district in Tamil Nadu.
    • The 40-inch telescope was installed in 1972 and started producing important astronomical discoveries soon after.
    • More than a generation of astronomers were trained at this telescope as well.

    Significant feats achieved by VBO

    The telescope set up by Professor Vainu Bappu has played a significant role in astronomy with major discoveries like-

    1. Presence of rings around the planet Uranus,
    2. New satellite of Uranus,
    3. Presence of an atmosphere around Ganymede which is a satellite of Jupiter
    4. Discovery and study of many ‘Be stars’, Lithium depletion in giant stars, optical variability in Blazars, the dynamics of the famous supernova SN 1987A and so on.

     

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  • World Ayurveda Congress: Aligning traditional medicine with modern medicines

    modern

    Context

    • Prime Minister Narendra Modi commended the recent growth of traditional medicine (TM), and Ayurveda in particular, while addressing the World Ayurveda Congress 2022 (WAC) earlier this month. Noting the lag in evidence despite considerable research, he gave a clarion call “to bring together medical data, research, and journals and verify claims (benefit) using modern science parameters”.

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    All you need to know about World Ayurveda Congress (WAC)

    • Platform by World Ayurveda foundation: The World Ayurveda Congress (WAC) is a platform established by World Ayurveda Foundation to propagate Ayurveda globally in its true sense.
    • Platform to connect various stakeholders in medicine: World Ayurveda Congress (WAC) is a platform to connect Ayurveda practitioners, medicine manufacturers, enthusiasts and academicians.
    • What is the mandate: World Ayurveda Congress (WAC) & Arogya Expo monitors progress and initiate missions and collect feedbacks.

    modern

    World Ayurveda Congress (WAC), 2022

    • 9th edition of WAC held at Panjim, Goa: The 9th edition of World Ayurveda Congress (WAC) & Arogya Expo was organized at PANJIM, GOA.
    • Organised by Ministry of AYSUSH on the principle of whole government approach (WGA): The WAC organised by the Ministry of AYUSH on the ‘Whole Government Approach’ (WGA) to foster and strengthen the research ecosystem for AYUSH systems.
    • What is Whole System Approach (WSA): The concept of WGA is in consonance with the “Whole System Approach” (WSA). WSA encompasses integrated and network participation of several stakeholders (including patients and the community) for better solutions (treatment outcomes) in a challenging and complex situation. IM is an important component of WSA in the current context.
    • Active Participation: The event witnessed the active participation of more than 40 countries and all states of India.
    • PM’s vision: To transform the healthcare system of the country and to develop a healthy society, there is a need to think holistically and integrate the Traditional medicine (TM) and modern medicine system (MM).

    World Ayurveda Foundation (WAF)

    • Aim of WAF: WAF is an initiative by Vijnana Bharati aimed at global propagation of Ayurveda, founded in 2011.
    • Objective and core principle: The objectives of WAF reflect global scope, propagation and encouragement of all activities scientific and Ayurveda related are the core principles.
    • Focus Areas: Support to research, health-care programmes through camps, clinics and sanatoriums, documentation, organization of study groups, seminars, exhibitions and knowledge initiatives to popularize Ayurveda in the far corners of the world are the broad latitudes of focus at WAF.

    modern

    What is Traditional Medicine?

    • According to WHO: The WHO describes traditional medicine as the total sum of the “knowledge, skills and practices indigenous and different cultures have used over time to maintain health and prevent, diagnose and treat physical and mental illness”.
    • Culmination of multiple ancient practices: Its reach encompasses ancient practices such as acupuncture, ayurvedic medicine and herbal mixtures as well as modern medicines.
    • Percentage of people use traditional medicine: of According to WHO estimates, 80% of the world’s population uses traditional medicine.

    Traditional medicine in India

    • It is often defined as including practices and therapies such as Yoga, Ayurveda, Siddha that have been part of Indian tradition historically, as well as others such as homeopathy that became part of Indian tradition over the years.
    • Ayurveda and yoga are practised widely across the country.
    • The Siddha system is followed predominantly in Tamil Nadu and Kerala.
    • The Sowa-Rigpa System is practised mainly in Leh-Ladakh and Himalayan regions such as Sikkim, Arunachal Pradesh, Darjeeling, Lahaul & Spiti.

