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Subject: Science and Technology

  • Introduce the concept of Artificial Intelligence (AI). How does AI help clinical diagnosis? Do you perceive any threat to privacy of the individual in the use of AI in healthcare?

    Artificial intelligence (AI) is a set of technologies that empowers computers to learn, reason, and perform a variety of advanced tasks in ways that used to require human intelligence, such as understanding language, analyzing data, and even providing helpful suggestions.

    AI in clinical diagnosis

    Early diagnosis: AI detects cancers, arrhythmias, and stroke risks early, enabling timely treatment. Eg- IBM Watson for Oncology

    Pattern recognition: AI analyzes patient records to predict diabetes, hypertension, and other diseases across populations. Eg- MadhuNetrAI Program

    Robotic process automation: AI automates billing, authorizations, and record updates, reducing workload and operational costs.

    AI-guided treatment: AI personalizes treatments using genetics, lifestyle, and medical history analysis. Eg- Genetika+ using stem cell technology and AI software to match antidepressants to patients and minimise side effects.

    Enhanced accuracy: AI interprets X-rays, CT scans, MRIs, and ECGs with high precision, reducing diagnostic errors.

    Medical image analysis: AI detects tumours, fractures, and eye diseases from scans with remarkable accuracy. Eg- Google DeepMind Health

    Health monitoring: Wearables track heart rate and activity, supporting preventive healthcare through continuous monitoring. Eg- Fitbit devices.

    Threats to Individual Privacy from AI in Healthcare

    Permanent Risk of Re-identification: Expert states that no anonymized dataset is permanently secure; mathematical advancements constantly improve de-anonymization science.

    Cyber Vulnerabilities: Eg- The 2022 AIIMS attack compromised data of 30 million individuals.

    Predictive Discrimination Harms AI predicts future health risks, potentially leading to workplace or insurance bias.

    Algorithmic Bias and Marginalization AI trained on affluent data may recommend suboptimal care for marginalized groups. Eg- : Amazon’s AI recruitment tool mirrored historical gender bias.

    Secondary use of patient data: Health data collected for treatment may later train AI algorithms without meaningful patient consent.

    Corporate surveillance: AI wearables monitoring vitals and behavior may enable profiling and commercial manipulation.

    While AI offers unprecedented breakthroughs in diagnostic accuracy, its clinical deployment must be balanced with absolute data protection.

  • Discuss several ways in which microorganisms can help in meeting the current fuel shortage.

    Microorganisms are microscopic organisms such as bacteria, fungi, archaea, and microalgae that can break down organic matter and produce useful energy compounds. Due to these capabilities, they are becoming important for sustainable energy production and the global clean energy transition.

    Ways Microorganisms Help in Meeting Fuel Shortage

    Bioethanol: Saccharomyces cerevisiae and Zymomonas mobilis ferment sugars and agricultural waste into ethanol. India achieved 10% ethanol blending in 2022 and targets 20% (E20) by 2025-26.

    Biodiesel: Microalgae such as Chlorella and Dunaliella produce lipid-rich biomass, which is converted into biodiesel through transesterification.

    Biogas through Anaerobic Digestion: Methanogens decompose sewage, food waste, and cow dung to produce methane-rich biogas. Eg- India’s GOBAR-dhan scheme.

    Biohydrogen Production: Certain photosynthetic bacteria and cyanobacteria can split water or organic compounds to release Hydrogen gas, the cleanest burning fuel.

    Microbial Fuel Cells (MFCs): Bacteria break down organic waste in wastewater and release electrons, generating electricity while simultaneously treating the wastewater.

    Biobutanol Production: Species like Clostridium acetobutylicum produce butanol through ABE (Acetone-Butanol-Ethanol) fermentation. Biobutanol is considered superior to ethanol.

    Syngas Fermentation: Acetogenic bacteria can convert synthesis gas (CO and H2 from industrial emissions or biomass gasification) into liquid fuels like ethanol and acetic acid.

    Microbial Enhanced Oil Recovery (MEOR): Microbes are injected into depleted oil wells where they produce surfactants and gases that decrease oil viscosity.

    For a country like India, which imports over 80% of its crude oil, scaling up microbial fuel technologies is essential for achieving Urja Atmanirbharta (Energy Self-reliance) and meeting the Panchamrit targets for net-zero emissions.

