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Subject: Basic Sciences

  • UK sees success in Mitochondrial Replacement Therapy

    mitochondria

    Central Idea

    • The birth of a baby using three persons’ DNA using Mitochondrial Replacement Therapy (MRT) in the UK has generated significant attention and discussion.
    • The baby has three parents, with the mitochondria coming from a donor in addition to the genetic material from the biological parents.
    • This pioneering technology was employed to prevent the baby from inheriting the mother’s mitochondrial disease.

    What is Mitochondria?

    Description
    Structure Membrane-bound organelles with outer and inner membranes
    Energy Production Generate ATP through cellular respiration and oxidative phosphorylation
    ATP Production Breakdown of carbohydrates, fats, and proteins in the inner membrane
    DNA and Replication Possess their own circular DNA (mtDNA) and can replicate independently
    Other Functions Involved in calcium signalling, apoptosis, and synthesis of molecules
    Inheritance Maternally inherited during fertilization
    Evolutionary Origin Arise from a symbiotic relationship with bacteria-like organisms
    Disorders Mutations or dysfunction can cause mitochondrial diseases

     

    • Certain defects in mitochondria can lead to mitochondrial diseases, impacting the function of energy-hungry tissues in various organs.
    • Mitochondrial diseases have no cure but can be treated, and their incidence is estimated to be one in 5,000 people.
    • In this case, the mother had a mitochondrial disease that she wanted to avoid passing on to her baby, but she did not want to use a donor egg.

    What is Mitochondrial Replacement Therapy (MRT)?

    • MRT is a medical technique used to prevent the transmission of certain mitochondrial diseases from a mother to her child.
    • It involves replacing faulty mitochondria in an egg or embryo with healthy mitochondria from a donor.
    • The procedure is typically performed using in vitro fertilization (IVF) techniques.
    • The nucleus, containing the majority of the genetic material, is transferred from the intended parents’ egg or embryo to a donor egg or embryo with healthy mitochondria.
    • The resulting embryo, with nuclear DNA from the intended parents and healthy mitochondria from the donor, is then implanted into the mother’s uterus for gestation.

    How does it work?

    • The father’s sperm fertilizes the eggs from the biological mother and a female donor with healthy mitochondria.
    • The genetic material from the donor’s egg is replaced with that of the biological parents, resulting in an egg with the parents’ DNA and the donor’s mitochondria.
    • This modified egg is then implanted into the mother’s uterus and carried to full term, resulting in a baby free from the mother’s mitochondrial disease.

    Uses of MRT

    • Prevention of Mitochondrial Diseases: MRT helps prevent the transmission of certain mitochondrial diseases from mothers to their children.
    • Family Planning: It enables individuals or couples with mitochondrial DNA mutations to have genetically related children without the risk of disease inheritance.
    • Improved Health: MRT can significantly improve the overall health and well-being of individuals by avoiding debilitating mitochondrial diseases.
    • Ethical Considerations: It provides an alternative to traditional donor egg options, allowing intended parents to have a child with their own genetic material while avoiding disease transmission.
    • Scientific Advancements: MRT contributes to scientific research and advancements in assisted reproductive technologies, expanding our understanding of mitochondrial biology and potential treatment options for mitochondrial disorders.

    Recent advancements in UK

    • The baby primarily carries DNA from its biological parents and a small percentage from the donor whose mitochondria was used during fertilization.

    Scientific process

    • Mitochondrial diseases are inherited from the mother, prompting research to find ways to protect infants from inheriting these diseases.
    • The Newcastle Fertility Clinic developed an advanced in vitro fertilization technique known as Mitochondrial Donation Treatment (MDT).

    Legal Facilitation of MDT

    • The UK government amended the law in 2015 to allow for mitochondrial replacement therapy (MRT) or MDT.
    • The Newcastle Fertility Centre became the first center to obtain a license to perform the procedure, and the first cases were approved in 2018.

    Issues with MRT

    • Transfer of Defective Mitochondria: There is a minimal risk of transferring small amounts of defective mitochondria along with healthy ones during the procedure.
    • Long-Term Safety: The long-term safety of MRT is still being studied, and ongoing monitoring is necessary to assess any potential risks or effects.
    • Ethical and Social Concerns: MRT raises ethical and social considerations related to the creation and destruction of embryos, use of donor gametes, and altering the germline.
    • Limited Availability: MRT is a highly regulated procedure, and its availability may be limited to specific countries or cases approved by regulatory bodies.
    • Emotional and Psychological Impact: Undergoing MRT involves emotional implications and decision-making, which can have an impact on individuals and couples involved.

