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Subject: Science and Technology

  • Chandrayaan-3 set for launch in August

    ISRO plans to execute the Chandrayaan-3 mission in August this year.

    What is Chandrayaan-3 Mission?

    • The Chandrayaan-3 mission is a follow-up of Chandrayaan-2 of July 2019, which aimed to land a rover on the lunar South Pole.

    Chandrayaan-2: A quick recap

    • Chandrayaan-2 consisted of an Orbiter, Lander and Rover, all equipped with scientific instruments to study the moon.
    • The Orbiter would watch the moon from a 100-km orbit, while the Lander and Rover modules were to be separated to make a soft landing on the moon’s surface.
    • ISRO had named the Lander module as Vikram, after Vikram Sarabhai, the pioneer of India’s space programme, and the Rover module as Pragyaan, meaning wisdom.

    Utility of the Orbiter

    • The Orbiter part of the mission has been functioning normally. It is carrying eight instruments.
    • Each of these instruments has produced a handsome amount of data that sheds new light on the moon and offers insights that could be used in further exploration.

    Inception of Chandrayaan 3

    • The subsequent failure of the Vikram lander led to the pursuit of another mission to demonstrate the landing capabilities needed for the Lunar Polar Exploration Mission proposed in partnership with Japan for 2024.

    Its design

    • The lander for Chandrayaan-3 will have only four throttle-able engines.
    • Unlike Vikram on Chandrayaan-2 which had five 800N engines with a fifth one being centrally mounted with a fixed thrust.
    • Additionally, the Chandrayaan-3 lander will be equipped with a Laser Doppler Velocimeter (LDV).

    Back2Basics: Chandrayaan-1 Mission

    • The Chandrayaan-1 mission was launched in October 2008 was ISRO’s first exploratory mission to the moon, in fact to any heavenly body in space.
    • The mission was designed to just orbit around the moon and make observations with the help of the instruments onboard.
    • The closest that Chandrayaan-1 spacecraft came to the moon was in an orbit 100 km from its surface.

     

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  • Artificial intelligence technologies have a climate cost

    Context

    While there is an allure to national dreams of economic prosperity and global competitiveness, underwritten by AI, there is an environmental cost.

    Issues with AI

    • Unfair race for dominance in AI:  A few developed economies possess certain material advantages right from the start, they also set the rules.
    • They have an advantage in research and development, and possess a skilled workforce as well as wealth to invest in AI.
    • Inequality in terms of governance: We can also look at the state of inequity in AI in terms of governance: How “tech fluent” are policymakers in developing and underdeveloped countries?
    • What barriers do they face in crafting regulations and industrial policy?
    • At the same time, there is an emerging challenge at the nexus of AI and climate change that could deepen this inequity.

    Climate impact of AI

    • The climate impact of AI comes in a few forms: The energy use of training and operating large AI models is one.
    •  In 2020, digital technologies accounted for between 1.8 per cent and 6.3 per cent of global emissions.
    •  In November 2021, UNESCO adopted the  In November 2021, UNESCO adopted the Recommendation on the Ethics of Artificial Intelligence, calling on actors to “reduce the environmental impact of AI systems, including but not limited to its carbon footprint.” , calling on actors to “reduce the environmental impact of AI systems, including but not limited to its carbon footprint.”

    Inequitable access to resources

    • Both global AI governance and climate change policy (historically) are contentious, being rooted in inequitable access to resources.
    • Developing and underdeveloped countries face a challenge on two fronts:
    • 1] AI’s social and economic benefits are accruing to a few countries.
    • 2] Most of the current efforts and narratives on the relationship between AI and climate impact are being driven by the developed West.

    Way forward

    • Assess technology-led priorities: Governments of developing countries, India included, should also assess their technology-led growth priorities in the context of AI’s climate costs.
    •  It is argued that as developing nations are not plagued by legacy infrastructure it would be easier for them to “build up better”.

    Consider the question “How Artificial Intelligence technologies could transform the world as we know it? What are the concerns with it?

    Conclusion

    It may be worth thinking through what “solutions” would truly work for the unique social and economic contexts of the communities in our global village.

