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Subject: Science and Technology

  • Traditional vaccines just as effective, say US Scientists

    Vaccines like Biological E’s Corbevax and Bharat Biotech’s Covaxin that are made by traditional methods are “just as effective” as the latest mRNA technology-based vaccines a/c to US scientists.

    What are Vaccines?

    • A vaccine is a biological preparation that provides active acquired immunity to a particular infectious disease.
    • It typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins.

    Types of Vaccines

    There are several types of vaccines, including:

    • Inactivated vaccines
    • Live-attenuated vaccines
    • Messenger RNA (mRNA) vaccines
    • Subunit, recombinant, polysaccharide, and conjugate vaccines
    • Viral vector vaccines

    [1] Inactivated vaccines

    • Inactivated vaccines use the killed version of the germ that causes a disease.
    • Inactivated vaccines usually don’t provide immunity (protection) that’s as strong as live vaccines.
    • So you may need several doses over time (booster shots) in order to get ongoing immunity against diseases.
    • Inactivated vaccines are used to protect against: Hepatitis A, Flu (shot only), Polio (shot only), Rabies etc.

    [2] Live-attenuated vaccines

    • Live vaccines use a weakened (or attenuated) form of the germ that causes a disease.
    • Because these vaccines are so similar to natural infection that they help prevent, they create a strong and long-lasting immune response.
    • Just 1 or 2 doses of most live vaccines can give you a lifetime of protection against a germ and the disease it causes.
    • They need to be kept cool in refrigerated conditions.
    • Live vaccines are used to protect against Measles, mumps, rubella (MMR), Rotavirus, Smallpox, Chickenpox, Yellow fever

    [3] Messenger RNA vaccines

    • Researchers have been studying and working with mRNA vaccines for decades and this technology was used to make some of the COVID-19 vaccines.
    • mRNA vaccines make proteins in order to trigger an immune response.
    • mRNA vaccines have several benefits compared to other types of vaccines, including shorter manufacturing times and, because they do not contain a live virus, no risk of causing disease in the person getting vaccinated.

    How does mRNA vaccine work?

    • The mRNA vaccines function differently from traditional vaccines.
    • Traditional vaccines stimulate an antibody response by injecting a human with antigens.
    • mRNA vaccines inject a fragment of the RNA sequence of a virus directly into the cells, which then stimulate an adaptive immune response mRNA fragment is a specific piece of the virus that carries instructions to build the antigen of the virus.
    • An advantage of RNA vaccines is that they stimulate cellular immunity.

     

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  • Gaganyaan and other new Missions in 2022

    After a rather muted 2021 in terms of satellite launches, Indian Space Research Organization (ISRO) is gearing up for a number of missions in 2022 including the launch of the first unmanned mission of Gaganyaan.

    Gaganyaan Mission

    • Gaganyaan is crewed orbital spacecraft intended to be the formative spacecraft of the Indian Human Spaceflight Programme (IHSP).
    • The IHSP was initiated in 2007 by ISRO to develop the technology needed to launch crewed orbital spacecraft into low Earth orbit.
    • The first uncrewed flight, named Gaganyaan 1, is scheduled to launch no earlier than June 2022 on a GSLV Mark III rocket.
    • ISRO had been working on related technologies and it performed a Crew Module Atmospheric Re-entry Experiment and a Pad Abort Test for the mission.
    • If completed in meantime, India will become the fourth nation to conduct independent human spaceflight after the Russia, US and China.

    Details of the project

    • The spacecraft is being designed to carry three people, and a planned upgraded version will be equipped with rendezvous and docking capability.
    • In its maiden crewed mission, this capsule will orbit the Earth at 400 km altitude for up to seven days with a two or three-person crew on board.
    • This Hindustan Aeronautics Limited (HAL) manufactured crew module had its first un-crewed experimental flight in 2014.
    • DRDO will provide support for critical human-centric systems and technologies like space-grade food, crew healthcare, radiation measurement and protection, parachutes for the safe recovery of the crew module and fire suppression system.

