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  • Zebrafish and its heart regeneration capacity

    Indian scientists have used the Zebrafish model and identified its genes that can promote heart regeneration.

    Try this PYQ:

    Q.With reference to India’s Biodiversity, Ceylon frogmouth, Coppersmith Barbet, Gray-chinned minivet and White-throated redstart are-

    (a) Birds

    (b) Primates

    (c) Reptiles

    (d) Amphibians

    Zebrafish

    • Zebrafish is a small (2-3 cm long) freshwater fish found in the tropical and subtropical regions.
    • The fish is native to South Asia’s Indo-Gangetic plains, where they are mostly found in the paddy fields and even in stagnant water and streams.
    • The fish become adults at three months and survive 2-3 years in a laboratory condition.
    • Its unique characteristics lie in its transparency during its embryonic stages, allowing observing all organs, including beating heart and blood circulation.

    Ability to heal their heart

    • The ability of Zebrafish to heal their heart after injury makes them an attractive model to investigate mechanisms governing the regenerative process.
    • Researchers worldwide are actively working to understand the mechanism behind the heart regeneration in Zebrafish for the last two decades.
    • Years of efforts have helped them identify the cellular communication network factor 2a (ccn2a), a gene that can promote heart regeneration by enhancing cardiomyocyte proliferation.
    • They have also observed that this gene resolves the transient collagenous fibrotic scar resulting in faster regeneration.

    Significance for humans

    • Cardiovascular diseases are the number 1 cause of deaths globally, taking an estimated 17.9 million lives each year, according to the World Health Organisation.
    • Humans cannot regenerate their hearts upon myocardial damage and a person who suffered a heart attack cannot functionally heal the damaged heart muscle, resulting in reduced pumping efficiency.
    • While on the other hand, this unique fish has the full potential to regenerate its heart and restore its function after injury.
    • Till now, there is no treatment available to restore the damaged heart function in humans. Hence scientists have sought to decode the heart regeneration processes using this model animal.
  • The Paris agreement is no panacea

    The article highlights the fact that the provisions of the Paris Agreement would not be enough to avert the catastrophic and irreversible changes resulting from the global emissions. 

    Past efforts for environmental protection

    • The most hopeful time for global cooperation in protection of the planet was between the time of the Stockholm Conference (1972) and the time of the Rio Conference (1992).
    •  Scientific evidence about role anthropogenic emission in global warming led to political initiatives to harmonise development and environment.
    • The historic consensus in Rio led to the adoption of the UN Framework Convention on Climate Change (UNFCC).
    • A distinction was made between the “luxury emissions” of the developed countries and the survival emissions of the developed countries, which were allowed to increase.
    • Moreover, a huge financial package was approved to develop environment-friendly technologies in developing countries.

    Copenhagen Accord: Abandonment of Rio Principles

    • After the adoption of UNFCC, Conference of the Parties was held in Berlin in 1995 where developed countries backed off from their commitments.
    • Though the G-77 was split, the Rio principles were maintained.
    • The Kyoto Protocol enshrined the Rio principles.
    • It fixed emission targets for developed countries and a complex set of provisions was included to satisfy their interests.
    • The end of the Kyoto Protocol and the abandonment of the spirit of the Rio principles were reflected in the Copenhagen Accord (2009).
    • Argument given was that a global climate action plan would be possible only if all reductions of the greenhouse gases were made voluntary.

    Paris Agreement: Making emission reduction voluntary

    • The Paris Agreement moved away from the principle of common but differentiated responsibilities.
    • All countries were placed on an equal footing by making reduction of greenhouse gas emissions voluntary.
    • It requires all parties to put forward their best efforts through nationally determined contributions (NDCs)

    Shortcomings in Paris Agreement

    • The NDCs so far submitted will not result in the desired objective of limiting increase of global warming to below 2°C.
    • The Paris Agreement requires that all countries — rich, poor, developed, and developing — slash greenhouse gas emissions.
    • But no language is included on the commitments the countries should make.
    • Nations can voluntarily set their emissions targets and incur no penalties for falling short of their targets.
    •  Further temperature rise, even of 1.5°C, may result in catastrophic and irreversible changes.
    • Even a 1°C hotter planet is not a steady state, says a report of the Intergovernmental Panel on Climate Change (IPCC).