    How TM modalities (such as Ayurveda or homoeopathy) can scientifically align with MM for a better outcome?

    • Remarkable success in treating neurological diseases: A recently established Department of IM in NIMHANS continued to show remarkable success in treating difficult neurological diseases with a team of Ayurvedic and MM physicians and carefully planned and monitored IM strategy.
    • CRD projects: Modern rheumatology practice in the Centre for Rheumatic Diseases (CRD) model includes critical elements of TM and Ayurveda, which have shown unequivocal evidence in CRD research projects
    • Evaluation based on other protocols: Several controlled protocols-based evaluations of standardised Ayurvedic drugs and other TM modalities (such as diet, exercise, yoga, and counselling), often in conjunction with MM, in arthritis patients, were completed.
    • Sustained clinical improvement in patients suffering from active Rheumatoid arthritis (RA): RA is a severely painful crippling lifelong autoimmune condition, mostly seen in women, and universally acknowledged as difficult to treat. Supervised and monitored IM intervention (including Ayurvedic drugs) over several years showed a consistently superior and sustained clinical improvement in patients suffering from active RA.

    modern

    Relationship between AYUSH and Modern medicines

    • AYUSH systems include Ayurveda, Homeopathy, Unani, Siddha, and other TM.
    • AYUSH systems and MM differ radically in several ways or so it seems.
    • Modern scientific research in Ayurveda is often at variance with classical Ayurveda.
    • Unlike MM, TM has at its core a personalised approach. MM is dominantly reductionist.
    • The ambitious futuristic programme of TM and IM by AYUSH is well-intended and in the right direction.

    Conclusion

    • TM and Ayurveda need to respond to the new world order, which has changed substantially recently. It is reasonably certain that MM and TM in the current format will continue to treat several medical disorders and altered health states. But evidence-based medicine will become the new mantra. Also, informed and empowered patients and people will continue to make the right choices.

    Mains question

    Q. What is World Ayurveda congress? What is tradition medicines? How Traditional medicines can align with modern medicines to treat several serious medical disorders.

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  • A resolution to ban kinetic ASAT tests

    resolution

    Context

    • There is growing momentum behind a global moratorium on destructive kinetic anti-satellite (ASAT) tests. A few days ago, the United Nations General Assembly (UNGA) passed a resolution calling for a ban on kinetic ASAT tests.

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    What the resolution is all about?

    • Sponsored by United states: The resolution was sponsored by the United States along with a number of other countries that have been concerned about the consequences of ASAT tests on the safety and sustainability of outer space.
    • Majority voted in support: As many as 155 countries voted in support of the resolution, nine voted against it, and nine others abstained.
    • Those who voted against the resolution: Belarus, Bolivia, Central African Republic, China, Cuba, Iran, Nicaragua, Russia, and Syria.
    • Countries with abstention: The nine abstentions were India, Laos, Madagascar, Pakistan, Serbia, Sri Lanka, Sudan, Togo, and Zimbabwe.

    resolution

    Provisions of the resolution over the ban of ASAT

    • No binding effect but urges to prevent arms race in outer space: The ASAT test-ban resolution has no binding effect on states and simply calls on states to put a stop to ASAT tests and to develop further practical steps and contribute to legally binding instruments on the prevention of an arms race in outer space.
    • Other space related resolutions also passed: Along with the ASAT test-ban resolution that was passed on December 7, there were several more space- and nuclear-related resolutions, including No First Placement of Weapons in Outer Space (NFP).
    • Support to minimize risks in space: Indeed, the resolution continues to support the broader efforts at developing “further practical steps” to minimize risks in space.

    What is ASAT?

    • ASATs (Anti-Satellite Weapons): According to a document of the United Nations Institute for Disarmament Research (UNIDIR), ASATs (Anti-Satellite Weapons) are aimed at destroying or disabling space assets, whether military or civilian, offensive or defensive.
    • They are generally of two types: kinetic and non-kinetic.
    1. Kinetic ASATs: They must physically strike an object in order to destroy it. Examples of kinetic ASATs include ballistic missiles, drones or any item launched to coincide with the passage of a target satellite. This means any space asset, even a communications satellite, could become an ASAT if it is used to physically destroy another space object.
    2. Non-kinetic ASATs: A variety of nonphysical means can be used to disable or destroy a space object. These include frequency jamming, blinding lasers or cyberattacks. These methods can also render an object useless without causing the target to break up and fragment absent additional forces intervening.

    resolution

    Why ASAT tests are to be banned?