    Other missions this year

    • Earth Observation Satellites: EOS-4 and EOS-6
    • Flights for Crew Escape System of Gaganyaan
    • Chandrayaan-03
    • Aditya Ll
    • XpoSat

    New projects

    • Venus mission
    • DISHA –a twin aeronomy satellite mission
    • TRISHNA, an ISRO-CNES [Centre national d’études spatiales] mission

     

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  • The functioning of INSACOG

    The Indian SARS-CoV-2 Consortium on Genomics (INSACOG) has sequenced about 1,00,000 samples.

    What is INSACOG?

    • INSACOG is a consortium of 10 labs and 18 satellite labs across India tasked with scanning COVID samples from patients and finding the variants that has led to spike in transmission.
    • The institutes involved include the laboratories of the Department of Biotechnology, Council of Scientific and Industrial Research, Indian Council of Medical Research, and the Health Ministry.
    • Its work began in January 2020, by sequencing all samples with a history of travel from the U.K. and a proportion of positive samples in the community.

    Tasks of INSACOG

    • The NCDC is tasked with coordinating collections of samples from the States as well as correlating disease with certain mutations.
    • It is mainly involved in genomic sequencing which is done by isolating the genetic material of the coronavirus samples.
    • It is also tasked with tracking certain combinations of mutations that become more widespread in India.

    What has it found so far?

    • The INSACOG sequenced about 1,00,000 samples as of early December 2021 when this data was last made publicly available.
    • The bulk of its effort has been focussed on identifying international ‘variants of concern’ (VoC) that are marked out by the WHO as being particularly infectious or pathogenic.
    • International travellers who arrive in India and test positive are the ones whose samples usually get sent to INSACOG for determining the genomic variant.

    Why is genome sequencing useful?

    • Understanding mutations: The purpose of genome sequencing is to understand the role of certain mutations in increasing the virus’s infectivity.
    • Immune response: Some mutations have also been linked to immune escape, or the virus’s ability to evade antibodies, and this has consequences for vaccines.
    • Effectiveness of vaccines: Labs across the world, including many in India, have been studying if the vaccines developed so far are effective against such mutant strains of the virus.
    • Evolution of viruses: Studies such as this have shown that Omicron, for instance, has evolved to evade antibodies much better than the Alpha or Delta variant. This prompted the push towards booster doses.

    How is it done?

    • Genomic sequencing is done by isolating the genetic material (RNA) of the coronavirus samples.
    • RNA consists of millions of nucleotide bases and genomic sequencing is about identifying and comparing the sequence in a given sample to a reference sample.
    • Changes in the sequence are clues to mutations that show that the virus may have undergone distinct changes at some key locations.
    • There are several approaches to genome sequencing — whole genome sequencing, next-generation sequencing — that have different advantages.
    • It has now evolved to a stage where large sequencers can process even thousands of samples simultaneously.

    Various challenges that INSACOG faces

    • Geographical variations: Given that COVID-19 is spreading, mutating and showing geographical variations, the original aim of the group was to sequence at least 5% of COVID-19 samples.
    • Shortage of funds: But only 1% has been achieved yet, primarily due to a shortage of funds, insufficient reagents and tools necessary to rapidly scale up.
    • Red-tapism: The INSACOG, in spite of being peopled by expert scientists, is ultimately within the Central government’s communication structure.
    • Infrastructure lacunae: Not all INSACOG labs have the same quality of equipment and manpower and therefore a surge or spike in some cities can mean difficulties in processing.

     

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  • What are Solid-State Batteries?

    After Twitter CEO Parag Agrawal, now another Indian origin is in the headline is Jagdeep Singh, CEO and founder of a US battery startup. The reason for his recent buzz for his breakthrough battery technology.

    About QuantumScape

    • QuantumScape Corp is a battery startup backed by Volkswagen AG.
    • Its solid-state battery — lithium metal with a solid electrolyte separating the two electrodes — is seen as an exceptionally bright prospect in E-Vehicle industry.

    What are Solid-state batteries?

    • A solid-state battery is a battery technology that uses solid electrodes and a solid electrolyte, instead of the liquid or polymer gel electrolytes found in lithium-ion or lithium polymer batteries.
    • Such batteries can provide potential solutions for many problems of liquid Li-ion battery, such as flammability, limited voltage, unstable solid-electrolyte interphase formation, poor cycling performance and strength.

    What are Li-ion Batteries?