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  • NeoCov Coronavirus found in Bats

    NeoCov coronavirus found in bats may pose threat to humans in the future, scientists caution.

    Coronavirus: A quick backgrounder

    • Coronaviruses are a large family of viruses that are known to infect animals and humans.
    • They are largely categorized into four genera — alpha, beta, gamma, and delta.
    • Broadly speaking, alpha and beta coronaviruses commonly infect mammals such as bats and humans, while Gamma and Delta mainly infect birds.

    Infecting humans: Through ‘Zoonotic Spillover’

    • While animals, including bats, are generally considered as the reservoirs of coronaviruses, rarely spillover events could occur.
    • It is possible for viruses that infect animals to jump to humans, a process which is known as zoonotic spillover.
    • Many major infectious diseases, including COVID-19, is widely thought to be a result of spillover.

    COVID-19 Pandemic

    • SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, belongs to the genus of beta coronavirus.
    • It is in fact the 7th type of coronavirus known to infect and cause severe disease in humans.

    How does it affect humans?

    • How a coronavirus latches onto special receptors on host cells depends on a key part of the virus known as its receptor-binding domain.
    • The differences in the receptor-binding domain of coronaviruses are therefore what determine the type of host receptor the virus will use and thus the host that it will be able to infect.
    • There are currently 4 well-characterized receptors for coronaviruses, including ACE2, which is used by SARS-CoV and SARS-CoV-2, and DPP4 used by MERS-CoV.

    What is NeoCoV?

    • NeoCoV is a bat coronavirus that was first identified in 2011.
    • It was identified in a species of bats known as Neoromicia, which is where the name NeoCoV was derived from.
    • Commonly known as aloe bats, this species is distributed in the Afro-Malagasy region.
    • NeoCoV shares an 85% similarity to MERS-CoV in the genome sequence, making it the closest known relative of MERS-CoV.

    Does NeoCoV infect humans and cause high mortality?

    • It is important to note that inherently, NeoCoV cannot interact with human receptors, implying that in its current form the virus cannot infect humans.
    • NeoCoV does not infect humans yet and has thus not caused any deaths.

    What does the preprint say and why is it important?

    • The study reports that despite their similarity, MERS-CoV and NeoCoV use different receptors to infect cells.
    • The bat coronavirus NeoCoV was found to use bat ACE2 receptors for efficiently entering cells.
    • The interaction between NeoCoV and bat ACE2 receptors is different from what is seen in other coronaviruses that utilize ACE2.
    • However, specific mutations artificially created in the receptor-binding domain of NeoCoV can enhance its efficiency to interact with human ACE2 receptors.
    • These mutations have not yet been seen in NeoCov isolates from natural settings.

    Conclusion

    • SARS-CoV-2 is not the first coronavirus to infect humans and cause large disease outbreaks, nor is it likely to be the last.
    • The study highlights that through further adaptation, coronaviruses like NeoCoV or other related viruses could potentially gain the ability to infect humans.

    Way forward

    • To prevent future outbreaks, it will thus be important to monitor this family of viruses for potential zoonosis while continuing research efforts on understanding the complex receptor usage of different coronaviruses.
    • Genomic surveillance of human and animal viruses is, therefore, the key to understanding the spectrum of viruses, and possibly provides early warning to potential spillover events.

     

    Try this question from CSP 2021:

    Q. The term ACE2â€Č is talked about in the context of:

    (a) genes introduced in the genetically modified plants

    (b) development of India’s own satellite navigation system

    (c) radio collars for wildlife tracking

    (d) spread of viral diseases

     

    [wpdiscuz-feedback id=”urgxa7d1zh” question=”Please leave a feedback on this” opened=”1″]Post your answers here.[/wpdiscuz-feedback]

     

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  • Small Satellite Launch Vehicle (SSLV)

    The new chairman of the ISRO Dr S Somanath has indicated inauguration of indigenous new launch rockets, called the Small Satellite Launch Vehicle (SSLV).

    What is SSLV?