    • Threat to peaceful utilization of outer space: ASAT tests represent a direct threat to peaceful utilization of outer space on which everyone in the global community depends.
    • Threat to safety of satellites: In recent years, there has been a spurt in activities that threaten the safety and functioning of satellites. The November 15, 2021, ASAT test by Russia, which destroyed the Cosmos 1408 satellite, is a case in point.
    • Space debris a potential hazard to Space station: The test created about 1,800 tracked pieces of space debris and possibly many more pieces that are difficult to track, and a hazard for astronauts aboard the International Space Station
    • Rare, high-tech, and risky to test: ASAT is an anti-satellite weapon that can target enemy satellites, blinding them or disrupting communications besides providing a technology base for intercepting ballistic missiles.

    resolution

    Way ahead

    • There are other initiatives underway in the U.N., such as the Open-Ended Working Group (OEWG) on reducing space threats through norms, rules, and principles of responsible behaviours.
    • Like the ASAT test ban, these are needed to make progress on the broader space security agenda.
    • Whether a legal measure or a norm, states have to take small preventative steps before space becomes completely a warfighting domain.

    Conclusion

    • Given the worsening space security conditions, with more countries pursuing development of ASATs and other counterspace capabilities, it is time that more countries join the current initiative to stop further ASAT tests. Unless countries can make a conscious decision to come together and work on ways to halt the current trends with regard to space weaponization, continued access to outer space is not a given.

    Mains question

    Q. What are ASATs? There is growing momentum behind a global moratorium on destructive kinetic anti-satellite (ASAT) tests. In light of this discuss Why ASAT must be banned?

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  • Why banyan, peepal trees live longer?

    banyan

    Researchers at the Indian Institute of Science Education and Research (IISER) Bhopal have found out the carried out whole genome sequencing of banyan and peepal from leaf tissue samples.

    Science behind long life: Multiple Signs of Adaptive-evolution (MSA)

    • Scientists identified 25,016 coding gene sequences in banyan and 23,929 in peepal.
    • Both trees faced a population bottleneck around 0.8 million years ago and evolved genes with multiple signs of adaptive evolution (MSA).
    • In banyan, the MSA genes are mainly involved in root growth, pollen tube and seed development, leaf formation, cell wall synthesis, metabolism and other developmental processes.

    How MSA prolongs the life?

    • Disease resistance and other stress tolerance gene families showed expansion as well as high expression, contributing to the plants’ long lifespan.
    • The MSA genes of peepal are associated with root cell elongation, cell proliferation, seed and pollen tube growth, lateral organ development, controlling flowering time, metabolism and intracellular transport.
    • The team zeroed in on 17 MSA genes in banyan and 19 MSA genes in peepal that are mainly related to well-developed morphology, and tolerance against drought, oxidative stress and pathogens.
    • Genes involved in growth-regulating auxin signalling and plant senescence-regulating pathways also showed evolutionary signatures.
    • Also, 88% and 89% of the MSA genes in banyan and peepal trees, respectively, are associated with tolerance against biotic and abiotic stress responses.
    • This, in turn, helps these plants to survive when faced with environmental challenges.

     

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  • How can mRNA vaccines help fight cancer?

    mrna

    The results of a trial of an experimental cancer vaccine built on the mRNA (messenger ribonucleic acid) platform, made by Moderna and MSD (Merck&Co.), have shown promising results.

    What is mRNA?

    mrna

    • Messenger RNA (mRNA) is a single-stranded RNA (Ribo Nucleic Acid) molecule that is complementary to one of the DNA strands of a gene.
    • The mRNA is an RNA version of the gene that leaves the cell nucleus and moves to the cytoplasm where proteins are made.
    • During protein synthesis, an organelle called a ribosome moves along the mRNA, reads its base sequence, and uses the genetic code to translate each three-base triplet, or codon, into its corresponding amino acid.