    • Lithium-ion batteries use aqueous electrolyte solutions, where ions transfer to and fro between the anode (negative electrode generally made of graphite) and cathode (positive electrode made of lithium), triggering the recharge and discharge of electrons.
    • The energy density of lithium-ion cells used in today’s mobile phones and electric vehicles is nearly four times higher than that of older-generation nickel-cadmium batteries.

    Its limitations

    • Low energy density: Despite improvements in technology over the last decade, issues such as long charging times and weak energy density persist.
    • Small appliances: While lithium-ion batteries are seen as sufficiently efficient for phones and laptops, they still lack the range that would make EVs a viable alternative.
    • Extreme reactivity: One major problem is that lithium metal is extremely reactive.
    • Corrosion of cells: The main form of lithium corrosion is dendrites (branched lithium structures) that grow out from the electrode and can potentially pierce the separator short-circuiting the cell.
    • Fire hazard: In current lithium-ion batteries, in which the electrolyte is a flammable liquid, dendrite formation can trigger a fire.

    What is the breakthrough?

    • QuantumScape claims to prevent dendrites formation.
    • It uses a solid-state separator technology that eliminates the side reaction between the liquid electrolyte and the carbon/graphite in the anode of conventional lithium-ion cells.
    • The replacement of the separator enables the use of a lithium-metal anode in place of the traditional
    • The lithium metal anode is more energy-dense than conventional anodes, which allows the battery to store more energy in the same volume, according to the company.

    Key advantages of QuantumScape Battery

    • The advantages of the solid-state battery technology include higher cell energy density (by eliminating the carbon anode), lower charge time (by eliminating the need to have lithium diffuse into the carbon particles in conventional lithium-ion cells).
    • It has the ability to undertake more charging cycles and thereby a longer life, and improved safety.
    • Lower cost could be a game-changer, given that at 30 per cent of the total cost, battery expenses are a key driver of the vehicle costs.

    India’s battery push

    • The centre is working on a blueprint for a project of around 4,000 MWh of grid-scale battery storage system at the regional load dispatch centres that control the country’s power grid, primarily to balance the vagaries of renewable generation.
    • Reliance Industries Ltd has announced plans to set up an Energy Storage Giga factory; state-owned NTPC Ltd has floated a global tender for a grid-scale battery storage project.
    • The Ministry of Heavy Industries issued a request for proposal for setting up manufacturing facilities for Advanced Chemistry Cell (ACC) battery storage in India.

     

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  • Status of 5G Rollout in India

    Delhi, Gurgaon, Mumbai, Bengaluru, Kolkata, Ahmedabad, Hyderabad, and Pune will be the first places to get 5G services next year in 2022, informed the Department of Telecommunications (DoT).

    Must read:

    [Burning Issue] 5G Technology

    What is 5G technology?

    • 5G or fifth generation is the latest upgrade in the long-term evolution (LTE) mobile broadband networks.
    • It’s a unified platform which is much more capable than previous mobile services with more capacity, lower latency, faster data delivery rate and better utilisation of spectrum.

    5G spectrum

    5G mainly works in 3 bands, namely low, mid and high-frequency spectrum — all of which have their own uses as well as limitations.

    (1) Low band spectrum

    • It has a great promise in terms of coverage and speed of internet and data exchange but the maximum speed is limited to 100 Mbps (Megabits per second).
    • So Telcos can use and install it for commercial cell phone users who may not have specific demands for very high speed internet, the low band spectrum may not be optimal for specialized needs of the industry.

    (2) Mid-band spectrum

    • It offers higher speeds compared to the low band, but has limitations in terms of coverage area and penetration of signals.
    • This band may be used by industries and specialized factory units for building captive networks that can be moulded into the needs of that particular industry.

    (3) High-band spectrum

    • It offers the highest speed of all the three bands, but has extremely limited coverage and signal penetration strength.
    • Internet speeds in the high-band spectrum of 5G has been tested to be as high as 20 Gbps (giga bits per second), while, in most cases, the maximum internet data speed in 4G has been recorded at 1 Gbps.

