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Subject: Basic Sciences

  • [pib] India’s First Indigenous Tumour Antigen SPAG9

    The National Institute of Immunology (NII) has received a trademark for India’s First Indigenous Tumor Antigen SPAG9.

    About SPAG9

    • India’s first indigenous tumor antigen SPAG9 was discovered by Dr Anil Suri in 1998 who is heading the Cancer Research Program at NII.
    • In a recent development, the SPAG9 antigen has received the trademark ASPAGNII-TM.
    • Currently, ASPAGNIITM is being used in dendritic cell (DC) based immunotherapy in cervical, ovarian cancer and will also be used in breast cancer.

    What is immunotherapy?

    • Immunotherapy is a new approach that exploits the body’s inner capability to put up a fight against cancer.
    • With this approach, either the immune system is given a boost, or the T cells are “trained’’ to identify recalcitrant cancer cells and kill them.
    • In this personalized intervention, those patients expressing SPAG9 protein can be treated with DC-based vaccine approach.
    • In DC-based vaccine, patient’s cells called monocytes from their blood are collected and modified into what are called dendritic cells.
    • These dendritic cells are primed with ASPAGNIITM and are injected back to the patient to help the ‘fighter’ cells, or T-cells, in the body to kill the cancer cells.

    Why need such therapy?

    • DC-based immunotherapy is safe, affordable and can promote antitumor immune responses and prolonged survival of cancer patients.
    • The ASPAGNIITM is a true example of translational cancer research and the Atmanirbhar Bharat spirit.
    • This will be a real morale boost in affordable, personalized, and indigenous products for cancer treatment.

    Answer this PYQ in the comment box:

    Q.‘RNA Interference (RNAi)’ technology has gained popularity in the last few years. why?

    1. It is used in developing gene silencing therapies
    2. It can be used in developing therapies for the treatment of cancer
    3. It can be used to developer hormone replacement therapies
    4. It can be used to produce crop plants that are resistant to viral pathogens

    Select the correct answer using the code given below.

    a) 1, 2 and 4

    b) 2 and 3

    c) 1 and 3

    d) 1 and 4 only

    The burden of cancer in India

    • Cancer kills 8.51 lakh people in India every year (International Agency for Research on Cancer, 2020).
    • As per World Health Organization (WHO), one in 10 Indians will develop cancer during their lifetime, and one in 15 will die of cancer.

  • China’s EAST Tokamak Device

    China’s Experimental Advanced Superconducting Tokamak (EAST), which mimics the energy generation process of the sun, set a new record.

    What is China’s ‘artificial sun’ EAST?

    • The Experimental Advanced Superconducting Tokamak (EAST) reactor is an advanced nuclear fusion experimental research device.
    • The purpose of the artificial sun is to replicate the process of nuclear fusion, which is the same reaction that powers the sun.
    • The EAST is one of three major domestic tokamaks that are presently being operated across the country.
    • Apart from the EAST, China is currently operating the HL-2A reactor as well as J-TEXT.
    • Since it first became operational in 2006, the EAST has set several records for the duration of confinement of exceedingly hot plasma.
    • The EAST project is part of the International Thermonuclear Experimental Reactor (ITER) facility, which will become the world’s largest nuclear fusion reactor when it becomes operational in 2035.
    • The project includes the contributions of several countries, including India, South Korea, Japan, Russia and the United States.

    How does the ‘artificial sun’ EAST work?

    • The EAST Tokamak device is designed to replicate the nuclear fusion process carried out by the sun and stars.
    • Nuclear fusion is a process through which high levels of energy are produced without generating large quantities of waste.
    • Previously, energy was produced through nuclear fission — a process in which the nucleus of a heavy atom was split into two or more nuclei of lighter atoms.

    Fission vs. Fusion

    • While fission is an easier process to carry out, it generates far more nuclear waste.
    • Unlike fission, fusion also does not emit greenhouse gases and is considered a safer process with a lower risk of accidents.
    • Once mastered, nuclear fusion could potentially provide unlimited clean energy and very low costs.

    But what is Fusion?

    • For nuclear fusion to occur, tremendous heat and pressure are applied on hydrogen atoms so that they fuse together. `
    • The nuclei of deuterium and tritium — both found in hydrogen — are made to fuse together to create a helium nucleus, a neutron along with a whole lot of energy.
    • Fuel is heated to temperatures of over 150 million degrees C so that it forms a hot plasma “soup” of subatomic particles.
    • With the help of a strong magnetic field, the plasma is kept away from the walls of the reactor to ensure it does not cool down and lose its potential to generate large amounts of energy.
    • The plasma is confined for long durations for fusion to take place.

