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Subject: Science and Technology

  • Ammonium Nitrate imports cause concern                                                                       

    Why in the News?

    • Ammonium Nitrate (AN) imports from Russia have sharply increased affecting domestic fertilizer companies in India.
      • The import of Ammonium Nitrate is concerning due to increased dependence on foreign supply, price disparity impacting domestic industries, and potential risks to national energy and security.

    What is Ammonium Nitrate?

    • Ammonium Nitrate (NHNO) is a nitrogen-rich, white, crystalline chemical compound.
    • It is soluble in water and commonly used in various industries.
    • Uses:
      • It is widely used as a fertilizer in agriculture.
      • It serves as a component for anaesthetic gases and cold packs.
      • It is also a key ingredient in commercial explosives used for mining and construction.
    • Ammonium nitrate is classified as an oxidizing substance under Grade 5.1 by the United Nations.
    • India’s Regulations:
      • AN is regulated under The Ammonium Nitrate Rules, 2012, and its manufacture or use requires a license.
      • The Explosives Act, 1884 defines ammonium nitrate as any compound with more than 45% AN by weight.
      • Storage Restrictions: Storing large quantities of AN in populated areas is illegal in India.
      • For manufacturing, companies need an industrial license under the Industrial Development and Regulation Act, 1951.

    Why is it a Cause of Concern?

    • Ammonium Nitrate is a primary component in explosive mixtures like ANFO (Ammonium Nitrate Fuel Oil).
    • Though not explosive on its own, it becomes highly dangerous when mixed with detonators like RDX or TNT.
    • It has been used in Improvised Explosive Devices (IEDs) by terrorist groups.
    • Accidents involving AN, like the Beirut port explosion in 2020, have raised serious concerns about its storage and handling.
    • Its widespread use in fertilizers leads to concerns about environmental impact, especially when mishandled.
    • Improper storage in populated areas can result in devastating accidents, which is why stringent regulations are in place to control its use, storage, and transport.

    PYQ:

    [2015] What can be the impact of excessive/inappropriate use of nitrogenous fertilizers in agriculture?

    1. Proliferation of nitrogen-fixing microorganisms in soil can occur.

    2. Increase in the acidity of soil can take place.

    3. Leaching of nitrate to the ground-water can occur.

    Select the correct answer using the codes given below:

    (a) 1 and 3 only

    (b) 2 only

    (c) 2 and 3 only

    (d) 1, 2 and 3

  • How good are Modern Telescopes?

    Why in the News?

    Modern telescopes, both on Earth and in space, expand our understanding of the universe by gathering and focusing light from distant celestial bodies, revealing cosmic secrets.

    Modern Telescopes: Everything you need to know

    Primary Functions and Features

    Purpose  • Telescopes serve as windows into space, revealing distant celestial bodies and helping explore the universe.
    • Their primary function is to gather more light than the human eye can, making faint objects visible.
    Types 1. Reflecting Telescopes:
    • Use mirrors to focus light and create images.
    • Most common in large observatories due to the use of parabolic mirrors, which prevent light scattering and offer clear images.
    2. Refracting Telescopes:
    • Use lenses to bend and focus light (Concave and Convex lenses used)
    • Limited by lens size, with a maximum of about 1 meter (e.g., Yerkes Observatory). Large lenses may sag, distorting the image.
    Primary purpose  • Telescopes are designed to collect more light than the human eye.
    • The light-gathering ability is proportional to the size of the aperture (opening).
    • Example: A small 70mm telescope collects 118 times more light than the human eye.

    Features of Telescopes

    Brightness and Magnitude • Celestial objects’ brightness is measured in apparent magnitude (lower numbers = brighter).
    • Examples: Sun (-26.78), Venus (-4.92), Sirius (-1.46), Andromeda Galaxy (+3.44).
    • Small telescopes can detect objects with magnitudes up to +11.2, which are 100 times fainter than what the human eye can see.
    Resolution and Detail • The resolution of a telescope determines how much detail it can show.
    • A small telescope can resolve details 1.47 arcseconds apart (40 times more detail than the human eye, which resolves details 60 arcseconds apart).

    Why are Telescopes set up on Mountains?

    Mountaintop benefits • High-altitude observatories are set up to reduce atmospheric distortion, which affects image quality (e.g., stars twinkling).
    • Space telescopes, like Hubble, are entirely above the atmosphere and provide clear, undistorted images.
    Adaptive Optics • Ground-based telescopes use adaptive optics to correct atmospheric distortions.
    • Lasers create artificial stars, and the telescope adjusts its mirrors to reduce twinkling.