     

     

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  • What is Carbon Dating? How does it work?

    carbon dating

    Central Idea: Allahabad high court ordered the ASI to conduct the carbon dating process of the ‘Shivling’ found in the premises of the Gyanvapi mosque, without causing any damage to the structure.

    What is Carbon Dating?

    • Carbon dating is a widely-used method for determining the age of organic materials that were once living.
    • The method is based on the radioactive decay of Carbon-14 (C-14), an isotope of carbon with an atomic mass of 14.
    • It works by measuring the ratio of C-12 to C-14 in the atmosphere, as well as in plants and animals that acquire carbon through photosynthesis or food consumption.

    The half-life concept

    • Carbon-14 has a half-life of 5,730 ± 40 years—i.e., half the amount of the radioisotope present at any given time will undergo spontaneous disintegration during the succeeding 5,730 years.
    • Because carbon-14 decays at this constant rate, an estimate of the date at which an organism died can be made by measuring the amount of its residual radiocarbon.

    Limitations of Carbon Dating

    • Carbon dating has certain limitations and cannot be applied in all circumstances.
    • It is not suitable for determining the age of non-living things such as rocks.
    • Carbon dating becomes less accurate for objects older than 40,000-50,000 years, as the amount of detectable C-14 becomes significantly small.
    • Other radiometric dating methods are employed to determine the age of inanimate objects, which rely on the decay of radioactive elements present in the material.
    • Examples of such methods include potassium-argon dating and uranium-thorium-lead dating, which analyze the ratios of specific isotopes to estimate the age of rocks.

    Other Dating Methods

    In addition to radiometric dating, there are alternative methods to determine the age of objects.

    • Cosmogenic nuclide dating: CRN is one such method that utilizes radioactive decay to estimate age and is commonly used to study the age of ice cores in Polar Regions.
    • Potassium-argon dating: A radiometric dating method that measures the ratio of potassium to argon isotopes in rocks to determine their age.
    • Uranium-thorium-lead dating: A radiometric dating method that analyses the ratios of uranium, thorium, and lead isotopes in rocks to estimate their age.

     

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  • Scientists help find new kind of Molecular Motor

    motor

    Central Idea: Researchers from the National Centre for Biological Sciences have discovered a new kind of molecular motor that has potential applications in biology and medicine.

    What is a molecular motor?

    • Cells use molecular motors to move things like organelles and molecules, and disruption of these processes can lead to diseases.
    • Molecular motors use biochemical energy to do mechanical work.

    What did the new study find?

    • The study found that EEA1, a long protein, can regain its rigid shape to create a new kind of two-part molecular motor.
    • EEA1 regains its rigid shape through a reaction called GTP hydrolysis, mediated by enzymes called GTPases.
    • The researchers believe this could mark a new class of molecular machines that operate as motors in a unique way with novel collective effects.

    Why is the finding significant?

    • The motor is different from most motors because it doesn’t produce a lever-like back-and-forth action and it uses GTP instead of ATP (Adenosine Tri Phosphate) for energy.
    • EEA1 exerts an entropic force on the membranes that it pulls, which is a unique feature.
    • The finding could have potential applications for understanding membrane fusion and for many other mechanochemical proteins or assemblies.

    What are the potential applications?

    • The discovery of the molecular motor could have potential applications in biology and medicine.
    • The study provides a general mechanism that is applicable to many mechanochemical proteins or assemblies that harness chemical energy for mechanical work in cells.

     

     

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  • Genome Sequencing and the Genome India Project

    genome

    The Department of Biotechnology recently said that the exercise to sequence 10,000 Indian human genomes and create a database under the Centre-backed Genome India Project is about two-thirds complete.

    What is the Genome India Project?

    • The Genome India Project has been described by those involved as the “first scratching of the surface of the vast genetic diversity of India”.
    • It involves over 20 scientists from institutions including the Indian Institute of Science (IISc) in Bengaluru and a few IITs.
    • It is inspired by the Human Genome Project (HGP 1990-2003) an international programme that led to the decoding of the entire human genome.