    What is the latest record and why does it matter?

    • The EAST reactor set a new record on Friday when it achieved a plasma temperature of 216 million degrees Fahrenheit and also managed to run for 20 seconds at 288 million degrees Fahrenheit.
    • To put this in perspective, the sun’s core only reaches about 15 million degrees Celsius, which means the reactor was able to touch temperatures that are 10 times hotter than that.
    • The next goal for the scientists behind the experimental reactor is to maintain the high temperature for a long period of time. Previously, the EAST had reached a record temperature of 100 million degrees Celsius in 2018.

    China is not the only

    • But China is not the only country that has achieved high plasma temperatures.
    • In 2020, South Korea’s KSTAR reactor set a new record by maintaining a plasma temperature of over 100 million degrees Celsius for 20 seconds.

  • [pib] “AmbiTAG”- India’s first indigenous temperature data logger

    IIT Ropar in (Punjab) has developed a first-of-its-kind IoT device – AmbiTag that records real-time ambient temperature during the transportation of perishable products, vaccines, and even body organs and blood.

    AmbiTag

    • Shaped like a USB device, AmbiTag continuously records the temperature of its immediate surroundings “from -40 to +80 degrees in any time zone for a full 90 days on a single charge.
    • Most of the similar devices available in the international market record data only for a duration of 30- 60 days.
    • It generates an alert when the temperature goes beyond a pre-set limit. The recorded data can be retrieved by connecting the USB with any computer.
    • So far, such devices are being imported by India in a massive quantity from other countries such as Singapore, Hong Kong, Ireland, and China.
    • The device has been developed under Technology Innovation Hub – AWaDH (Agriculture and Water Technology Development Hub) and its Startup ScratchNest.

    Its applications

    • The device helps know whether that particular item transported from anywhere in the world is still usable or perished because of temperature variation.
    • This information is particularly critical for vaccines including the Covid-19 vaccine, organs, and blood transportation.
    • Besides perishable items including vegetables, meat, and dairy products it can also monitor the temperature of animal semen during transit.

  • [pib] National AI Portal INDIAai

    The ‘National AI Portal (https://indiaai.gov.in)’, celebrated its first anniversary on May 28, 2021.

    National AI Portal

    • INDIAai is the National AI Portal of India – a central hub for everything AI in India and beyond.
    • A joint initiative of MeitY, NeGD and NASSCOM, the website aims to be the trusted content powerhouse in the backdrop of India’s journey to global prominence in Artificial Intelligence.
    • It serves as a central hub for AI related news, learning, articles, events and activities etc., in India and beyond.
    • It has been set up to prepare the nation for an AI future.
    • It is the single central knowledge hub on artificial intelligence and allied fields for aspiring entrepreneurs, students, professionals, academics, and everyone else.
    • The portal focuses on creating and nurturing a unified AI ecosystem for driving excellence and leadership in India’s AI journey, to foster economic growth and improve lives through it.

    B2BASICS

    Artificial intelligence (AI) is a wide-ranging branch of computer science concerned with building smart machines capable of performing tasks that typically require human intelligence. AI is an interdisciplinary science with multiple approaches, but advancements in machine learning and deep learning are creating a paradigm shift in virtually every sector of the tech industry.

  • [pib] Bharat Ratna Professor CNR Rao

    Bharat Ratna Professor C.N.R. Rao has received the International Eni Award 2020 for research into renewable energy sources and energy storage, also called the Energy Frontier award.

    Who is CNR Rao?

    • Rao is an Indian chemist who has worked mainly in solid-state and structural chemistry.
    • Rao is one of the world’s foremost solid state and materials chemists. He has contributed to the development of the field over five decades.

    His scientific contributions

    His work on transition metal oxides has led to a basic understanding of novel phenomena and the relationship between materials properties and the structural chemistry of these materials.

    • Rao was one of the earliest to synthesize two-dimensional oxide materials such as La2CuO4.
    • He was one of the first to synthesize 123 cuprates, the first liquid nitrogen-temperature superconductor in 1987. He was also the first to synthesis Y junction carbon nanotubes in the mid-1990s.
    • His work has led to a systematic study of compositionally controlled metal-insulator transitions.
    • Such studies have had a profound impact in application fields such as colossal magnetoresistance and high-temperature superconductivity.
    • He has made immense contributions to nanomaterials over the last two decades, besides his work on hybrid materials.