    About the New Segmented Mirrors

    Overcoming Mirror Limitations • Large mirrors (over 8.5 meters) can sag under their own weight.
    Segmented mirrors solve this by using smaller sections to create larger, effective mirrors (e.g., Extremely Large Telescope (ELT) with a 39.3-meter aperture).
    Notable Telescopes  Large Binocular Telescope (LBT): Two 8.4-meter mirrors, combined aperture of 11.9 meters.
    Extremely Large Telescope (ELT): Under construction in Chile, it will have a 39.3-meter aperture.
    Subaru Telescope (Hawaii): Captured objects with a magnitude of +27.7, 100 million times fainter than what the human eye can see.

     

    PYQ:

    [2015] In the context of modern scientific research, consider the following statements about ‘IceCube’, a particle detector located at South Pole, which was recently in the news:

    1. It is the world’s largest neutrino detector, encompassing a cubic kilometre of ice.

    2. It is a powerful telescope to search for dark matter

    3. It is buried deep in the ice.

    Which of the statements given above is/are correct?

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3 only

  • What is OpenAI o1?

    Why in the News?

    • OpenAI has introduced OpenAI o1, the first in a series of advanced AI models under its Project Strawberry initiative.
      • This new model is designed for tackling more complex tasks in science, coding, and maths.

    About OpenAI o1 

    • This model has been built to approach problems like humans, carefully considering various angles before arriving at an answer.
    • It improves its performance by learning from different perspectives and checking its output for errors.
    • In trials, the upcoming version of the o1 model performed on par with PhD students in areas like physics, chemistry, and biology, and excelled particularly in maths and coding.
    • For instance, it solved 83% of problems in a math contest, compared to earlier versions which solved just 13%.
      • In coding, the model ranked higher than 89% of participants.

    Key Features and Offerings

    • OpenAI is also releasing OpenAI o1-Mini, an economical version designed for developers, offering similar reasoning capabilities at 80% lower cost compared to the o1-preview version.
    • The o1 model excels in generating and debugging complex code and is expected to assist in software development, data analysis, and problem-solving tasks.

    Safety Measures

    • OpenAI has introduced new training methods to ensure the safety of these models, improving their ability to follow safety guidelines and prevent AI jail-breaking.
      • Jailbreaking is a form of hacking that aims to bypass an AI model’s ethical safeguards and elicit prohibited information.
    • In safety tests, the new version scored 84/100, a significant improvement from the previous 22/100 score.
    • The company is collaborating with UK and US governments on AI safety and conducting red teaming to identify and address any weaknesses.
  • India’s Sickle Cell Challenge  

    Why in the News?

    The Prime Minister has reaffirmed the government’s dedication to addressing sickle cell disease, a genetic blood disorder that alters the shape of red blood cells.

    About the National Sickle Cell Anaemia Elimination Mission:

    • The Union Budget 2023-24 announced a mission to eliminate sickle cell anemia by 2047. The mission focuses on awareness and screening programs for people ages 0 to 40.
    • The mission aims to reduce the burden of sickle cell disease, which primarily affects India’s tribal belt (Odisha, Jharkhand, Chhattisgarh, Madhya Pradesh, Maharashtra).
    • These include nationwide screening programs and the inclusion of vital medicines like hydroxyurea in the essential medicines list, improving access to treatment.

    Challenges faced by the Indian Government:

    • High Disease Burden: India has the world’s second-largest burden of sickle cell disease, with over a million affected individuals, primarily in tribal areas.
    • Low Treatment Coverage: Only 18% of those affected receive consistent treatment, with significant drop-offs in screening, diagnosis, and treatment adherence.
    • Stigma and Misinformation: Social stigma around the disease, myths such as “God’s curse” or “black magic,” and mistrust of public health systems, particularly in tribal areas, result in delayed diagnosis and treatment.
    • Treatment Adherence Issues: Challenges include inconsistent availability of medicines like hydroxyurea, long travel distances for treatment, and stock shortages at health centers.
    • Poor Vaccination Coverage: Vaccination, which reduces infection rates and improves quality of life, remains inadequate in many affected regions.
    • Research and Development: The lack of ongoing research into treatments and understanding of the disease in India, and the unaffordability of emerging therapies like gene therapy, hinder long-term progress.
    • Financial and Operational Gaps: Health systems in tribal areas require additional funding and operational strengthening to address region-specific health challenges effectively.

    What are the WHO recommendations?