  • What are asteroids? How real is the threat of them causing extinction of life? What strategies have been developed to prevent such a catastrophe?

    Asteroids are rocky, airless remnants from the early formation of the solar system, primarily orbiting the Sun between Mars and Jupiter (asteroid belt). Some asteroids, known as Near-Earth Objects (NEOs), have orbits that bring them close to Earth, raising concerns about impact hazards.

    Key facts about asteroids

    Types –

    C-type (carbonaceous, most common)

    S-type (silicaceous)

    M-type (metal-rich)

    The total mass of all the asteroids combined is less than that of Earth’s Moon.

    Threat from asteroids

    Historical Evidence – The Chicxulub asteroid impact (~66 million years ago) led to the extinction of dinosaurs.

    Probability Assessment

    Extinction-level asteroids (>10 km) are extremely rare

    City or regional-scale impacts (50-300 m) are more frequent and pose serious human and economic risks.

    Current Scientific Consensus

    Low probability, high impact risk.

    No known large asteroid is on a confirmed collision course with Earth in the foreseeable future.

    No global policy framework or convention to prevent asteroid impact

    Strategies Developed to Prevent or Mitigate Asteroid Impact

    Detection and Tracking – Ground- and space-based surveys continuously monitor NEOs.

    Kinetic Impact Deflection – A spacecraft collides with the asteroid to slightly alter its trajectory. Demonstrated successfully by NASA’s DART mission (2022).

    Gravity Tractor – A spacecraft hovers near the asteroid, using mutual gravitational attraction to gradually change its path.

    Nuclear Deflection (Last Resort) – Use of a nuclear device near (not on) the asteroid to vaporise surface material.

    NASA’s Jet Propulsion Laboratory, accurately characterizes the orbits of all known near-Earth objects, predicts their close approaches with Earth

    The International Asteroid Warning Network (IAWN) – UN-endorsed, global collaboration of over 60 scientific institutions that detects, tracks, and characterizes Near-Earth Objects (NEOs).

    United Nations Committee on the Peaceful Uses of Outer Space (COPUOS) has recognised asteroid impact hazards as a global risk transcending national boundaries.

    While extinction-level impacts are extremely rare, the consequences would be catastrophic, justifying sustained vigilance.

  • The world is facing an acute shortage of clean and safe freshwater. What are the alternative technologies which can solve this crisis? Briefly discuss any three such technologies citing their key merits and demerits.

    As per the report of the Global Commission on the Economics of Water, the world’s water systems are under “unprecedented stress” and the demand for fresh water will outstrip supply by 40% by 2030.

    Global freshwater Crisis

    4.4 billion people lack access to safe drinking water

    703 million people have no access to clean drinking water.

    Agriculture consumes 70% of the world’s freshwater

    India

    4% of the world’s freshwater resources

    600 million Indians experience water scarcity. (NITI Aayog)

    By 2030, 700 million people could be displaced due to water shortages (UNICEF, 2025)

    Global water crisis could result in losses of up to $8 trillion over the next 25 years (Global Commission on the Economics of Water, 2024)

    Alternative Technologies That Can Solve the Freshwater Crisis

    Desalination Technologies to convert seawater/brackish water into potable water.

    Wastewater Recycling & Reuse through Membrane Bioreactors (MBR), tertiary treatment and advanced oxidation.

    Atmospheric Water Harvesting using condensation (cooling below dew point).

    Solar Distillation for low-cost, off-grid evaporation-condensation.

    Managed Aquifer Recharge (MAR) using recharge wells, percolation tanks and treated wastewater.

    Fog & Dew Harvesting in coastal and high-elevation areas.

    Smart Irrigation Technologies (drip, soil moisture sensors) to reduce agricultural water demand.

    Precision Leak Detection Systems using IoT to minimise distribution losses.

    Rainwater Harvesting Systems integrated with rooftops, storage tanks and recharge pits.

    Floating Solar + Desal Units for dual energy-water generation.

    Three Technologies With Key Merits and Demerits

    Atmospheric Water Harvesting (AWH) – Eg – Source Hydropanels deployed in Ladakh schools.

    Merits:

    Decentralized, off-grid water access for remote areas.