    Stipulated bands for roll-out

    • While the low band spectrum has shown great promise in terms of coverage and speed of Internet and data exchange, the maximum speed is limited to 100 Mbps (Megabits per second).
    • This means that while telecoms can use and install it for commercial cellphone users who may not have specific demands for very high speed Internet.
    • However the low band spectrum may not be optimal for specialised needs of the industry.
    • The mid-band spectrum, on the other hand, offers higher speeds compared to the low band, but has limitations in terms of coverage area and penetration of signals.

    Where does India stand in the 5G technology race?

    • Like other global players, India had, in 2018, planned to start 5G services as soon as possible, with an aim to capitalise on the better network speeds and strength that the technology promised.
    • India’s private telecom players have been urging the DoT to lay out a clear road map of spectrum allocation and 5G frequency bands.

    Issues in roll-out

    • Monopoly: One big hurdle, however, is the lack of flow of cash and adequate capital with some players due to an existing monopoly.
    • AGR dues: There is an ongoing dispute between the telecoms and the government mainly over the definition of Adjusted Gross Revenue.
    • Device upgrade: As far as commercial smartphones are concerned, some newer devices in the market claim to be 5G-ready but are much costlier.

    Why is there early roll-out in big cities?

    • Services penetration: One of the reasons why the bigger cities were chosen for these trials is their telecom services penetration, making it easier to convince more people to upgrade from 4G.
    • Cost management: Since the costs for 5G services are initially going to be on the higher side, it would be wise to test the service in areas where more consumers would find them affordable.
    • Testing ground: A third reason is that cities provide all kinds of locations, such as walled complexes and open spaces, that are suitable for testing of various 5G bands.

    What is the global progress on 5G?

    More than governments, global telecom companies have started building 5G networks and rolling it out to their customers on a trial basis.

    • South Korea: Samsung, which had started researching on 5G technology way back in 2011, has taken the lead when it comes to building the hardware for 5G networks for several companies.
    • USA: In countries like the US, companies such as AT&T, T-mobile, and Verizon have taken the lead when it comes to rolling out commercial 5G for their users.
    • China: In other countries such as China, some of the telecoms such as China Unicom had started 5G trials as early as 2018, and have since rolled out the commercial services for users.

    What changes for consumers with 5G?

    • One of the major changes will be in terms of rich experiences on their phones and other connected devices.
    • For instance, users will be able to stream videos with multiple camera angles during sports matches or even play immersive video games using VR headsets or other accessories.
    • This next-generation telecom network will also enable a mesh of connected Internet of Things (IoT)-enabled devices and services with zero-fail rate, as in the case of connected cars.
    • 5G could also draw high-speed mobile broadband connectivity to replace existing broadband services, especially in locations where these services are constrained, provided there isn’t a huge price differential.

     

    Try this question from CSP 2019:

     

    With reference to communication technologies, what is/are the difference/differences between LTE (Long-Term Evolution) and VoLTE (Voice over Long-Term Evolution)?

    1. LTE ‘is commonly marketed as 3G and VoLTE is commonly marketed as advanced 3G.
    2. LTE is data-only technology and VoLTE is voice-only technology.

    Select the correct answer using the code given below.

    (a) 1 only

    (b) 2 only

    (c) Both 1 and 2

    (d) Neither 1 nor 2

     

    [wpdiscuz-feedback id=”nqicad1d3m” question=”Please leave a feedback on this” opened=”1″]Post your answers here.[/wpdiscuz-feedback]

     

     

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  • Study of distant Magnetar reveals facets of the Exotic Star

    An international group of researchers has succeeded in measuring for the first time the characteristics of a flare on a distant magnetar.

    What is a Magnetar?

    • Magnetars are the most magnetic stars in the universe.
    • It is a rare compact type of neutron star teeming with energy and magnetism.
    • It is an exotic type of neutron star, its defining feature that it has an ultra-powerful magnetic field.
    • The field is about 1,000 times stronger than a normal neutron star and about a trillion times stronger than the Earth’s.
    • Magnetars are relatively rare objects, with only about thirty having been spotted within the Milky Way so far.

    What is the recent study?

    • The studied magnetar is about 13 million light years away, in the direction of the NGC 253, a prominent galaxy in the Sculptor group of galaxies.
    • Its flare spewed within a few tenths of a second as much energy as the Sun would shed in 100,000 years.
    • It was captured accidentally on April 15, 2020, by the Atmosphere-Space Interactions Monitor instrument (ASIM) of the International Space Station.
    • This is the first study to characterize such a flare from so distant a magnetar.