    Answer this PYQ from CSP 2020 in the comment box:

    Q. With reference to carbon nanotubes, consider the following statements:

    1. They can be used as carriers of drugs and antigens in the human body.
    2. They can be made into artificial blood capillaries for an injured part of the human body.
    3. They can be used in biochemical sensors.
    4. Carbon nanotubes are biodegradable.
    Which of the statements given above are correct?
    (a) 1 and 2 only
    (b) 2, 3, and 4 only
    (c) 1, 3, and 4 only
    (d) 1, 2, 3 and 4

    Citations for the Energy Frontiers award

    • Professor Rao has been working on hydrogen energy as the only source of energy for the benefit of all mankind.
    • Hydrogen storage, photochemical and electrochemical production of hydrogen, solar production of hydrogen, and non-metallic catalysis were the highlights of his work.
    • The EF award has been conferred for his work on metal oxides, carbon nanotubes, and other materials and two-dimensional systems, including graphene, boron-nitrogen-carbon hybrid materials, and molybdenum sulfide (Molybdenite – MoS2) for energy applications and green hydrogen production.
    • Green hydrogen production can be achieved through various processes, including the photodissociation of water, thermal dissociation, and electrolysis activated by electricity produced from solar or wind energy.

    Significance of this award

    • This is considered to be the Nobel Prize in Energy Research.

  • Semiconductor chips shortage, and how carmakers are coping

    A shortage of inputs, especially semiconductor chips, has made India-based car manufactures and premium bike makers curtail production across categories.

    Do you know?

    Electronic parts and components today account for 40% of the cost of a new internal combustion engine car, up from less than 20% two decades ago.

    Chip famine

    • The trigger point was the beginning of the Covid-19 pandemic and the subsequent lockdowns across the world that forced shut crucial chip-making facilities in countries including Japan, South Korea, China and the US.
    • A key feature in a chip shortage is that it almost always causes cascading effects, given that the first one creates pent-up demand that becomes the cause for the follow-up famine.

    Why such famine?

    • The COVID-19 pandemic caused disruptions in supply chains and logistics.
    • This is coupled with a 13% increase in global demand for PCs owing to some countries’ shift to a stay-at-home economy.
    • This has impacted the availability of key chips necessary for the manufacturing of a broad range of electronics being a necessary component of every industry.

    What is the impact of the chip famine?

    • Consumers of semiconductor chips, which are mainly car manufacturers and consumer electronics manufactures, have not been receiving enough of this crucial input to continue production.
    • There were two reasons for this: a steady decline in input prices and improvements in the processing power of chips.
    • The number of transistors mounted in IC circuit chips has doubled every two years.
    • Notably, the increase in chip consumption over the last decade is also partly attributable to the rising contribution of electronic components in a car’s bill of materials.

    How have vehicle makers responded?

    • Supply constraints are learned to have caused some output issues at notable Indian auto firms.
    • In addition to delaying vehicle deliveries, some companies have reportedly started discarding features and high-end electronic capabilities on a temporary basis.

  • [pib] Magnetospheric Multiscale Mission

    Indian Scientists have developed a theory that helps understand the complicated nature of Sun-Earth interaction’s happening in the magnetosphere

    Magnetospheric Multiscale (MMS) Mission

    • The Magnetospheric Multiscale (MMS) Mission is a NASA robotic space mission to study the Earth’s magnetosphere, using four identical spacecraft flying in a tetrahedral formation.
    • The mission is designed to gather information about the microphysics of magnetic reconnection, energetic particle acceleration, and turbulence⁠—processes that occur in many astrophysical plasma.
    • Indian researchers have developed a theory that solves every bit of uncertainty regarding the conflict between the observations from MMS Mission.

    Answer this PYQ in the comment box:

    Q.Consider the following statements:

    1. The Earth’s magnetic field has reversed every few hundred thousand years.
    2. When the Earth was created more than 4000 million years ago, there was 54% oxygen and no carbon dioxide.
    3. When living organisms originated, they modified the early atmosphere of the Earth.

    Which of the statements given above is/ are correct? (CSP 2018)

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

    What is the Magnetosphere?

    • The magnetosphere is the region of space surrounding Earth where the dominant magnetic field is the magnetic field of Earth, rather than the magnetic field of interplanetary space.
    • It is formed by the interaction of the solar wind with Earth’s magnetic field.