    Conclusion

    The IPCC report acknowledges that “the pathways to avoiding an even hotter world would require a swift and complete transformation not just of the global economy but of society too”. This will only be possible if the world rejects nationalism and parochialism and adopts collaborative responses to the crisis. The Paris Agreement falls short of that imperative.

  • Farmers’ protest

    Farmers all across the Punjab and Haryana have marched to New Delhi over the new legislations.

     Major cause of Farmers’ protest

    • Much of the opposition really is just to one of the three laws. It is the Farmers’ Produce Trade and Commerce (Promotion and Facilitation)  Act and its provisions that are seen as weakening the APMC mandis.
    • Even in that one — the act — there are only some contentious provisions, which, although key, can still leave doors open for negotiation.

    A fight for privilege

    • Farmers, if anything, would gain from removal of stocking restrictions on the trade, as it potentially translates into unlimited buying and demand for their produce.

    The contentious one: FPTC Act

    • The FPTC Act is a bone of contention. It permits sale and purchase of farm produce outside the premises of APMC mandis.
    • Such trades (including on electronic platforms) shall attract no market fee, cess or levy “under any State APMC Act or any other State law”.
    • An issue here is the very right of the Centre to enact legislation on agricultural marketing.
    • Article 246 of the Constitution places “agriculture” and “markets and fairs” in the State List.
    • But entry 42 of the Union List empowers the Centre to regulate “inter-State trade and commerce”.

    An example of Central hegemony

    • While trade and commerce “within the State” is under entry 26 of the State List, it is subject to the provisions of entry 33 of the Concurrent List.
    • Under this, the Centre can make laws that would prevail over those enacted by the states.
    • Entry 33 of the Concurrent List covers trade and commerce in “foodstuffs, including edible oilseeds and oils”, fodder, cotton and jute.
    • The Centre, in other words, can very pass any law that removes all impediments to both inter- and intra-state trade in farm produce, while also overriding the existing state APMC Acts. The FPTC Act does precisely that.

    Farmers question

    • Some experts make a distinction between agricultural “marketing” and “trade”.
    • Agriculture per se would deal with everything that a farmer does — right from field preparation and cultivation to also sale of his/her own produce.
    • The act of primary sale at a mandi by the farmer is as much “agriculture” as production in the field.
    • “Trade” begins only after the produce has been “marketed” by the farmer.

    The centre’s overriding logic behind

    • Going by this interpretation, the Centre is within its rights to frame laws that promote barrier-free trade of farm produce (inter- as well as intra-state) and do not allow stockholding or export restrictions.
    • But these can be only after the farmer has sold.
    • Regulation of first sale of agricultural produce is a “marketing” responsibility of the states, not the Centre.

    What do farmers’ want?

    • Farmers would want no restrictions on the movement, stocking and export of their produce.
    • For example, Maharashtra’s onion growers have vehemently opposed the Centre’s resort to ban on exports and imposition of stock limits whenever retail prices have tended to go up.
    • But these restrictions relate to “trade”.
    • When it comes to “marketing” — especially dismantling of the monopoly of APMCs — farmers, especially in Punjab and Haryana, aren’t very convinced about the “freedom of choice to sell to anyone and anywhere” argument.

    Where lies the major issue?

    • Much of government procurement at minimum support prices (MSP) — of paddy, wheat and increasingly pulses, cotton, groundnut and mustard — happens in APMC mandis. 
    •  In a scenario where more and more trading moves out of the APMCs, these regulated market yards will lose revenues.
    • They may not formally shut, but it would become like BSNL versus Jio.
    • And if the government stops buying, farmers will be left with only the big corporates to sell to.

    What could be negotiated?

    • If the protesting farmer union leaders were to sit down at the negotiating table, the government can possibly get them to agree to drop the demand on repealing all the three laws.
    • Their problem is essentially about the FPTC Act and its provisions that they see as weakening the APMC mandis.
    • These may be just fears, but they aren’t small.
    • From the government’s standpoint, the elephant in the room would be if the farmers insist on an additional demand: Making MSP a legal right.
    • This  would be still impossible to meet, even if the three farm laws were to be put on hold.