    • The SSLV is a small-lift launch vehicle being developed by the ISRO with payload capacity to deliver:
    1. 600 kg to Low Earth Orbit (500 km) or
    2. 300 kg to Sun-synchronous Orbit (500 km)
    • It would help launching small satellites, with the capability to support multiple orbital drop-offs.
    • In future a dedicated launch pad in Sriharikota called Small Satellite Launch Complex (SSLC) will be set up.
    • A new spaceport, under development, near Kulasekharapatnam in Tamil Nadu will handle SSLV launches when complete.
    • After entering the operational phase, the vehicle’s production and launch operations will be done by a consortium of Indian firms along with NewSpace India Limited (NSIL).

    Vehicle details

    (A) Dimensions

    • Height: 34 meters
    • Diameter: 2 meters
    • Mass: 120 tonnes

    (B) Propulsion

    • It will be a four stage launching vehicle.
    • The first three stages will use Hydroxyl-terminated polybutadiene (HTPB) based solid propellant, with a fourth terminal stage being a Velocity-Trimming Module (VTM).

    SSLV vs. PSLV: A comparison

    • The SSLV was developed with the aim of launching small satellites commercially at drastically reduced price and higher launch rate as compared to Polar SLV (PSLV).
    • The projected high launch rate relies on largely autonomous launch operation and on overall simple logistics.
    • To compare, a PSLV launch involves 600 officials while SSLV launch operations would be managed by a small team of about six people.
    • The launch readiness period of the SSLV is expected to be less than a week instead of months.
    • The SSLV can carry satellites weighing up to 500 kg to a low earth orbit while the tried and tested PSLV can launch satellites weighing in the range of 1000 kg.
    • The entire job will be done in a very short time and the cost will be only around Rs 30 crore for SSLV.

    Significance of SSLV

    • SSLV is perfectly suited for launching multiple microsatellites at a time and supports multiple orbital drop-offs.
    • The development and manufacture of the SSLV are expected to create greater synergy between the space sector and private Indian industries – a key aim of the space ministry.

    Back2Basics:

  • What is Antimicrobial Resistance (AMR)?

    The Global Research on Antimicrobial Resistance (GRAM) report published in The Lancet provides the most comprehensive estimate of the global impact of Antimicrobial Resistance (AMR) so far.

    What is AMR?

    • Antimicrobial resistance (AMR or AR) is the ability of a microbe to resist the effects of medication that once could successfully treat the microbe
    • Antibiotic resistance occurs naturally, but misuse of antibiotics in humans and animals is accelerating the process.
    • A growing number of infections – such as pneumonia, tuberculosis, gonorrhoea, and salmonellosis – are becoming harder to treat as the antibiotics used to treat them become less effective.
    • It leads to higher medical costs, prolonged hospital stays, and increased mortality.

    How does it occur?

    • Antibiotics are medicines used to prevent and treat bacterial infections.
    • Antibiotic resistance occurs when bacteria change in response to the use of these medicines.
    • Bacteria, not humans or animals, become antibiotic-resistant.
    • These bacteria may infect humans and animals, and the infections they cause are harder to treat than those caused by non-resistant bacteria.

    What did the GRAM report find?

    • AMR is a leading cause of death globally, higher than HIV/AIDS or malaria.
    • As many as 4.95 million deaths may be associated with bacterial AMR in 2019.
    • Lower respiratory tract infections accounted for more than 1.5 million deaths associated with resistance in 2019, making it the most common infectious syndrome.

    The six leading pathogens for deaths associated with resistance were:

    1. Escherichia coli (E. Coli)
    2. Staphylococcus aureus
    3. Klebsiella pneumonia
    4. Streptococcus pneumonia
    5. Acinetobacter baumannii
    6. Pseudomonas aeruginosa

    What are the implications of this study?

    • Common infections such as lower respiratory tract infections, bloodstream infections, and intra-abdominal infections are now killing hundreds of thousands of people every.
    • This includes historically treatable illnesses, such as pneumonia, hospital-acquired infections, and foodborne ailments.

    Way forward

    • Doctors recommend greater action to monitor and control infections, globally, nationally and within individual hospitals.
    • Access to vaccines, clean water and sanitation ought to be expanded.
    • The use of antibiotics unrelated to treating human disease, such as in food and animal production must be “optimised” and finally they recommend being “more thoughtful”.