    How do magnetars form?

    • During the course of their evolution, massive stars – with masses around 10-25 times the mass of the Sun – eventually collapse and shrink to form very compact objects called neutron stars.
    • A subset of these neutron stars is the so-called magnetars which possess intense magnetic fields.
    • These are highly dense and have breathtakingly high rotation speeds – they have rotational periods that can be just 0.3 to 12.0 seconds.

    What characterizes Magnetars?

    (1) Violent flares

    • The observed giant flare lasted approximately 160 milliseconds and during this time 1039 joules of energy was released.
    • The flare spewed as much energy in a tenth of a second that our Sun will radiate in 100,000 years.

    (2) Starquakes

    • Eruptions in magnetars are believed to be due to instabilities in their magnetosphere, or “starquakes” produced in their crust – a rigid, elastic layer about one kilometer thick.
    • This causes waves in the magnetosphere, and interaction between these waves causes dissipation of energy.

     

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  • How James Webb Telescope seeks to unlock Universe’s Secrets

    Today, NASA’s James Webb Space Telescope (JWST), the largest and most powerful space telescope ever built, will be launched from French Guiana, on the northeast coast of South America on the European Ariane 5 rocket.

    James Webb Space Telescope

    • JWST is a space telescope jointly developed by NASA, the European Space Agency (ESA), and the Canadian Space Agency (CSA).
    • It is planned to succeed the Hubble Space Telescope as NASA’s flagship astrophysics mission.
    • It will conduct a broad range of investigations across the fields of astronomy and cosmology, including:
    1. Observing some of the most distant events and objects in the universe such as the formation of the first galaxies
    2. Detailed atmospheric characterization of potentially habitable exoplanets

    How is it different from other telescopes?

    • JWST is much more powerful and has the ability to look in the infrared spectrum, which will allow it to peer through much deeper into the universe, and see through obstructions such as gas clouds.
    • As electromagnetic waves travel for long distances, they lose energy, resulting in an increase in their wavelength.
    • An ultraviolet wave, for example, can slowly move into the visible light spectrum and the infrared spectrum, and further weaken to microwaves or radio waves, as it loses energy.
    • Hubble was designed to look mainly into the ultraviolet and visible regions of the electromagnetic spectrum.
    • JWST is primarily an infrared telescope, the first of its kind.

    Special features of JWST

    (1) Time machine in space

    • Powerful space telescopes, like JWST or the Hubble Telescope, are often called time machines because of their ability to view very faraway objects.
    • The light coming from those objects, stars or galaxies, which is captured by these telescopes, began its journey millions of years earlier.
    • Essentially, what these telescopes see are images of these stars or galaxies as they were millions of years ago.
    • The more distant the planet or star, the farther back in time are the telescopes able to see.

    (2) Farthest from Earth

    • JWST will also be positioned much deeper into space, about a million miles from Earth, at a spot known as L2.
    • It is one of the five points, known as Lagrange’s points, in any revolving two-body system like Earth and Sun, where the gravitational forces of the two large bodies cancel each other out.
    • Objects placed at these positions are relatively stable and require minimal external energy to keep them there. L2 is a position directly behind Earth in the line joining the Sun and the Earth.
    • It would be shielded from the Sun by the Earth as it goes around the Sun, in sync with the Earth.

    (3) Engineering marvel

    • JWST has one large mirror, with a diameter of 21 feet (the height of a typical two-storey building), that will capture the infra-red light coming in from the deep universe while facing away from the Sun.
    • It will be shielded by a five-layer, tennis court-sized, kite-shaped sunscreen that is designed to block the heat from Sun and ensure the extremely cool temperatures that the instruments are built to operate at.
    • Temperatures on the sun-facing side can get as high as 110°C, while the other side would be maintained at –200° to –230°C.
    • The extremely cold temperatures are needed to detect the extremely faint heat signals from distant galaxies.
    • The mirror as well as the sunscreen is so large they could not have fit into any rocket. They have been built as foldable items and would be unraveled in space.