    What are mRNA vaccines?

    • mRNA vaccines work by introducing a piece of mRNA that corresponds to a viral protein, usually a small piece of a protein found on the virus’s outer membrane.
    • Individuals who get an mRNA vaccine are not exposed to the virus, nor can they become infected with the virus by the vaccine.
    • As part of a normal immune response, the immune system recognizes that the protein is foreign and produces specialized proteins called antibodies.
    • Antibodies help protect the body against infection by recognizing individual viruses or other pathogens, attaching to them, and marking the pathogens for destruction.
    • Once produced, antibodies remain in the body, even after the body has rid itself of the pathogen, so that the immune system can quickly respond if exposed again.

    How does the vaccine work?

    • The personalized cancer vaccine uses the same messenger-RNA technology that was used to produce the COVID vaccine.
    • It allows the body’s immune system to seek and destroy cancerous cells, in this case melanoma, but with the hope that it could lead to new ways to fight other types of cancers too.

    Why is it a significant feat?

    • The cancer vaccine showed a 44% reduction in the risk of dying of cancer or having the cancer progress.
    • As a personalized cancer vaccine, it is tailor-made for every patient.
    • As a consequence, it is expected to be very expensive to make.
    • But oncologists across the world have welcomed this as an exciting new opportunity in cancer care.

     

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  • A milestone in fusion energy

    fusion

    Context

    • For more than nine decades scientists have tried to replicate the process that produces energy for the sun and the stars fusion. On Tuesday, researchers at the National Ignition Facility (NIF) in California, USA, announced a milestone in this endeavor.

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    fusion

    What is the research?

    • Merged two nuclei to produce a heavier nucleus: They merged two nuclei to produce a heavier nucleus. Their reactor produced about 1.5 times more energy than what was used in the process. In all the earlier attempts to harness the power of fusion, the reactors used up more energy than what was produced.
    • It will take at least two decades to be pioneered: But scientists say that it will be at least two decades before the process pioneered in the California laboratory can be scaled up.
    • Still a great leap where the world is in search of green technologies: Even then, in a world desperately searching for technologies that can power the developmental needs of nations without adding to the GHG load, the breakthrough at NIF has generated excitement.

    What is Fusion?

    • Fusion works by pressing hydrogen atoms into each other with such force that they combine into helium, releasing enormous amounts of energy and heat.
    • This process occurs in our Sun and other stars.
    • Creating conditions for fusion on Earth involves generating and sustaining a plasma.
    • Plasmas are gases that are so hot that electrons are freed from atomic nuclei.

    fusion

    What is Fusion Energy?

    • The process releases energy because the total mass of the resulting single nucleus is less than the mass of the two original nuclei.
    • The leftover mass becomes energy.

    Why is it perceived as energy of the future?

    • Carbon free: Fusion Reactions could one day produce nearly limitless, carbon-free energy, displacing fossil fuels and other traditional energy sources.
    • Efficient: Net energy gain has been an elusive goal because fusion happens at such high temperatures and pressures that it is incredibly difficult to control.
    • Clean: Unlike other nuclear reactions, it doesn’t create radioactive waste.

    fusion

    Why it is considered as significant research, though it will take at least two decades to be commercialized?

    • Countries are shifting towards renewable energies: Several countries are shifting to renewable energies to meet their international climate-related commitments. Yet, power generation currently is responsible for 25-30 per cent of global GHG emissions.
    • Unstable nature of renewables: The inherently unstable nature of renewables means that countries find it very difficult to jettison fossil-fuel energy sources.
    • Nuclear energy is relatively cleaner: Conventionally-produced nuclear energy that uses fission technology is relatively cleaner. But accidents at Chernobyl in 1986 and Fukushima in 2011 have raised serious questions over the safety of fission-powered plants. According to the IEA’s best-case scenario, the world’s nuclear energy generation capacity is likely to double by 2050 compared to 2020.

    Conclusion

    • The global body has repeatedly flagged concerns about the efficacy of the nuclear reactors by and large in the US and Europe given that about two-thirds of them have been in operation for more than 30 years. It has also maintained that the realisation of the best-case scenario would require significant investments in innovative nuclear technologies.