    No reliance on groundwater or rainfall.

    Scalable from household to community systems.

    Demerits:

    Low yield in low-humidity climates.

    High per-litre cost for advanced AWH systems.

    Requires maintenance of filters/desiccants.

    Wastewater Recycling & Reuse – Eg – Singapore’s NEWater, Nagpur’s Bhandewadi recycling plant.

    Merits:

    Reduces pressure on freshwater sources by closing the loop.

    Low energy requirement compared to desalination.

    Ensures year-round supply, even in dry regions.

    Demerits:

    Public resistance to potable reuse (“yuck factor”).

    Risk of contamination if systems are poorly maintained.

    High initial investment for advanced tertiary treatment.

    Desalination using Reverse Osmosis & Thermal Distillation– Eg – Israel’s Sorek RO plant, India’s Minjur RO plant (Chennai).

    Merits:

    Large and climate-independent supply from oceans.

    Useful for coastal megacities facing groundwater depletion. Eg- Mumbai

    Continuous and reliable output even in droughts.

    Demerits:

    High energy consumption, increasing carbon footprint.

    Brine discharge harms marine ecosystems.

    High capital and operating cost for poorer regions.

    A portfolio approach, not a single technology, will determine long-term water security.

  • What is the present world scenario of intellectual property rights with respect to life materials? Although, India is second in the world to file patents, still only a few have been commercialized. Explain the reasons behind this less commercialization.

    IPR grants legal rights over innovations, while life materials include genes, microorganisms, and GMOs. Their intersection determines ownership and commercialization of biological resources, shaping biotechnology, healthcare, agriculture, and innovation-driven economic growth.

    Present World Scenario of IPRs with Respect to Life Materials

    Biotechnology: Increased patents on GMOs and gene-editing technologies, though patent laws differ across countries. Eg- CRISPR-Cas9 patents in the US and restrictions in the EU.

    Ethical concerns: Patenting genes and life forms can create monopolies and limit public access to healthcare and seeds. Eg- Myriad Genetics BRCA1 gene patent case.

    Developing nations’ approach: often oppose patents on essential medicines and biological resources. Eg- India rejected Novartis Glivec patent under Section 3(d).

    TRIPS and global standards:

    The TRIPS Agreement requires patent protection but allows safeguards for public health and biodiversity.

    With the WTO moratorium ending after MC 14 Meet, countries can now challenge public-health measures like compulsory licensing for harming expected profits.

    Open-source movements: Open-access biological initiatives encourage collaborative innovation and protect farmers’ rights. Eg- Open Source Seed Initiative.

    Biopiracy: Unauthorized patenting of biological resources and traditional knowledge exploits indigenous communities without fair compensation.

    Reasons for Low Commercialization in India

    Weak industry-academia linkage: Limited collaboration between research institutions and industries restricts market adoption. Eg- About 13.8% of CSIR patents are licensed.

    “Valley of Death” funding gap: Indian universities lack sufficient funding to scale laboratory research and prototypes into commercially viable products through testing and trials.

    Weak Patent Quality: Many patents suffer from vague claims, weak disclosures, or insufficient novelty, making them vulnerable to litigation and revocation.

    Slow regulatory machinery: Patent approvals and clearances in India often take 5-7 years, delaying commercialization and reducing technological relevance.

    Complex tech-transfer policies: Fragmented institutional IP policies create legal uncertainty, discouraging industry partnerships.

    Lack of Skilled IP Management: Limited expertise in licensing, prior-art research, and market-oriented commercialization, causing many patents to remain commercially unused.

    Misaligned objectives: Universities and researchers prioritize patent filings for rankings and grants, while industries seek scalable, market-ready technologies.

    Low absorptive capacity: Most universities lack strong innovation ecosystems and technology-transfer infrastructure beyond elite institutions like IITs.

    Poor commercialization infrastructure: India lacks strong incubators and technology-transfer systems.

    Global competition: Indian innovations face competition from dominant multinational corporations. Eg- Pfizer global market dominance.

    Inadequate Innovation Ecosystem: Support systems such as advanced laboratories, industry mentors, commercialization hubs, and global market integration remain uneven across regions.