    About Human Genome Project (HGP)

    Description
    Description HGP was a global research effort aimed at mapping and sequencing the entire human genome, which is the complete set of genetic instructions for building and maintaining a human being.
    Timeframe Began in 1990 and was completed in 2003.
    Collaborators A collaborative effort involving scientists from many countries.
    Coordinators Institutes of Health (NIH) and the US Department of Energy (DOE), US
    Achievements Scientists were able to identify the location of many human genes and provide information about their structure and organization.
    Impact It has led to the development of new diagnostic tools and therapies for a wide range of genetic disorders and has provided valuable insights into the basic biology of human development and evolution.
    Fields affected Medicine, biotechnology, and pharmaceuticals.

     

    What is a Genome?

    • Every organism’s genetic code is contained in its Deoxyribose Nucleic Acid (DNA), the building blocks of life.
    • The discovery that DNA is structured as a “double helix” by James Watson and Francis Crick in 1953, started the quest for understanding how genes dictate life, its traits, and what causes diseases.
    • A genome is all the genetic matter in an organism. It is defined as “an organism’s complete set of DNA, including all of its genes.
    • Each genome contains all of the information needed to build and maintain that organism.
    • In humans, a copy of the entire genome contains more than 3 billion DNA base pairs.
    • Each pair consists of 23 pairs of chromosomes for a total of 46 chromosomes, which means that for 23 pairs of chromosomes in each cell, there are roughly 20,500 genes located on them.

    What does genome mapping tell us?

    • Some of the genes are lined up in a row on each chromosome, while others are lined up quite close to one another and this arrangement might affect the way they are inherited.
    • For example, if the genes are placed sufficiently close together, there is a probability that they get inherited as a pair.
    • Genome mapping, therefore, essentially means figuring out the location of a specific gene on a particular region of the chromosome and also determining the location of and relative distances between other genes on that chromosome.

    How did it help during the pandemic?

    • Genomic sequencing became a crucial tool in the fight against COVID-19 to track emerging variants, conduct further studies, and develop vaccines.
    • In January 2020, Chinese scientist Yong-Zhen Zhang sequenced the genome of the novel coronavirus and shared it online, allowing researchers to study the virus’s genetic code.
    • India also implemented a sequencing framework, the Indian SARS-COV-2 Genomics Consortia (INSACOG), to scan coronavirus samples from patients and flag the presence of variants.

    What is the significance of GIP?

    • HGP has a major diversity problem as most genomes (over 95%) mapped under HGP have been sourced from urban middle-class white people.
    • Thus, HGP should not really be seen as representative of the human genome.

    In this context, the GIP aims to vastly add to the available information on the human species and advance the cause, both because of the scale of the Indian population and the diversity here. This diversity can be depicted by:

    1. Horizontal Diversity: The Indian subcontinent has been the site of huge migrations, where the first migrations were from Africa. Also, there have been periodic migrations by various populations from all around the world, making this a very special case of almost all races and types intermingling genetically.
    2. Vertical Diversity: There has been endogamy or inter-marriage practised among distinct groups, resulting in some diseases passed on strictly within some groups and some other traits inherited by just some groups.

    Its applications

    • Personalized Medicine: Genome sequencing can help in the development of personalized medicine. By analyzing a patient’s genetic makeup, doctors can determine the best course of treatment for a particular disease. This approach can help in the early detection of diseases, identifying the risk of inherited diseases, and providing targeted therapies.
    • Disease Diagnosis: Genome sequencing can be used to diagnose genetic disorders that are caused by mutations in a single gene, such as cystic fibrosis and sickle cell anemia. It can also help in identifying the genetic causes of complex diseases such as cancer, Alzheimer’s, and diabetes.
    • Drug Development: Genome sequencing can help in the development of new drugs by identifying targets for drug therapy. It can also help in the identification of biomarkers that can be used to monitor the effectiveness of drugs.
    • Agriculture: Genome sequencing can help in the development of improved crops and livestock by identifying genes that control traits such as yield, disease resistance, and quality.
    • Forensics: Genome sequencing can be used in forensic investigations to identify suspects by analyzing their DNA. It can also help in identifying missing persons and victims of disasters.

    Challenges involved

    • Fear of Scientific Racism: In India, a nation divided by identity politics, scientific work in mapping genetic groups may further strengthen the divisions in the society based on the prevalent notion of race.
    • Data & Storage: India is yet to pass a Data Privacy Bill with adequate safeguards and launching the GIP before the privacy question is settled could give rise to another set of problems.
    • Medical Ethics: In a project that aims only to create a database of genetic information poses a risk of doctors privately performing gene modification.

