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Subject: Science and Technology

  • Pralay Missile 

    Why in the News?

    The Defence Research and Development Organisation (DRDO) successfully conducted two consecutive test flights of the Pralay missile from the Dr. A.P.J. Abdul Kalam Island off Odisha’s coast.

    Pralay Missile 

    About Pralay Missile:

    • Developer: Defence Research and Development Organisation (DRDO), led by Research Centre Imarat (RCI) with Indian industry support.
    • Purpose: Tactical surface-to-surface missile for precision strikes along sensitive borders like the Line of Actual Control (LAC) and Line of Control (LoC).
    • Role: Enhances India’s conventional deterrence in short-range battlefield operations.
    • Targets: Designed to destroy high-value assets—radars, command centers, airstrips, and military infrastructure.

    Key Features:

    • Type: Quasi-ballistic surface-to-surface missile
    • Range: 150–500 km
    • Payload: 500–1,000 kg (conventional warheads)
    • Propulsion: Solid-propellant rocket motor
    • Launcher: Mobile platform for rapid deployment
    • Guidance: Advanced inertial navigation with <10 m Circular Error Probable (CEP)
    • Terminal Speed: Up to Mach 6.1
    • Maneuverability: Capable of mid-air trajectory changes to evade interception
    [UPSC 2023]  Consider the following statements:

    1. Ballistic missiles are jet-propelled at subsonic speeds throughout their fights, while cruise missiles are rocket-powered only in the initial phase of flight. 2. Agni-V is a medium-range supersonic cruise missile, while BrahMos is a solid-fuelled intercontinental ballistic missile.

    Which of the statements given above is/are correct?

    Options: (a) 1 only (b) 2 only (c) Both 1 and 2 (d) Neither 1 nor 2*

     

  • Novel Microscope observes Molecular Motion

    Why in the News?

    Over a century after Einstein explained Brownian motion, California Institute of Technology (Caltech) scientists have created a powerful microscope that shows molecules moving in real time at an extremely tiny scale.

    Novel Microscope observes Molecular Motion

    What is Brownian Motion?

    • Definition: Random movement of tiny particles in a fluid due to constant collisions with surrounding molecules.
    • Significance: Validated the existence of atoms and molecules; explained by Albert Einstein in 1905.
    • Particle Behavior: Smaller particles move faster and more erratically; larger ones move slower.

    About Caltech Microscope:  

    • Resolution: Angstrom-level (1 Å = 0.0000000001 m).
    • Speed: Captures hundreds of billions of frames per second.
    • Advantage: Wide-field, single-shot imaging with no sample damage.
    • How It Works?
      • Setup: Fluorescent molecules in water illuminated by ultrafast lasers.
      • Light Capture: Scattered light directed via Digital Micromirror Device.
      • Streak Imaging: Light converted to electron patterns revealing molecular size.
      • Reading Size: Faster changes = smaller molecules; slower = larger.
    [UPSC 2000] Which one of the following can be used to confirm whether drinking water contains a gamma emitting isotope or not?

    Options: (a) Microscope (b) Lead plate (c) Scintillation counter* (d) Spectrophotometer

     

  • Bamboo-Polymer Composite as alternative to Plastics

    Why in the News?

    IIT Guwahati researchers have created a strong, eco-friendly material using bamboo and biodegradable plastic to replace regular plastic in car interiors and other uses.

    About the Bamboo-Polymer Composite:

    • Origin: Made using Bambusa tulda, a fast-growing bamboo from Northeast India.
    • Composition: Reinforced with bio-based and petroleum-based epoxies for strength.
    • Objective: Reduce dependence on synthetic plastics in industrial sectors.
    • Process: Bamboo fibres undergo alkali treatment to bond well with polymers.
    • Evaluation: Tested across 17 parameters—tensile strength, water resistance, cost, etc.

    Key Features and Benefits:

    • High Strength: Suitable for load-bearing automotive components.
    • Thermal Stability: Can withstand high interior vehicle temperatures.
    • Low Moisture Absorption: Ideal for humid environments.
    • Eco-Friendly: Biodegradable, lowers environmental impact.
    • Cost-Effective: ₹4300 per kg—commercially viable.
    • Best Variant: Bamboo + bio-based epoxy FormuLite chosen through performance scoring.