     

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  • Web 3.0: A vision for the future

    The concept of Web3, also called Web 3.0, used to describe a potential next phase of the internet, created quite a buzz in 2021.

    What is Web3?

    • The model, a decentralized internet to be run on blockchain technology, would be different from the versions in use, Web 1.0 and Web 2.0.
    • In web3, users will have ownership stakes in platforms and applications unlike now where tech giants control the platforms.

    Previous versions of Web

    To understand web3, we should start with Web 1.0 and Web 2.0.

    [1] Web 1

    • Web 1.0 is the world wide web or the internet that was invented in 1989. It became popular from 1993.
    • The internet in the Web 1.0 days was mostly static web pages where users would go to a website and then read and interact with the static information.
    • Even though there were e-commerce websites in the initial days it was still a closed environment and the users themselves could not create any content or post reviews on the internet.
    • Web 1.0 lasted until 1999.

    [2] Web 2

    • Web 2.0 started in some form in the late 1990s itself though 2004 was when most of its features were fully available. It is still the age of Web 2.0 now.
    • The differentiating characteristic of Web 2.0 compared to Web 1.0 is that users can create content.
    • They can interact and contribute in the form of comments, registering likes, sharing and uploading their photos or videos and perform other such activities.
    • Primarily, a social media kind of interaction is the differentiating trait of Web 2.0.

    What are some of the concerns?

    • In Web 2.0, most of the data in the internet and the internet traffic are owned or handled by very few behemoth companies ex. Google.
    • This has created issues related to data privacy, data security and abuse of such data.
    • There is a sense of disappointment that the original purpose of the internet has been distorted.
    • It is in this context that the buzz around Web3 is significant.

    Dawn of Web3

    • Gavin Wood, founder of Ethereum, a block chain technology company, used the term Web3 first in 2014 and in the past few years many others have added to the idea of Web3.
    • In 2021, owing to the popularity of crypto-currency, more discussions happened on Web3.

    How will Web3 address the problems of data monopoly?

    Web3 will deliver decentralized and fair internet where users control their own data.

    • Currently if a seller has to make a business to the buyer, both the buyer and seller need to be registered on a “shop” or “platform” like Amazon or Ebay or any such e-commerce portal.
    • What this “platform” currently does is that it authenticates that the buyer and seller are genuine parties for the transaction.
    • Web3 would try to remove the role of the “platform”.
    • For the buyer to be authenticated, the usual proofs aided by block chain technology will be used. The same goes for the seller.

    How is blockchain technology used here?

    • With block chain, the time and place of the transaction are recorded permanently.
    • Thus, Web3 enables peer to peer (seller to buyer) transaction by eliminating the role of the intermediary. This concept can be extended to other transactions also.
    • Consider a social media application where you want to share pictures with your followers.
    • It could be a broadcast operation from you aided by blockchain and you don’t need social media accounts for all the participants to be able to perform this.

    Another key feature: Decentralized Autonomous Organization

    • The key concepts in Web3 seen so far are peer to peer transaction and block chain.
    • The spirit of Web3 is Decentralized Autonomous Organization (DAO).
    • DAO is all about the business rules and governing rules in any transaction are transparently available for anyone to see and software will be written conforming to these rules.
    • Crypto-currency and block chain are technologies that follow the DAO principle.
    • With DAO, there is no need for a central authority to authenticate or validate.

    Will it take off?

    • We don’t know yet if Web3 will become the dominant mode of handling the internet but the questions it raises are relevant.
    • Web3 is in its very initial days and there is no consensus if it will take off like Web 1.0 or Web 2.0 did.
    • There is much skepticism from top tech brains in the industry and the academic community that Web3 does not solve the problems it purports to solve.

     

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  • Xeno-Transplantation and Related Issues

    Recently, the University Of Maryland School Of Medicine announced that it had successfully transplanted a genetically-modified pig heart into a patient with severe ailments.

    What is Xenotransplantation?

    • Xenotransplantation, or transplanting organs across different species, was first tried in humans in the 1980s.
    • The experiment was abandoned after the famous case of the American Baby Fae who was born with a congenital heart defect and received a baboon heart in 1984.
    • However, pig heart valves have been used for replacing damaged valves in humans for over 50 years now.
    • Nowadays, harvesting organs from genetically engineered pigs is seen as a viable alternative to meet organs shortage.