     

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  • Microbes found near Mt. Everest

    Central idea

    • Researchers conducted a genetic analysis of microbial communities on the South Col of Sagarmatha (Mount Everest).
    • The article examines the human microbiota on the inhospitable slopes of Mount Everest esp. the South Col ridge.

    Microbial Communities on the South Col

    • Microbial communities were collected from sediment samples left by human climbers on the South Col, 7,900 meters above sea level (msl).
    • The South Col is inhospitable due to low oxygen, strong winds, high levels of UV radiation, and temperatures below minus 15 degrees Celsius.
    • Visible signs of life are absent above 6,700 msl except for a few species of moss and a jumping spider.
    • Microbes are carried to high altitudes by birds, animals, winds, and dust particles.

    Microbes found

    • Using sophisticated methods such as 16S and 18S rRNA sequencing, the microbe hunters were able to identify the bacteria and other microorganisms found on the South Col.
    • 16s rRNA is a component of the 30S subunit in prokaryotic ribosomes while 18s rRNA is a component of the 40S subunit in eukaryotic ribosomes.
    • 16S ribosomal RNA (rRNA) sequencing is an amplicon sequencing technique used to identify and compare species of bacteria present within a given sample.
    • 16S rRNA gene sequencing is used to study phylogeny and taxonomy of samples from complex microbiomes or environments that are difficult or impossible to study.
    • Microbes like Modestobacter altitudinis and the fungus, naganishia, which are known to be UV-resistant survivors are found there.

    History of Mount Everest and Naming

    • Nepal’s eminent historian, late Baburam Acharya, gave the Nepali name Sagarmatha to Mount Everest in the 1960s.
    • Andrew Waugh, British Surveyor General of India, discovered Mount Everest in 1847 and named it after his predecessor, Sir George Everest.
    • Radhanath Sikdar, an Indian mathematician and surveyor, was the first person to show that Mount Everest was the world’s highest peak in 1852, with the help of a special device.

     

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  • What is Garbh-Ini Program?

    Central idea: The scientists working in the Garbh-Ini program have identified 19 single nucleotide polymorphisms (SNPs) or genetic markers that are associated with preterm or premature birth.

    What is Garbh-Ini?

    • It is an interdisciplinary research program in India that focuses on the advanced research of birth outcomes.
    • It is a collaborative initiative under the Department of Biotechnology.
    • It is led by DBT-Translational Health Science and Technology Institute (THSTI) in the NCR Biotech cluster, Faridabad, in collaboration with DBT-NIBMG, Kalyani, DBT-Regional Centre for Biotechnology (RCB), Gurugram Civil Hospital, and other organizations.
    • The program aims to use advanced technology to improve maternal and child health outcomes and address the high incidence of preterm births in India.

    What are Single Nucleotide Polymorphisms (SNPs)?

    • Genetic markers are specific sequences of DNA that can be used to identify an individual or a particular trait.
    • Single nucleotide polymorphisms (SNPs) are the most common type of genetic variation that occurs in the DNA sequence.
    • SNPs occur when a single nucleotide (A, C, T, or G) in the DNA sequence is altered.
    • These changes can occur in any region of the genome and can be used as genetic markers to identify specific traits or disease susceptibility.

    Significance of the Study

    • The study is significant as it identifies 19 SNPs or genetic markers that are associated with preterm or premature birth.
    • Out of these 19 SNPs, five were found to be associated with an increased risk of early preterm birth (birth before 33 weeks) and can be used to predict premature births.
    • This is the first study in South Asia to identify genetic markers associated with preterm births, and it has significant implications for improving maternal and child health outcomes in India.

     

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  • Centre gives nod for National Quantum Mission (NQM)

    quantum

    Central idea: The Union Cabinet has approved the National Quantum Mission (NQM) with a budget of ₹6,003 crore. The mission aims to fund research and development in quantum computing technology and associated applications.

    What is Quantum Computing?

    Explanation
    What is it? A type of computing that uses quantum-mechanical phenomena to perform operations on data.
    Qubits Quantum bits, which can be 0, 1, or both simultaneously (a superposition of 0 and 1).
    Computational speed It can perform certain calculations much faster than traditional computing, especially for complex algorithms and large amounts of data.
    Entanglement The use of entanglement allows quantum computing to process multiple pieces of data simultaneously, further increasing computational power.
    Research Governments, universities, and private companies around the world are researching quantum computing.
    Challenges Building practical quantum computers is a major challenge due to the fragility of qubits and the difficulty of controlling and measuring them accurately.
    Development stage Quantum computing is still in its early stages of development.