    Applications:

    • Automotive: Dashboards, door panels, seat backs.
    • Electronics & Packaging: Lightweight, durable material.
    • Aerospace: Used for sustainable composite components.
    • Construction: Green alternative for interiors and fixtures.
    [UPSC 2021] Consider the following statements:

    1. Carbon fibres are used in the manufacture of the components used in automobiles and aircrafts.

    2. Carbon fibres once used cannot be recycled.

    Which of the statements given above is/are correct?”

    Options: (a) 1 only* (b) 2 only (c) Both 1 and 2 (d) Neither 1 nor 2

     

  • UAV Launched Precision Guided Missile (ULPGM)-V3

    Why in the News?

    DRDO has successfully test-fired the UAV-Launched Precision Guided Missile (ULPGM)-V3.

    UAV Launched Precision Guided Missile (ULPGM)-V3

    About ULPGM-V3:

    • Overview: It is a fire-and-forget air-to-surface missile developed by Defence Research and Development Organisation (DRDO).
    • Variants: It is an upgraded version of V1 and V2, with improved range, autonomy, and targeting precision.
    • Development: Collaboration by Adani Defence, Bharat Dynamics, Newspace Research Technologies, and over 30 Indian MSMEs/startups.

    Key Features:

    • Weight: 12.5 kg
    • Range: 10 km (day), 2.5 km (night)
    • Accuracy: Passive homing infrared with HD dual-channel accuracy (~10 cm)
    • Warhead Options: Anti-armour, penetration-cum-blast, pre-fragmentation
    • Guidance: Fully autonomous with two-way datalink for mid-course updates
    • Environment: Operates in plains and high-altitude regions, day and night
    [UPSC 2025] With reference to Unmanned Aerial Vehicles (UAVs), consider the following statements:

    I. All types of UAVs can do vertical landing. II. All types of UAVs can do automated hovering. III. All types of UAVs can use battery only as a source of power supply.

    Which of the statements given above are correct?

    (a) Only one (b) Only two (c) All the three (d) None *

     

  • AdFalciVax Vaccine for Malaria

    Why in the News?

    The Indian Council of Medical Research (ICMR) has introduced AdFalciVax, a new malaria vaccine candidate targeting Plasmodium falciparum.

    About AdFalciVax

    • Developer: Indian Council of Medical Research (ICMR); private partners will handle trials and manufacturing.
    • Vaccine Type: Chimeric recombinant vaccine targeting Plasmodium falciparum, the deadliest malaria parasite.
    • Technology:
      • Circumsporozoite Protein (CSP): Offers direct protection to the vaccinated individual.
      • Pro6C Protein: A hybrid of Pfs230 and Pfs48/45 that blocks transmission via mosquitoes.
    • Key Advantages
      • Dual Benefit: Provides personal protection and reduces community transmission.
      • Full-length CSP: Promotes a stronger and longer immune response compared to current vaccines.
      • High Efficacy in Animals: Over 90% protection in animal models (human trials pending).
      • Stability: Contains alum as an adjuvant — safe, effective, and stable at room temperature for 9 months.

    Malaria Control in India:

    • Progress:
      • Malaria deaths reduced from 1,151 in 1995 to 83 in 2022 (National Vector Borne Disease Control Programme).
      • World Health Organization estimates are higher (5,511 deaths in 2022).
    • Current Limitation: India’s dominant malaria strain is Plasmodium vivax, which AdFalciVax does not target.

     

    [UPSC 2010] Widespread resistance of malarial parasite to drugs like chloroquine has prompted attempts to develop a malarial vaccine to combat malaria. Why is it difficult to develop an effective malaria vaccine ?

    (a) Malaria is caused by several species of Plasmodium*

    (b) Man does not develop, immunity to malaria during natural infection

    (c) Vaccines can be developed only against bacteria

    (d) Man is only an intermediate host not the definitive host.

     

  • Spare live animals, move to biological models

    Why in the News?

    There is growing ethical and scientific concern over the continued use of animal testing in laboratories, as evidence mounts that such methods are often ineffective in predicting human responses. The legal and moral shift in India specifically, an amendment to the Prevention of Cruelty to Animals Act, 1960, to promote the use of bioartificial models over live animals in experimentation.

    What about the Prevention of Cruelty to Animals Act, 1960?

    The Prevention of Cruelty to Animals Act, 1960 is an Indian law enacted to prevent the infliction of unnecessary pain or suffering on animals and to promote their well-being.