    • Early Identification: Implement newborn screening programs to identify sickle cell disease at birth.
    • Integration into Health Systems: Sickle cell management should be integrated into national health services. This includes establishing specialized centers for comprehensive care and ensuring that primary healthcare providers are trained in managing sickle cell disease.
    • Public Education and Awareness: Conduct public education campaigns to raise awareness about sickle cell disease, reduce stigma, and inform communities about genetic risks and prevention strategies.
    • Genetic Counseling: Provide genetic counselling to families, especially in communities with high prevalence, to inform them about the risks of having children with sickle cell disease and the importance of carrier screening.

    Mains PYQ:

    Q Stem cell therapy is gaining popularity in India to treat a wide variety of medical conditions including leukaemia, Thalassemia, damaged cornea and several burns. Describe briefly what stem cell therapy is and what advantages it has over other treatments. (UPSC IAS/2017)

  • The grave threat from AMR

    Why in the News?

    Ahead of the UN General Assembly High-Level Meeting on antimicrobial resistance, WHO published its first-ever guidance on Antibiotic pollution from manufacturing.

    Common Pathogens Found in India

    The three most common pathogens associated with antimicrobial resistance (AMR) in India, as reported by the Indian Council of Medical Research (ICMR), are:

    • Escherichia coli (E. coli): Known for causing gut infections, E. coli has shown a significant decrease in susceptibility to antibiotics, particularly carbapenems, from 81.4% in 2017 to 62.7% in 2023.
    • Klebsiella pneumoniae: This pathogen can lead to pneumonia and urinary tract infections. Its susceptibility to carbapenem-class antibiotics has also declined, with rates dropping from 58.5% to 35.6% and from 48% to 37.6% between 2017 and 2023.
    • Acinetobacter baumannii: Primarily associated with hospital-acquired infections, this pathogen has a high resistance rate to carbapenems, standing at 88% in 2023.

    What is Antimicrobial Resistance (AMR) and Why is it a Cause for Concern?

    • Antimicrobial resistance (AMR) occurs when pathogens evolve to survive despite the presence of antimicrobial drugs, rendering standard treatments ineffective. This situation arises mainly due to the misuse and overuse of antibiotics, leading to the development of resistant strains or “superbugs.” 
    • According to the WHO, emergence and spread of AMR could significantly undermine the effectiveness of antibiotics globally, impacting healthcare outcomes, especially for patients with multiple diseases.

    Why is AMR Increasing?

    Several factors contribute to the increasing rates of AMR in India:

    • Self-medication: Many individuals self-prescribe antibiotics for conditions like fever without proper medical consultation, often for viral infections where antibiotics are ineffective.
    • Prescribing habits: A significant percentage of antibiotics are prescribed not for treating infections but for prevention. Doctors often resort to broad-spectrum antibiotics without conducting necessary diagnostic tests, leading to inappropriate usage.
    • Lack of regulation: The management of pharmaceutical waste from antibiotic manufacturing is largely unregulated, contributing to environmental pollution and the spread of resistant bacteria.

    What needs to be done?

    • Prevention of Infections: Implementing better hygiene practices, improving sanitation, and promoting vaccinations can help reduce the incidence of infections, thereby decreasing the reliance on antibiotics.
    • Education for Healthcare Providers: Train doctors to prescribe antibiotics judiciously, reserve stronger antibiotics for hospital patients, and emphasise the importance of diagnostic testing, which can help ensure appropriate antibiotic use.
    • Regulatory Improvements: Strengthening regulations around antibiotic manufacturing and waste management is crucial for controlling antibiotic pollution and preventing the emergence of resistant strains.

    Mains PYQ:

    Q Can overuse and free availability of antibiotics without Doctor’s prescription, be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.  (UPSC IAS/2016)

  • Polaris Dawn: SpaceX’s Mission for First private Spacewalk

    SpaceX launched its Polaris Dawn Mission sending a four-person crew of civilians on a first-ever commercial spacewalk into Earth's Van Allen radiation belts.

    Why in the News?

    SpaceX launched its Polaris Dawn Mission sending a four-person crew of civilians on a first-ever commercial spacewalk into Earth’s Van Allen radiation belts.

    What is Polaris Dawn Mission?

    • It is a privately-funded space mission led by billionaire entrepreneur Jared Isaacman, in collaboration with SpaceX.
    • It is set to be the first non-government mission to conduct a spacewalk.
    • This 700km altitude will surpass the current record held by NASA’s Gemini 11 mission in 1966.
    • The mission will test new spacesuits designed by SpaceX to protect astronauts from high radiation levels encountered in the Van Allen Belts.

    What are the Van Allen Belts?

    • The Van Allen Belts are two zones of charged particles that surround Earth, held in the magnetosphere.
    • These belts were discovered in 1958 by American physicist James Van Allen.

    Why are the Van Allen Belts dangerous for Humans?