    Mains question

    Q. Recently researchers at the National Ignition Facility (NIF) in USA tried to replicate the process that produces energy for the sun and the stars fusion, discuss the significance of this research.

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  • What is DNA Fingerprinting?

    dna

    Delhi Police has established identity of a victim of brutal murder and mutilation by DNA fingerprinting.

    What is DNA fingerprinting?

    • DNA fingerprinting was first developed in 1984 by Alec Jeffreys in the UK, after Jeffreys discovered that no two people could have the same DNA sequence.
    • Within three years of the discovery, the UK achieved the world’s first conviction based on DNA evidence in a case of rape and murder.

    How is DNA fingerprinting done?

    • Each person’s DNA, except for identical twins, is unique.
    • By analyzing selected DNA sequences (called loci), a crime laboratory can develop a profile to be used in identifying a suspect.
    • DNA can be extracted from many sources, such as hair, bone, teeth, saliva, and blood.
    • Because there is DNA in most cells in the human body, even a minuscule amount of bodily fluid or tissue can yield useful information.
    • Samples may even be extracted from used clothes, linen, combs, or other frequently used items.

     

    Deoxyribonucleic Acid (DNA)

    • DNA is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA.
    • Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).
    • Mitochondria are structures within cells that convert the energy from food into a form that cells can use.
    • The information in DNA is stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T).
    • Human DNA consists of about 3 billion bases, and more than 99 percent of those bases are the same in all people.
    • The order, or sequence, of these bases determines the information available for building and maintaining an organism, similar to the way in which letters of the alphabet appear in a certain order to form words and sentences.

    How it is used in criminal investigation?

    • DNA evidence is used to solve crimes in two ways:
    1. If a suspect is known, that person’s DNA sample can be compared to biological evidence found at a crime scene to establish whether the suspect was at the crime scene or whether they committed the crime.
    2. If a suspect is not known, biological evidence from the crime scene can be analyzed and compared to offender profiles in existing DNA databases to assist in identifying a suspect.
    • Beyond its accuracy, DNA fingerprinting can also sift through crime scene evidence in different ways, previously unavailable to investigators.
    • For instance, advanced DNA fingerprinting can make separate prints of various individuals even from a sample mixture found at the crime scene — this is of help during gang rape investigations as each perpetrator can be individually identified.

    DNA fingerprinting in India

    • By 1988, Lalji Singh, who had been in the UK from 1974 to 1987 on a Commonwealth Fellowship, developed DNA fingerprinting for crime investigations in Hyderabad.
    • Today, Lalji Singh, who passed away in 2017, is known as “the father of DNA fingerprinting in India.”
    • In 1989, DNA fingerprinting was first used in a case by the Kerala Police.
    • By the early 1990s, the technology had begun to be used for establishing paternity, and to link criminals and identify victims in sensational crimes.
    • From the 2000s onwards, the technology became a staple in rape cases where vaginal swab samples were matched with semen samples from suspects.

    Challenges with DNA fingerprinting in India

    • It is vital to ensure that the DNA of the investigators does not get mixed with that of the victims or the suspects.
    • Thus, picking up samples from a crime scene with sterile tools and storing samples in a proper manner are crucial for the evidence to stand a judicial test.
    • While India has rules and guidelines regarding this, India’s police forces have a lot of catching up to do with counterparts overseas.
    • While central agencies such as CBI have the expertise to ensure that crime scenes are protected and correct procedure is followed, state police forces are inadequately trained or fully equipped.

    Issues with such technology

    • The problem is not limited to the police awareness.
    • The capacity for DNA fingerprinting in the country itself is lacking.
    • DNA fingerprinting is available only at a few places — Maharashtra, West Bengal, Delhi, Hyderabad and Chandigarh.
    • Advanced practices in the technology are limited to the Centre for DNA Fingerprinting and Diagnostics (CDFD) in Hyderabad.

     

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  • US scientists announce breakthrough in Fusion Energy

    fusion

    US announced a “major scientific breakthrough” in the decades-long quest to harness fusion, the energy that powers the sun and stars.