    Key features:

    • Prohibits cruelty towards animals such as beating, kicking, overloading, or mutilating them.
    • Establishes the Animal Welfare Board of India (AWBI) to advise the government on animal protection laws and promote animal welfare.
    • Allows for penalties and punishment (fines or imprisonment) for violating its provisions, though critics say these are often outdated and too lenient.

    Why is an amendment to the Prevention of Cruelty to Animals Act, 1960 legally and morally necessary in India?

    • Outdated Penalties and Definitions: The current Act imposes minimal fines (as low as ₹50), which fail to act as deterrents against cruelty. An amendment is needed to introduce stricter punishments and update definitions to match modern ethical standards.
    • Rising Incidents of Animal Abuse: With growing reports of gruesome cruelty (e.g., dog killings, abuse in labs), there is a need for laws that reflect the moral conscience of today’s society and recognize animal sentience.
    • Global Commitments and Standards: India aspires to be a leader in global bioethics and sustainability. Amending the Act would align national laws with international treaties like the Universal Declaration on Animal Welfare, enhancing India’s moral and legal credibility.

    How can regenerative medicine and tissue engineering reduce animal testing?

    • Development of Human-like Organ Models: Scientists can grow 3D human tissues (like liver, heart, or skin) in the lab, which can be used to test drug toxicity and effectiveness. Eg: The “liver-on-a-chip” developed by Emulate Inc. mimics human liver functions and replaces animal use in drug screening.
    • Personalized Disease Models: Patient-derived stem cells can be used to create tissue models that reflect individual genetic profiles, allowing more accurate predictions of drug reactions without animals. Eg: In cystic fibrosis research, mini lungs (organoids) grown from patient cells are used to test responses to various treatments.
    • Accelerated Drug Development and Safety Testing: Tissue-engineered models provide faster and more ethical platforms for early-stage drug testing, reducing the need for preliminary animal trials. Eg: Skin tissue models like EpiDerm are widely used to test cosmetics and chemicals for irritation and toxicity, replacing rabbit skin tests.

    What limitations exist in using animals for toxicity and medical research?

    • Biological Differences: Animals and humans often respond differently to substances, making results less reliable when applied to humans. Eg: A drug safe in mice might cause severe side effects in humans.
    • Inability to Replicate Human Diseases Accurately: Many complex human diseases like Alzheimer’s or cancer cannot be fully mimicked in animals, leading to incomplete or misleading data. Eg: Alzheimer’s treatments successful in animals have failed in human trials.

    Why is a change in societal values crucial for ensuring animal welfare in scientific practices?

    • Shifting Public Opinion Influences Policy: When society becomes more ethically aware about animal suffering, it puts pressure on governments and institutions to adopt humane research standards and fund alternatives to animal testing.
    • Promotes a Culture of Compassion in Science: Changing values encourage scientists to prioritise non-animal methods and view animal welfare as integral to ethical and responsible research, not just a legal requirement.

    What are the steps taken by the Indian government? 

    • Ban on Animal Testing for Cosmetics: In 2014, India became the first country in Asia to ban animal testing for cosmetic products and ingredients.
    • Promotion of Alternative Methods: The government supports institutions like the Indian Council of Medical Research (ICMR) and National Centre for Alternatives to Animal Experiments (NCAAE) to develop in-vitro and computer-based models.
    • Regulatory Reforms: Revisions in Drugs and Cosmetics Rules and CPCSEA guidelines aim to reduce, refine, and replace animal use by encouraging ethical review and stricter compliance protocols.

    Way forward: 

    • Strengthen Investment in Alternatives: Increase funding for regenerative medicine, organoids, and AI-based simulations to provide scalable, ethical, and scientifically advanced testing methods.
    • Enhance Public Awareness and Education: Launch nationwide campaigns to promote animal ethics in science, encouraging academic institutions and industries to adopt humane practices and reduce dependence on animal models.

    Mains PYQ:

    [UPSC 2017] Stem cell therapy is gaining popularity in India to treat a wide variety of medical conditions including Leukaemia, Thalassemia, damaged cornea and several burns. Describe briefly what stem cell therapy is and what advantages it has over other treatments?

    Linkage: The article explicitly advocates for a shift from animal experimentation to methods like tissue engineering or regenerative medicine. Stem cell therapy is a direct application and a significant development within the field of regenerative medicine.