    Findings of the Indian Researchers

    • The MMS spacecraft observed negative monopolar potential (electric field potentials which can be visualized in the form of single-humped pulse-type structures).
    • The scientific community suddenly recognized its importance, and publications were presented.
    • However, none of the available theories could explain the characteristics of these structures due to the exotic background conditions.
    • Indian theory provides a better understanding of their characteristics and sheds light on the generation of these structures.
    • This has lead to the unraveling of nature’s greatest mystery that causes phenomena -plasma transport and heating of plasma- the fourth state of matter after solid, liquid, and gas.

  • National Programme on Advanced Chemistry Cell Battery Storage

    About the scheme

    • The Cabinet, chaired by Prime Minister has approved the proposal of Department of Heavy Industry for implementation of the Production Linked Incentive (PLI) Scheme ‘National Programme on Advanced Chemistry Cell (ACC) Battery Storage’.
    • Each selected ACC battery Storage manufacturer would have to commit to set-up an ACC manufacturing facility of minimum five (5) GWh capacity and ensure a minimum 60% domestic value addition at the Project level within five years.
    • Furthermore, the beneficiary firms have to achieve a domestic value addition of at least 25% and incur the mandatory investment Rs.225 crore /GWh within 2 Years (at the Mother Unit Level) and raise it to 60% domestic value addition within 5 Years, either at Mother Unit, in-case of an Integrated Unit, or at the Project Level, in-case of “Hub & Spoke” structure.
    • The scheme will help in achieving manufacturing capacity of Fifty (50) Giga Watt Hour (GWh) of ACC and 5 GWh of “Niche” ACC with an outlay of Rs.18,100 crore.

    About ACC

    • ACCs are the new generation of advanced storage technologies that can store electric energy either as electrochemical or as chemical energy and convert it back to electric energy as and when required.

    Benefits of the scheme

    • Setup a cumulative 50 GWh of ACC manufacturing facilities in India under the Programme.
    • Direct investment of around Rs.45,000 crore in ACC Battery storage manufacturing projects.
    • Facilitate demand creation for battery storage in India.
    • Facilitate Make-ln-lndia: Greater emphasis upon domestic value-capture and therefore reduction in import dependence.
    • Net savings of Indian Rs. 2,00,000 crore to Rs.2,50,000 crore on account of oil import bill reduction during the period of this Programme due to EV adoption as ACCs manufactured under the Programme is expected to accelerate EV adoption.
    • The manufacturing of ACCs will facilitate demand for EVs, which are proven to be significantly less polluting.
    • As India pursues an ambitious renewable energy agenda, the ACC program will be a key contributing factor to reduce India’s Green House Gas (GHG) emissions which will be in line with India’s commitment to combat climate change.
    • Import substitution of around Rs.20,000 crore every year.
    • The impetus to Research & Development to achieve higher specific energy density and cycles in ACC.
    • Promote newer and niche cell technologies.

  • What is 2-deoxy-D-glucose (2-DG) and is it effective against Covid?

    About the drug

    • DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the Drug Controller General of India (DCGI).
    •  2-DG halts the spread of COVID-19 inside the body cells.
    • Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence.
    • In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints.
    • A significantly favourable trend (2.5 days difference) was seen in terms of the median time to achieving normalisation of specific vital signs parameters when compared to SoC.

    How 2-DG reduces dependence on oxygen

    • The 2 DG drug, like glucose, spreads through the body, reaches the virus-infected cells and prevents virus growth by stopping viral synthesis and destroys the protein’s energy production.
    • The drug also works on virus infection spread into lungs which help us to decrease patients dependability on oxygen.

     

  • Hottest planet in the known universe discovered

    About the plane

    • TOI-1431b, also known as MASCARA-5b, was found 490 light-years from Earth and could be the hottest planet in the known universe.
    • Researchers at the University of Southern Queensland’s Centre for Astrophysics in Toowoomba led the global team that made the discovery.
    • NASA’s Training Exoplanet Survey Satellite first flagged TOI-1431b as a possible planet in late 2019.
    • Dayside temperature reaches approximately 2700 degrees celcius and nightside temperature approaches approximately 2300 degrees celcius – no life could survive in its atmosphere.
    • This temperature is significantly greater than the melting point of most metals, many of which will turn to liquid at under 2000 degrees celcius.
    • Titanium melts at 1670 degrees, platinum at 1770 degrees, and stainless steel at between 1375 and 1530 degrees.

    Planet with a retrograde orbit

    • These types of planets, known as ultra-hot Jupiters, are rarely discovered but this particular one is even more unusual due to its retrograde orbit.
    • In our Solar System, all the planets orbit in the same direction that the Sun rotates and they’re all along the same plane.
    • This new planet’s orbit is tilted so much that it is actually going in the opposite direction to the rotation of its host star.