    What is Fusion?

    • Fusion works by pressing hydrogen atoms into each other with such force that they combine into helium, releasing enormous amounts of energy and heat.
    • This process occurs in our Sun and other stars.
    • Creating conditions for fusion on Earth involves generating and sustaining a plasma.
    • Plasmas are gases that are so hot that electrons are freed from atomic nuclei.

    How is it carried out?

    fusion

    • Three conditions must be fulfilled to achieve fusion in a laboratory:
    1. Very high temperature (on the order of 150,000,000° Celsius);
    2. Sufficient plasma particle density (to increase the likelihood that collisions do occur); and
    3. Sufficient confinement time (to hold the plasma, which has a propensity to expand, within a defined volume).
    • At extreme temperatures, electrons are separated from nuclei and a gas becomes a plasma—often referred to as the fourth state of matter.
    • Fusion plasmas provide the environment in which light elements can fuse and yield energy.

    Fusion Energy

    • The process releases energy because the total mass of the resulting single nucleus is less than the mass of the two original nuclei.
    • The leftover mass becomes energy.

    What did the US achieve?

    • The US experiment uses a process called inertial confinement fusion.
    • It involved bombarding a tiny pellet of hydrogen plasma with the world’s biggest laser.

    Why is it perceived as energy of the future?

    • Carbon free: Fusion Reactions could one day produce nearly limitless, carbon-free energy, displacing fossil fuels and other traditional energy sources.
    • Efficient: Net energy gain has been an elusive goal because fusion happens at such high temperatures and pressures that it is incredibly difficult to control.
    • Clean: Unlike other nuclear reactions, it doesn’t create radioactive waste.

    Fusion still far from reality. Why?

    • Significant though the achievement is, it does little to bring the goal of producing electricity from fusion reactions any closer to reality.
    • By all estimates, use of the fusion process for generating electricity at a commercial scale is still two to three decades away.
    • The technology used in the US experiment might take even longer to get deployed.

    India’s progress: ITER project

    • International Thermonuclear Experimental Reactor (ITER) is one of the most ambitious energy projects in the world today.
    • The idea for an international joint experiment in fusion was first launched in 1985.
    • In southern France, 35 nations* are collaborating to build the world’s largest tokamak, a magnetic fusion device that has been designed to prove the feasibility of fusion.
    • ITER is funded and run by seven member parties: China, the European Union, India, Japan, Russia, South Korea and the United States.

     

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  • What is Base Editing?

    A teenage cancer patient suffering from T-cell acute lymphoblastic leukaemia (T-ALL) has defeated her seemingly incurable cancer with the help of base editing technique.

    Base Editing

    • Bases are the language of life. The four types of base – adenine (A), cytosine (C), guanine (G) and thymine (T) – are the building blocks of our genetic code.
    • Just as letters in the alphabet spell out words that carry meaning, the billions of bases in our DNA spell out the instruction manual for our body.
    • Base editing allows scientists to zoom to a precise part of the genetic code and then alter the molecular structure of just one base, converting it into another and changing the genetic instructions.
    • The large team of doctors and scientists used this tool to engineer a new type of T-cell that was capable of hunting down and killing cancerous T-cells.

    base-editing

    What is T-Cell?

    • T (thymus) cells are type of white blood cell.
    • They are part of the immune system and develop from stem cells in the bone marrow.
    • They help protect the body from infection and may help fight cancer.
    • Also called T lymphocyte and thymocyte.

    How base editing helped this teenage cancer patient?

    • Doctors started with healthy T-cells that came from a donor and set about modifying them.
    • The first base edit disabled the T-cells targeting mechanism so they would not assault patient’s body.
    • The second removed a chemical marking, called CD7, which is on all T-cells.
    • The third edit was an invisibility cloak that prevented the cells being killed by a chemotherapy drug.
    • The final stage of genetic modification instructed the T-cells to go hunting for anything with the CD7 marking on it so that it would destroy every T-cell in patient’s body – including the cancerous ones.
    • That’s why this marking has to be removed from the therapy – otherwise it would just destroy itself.
    • If the therapy works, the patient’s immune system – including T-cells – will be rebuilt with the second bone-marrow transplant.

     

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