  • Javelin Anti-Tank Guided Missiles (ATGMs)

    Why in the News?

    India has formally submitted a Letter of Request (LoR) to the United States seeking the co-production of Javelin anti-tank guided missiles (ATGMs) under the ‘Make in India’ initiative.

    Javelin Anti-Tank Guided Missiles (ATGMs)

    About the Javelin Missile:

    • About: American-made man-portable anti-tank guided missile (ATGM).
    • Developers: Jointly developed by Raytheon and Lockheed Martin.
    • Purpose:
      • Defeats heavily armoured vehicles such as main battle tanks.
      • Effective against bunkers, fortifications, and helicopters.
    • Operational Since: Entered service with the U.S. military in 1996.

    Key Features:

    • Range:
      • Standard effective range: 2.5 km.
      • Advanced variants: Can reach up to 4 km.
    • Weight: Approximately 5.11 kg.
    • Technology:
      • Employs a “fire-and-forget” system.
      • No need for operator guidance after launch.
    • Target Engagement Modes:
      • Direct attack mode: For conventional engagement.
      • Top-attack mode: Hits the weaker top armour of tanks.
    • Mobility & Safety:
      • Soldiers can relocate or reload immediately after launch.
      • Uses infrared guidance allowing quick post-launch cover.
    [UPSC 2018] What is “Terminal High Altitude Area Defense (THAAD)”, sometimes seen in the news?

    Options: (a) An Israeli radar system (b) India’s indigenous anti-missile programme (c) An American anti-missile system* (d) A defence collaboration between Japan and South Korea

     

  • Planetary Formation observed around HOPS‑315 Star

    Why in the News?

    A study in Nature has provided the first observational evidence of solid rock forming from vapour in a distant star system HOPS-315, marking early planet formation.

    About HOPS-315:

    • Type: A young star system located in the Orion constellation.
    • Protoplanetary Disc: Surrounded by a flat, rotating disc of gas and dust, where new planets can form.
    • Orientation: The disc’s tilt offers a clear line of sight from Earth, allowing deep observation.
    • Observational Tools:

    Clue on New Planet Formation:

    • Rock Vapour Crystallisation: Scientists captured rock vapour cooling and forming crystals, marking the first direct observation of solid matter forming around a star.
    • Detected Elements:
      • Silicon monoxide gas at 470 Kelvin, close to the star.
      • Crystalline silicates such as forsterite, enstatite, and silica found within 2.2 astronomical units of the star.

    Scientific Significance:

    • Similarity to Earth: The crystallisation mimics processes found in primitive meteorites on Earth.
    • Chemical Confirmation: Suggests universal chemical processes in early planet formation across star systems.
    • Location of Minerals: Crystals were detected in the disc’s atmosphere, not in stellar outflows.
    • Temperature Conditions: Simulations confirmed dust vaporises and re-forms into solids at around 1300 Kelvin.
    • Formation Stage: Marks the earliest stage of rocky planet formation ever observed.
    [UPSC 2015] The term ‘Goldilocks Zone’ is often seen in the news in the context of-

    Options: (a) the limits of habitable zone above the surface of the Earth (b) regions inside the Earth where shale gas is available (c) search for the Earth-like planets in outer space* (d) search for meteorites containing precious metals

     

  • [pib] 10 years of Winter Fog Experiment (WiFEX)

    Why in the News?

    The Winter Fog Experiment (WiFEX) at Delhi’s IGI Airport, has marked 10 years of pioneering research on dense winter fog in North India.

    [pib] 10 years of Winter Fog Experiment (WiFEX)

    About Winter Fog Experiment (WiFEX):

    • Purpose: It is a long-term, open-field research project dedicated to studying winter fog—a major hazard in North India.
    • Launch: Initiated in 2015 at Indira Gandhi International Airport, New Delhi.
    • Lead Institution: Managed by the Indian Institute of Tropical Meteorology (IITM) under the Ministry of Earth Sciences.
    • Supporting Agencies: Supported by the India Meteorological Department (IMD) and the National Centre for Medium Range Weather Forecasting.
    • Objective: To understand fog variability, dynamics, and microphysics, and to improve fog forecasting across the Indo-Gangetic Plain.