    Way Forward

    Shift from quantity-driven patenting to quality-driven innovation by rewarding commercially viable and genuinely novel research.

    Strengthen industry-academia collaboration through technology transfer offices, IP centres, and startup incubation ecosystems. E.g Bayh-Dole model of the United States.

    Emulate China’s metrics-based databases, using big data analytics to isolate high-value patents

    Develop specialized biotechnology and pharmaceutical IP commercialization hubs on the lines of innovation clusters in South Korea and Israel.

    Utilize the 2024 Patent Rules, advance renewal discounts, and expanded startup facilitator schemes to protect emerging technologies.

    Align academic incentives away from mere patent counts toward innovation impact, technology transfer, and market adoption.

    Enhance venture capital support, FDI confidence, and startup financing by ensuring strong and enforceable intellectual property rights.

    Promote uniform state-level IP policies, single-window commercialization portals, and support for SMEs and rural innovators.

    With the above measures India can convert its patents into drivers of innovation, technological self-reliance, and the vision of Viksit Bharat 2047.

    Nuclear energy

  • What is the technology being employed for electronic toll collection on highways? What are its advantages and limitations? What are the proposed changes that will make this process seamless? Would this transition carry any potential hazards?

    The total length of National Highways in India is around 1.5 Lakh km. India currently uses FASTag, based on RFID (Radio Frequency Identification) technology.

    Passive RFID tagRFID readers

    Advantages of FASTag-Based Electronic Tolling

    Reduced Congestion – Minimises stoppages, reduces queueing, and cuts travel time

    Continuous movement lowers Fuel Consumption & Emissions

    Improved Revenue Realisation- Eliminates leakages, cash handling issues, and human errors.

    Better Traffic Management due to real-time vehicle data – enhances logistics efficiency.

    Digital Financial Inclusion –Promotes cashless payments and creates digital transaction footprint

    Limitations of the Current FASTag System

    RFID Reading Errors- Faulty tags or improper placement cause delays.

    Congestion during peak hours.

    Bank downtime results in payment failures and traffic jams.

    Fraud & Misuse- Cloning of RFID tags, misuse of blacklisted/invalid tags.

    Inadequate adaption – Eg- non availability in rural areas

    Proposed Changes to Make Tolling Seamless

    Expansion of ETC lanes – 100% coverage by 2025

    ANPR (Automatic Number Plate Recognition)-Based Tolling

    GPS-based – Vehicles fitted with GPS devices and toll are charged based on the distance travelled on a highway.

    Free-Flow Tolling (FFT) Corridors – open road tolling for uninterrupted movement.

    Integration with NHAI’s ‘One Vehicle One FASTag’ Drive

    Potential Hazards in Transition to New Tolling Systems

    Privacy & Surveillance Concerns – Eg- Continuous GPS tracking and ANPR imaging

    Cybersecurity Risks- vulnerability to hacking, spoofing, or data breaches.

    ANPR systems may misread plates due to dirt, or damaged plates.

    Digital Divide – Eg- 33% rural population is digitally literate (NFHS-5)

    Technical Failures- Weather, fog, rain etc can affect ANPR accuracy and system reliability.

    Replacing toll plazas with nationwide FFT infrastructure requires massive investment.

    Addressing these concerns can ensure efficient, seamless, congestion-free highways.

  • How can India achieve energy independence through clean technology by 2047? How can biotechnology play a crucial role in this endeavour?

    Energy independence by 2047 is central to India’s Viksit Bharat vision. Clean, indigenous and sustainable technologies are key for realisation of this vision.

    Energy independence through clean technology by 2047

    Expansion of renewable energy – Scale up solar, wind, hydro and offshore wind to meet 1000+ GW by 2047.

    Green hydrogen as a fuel of the future – Expand National Green Hydrogen Mission for use in steel, fertilisers, transport and power storage.

    Energy storage and grid modernisation

    Strengthen Battery Energy Storage Systems (BESS) and pumped hydro storage.

    Create smart grids, microgrids and AI-based demand management.

    Electric mobility transition

    Electrify public transport, freight. Eg- PM e-Bus Sewa

    Promote EV manufacturing + battery ecosystem under PLI and PM-eDrive.

    Make in India and supply Chain resilience

    Strengthen domestic solar, battery and electrolyser manufacturing.