     

  • RT-LAMP: a new technology for detecting COVID-19

    Indian Council of Medical Research has recently validated the LAMP technology for COVID-19 testing.

    What is RT-LAMP?

    • RT-LAMP stands for Reverse Transcriptase loop-mediated isothermal amplification) technology.
    • Agappe Diagnostics has recently developed the technology indigenously, and their kit has been validated and approved by the ICMR for marketing.
    • It is named LUME Screen nCoV.

    How does it work?

    • RT-LAMP technology is a one-step nucleic acid amplification method to multiply specific sequences of RNA of the coronavirus.
    • The RNA is first made into cDNA (copy DNA) by the usual reverse transcription. Then, the DNA is amplified by the LAMP technique.

    Current method

    • •The current method diagnosis is the real time reverse transcription polymerase chain reaction (RT-PCR) test which detects the presence of viral nucleic acids in nasopharyngeal swab samples.
    • But it has certain shortcomings.
    • The test requires complex and costly equipment. It requires extensive training for potential users.

    Benefits of LAMP over RT-PCR

    • The LAMP technology is superior to the PCR technology–based COVID-19 kits where specificity is around 95% only.
    • As the specificity and sensitivity of the test is about 95%, there is a possibility of false negative results.
    • The turnaround time is about 10 hours, so that the result will be available only by the next day.
    • In remote places, the turnaround time further increases depending on the distance the samples need to travel.
    • In short, the RT-PCR does not have the capacity to keep pace with the increasing demand.
    • The LAMP technology does not need laborious preparation as in the case of RT-PCR. LAMP is cost effective and does not need complex expensive equipment.

     

  • To be taken seriously, Quad needs military heft

    The article suggests projection of naval power to ensure the stability in the Indian Ocean. 

    Quad conducts Malabar exercise

    • In November, the Quad converged to continue the Malabar series, with a total of just eight ships.
    • The idea of Quad is to form a grouping of democratic nations in the Indian Ocean, and use naval power to convey a message to Beijing.
    • The message a grouping of eight ships would convey to a nation thinking in terms of five aircraft carriers remains would not be taken seriously.

    Importance of naval power in ensuring oceanic stability

    • There is no substitute for naval power to ensure oceanic stability, but one alternative lies in the area of Maritime Domain Awareness (MDA). 
    • Perhaps, some thought may already have been given to MDA in the twin agreement to BECA (Basic Exchange and Cooperation Agreement), and Maritime Information Sharing Technical Agreement (MISTA) signed between India and the US.
    • There is little information available in the public domain about MISTA.
    • But MISTA should cover an omnibus agreement for Maritime Patrol Aircraft (MPA) operating and information sharing for the entire Indo-Pacific.
    • The Pacific has a high density of MPA assets, while they are sparse in the Indian Ocean, particularly the western Indian Ocean.
    • The Australians can cover the Malacca Straits, but for the west Indian Ocean, the US will probably have to base a squadron of P-8 aircraft at Masirah or Diego Garcia.
    • Today, the primary weapon system of most warships is the surface-to-surface missile, with ranges of up to 200 km.
    • The ships’ sensor range is only up to 100 km.
    • So, accurate target information has to be supplied beyond 100 km by aircraft or helicopters in what is called Over the Horizon Targeting (OTHT).
    • With the Indo-Pacific fully covered by the MPAs of the Quad, a PLAN ship in the Indian Ocean is in imminent danger of being sunk at will

    Conclusion

    A public announcement of a division of the Indo-Pacific into areas of responsibility for MDA, between members of the Quad will send an unmistakable signal to Beijing. With a desultory Quad naval exercise, once a year of a few ships, Beijing will only be amused that a “threat” exists to its ambition to become a global power.

  • Stepping out of the shadow of India’s malnutrition

    The article takes stock of the food insecurity and malnutrition in India with the aid of two recently published reports.