    How the pigs are genetically engineered?

    • The donor pig underwent 10 genetic modifications, by which the genes responsible for the rapid rejection of foreign organs by the human body were inactivated or knocked out.
    • Four pig genes were removed, and six human genes were added.
    • “GalSafe” pigs, or pigs that had undergone editing to knock out a gene that codes for Alpha-gal (a sugar molecule) were used.
    • Alpha-gal can elicit a devastating immune response in humans.
    • GalSafe pigs have been well studied, and are approved by the US Food and Drug Administration (FDA) for use in pharmacology.

    Why pursue xenotransplantation?

    • Modern scientific supporters of xenotransplantation argue that the potential benefits to society outweigh the risks, making pursuing xenotransplantation the moral choice.
    • None of the major religions object to the use of genetically modified pig organs for life-saving transplantation.

    A crucial case in India

    • Harvesting organs from genetically engineered pigs is seen as a viable alternative to meet organs shortage.
    • According to the health ministry, around 0.18 million people in India are estimated to suffer from renal failure every year, but only about 6,000 renal transplants are carried out in the country.
    • About 25,000-30,000 liver transplants are needed annually in India but only about 1,500 are being performed.
    • In the case of the heart, 50,000 people suffer from heart failure and are in need of a heart transplant.
    • Yet, only 10-15 heart transplants are carried out in India each year.

    Issues with Xenotransplantation

    Besides scientific challenges, there are several ethical challenges to overcome:

    • Animal rights: Many, including animal rights groups, strongly oppose killing animals to harvest their organs for human use.
    • Decreased life expectancy: In the 1960s, many organs came from the chimpanzees, and were transferred into people that were deathly ill, and in turn, did not live much longer afterwards.
    • Religious violations: Certain animals such as pork are strictly forbidden in Islam and many other religions.
    • Informed consent: Autonomy and informed consent are important when considering the future uses of xenotransplantation.
    • Threats of zoonosis: The safety of public health is a factor to be considered. We are already battling the biggest zoonotic disease threat.

     

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  • Carbon Footprints of Cryptocurrencies

    Bitcoin prices are rising these days and so will be its mining. As cryptocurrency will become mainstream, its carbon footprint cannot be ignored.

    What are Cryptocurrencies?

    Cryptocurrency

    Global crypto market

    • In 2019, the global cryptocurrency market was approximately $793 million.
    • It’s now expected to reach nearly $5.2 billion by 2026, according to a report by the market research organization Facts and Factors.
    • In just one year—between July 2020 and June 2021—the global adoption of cryptocurrency surged by more than 880 percent.

    Carbon footprints of Bitcoins

    • Increasing popularity of cryptocurrency has environmentalists on edge, as the digital “mining” of it creates a massive carbon footprint due to the staggering amount of energy it requires.
    • A/c to the Bitcoin Energy Consumption Index, the carbon footprint of Bitcoin is equivalent to that of New Zealand.
    • Both emit nearly 37 megatons of carbon dioxide into the atmosphere every year.

    What is Mining?

    • Mining is a process in which computational puzzles are solved in order to verify transactions between users, which are then added to the blockchain.
    • In simpler terms, the works are created, or “minted,” through a process called proof-of-work (PoW), which establishes its unique identity.

    How do cryptocurrencies create such a footprint?

    • Unlike mainstream traditional currencies, bitcoin is virtual and not made from paper or plastic, or even metal.
    • Bitcoin is virtual but power-hungry as it is created using high-powered computers around the globe.
    • Bitcoin is created when high-powered computers compete against other machines to solve complex mathematical puzzles.
    • This is an energy-intensive process that often relies on fossil fuels, particularly coal, the dirtiest of them all.

    Conclusion

    • What this means is that, unlike traditional currency or gold, Bitcoin is not solely a settlement layer, not solely a store of value, and not solely a medium of exchange.
    • This makes Bitcoin’s relative energy consumption productive in comparison to comparative sectors, given its robust potential uses.
    • The promise of such an endeavor offers hope for a more sustainable cryptocurrency future.
    • Whether this will make much difference to the climate crisis in light of government and industrial inaction remains to be seen.