    Secure supply chains through National Critical Mineral Mission. Eg- lithium supply from Argentina

    Energy efficiency & circular economy

    Expand PAT scheme

    Promote circular economy in energy storage, e-waste and batteries.

    Role of Biotechnology

    Ethanol Blending under the National Bio-Energy Mission can reduce petrol imports and stubble burning.

    Biogas and Compressed Biogas (CBG) under SATAT scheme and Gobardhan Mission can ensure rural energy self-sufficiency.

    Algal biofuel technology – High yield per hectare and non-competitive with food crops.

    Waste-to-Energy using anaerobic digestion, enzymatic conversion and microbial fuel cells. (Swachh Bharat + Energy security)

    Bio-hydrogen and bio-electricity enables low-cost, decentralised green energy.

    Steps Taken

    BioE3 Policy – innovation-driven research & high-performance biomanufacturing.

    Bio-RIDE – To bridge academia–industry gap and ensure lab-to-market transition

    Emerging Frontiers in Biotechnology Programme for cutting-edge biotechnology research

    As PM Modi stated, “India’s energy independence will be the foundation of its economic independence.” Clean technology is core pillar of this vision

    Agriculture

    Cropping Pattern

  • The fusion energy programme in India has steadily evolved over the past few decades. Mention India’s contributions to the international fusion energy project International Thermonuclear Experimental Reactor (ITER). What will be the implications of the success of this project for the future of global energy?

    Nuclear energy contributes approximately 3.1% to India’s total electricity generation, with an installed capacity of 8,880 MW.

    Evolution of Fusion Energy Programme in India

    The Early Phase (1950s-1980s): India was one of the first countries to announce a national fusion programme at the 1955 Geneva Conference.

    Indigenous Technology (1980s-2000s):

    Establishment of the Institute for Plasma Research (IPR) in 1986.

    Built its first indigenous tokamak ADITYA in 1989.

    Followed by the SST-1 (Steady-State Superconducting Tokamak)

    Global Integration (2005-Present): India joined ITER in 2005 as a full partner. Today, ITER-India manages India’s commitments, involving major industrial players like L&T and BHEL.

    India’s Contributions to ITER

    India is responsible for 9.1% of the construction cost (approx. $2.2 billion)

    The Cryostat: high-vacuum pressure chamber (30m*30m), designed to insulate the ultra-hot plasma from the outside world.

    In-Wall Shielding: India supplied 4,500 blocks of borated and ferritic steel to protect the reactor from neutron radiation.

    Cooling Water Systems: Responsible for the complex heat rejection systems required to manage the thermal load.

    Cryolines: Development of specialized pipelines to transport liquid helium at -269°C.

    Implications of Success for Future Global Energy

    Unlimited Fuel Supply: Fusion uses Deuterium (from seawater) and Tritium (from Lithium). One liter of seawater provides energy equivalent to 300 liters of gasoline.

    Unlike solar/wind, fusion provides a constant power supply without $CO_2$ emissions, vital for the Global Net Zero goals.

    Inherent Safety: There is no risk of a “meltdown.” If the plasma is disturbed, the reaction simply ceases instantly.

    Minimal Waste: It produces no long-lived high-level radioactive waste as plant components can be recycled within 100 years.

    High Energy Density: A fusion plant requires significantly less land than a solar farm to produce the same Terawatt-hours of energy.

    Geopolitical Stability: Energy “resource wars” could end, as the fuel (Deuterium/Lithium) is distributed globally, unlike oil or gas.

    Space Exploration: Compact fusion technology could revolutionize deep-space travel by providing high-thrust, long-duration propulsion.

    Technological Spin-offs: Research for ITER has already advanced superconducting magnets (used in MRIs) and high-power microwave technologies.

    Thus, fusion technology can help in transitioning from the Age of Combustion to the Age of Fusion.

  • Consider the following statements

    Consider the following statements:
    1. A widely used musical scale called diatonic scale has seven frequencies.
    2. The frequency of the note Sā is 256 Hz and that of Nī is 512 Hz.

  • Consider the following statements

    Consider the following statements :
    1. INS Sindhughosh is an aircraft carrier.
    2. INS Viraat is a submarine.
    Which of the statements given above is/are correct ?