    Reports about food security in India

    • Two recent reports — “The State of Food Security and Nutrition in the World 2020” by the Food and Agricultural Organization of the United Nations and the 2020 Hunger report, “Better Nutrition, Better Tomorrow” by the Bread for the World Institute  – document staggering facts about Indian food insecurity and malnutrition.
    • The reports use two globally recognised indicators, Prevalence of Undernourishment (PoU) and the Prevalence of Moderate or Severe Food Insecurity (PMSFI).
    • Using these indicators, the reports indicate India to be one of the most food-insecure countries, with the highest rates of stunting and wasting among other South Asian countries.

    Comparing rate of reduction in malnutrition with neighbouring countries

    • Malnutrition in India has not declined as much as the decline has occurred in terms of poverty.
    • On the contrary, the reduction is found to be much lower than in neighbouring China, Pakistan, Nepal and Bangladesh.
    • The decline in China is way higher than that of India, even though it had started with lower levels of PoU in 2000.

    Food security during pandemic and National Food Security Act 2013

    • Two crucial elements still got left out in the National Food Security Act – 2013.
    • These two elements are the non-inclusion of nutritious food items such as pulses and exclusion of potential beneficiaries.
    • Because of this, the current COVID-19 pandemic would make the situation worse in general, more so for vulnerable groups.
    • Though States have temporarily expanded their coverage in the wake of the crisis, the problem of malnutrition is likely to deepen in the coming years.
    • Hence, a major shift in policy has to encompass the immediate universalisation of the Public Distribution System which should definitely not be temporary in nature.

    Conclusion

    The need of the hour remains the right utilisation and expansion of existing programmes to ensure that we arrest at least some part of this burgeoning malnutrition in the country.

  • Brain Electrical Oscillation Signature Profiling (BEOSP)

    A brain electrical oscillation signature profiling (BEOSP) test will be conducted on the convicts of the alleged rape and murder in Hathras, Uttar Pradesh.

    Note: According to Article 20(3) of the Indian constitution, no person accused of any offence shall be compelled to be a witness against himself. The privilege against self-incrimination is a fundamental canon of common criminal law jurisprudence.

    What is the BEOSP test?

    • BEOSP also known as brain fingerprinting is a neuro-psychological method of interrogation in which the accuser’s participation in the crime is investigated by studying their brain’s response.
    • The BEOSP test is carried out via a process known as an electroencephalogram, conducted to study the electrical behaviour of the human brain.
    • Under this test, the consent of the accused is first taken and they are then made to wear caps with dozens of electrodes attached to them.
    • The accused are then shown visuals or played audio clips related to the crime to check if there is any triggering of neurons in their brains which then generate brainwaves.
    • The test results are then studied to determine the participation of the accused in a crime.

    What differentiates a BEOSP test from a polygraph or a lie detector?

    • The BEOSP procedure does not involve a question-answer session with the accused and is rather a neuro psychological study of their brain.
    • In a polygraph test, the accused person’s physiological indicators are taken into account which includes blood pressure, pulse rate, respiration and skin conductivity.
    • While a person might be able to control their pulse rate and BP even in times of distress, a BEOSP test

    Can these tests be admitted as evidence?

    • Not as a standalone, a/c to the 2010 Supreme Court judgment in the Selvi v. State of Karnataka case.
    • The bench observed that narco analysis, polygraph and brain mapping tests cannot be forced upon any individual without their consent and the test results cannot be admitted solely as evidence.
    • However, any information or material discovered during the tests can be made part of the evidence, observed the bench.
  • BrahMos Missiles and their significance for Armed Forces

    India’s Armed forces are conducting back-to-back tests of various versions of BrahMos missile.

    Take a quick look at India’s missile arsenal:

    [Prelims Spotlight] Missiles

    The BrahMos Missiles

    • A combination of the names of Brahmaputra and Moskva rivers, BrahMos missiles are designed, developed and produced by BrahMos Aerospace, a joint venture company set up by DRDO and Mashinostroyenia of Russia.
    • It is a two-stage missile with a solid propellant booster as the first stage and liquid ramjet as the second stage.
    • The cruise missiles like BrahMos are a type of systems known as the ‘standoff range weapons’ which are fired from a range sufficient to allow the attacker to evade defensive fire from the adversary.
    • These weapons are in the arsenal of most major militaries in the world.
    • The versions of the BrahMos that are being tested have an extended range of around 400 km, as compared to its initial range of 290 km, with more versions of higher ranges currently under development.