    Back2Basics: Bitcoin Energy Consumption Index

     

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  • Zebrafish study reveals how the brain makes its connections

    Recent work by researchers at the National Centre of Biological Sciences, Bengaluru, has thrown light on what stimulates the synapses (connection of nerve cells) to form.

    What are Synapses?

    • Neurons, or nerve cells, in the brain connect by means of junctions known as synapses through which they transmit signals.
    • There are two types of synapses – chemical and electrical:

    (1) Chemical Synapse

    • In this, there is a space of about 20 nanometres between two neurons, and the way they communicate is this: One neuron converts electrical signal into chemical signals.
    • This chemical is released into the synaptic space and the receiving neuron converts the chemical signal back into an electrical signal.

    (2) Electrical synapse

    • In these synapses, the two neurons have a physical connection and the conversion of electrical to chemical need not occur, and they communicate directly.
    • Electrical synapses are like a physical wire, communication is faster but they are also fewer in number.

    Observing these synapses

    • Researchers from TIFR-National Centre of Biological Sciences, Bengaluru, have chosen Zebrafish as a model organism to study this process.
    • Zebrafish are transparent and neuron development in larval zebrafish can be observed from day to day by injecting a dye or by engineering the fish to express fluorescent proteins.
    • It was observed that electrical synapses are formed before chemical synapses, they are like a blueprint in which neurons make a handshake. This results in the making of chemical synapses.
    • Research on organisms such as leeches showed that if you remove electrical synapses, the chemical synapses do not form.
    • However, the mechanism of how it happens in higher organisms such as vertebrates was not known.

    What induces these synapses?

    • The group observed that knocking out a particular protein known as the gap junction delta 2b (gjd2b) in the cerebellum of zebrafish affected levels of the enzyme CaMKII.
    • Levels of CaMKII were seen to increase in the Purkinje neurons in the cerebellum.
    • These neurons and the cerebellum itself control coordination of movements in the organism.

    Why study this?

    • In humans for example, excess abuse of alcohol leads to damage of these cells, which results in lack of coordination in movement.
    • The cerebellum shows an evolutionary continuity in all vertebrates, so, too, the Purkinje neurons.
    • Even though fish and humans diverged from a common ancestor about 500 million years ago, the cerebellum has been evolutionarily conserved.
    • While zebrafish have about 300-400 Purkinje neurons, humans have thousands of these.

     

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  • Omisure: India’s first RT-PCR kit to identify Omicron strain

    Omisure — India’s first home-grown testing kit has recently received approval from the Drugs Controller General of India.

    About Omisure

    • Omisure is an omicron detecting RT-PCR kit developed by the Mumbai-based Tata Medical and Diagnostics Ltd (TATA MD) in partnership with the Indian Council of Medical Research (ICMR).
    • It can differentiate the omicron strain of the novel coronavirus from the delta, alpha and the other variants in under four hours.
    • It can diagnose this variant in a single step

    How does it work?

    • This new kit can identify the Omicron variant by targeting two regions of the S or the spike gene.
    • This gene codes for the spike protein, which helps the novel coronavirus enter and infect human cells.
    • The S, the Enveloped (E), and Nucleocapsid (N) genes are some of the targets of conventional RT-PCR tests.
    • When it detects these genes, a patient sample is labelled positive. As omicron bears heavy mutations in the S gene, the RT-PCR can sometimes miss it.
    • The absence of S gene likely indicates omicron’s presence.
    • This is called S gene dropout or S gene target failure — and is one of the targets of Omisure.

    How does Omisure compare with gene sequencing?

    • Gene sequencing reads the order of nucleotides, which are the building blocks of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
    • Despite being considered the gold standard, sequencing has a few limitations.
    • It is slow, expensive and complicated. It is a multi-step process.
    • It begins with extracting the virus’ RNA from patient samples, converting it into DNA, amplifying or multiplying it through RT-PCR before finally sending it for gene sequencing.
    • This entire process can take as many as three days.

    Back2Basics:

    PCR Test for Diagnosis of the COVID-19

     

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