    Key Features:

    • Network: Began at Indira Gandhi International Airport; expanded to Jewar Airport (Noida) and Hisar (Haryana).
    • Instruments Used: Includes micrometeorology towers, ceilometers, and high-frequency sensors.
    • Data Collected: Covers temperature profiles, humidity, wind, turbulence, soil heat flux, and aerosol concentrations.
    • Scientific Goal: To model the full fog life cycle and develop operational forecasting systems.
    • Next Phase – WiFEX-II:
      • Will provide localized, runway-specific fog forecasts.
      • Will expand to more airports for real-time winter decision-making.

    Outcomes:

    • Forecasting Model: A high-resolution fog prediction model with 3-km resolution and 85% accuracy for very dense fog (visibility <200 metres).
    • Operational Benefits: Reduced flight delays and diversions; enhanced runway safety.
    • Research Insights: Clarified the role of air pollution, urban heat islands, and land-use changes in fog formation.
    • Significance:
      • Aviation Planning: Helps airlines, pilots, and passengers manage winter fog disruptions.
      • Science-Policy Link: Demonstrates successful collaboration between scientific institutions and public policy to address climate and aviation challenges.
    [UPSC 2014] Photochemical smog is a resultant of the reaction among-

    Options: (a) NO2, O3 and peroxyacetyl nitrate in the presence of sunlight ** (b) CO2, O2, and peroxyacetyl nitrate in the presence of sunlight (c) CO, CO2, and NO2 at low temperature (d) high concentration of NO2, O3 and CO in the evening

     

  • Gujarat’s Tribal Genome Sequencing Project

    Why in the News?

    Gujarat has launched India’s first Tribal Genome Sequencing Project to map tribal genetic data, contributing to the national Genome India Project (GIP).

    About the Gujarat Tribal Genome Project:

    • Launch & Duration: Announced in Gujarat’s 2025–26 budget; spans 5 years under Gujarat Biotechnology Research Centre (GBRC).
    • Target Population: Focuses on genome sequencing of tribal communities forming ~15% of Gujarat’s population (~1 crore).
    • Objective: Addresses under-representation in Genome India Project (GIP), which had only ~100 tribal samples from Gujarat.
    • Sample Size: Involves 4,158 individuals, including 378 trio families, to create a 2,000-sample reference genome panel.
    • Data Collection: Includes blood, stool, genealogical, physiological, and lifestyle information.

    Key Features:

    • Precision Medicine Applications
      • Early Detection: Enables screening for sickle cell anaemia, G6PD deficiency, BRCA-linked cancers.
      • Gene-Trait Mapping: Explores genetic links to traits like agility and archery.
    • Genomic Sampling Protocol
      • Filtering: Uses SNP genotyping to remove closely related samples.
      • Sequencing: Conducts Whole Genome Sequencing (WGS) on 2,000 diverse samples via Illumina NovaSeq 6000.
      • Data Security: Employs double encryption for privacy and anonymity.

    About the Genome India Project (GIP):

    • Launch: Initiated in January 2020 by the Department of Biotechnology (DBT).
    • Structure: Multi-institutional consortium involving top Indian research bodies.
    • Objectives
      • Diversity Mapping: Decode genetic variation across Indian population.
      • Reference Panel: Build Single Nucleotide Polymorphism (SNP) -based haplotype database for Indian genomes.
      • Biobank Creation: Establish DNA reserves for research and therapy development.
    • Key Achievements
      • Sequencing Scale: 10,074 genomes sequenced from 99 ethnic groups.
      • Data Storage: Securely stored at Indian Biological Data Centre (IBDC), Faridabad.
      • Insights: Revealed rare traits aiding affordable diagnostics and predictive tools.
    • Significance
      • Global Impact: Offers India-specific insights to global genomics research.
      • Healthcare Value: Enables evidence-based, genetically informed policy and diagnosis.
    [UPSC 2017] With reference to agriculture in India, how can the technique of ‘genome sequencing’, often seen in the news, be used in the immediate future?

    1. Genome sequencing can be used to identify genetic markers for disease resistance and drought tolerance in various crop plants

    2. This technique helps in reducing the time required to develop new varieties of crop plants

    3. It can be used to decipher the host-pathogen relationships in crops

    Select the correct answer using the code given below:

    Options: (a) 1 only (b) 2 and 3 only (c) 1 and 3 only (d) 1, 2 and 3