     

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  • Program for Development of Semiconductors and Display Manufacturing Ecosystem in India

    The Union Cabinet has approved a ₹76,000 crore scheme to boost semiconductor and display manufacturing in the country.

    About the Program

    • The scheme would provide financial support of up to 50% of the project cost for setting up semiconductor and display fabrication units.
    • The scheme was aimed at making India a global hub of electronic system design and manufacturing, the statement noted.
    • In addition, the Centre would work with the States to set up high-tech clusters with the necessary infrastructure such as land and semiconductor-grade water.

    Components of the mission

    [1] Semiconductor Fabs and Display Fabs

    • This shall extend fiscal support of up to 50% of project cost to eligible applicants.
    • The govt will work closely with the states establish High-Tech Clusters with requisite infrastructure in terms of land, semiconductor grade water, high quality power, logistics and research.

    [2] Semi-conductor Laboratory (SCL):

    • The Ministry of Electronics and Information Technology will take requisite steps for the modernization and commercialization of the Semi-conductor Laboratory (SCL).
    • MeitY will explore the possibility for the Joint Venture of SCL with a commercial fab partner to modernize the brownfield fab facility.

    [3] Semiconductor Design Companies:

    • The Design Linked Incentive (DLI) Scheme shall extend product design linked incentive of up to 50% of eligible expenditure and product deployment linked incentive of 6% – 4% on net sales for five years.
    • Support will be provided to 100 domestic companies of semiconductor design for Integrated Circuits (ICs), Chipsets, System on Chips (SoCs), Systems & IP Cores.

    [4] India Semiconductor Mission:

    • In order to drive the long-term strategies for developing sustainable semiconductors and display ecosystem, a specialized and independent ISM will be set up.
    • The ISM will be led by global experts in the semiconductor and display industry.
    • It will act as the nodal agency for efficient and smooth implementation of the schemes on Semiconductors and Display ecosystem.

    [5] Chips to start-ups Program

    • This program would develop 85,000 well-trained engineers, he claimed. Semiconductor designers would be given the opportunity to launch start-ups.
    • The government would bear 50% of the expense under the design-linked incentive scheme.
    • The entire programme would lead to 35,000 high-quality direct jobs and 1 lakh indirect employment.

    Significance of the scheme

    • In the current geopolitical scenario, trusted sources of semiconductors and displays hold strategic importance and are key to the security of critical information infrastructure.
    • The approved program will propel innovation and build domestic capacities to ensure the digital sovereignty of India.
    • It will also create highly skilled employment opportunities to harness the demographic dividend of the country.
    • Development of semiconductor and display ecosystem will have a multiplier effect across different sectors of the economy with deeper integration to the global value chain.

     

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  • 5G Network and Aviation Safety

    The US Federal Aviation Administration (FAA) has issued directives to create a framework as well as gather more information about the potential effects of 5G on crucial aviation safety equipment.

    What is 5G technology?

    • 5G or fifth generation is the latest upgrade in the long-term evolution (LTE) mobile broadband networks.
    • It mainly works in 3 bands, namely low, mid and high-frequency spectrum — all of which have their own uses as well as limitations.

    Three bands of 5G

    • The low band spectrum has shown great promise in terms of coverage and speed of internet and data exchange, the maximum speed is limited to 100 Mbps (Megabits per second).
    • This means that while telcos can use and install it for commercial cellphones users who may not have specific demands for very high-speed internet, the low band spectrum may not be optimal for specialised needs of the industry.
    • The mid-band spectrum, on the other hand, offers higher speeds compared to the low band but has limitations in terms of coverage area and penetration of signals.
    • Telcos and companies, which have taken the lead on 5G, have indicated that this band may be used by industries and specialised factory units for building captive networks that can be moulded into the needs of that particular industry.
    • The high-band spectrum offers the highest speed of all the three bands, but has extremely limited coverage and signal penetration strength.
    • Internet speeds in the high-band spectrum of 5G have been tested to be as high as 20 Gbps (gigabits per second), while, in most cases, the maximum internet data speed in 4G has been recorded at 1 Gbps.

    What is the issue?

    • There is a threat of potential radar altimeter interference from 5G cellular in the 3700 MHz-3800 MHz frequency or the C-band.
    • The 3700-4200 MHz band is close to the 4200 MHz-4400 MHz range used by aircraft radio altimeters.