     

    National Quantum Mission (NQM)

    Mission duration 2023-2031
    Total cost Rs. 6,003.65 crore
    Leading Department Department of Science and Technology (DST)
    Supporting departments Other government departments
    Focus Development of physical qubit-based quantum computers
    Applications Healthcare and diagnostics, defense, energy, and data security
    India’s positioning Among the top six nations involved in quantum research and development

     

    Key focus areas

    (1) Thematic Hubs

    • The mission will be structured around four broad themes:
    1. Quantum Computing,
    2. Quantum Communication,
    3. Quantum Sensing and Metrology, and
    4. Quantum Material and Devices.
    • Thematic hubs will be established at research institutes and R&D centres already working in the field.
    • The effort is to create an ecosystem that favours quantum technology development in the country.

    (2) Satellite-based Communication

    • One of the key areas of focus for the NQM will be the development of satellite-based secure communication between ground stations and receivers located within a 3,000 km range over the first three years.
    • NQM will lay communication lines using Quantum Key Distribution over 2,000 km for satellite-based communication within Indian cities.
    • Tests will be conducted in the coming years for long-distance quantum communication, especially with other countries.

    (3) Quantum Computing

    • The mission will focus on developing quantum computers (qubit) with physical qubit capacities ranging between 50 – 1000 qubits, developed over the next eight years.
    • The development of computers up to 50 physical qubits will take three years.
    • 50 – 100 physical qubits will be developed in five years, and computers up to 1000 physical qubits will be developed in eight years.

    Applications

    • The mission would have a wide range of applications, including in healthcare and diagnostics, defense, energy, and data security.
    • Quantum technologies are expected to be far more powerful than traditional computing systems and capable of performing the most complex problems in a highly secure manner.

    Various challenges

    • Sub-zero temperatures: Current prototype systems require extremely cold (close to -273 C) conditions to work, along with developing the materials capable of such computations.
    • Still evolving: Quantum computers are still a work in progress globally, and no one has built a practical computer that can actually work and solve meaningful problems.
    • No global breakthrough: IBM, D-Wave of Canada or China’s Zuchongzhi 2.1, all of whom have prototype systems, have not built a quantum computer that can solve a problem that anybody cares about.

    Conclusion

    • The NQM represents a significant step forward for India’s research and development efforts in the quantum technology sector.
    • By focusing on the development of quantum computers and related technologies, the country is positioning itself as a key player in this field, with wide-ranging applications across multiple sectors.

     

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  • How Web3 differs from Web2?

    web

    Central idea: The article discusses the key features of Web3, including its decentralized nature, peer-to-peer transactions, and greater control over data and digital assets for users.

    What is Web3?

    • Web3, also known as Web 3.0, is the next generation of the World Wide Web that emphasizes decentralization, security, and user privacy.
    • It is essentially a vision of the internet where users have more control over their data, identities, and online interactions.
    • It is built on blockchain technology, which enables peer-to-peer transactions without the need for intermediaries such as banks, governments, or other third parties.
    • This decentralized approach to the web allows for greater transparency and trust, as well as more secure and private transactions.
    • Web3 technologies include blockchain platforms like Ethereum, IPFS (InterPlanetary File System) for distributed file storage, decentralized identity systems like uPort, and decentralized marketplaces like OpenBazaar.

    Features of Web 3

    Feature

    Web3

    Web2

    Centralisation

    		 Decentralised Centralised

    Intermediaries

    		 Peer-to-peer Rely on intermediaries

    Data ownership and control

    		 Users have control Large corporations have control

     

    Challenges for Web3:

    Challenge

    Scalability

    		 Current blockchain infrastructure can only handle a limited number of transactions per second.

    User Adoption

    		 Despite being around for over a decade, blockchain technology is still relatively unknown to the general public.

    Interoperability

    		 Web3 is being developed by different organisations, each with their own unique vision for the technology, leading to challenges in integration.

    Complexity

    		 Technical expertise is required to use and understand Web3, which may be a barrier for some users.

     

    Examples of Web3 use:

    Use

    Cryptocurrencies

    		 Built on blockchain technology, cryptocurrencies enable secure, decentralised transactions without the need for intermediaries.

    Decentralised Finance

    		 Aims to build a new financial system on top of blockchain technology. DeFi applications enable users to borrow, lend, and trade crypto.

    Decentralised storage

    		 Used to create decentralised social networks and develop decentralised identity verification systems.