    Various versions

    • Various versions of the BrahMos, including those which can be fired from land, warships, submarines and Sukhoi-30 fighter jets have already been developed and successfully tested in the past.
    • The earliest versions of the ship launched BrahMos and land-based system are in service of the Indian Navy and the Indian Army since 2005 and 2007 respectively.
  • What is Federated Learning?

    An improvement in a Machine Learning (ML) model, called ‘federated learning’, is said to enable companies to develop new ways of collecting anonymous data without compromising their privacy.

    Data privacy is the right of a citizen to have control over how personal information is collected and used. Data protection is a subset Right of Privacy under Article 21 of the Indian Constitution.

    What is ‘federated learning’?

    • Federated learning is an ML method used to train an algorithm across multiple decentralised devices or servers holding data samples.
    • It doesn’t exchange data with the devices, meaning there is no central dataset or server that stores the information.
    • Standard ML models require all data to be centralised in a single server. Implementation of federated learning eliminates the need for maintaining a storage hub.
    • The term was first introduced in a 2016 Google study titled ‘Communication-efficient learning of deep networks from decentralized data.’
    • Google emphasised mobile phones and tablets, stating that modern devices contain special features like speech recognition and image models that can store large amounts of data.
    • Since then, Google has used the technique is various products, including Gboard, which provides text and phrase suggestions to the keyboard.

    How this works

    • Federated learning aims to train an algorithm, like deep neural networks, on multiple local datasets contained in local nodes, without explicitly exchanging data.
    • The general principle involves simply exchanging parameters between these nodes. Parameters include a number of federated learning rounds, the total number of nodes, and learning rate.
    • The distinct advantage of the model is its ability to reduce privacy and security risks by limiting the attack surface to only the device, rather than the device and the cloud, Google stated in the study.

    Why need such technology?

    • Smart home devices like speakers and smartwatches collect and share data with other devices and systems over the network.
    • These Internet of Things (IoT) devices are equipped with sensors and software that store a user’s private information like body measurements and location.
    • This large chunk of stored data is used by the device makers to improve their products and services.

    Applications

    • Federated learning is said to have application in healthcare, where hospitals and pharmaceutical companies can exchange data for treating diseases without sharing private clinical information.
  • Giant Metrewave Radio Telescope (GMRT)

    The Giant Metrewave Radio Telescope (GMRT) has been selected as a ‘Milestone’ facility by the U.S.-based Institute of Electrical and Electronics Engineers (IEEE).

    Note: GMRT is not an ISRO mission.

    About GMRT

    • The GMRT located near Pune is an array of thirty fully steerable parabolic radio telescopes of 45-metre diameter, observing at metre wavelengths.
    • It is operated by the National Centre for Radio Astrophysics (NCRA), a part of the Tata Institute of Fundamental Research, Mumbai.
    • It was conceived and built under the direction of Late Prof. Govind Swarup from 1984 to 1996.
    • At the time it was built, it was the world’s largest interferometric array offering a baseline of up to 25 kilometres (16 mi).
    • Astronomers from all over the world regularly use this telescope to observe many different astronomical objects such as HII regions (interstellar atomic hydrogen that is ionized), galaxies, pulsars, supernovae, and Sun and solar winds.

    A significant feat

    • IEEE is the world’s largest technical professional organisation dedicated to advancing technology in all areas related to electrical and electronics engineering.
    • The IEEE Milestones programme honours significant technical achievements which have a global or regional impact. This is only the third such IEEE ‘Milestone’ recognition for an Indian contribution.
    • The previous two Indian IEEE Milestones were for the pioneering work done by Sir J.C. Bose to demonstrate the generation and reception of radio waves in 1895 (recognised in 2012), and for the Nobel Prize-winning (in 1930) ‘scattering of light’ phenomenon observed by Sir C.V. Raman in 1928.