    Potential impacts

    • Operations by aircraft including large jets could be limited or prohibited from using certain landing and navigation systems in places where there is scope for potential interference from new 5G cellular networks.
    • The restrictions could be severe for smaller aircraft and helicopters.
    • Overall, these could result in flight cancellations, delays or diversions in 46 places where these towers are, according to an aviation report.

    What is the aircraft equipment that can be affected?

    • The radio altimeter measures height (not altitude) of the aircraft above the surface immediately below the plane. It transmits a radio signal directly below.
    • There are various other systems that depend on inputs from the radio altimeter — for example, predictive wind shear, ground proximity warning system, traffic collision avoidance system, and auto land.
    • These effects are only when the aircraft is close to the ground, i.e. up to 2,500 ft above ground level (depending on the aircraft make).
    • Any disturbance to internal radio altimeter readings caused by 5G or other equipment transmitting in frequency bands close to it can result in disastrous effects on crucial systems during approach/landing.

    Impact of mobile phones

    • 5G devices can interfere with aircraft altitude instruments and recommended that they should be turned off (or put to flight mode) during flight.
    • Experts believe that electrical interference from a mobile phone could have been a factor in the crash of a small aircraft.
    • The navigation system of the small aircraft could be disrupted by mobile phone signals.
    • But up until now, there has been no evidence of a mobile phone having caused a crash.

    What about the implications for India?

    • Pilots in India are aware of the implications of 5G in the country.
    • However, in India, 5G could be rolled out in the 3.2 GHz-3.6 GHz band, which may not have the potential to interfere with aircraft operations.

     

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  • What are Chaperone Proteins?

     

    Chaperones are a functionally related group of proteins assisting protein folding in the cell under physiological and stress conditions.

    What are Chaperones?

    • DNA is a linear chain of nucleotides, portions of which are faithfully transcribed into linear messenger RNA.
    • The message in this RNA is translated into strings of amino acids – proteins.
    • Proteins need to take a precise three-dimensional shape to become functional entities.
    • This protein folding does not happen all by itself, at least most of the time.
    • A special bunch of proteins called molecular chaperones assist in correctly folding the protein.

    Functions of chaperone proteins

    • In biological systems, Chaperones play crucial roles.
    • Many molecular chaperones belong to the class of “heat shock” proteins (or stress-response proteins).
    • This is because whenever an organism is subjected to elevated temperatures – a heat shock – proteins in the system begin to lose their native shapes, and chaperones are produced in large quantities to restore order.

    General need of chaperones

    Chaperones are needed under physiological conditions too, for normal cellular function since misfolding of proteins can cause a number of diseases.

    • Alpha-synuclein protein, present in neurons, is wrongly folded in Parkinson’s disease.
    • Brains of Alzheimer’s patients have plaques formed from aggregates of amyloid beta-peptide.
    • This accumulation of amyloid fibrils is toxic, leading to widespread destruction of neurons – a ‘neurodegenerative’ disorder.
    • Aberrant folding of crystallins of the eye lens leads to cataracts.

    Types of Chaperones

    • Major chaperones in humans include HSP70, HSC70 and HSP90: the numbers express the size of the proteins in kilodaltons.
    • In normal cells 1%–2% of all proteins present are heat shock proteins.
    • This number rises threefold during stressful conditions.

    HSC70: The molecular thermometer

    • HSC70 appears to be more like a molecular thermometer, with an ability to sense cold temperatures.
    • It is induced by heat, whereas HSC70 is always present at high levels in normal cells.
    • This knowledge comes from the study of an intriguing set of disorders, exemplified by Familial Cold Autoinflammatory Syndrome (FCAS).

    HSC70 and HSP90: Role in Cancer

    • Cancer cells divide at a break-neck pace, and heat shock proteins are very important in maintaining the stressful cancerous state.
    • An overabundance of heat shock proteins in cancer cells is an indicator of a poor prognosis. Cancerous cells accumulate mutations in proteins that would normally suppress tumours.
    • HSP70 and HSP90 play the roles of villains, as they continue to fold the mutated proteins, thus allowing tumor progression.

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