     

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  • Indian scientists identify and probe EMIC waves

    emic

    Central idea

    • Scientists working at the Indian Antarctic Station, Maitri, have identified and probed Electromagnetic Ion Cyclotron (EMIC) waves to study their characteristics.
    • The study aims to understand the impact of energetic particles in the radiation belts on low orbiting satellites.

    About Indian Antarctic Station, Maitri

    Description
    Name Maitri Antarctic Station (Friendship Research Centre)
    Establishment 1984
    Location Schirmacher Oasis, East Antarctica
    Distance from other stations 5 km away from Novolazarevskaya Station
    Purpose Conducting scientific research as part of the Indian Antarctic Programme
    Features Second permanent research station of India in Antarctica
    Named by Then-PM Indira Gandhi
    First camp commander Squadron Leader D.P. Joshi
    First huts Completed in 1989 by the IV Antarctica Expedition

     

    What are EMIC Waves?

    • Electromagnetic Ion Cyclotron (EMIC) waves are a type of plasma wave that occurs in the Earth’s magnetosphere.
    • They are caused by the interaction of energetic particles in the radiation belts with the Earth’s magnetic field.
    • These waves have frequencies in the range of a few hundred hertz to a few kilohertz and are known to play an important role in the acceleration and loss of energetic particles in the Earth’s magnetosphere.
    • The study of EMIC waves is important for understanding the effects of space weather on satellite communication and navigation systems.

    Identification and study of EMIC waves

    • A team of scientists from the Indian Institute of Geomagnetism (IIG) analysed data collected between 2011 and 2017 by the Induction Coil Magnetometer.
    • The device was installed at the Indian Antarctic station Maitri to bring out several aspects of the ground observation of the EMIC waves.

    Significance of the study

    • This study is important to improve our understanding of EMIC wave modulation and how they interact with energetic particles that impact satellites and their communication.
    • It could help understand the impact of energetic particles in the radiation belts on low orbiting satellites and lead to improved satellite communication systems.

    Back2Basics:  Indian Antarctic Programme

    • It is a scientific program run by the National Centre for Antarctic and Ocean Research under the Ministry of Earth Sciences.
    • It was launched in 1981 and since then India has been operating research stations in Antarctica.
    • It gained global acceptance with India’s signing of the Antarctic Treaty and subsequent construction of the Dakshin Gangotri Antarctic research base in 1983, superseded by the Maitri base from 1989.
    • The program conducts research in areas such as geology, oceanography, atmospheric sciences, and earth sciences.
    • India currently operates two permanent research stations in Antarctica – Maitri and Bharati.
    • The program also has plans to set up a third research station called ‘Siddhanta’ in the coming years.
    • Apart from conducting research, the program also engages in logistics support, environmental monitoring, and outreach activities.

     

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  • Plant ‘cries’: Recalling Jagadish Chandra Bose

    bose

    Central idea

    • A recent discovery by researchers from Tel Aviv University in Israel, that plants make distinct sounds in the ultrasonic range when faced with stress, made headlines around the world.
    • However, Indians who had grown up hearing about Jagadish Chandra Bose’s work, more than a century ago, on plant physiology and their ability to feel pleasure and pain, were not surprised.

     

    Details
    Who was JC Bose? – Born in 1858 in Mymensingh, Bengal.

    – A polymath who made significant contributions to physics, biophysics, and plant physiology

    – Graduated from Calcutta University with honors in physics and studied in London and Cambridge.
    Notable works – Developed sensitive instruments for wireless telegraphy and demonstrated the first-ever wireless transmission of microwaves in 1895.

    – Showed that plants produce electrical signals in response to stimuli and made significant contributions to biophysics.
    Recognition & Controversy – Despite his contributions, he was not awarded a Nobel Prize, which many believe he deserved.

    – Refused to obtain patents for his work and rejected the idea of making money from science.

    – Claimed that even inanimate inorganic matter could respond to stimulus and regarded plants as intermediates in a continuum between animals and non-living materials, which was not easily accepted by his contemporaries.
    Legacy and Significance – Founded the Bose Institute, a premier research institute in India.

    – The crater Bose on the Moon is named after him.

    – Regarded as one of India’s greatest scientists, and his legacy continues to inspire future generations of scientists.
    Significance – Bose’s work on plant physiology and biophysics was ahead of his time and not fully understood by his contemporaries.

    – However, over the years, much of his work has been confirmed.

     

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