    • The Van Allen Belts are dangerous for humans because they contain high levels of radiation that can pose significant health risks to astronauts.
    • The belts are filled with charged particles that can cause radiation sickness, damage human tissues, and increase the risk of cancer. 

     

    PYQ:

    [2011] What is the difference between asteroids and comets?

    1. Asteroids are small rocky planetoids, while comets are formed of frozen gases held together by rocky and metallic material.
    2. Asteroids are found mostly between the orbits of Jupiter and Mars, while comets are found mostly between Venus and Mercury.
    3. Comets show a perceptible glowing tail, while asteroids do not.

    Which of the statements given above is/are correct?

    (a) 1 and 2 only
    (b) 1 and 3 only
    (c) 3 only
    (d) 1, 2 and 3

  • Ovarian Cancer: Understanding the Silent Killer

    Why in the News?

    • In India, Ovarian Cancer ranks among top three cancers affecting women, accounting for 6.6% of all female cancer cases.
      • In 2022, India alone reported 47,333 new ovarian cancer cases and 32,978 deaths, emphasizing the critical need for awareness, early detection, and effective treatment.

    What is Ovarian Cancer?

    Details
    About Referred to as the “silent killer” due to its subtle symptoms like bloating, pelvic pain, loss of appetite, and frequent urination. Late diagnosis is common.
    Common Symptoms • Bloating
    • Pelvic/abdominal pain
    • Loss of appetite
    • Frequent urination
    • Indigestion, back pain, fatigue, and weight loss
    Cancer Subtypes Type I tumours: Less common, early diagnosis, better prognosis
    Type II tumours: More common, aggressive, diagnosed at advanced stages
    Screening • No effective screening tests available
    CA125 blood test used post-diagnosis but not recommended for routine screening due to limited specificity
    Genetic Risk Factors • Linked to mutations in BRCA1/BRCA2 genes, increasing risk by up to 50%
    Genetic testing aids in personalized risk management
    Endometriosis • Associated with a higher risk of certain ovarian cancers, though overall risk remains low
    Lifestyle Factors Mixed evidence regarding talcum powder usage and its potential link to ovarian cancer
    Hair products (dyes, straighteners) may increase risk, though further research is required
    HRT & Genetic Counselling Hormone replacement therapy (HRT) is linked to a higher risk of ovarian cancer
    Genetic counselling helps at-risk individuals with preventive measures
  • PresVu: India’s First Eye Drop for Presbyopia

    Why in the News?

    Mumbai-based Entod Pharmaceuticals has announced that the Drug Controller General of India (DCGI) has approved its new eye drop, PresVu, aimed at reducing the dependency on reading glasses for individuals with presbyopia.

    What is Presbyopia?

    • Presbyopia is an age-related condition where the eyes gradually lose the ability to focus on nearby objects, typically developing after the age of 40.
    • Spectacles are one of the most commonly recommended solutions for managing presbyopia.

    How does PresVu work? 

    • The active ingredient in PresVu is pilocarpine, a compound that contracts the iris muscles, controlling the size of the pupil and helping individuals focus better on nearby objects.
    • PresVu also uses an advanced dynamic buffer technology to adapt to the pH levels of tears, ensuring consistent efficacy and safety for extended use over the years.
    • However, PresVu’s effects are temporary, typically lasting between four to six hours, and it is prescription-only.
    • PresVu should not be used by individuals with iris inflammation.
    • Regular use may lead to side effects such as:
      • Itching and redness
      • Eyebrow pain
      • Muscle spasms in the eyes

    Is this a Novel Therapy?

    • Although Entod claims PresVu is novel, the main compound, pilocarpine, has been available in India for decades and is commonly used as a first-line therapy for cataracts.
    • Pilocarpine’s ability to temporarily improve the depth of focus has been explored in other countries, including the United States, where the FDA approved a pilocarpine eye drop for presbyopia in 2021.
    • In India, the government regulates the ceiling price of pilocarpine in 4% and 2% concentrations, whereas PresVu contains 1.25%.

    PYQ:

    [2018] Appropriate local community-level healthcare intervention is a prerequisite to achieve ‘Health for All’ in India. Explain.

  • BepiColombo Mission

    BepiColombo

    Why in the News?

    • On Thursday, the ESA-Japan spacecraft “BepiColombo” made its closest approach to Mercury, capturing detailed images of its sunrise-lit surface and revealing the planet’s south pole.

    Highlights of the Latest Flyby:

      • BepiColombo uses flybys of Earth, Venus, and Mercury to slow down and enter orbit around Mercury. This approach gives scientists new information about Mercury’s south pole and its unusual peak ring craters, which haven’t been studied much before.

      Note: Flybys are close passes of a spacecraft near a planet or celestial body

    About BepiColombo Mission:

    Details
    Collaboration  European Space Agency (ESA) and Japan Aerospace Exploration Agency (JAXA)
    Launch Date
    • October 20, 2018
    • Expected to enter Mercury’s orbit by late 2026.
    Launch Vehicle Ariane 5 Rocket
    Objectives
    • Study Mercury’s magnetic field
    • Investigate surface composition and geology
    • Analyze Mercury’s interaction with solar wind
    • Study exosphere and geological history
    Spacecraft Components
    • ESA’s Mercury Planetary Orbiter (MPO):  Focus on surface and interior study
    • JAXA’s Mercury Magnetospheric Orbiter (MIO): Focus on magnetic field and surrounding space
    Planned Flybys
    • 6 (Flybys of Earth, Venus, and Mercury)
    • Ongoing, with 4 out of 6 Mercury flybys completed
    Craters Studied Vivaldi Crater, Stoddart Crater
    Significance Second mission ever to orbit Mercury (after NASA’s Messenger, 2004)
    Challenges
    • Mercury’s proximity to the Sun accelerates spacecraft, requiring multiple flybys to slow down
    • Thruster issues causing mission delay

     

    PYQ:

    [2008] What is the purpose of the US Space Agency’s Themis Mission, which was recently in the news?

    (a) To study the possibility of life on Mars.

    (b) To study the satellites of Saturn.

    (c) To study the colourful display of high latitude skies.

    (d) To build a space laboratory to study the stellar explosions.

  • What is Helium and why is it used in Rockets?

    Why in the News?

    Two NASA astronauts aboard Boeing’s Starliner will remain on the International Space Station (ISS) for an extended period due to issues with a faulty propulsion system, including helium leaks.

    helium

    About Helium

    • Helium is inert, meaning it does not react or combust when exposed to other substances.
    • This makes it ideal for pressurization and cooling systems in rockets and spacecraft.
    • With an atomic number of 2, Helium is second lightest element after hydrogen, helping to keep the rocket’s weight low, which is crucial for achieving the necessary speeds and altitudes to reach orbit.
    • It has an extremely low boiling point (-268.9°C), allowing it to stay in a gaseous state in super-cold environments, where many rocket fuels are stored.
    • Though non-toxic, helium cannot be inhaled on its own as it displaces oxygen, which is vital for human respiration.

    How is Helium used for space applications?

    • Fuel Tank Pressurization: Helium pressurizes fuel tanks, ensuring a consistent flow of fuel to the rocket’s engines, even as the fuel is burned.
    • Cooling Systems: It also plays a key role in cooling systems, particularly in environments where rocket fuel and oxidizer need to be stored at extremely low temperatures.
    • Maintaining Tank Pressure: As fuel and oxidizer are consumed, helium fills the empty space left behind, ensuring the overall pressure inside the tanks remains stable.

    Is Helium prone to leaks?

    • Helium’s small atomic size and low molecular weight make it prone to leaking through tiny gaps or seals in storage tanks and fuel systems.
    • Since helium is rare in Earth’s atmosphere, even minor leaks are easily detectable, making it a valuable tool for spotting potential faults in spacecraft fuel systems.
    • Examples of Leaks:
      • In May, hours before Boeing’s Starliner spacecraft attempted its first astronaut launch, sensors detected a small helium leak in one of its thrusters.
      • After Starliner launched in June, additional leaks were found in space, prompting NASA to return the spacecraft to Earth without its crew.

    Alternatives to Helium

    • Argon and Nitrogen: Some rocket launches have experimented with other inert gases like argon and nitrogen, which are sometimes cheaper, but helium remains the industry standard.
    • Ariane 6’s Novel System: Europe’s new Ariane 6 rocket abandoned helium in favor of a pressurization system that converts small amounts of its liquid oxygen and hydrogen into gas for pressurizing the fuel.
      • However, during Ariane 6’s debut launch, this system failed in space, adding to the global rocket industry’s pressurization challenges.

    PYQ:

    [2012] A team of scientists at Brookhaven National Laboratory included those from India created the heaviest anti-matter (anti-helium nucleus). What is/are the implication/implications of the creation of anti-matter?

    1. It will make mineral prospecting and oil exploration easier and cheaper.

    2. It will help prove the possibility of the existence of stars and galaxies made of anti-matter.

    3. It will help understand the evolution of the universe.

    Select the correct answer using the codes given below:

    (a) 1 only

    (b) 2 and 3 only

    (c) 3 only

    (d) 1, 2 and 3