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  • Food Safety Standards – FSSAI, food fortification, etc.

    Decline in Food Safety Standards across India: A Closer Look

    DOMR | Economics | Mains Paper 3: Food Processing & Related Industries In India

    food safety

    Central Idea

    • Four years after the Food Safety and Standards Authority of India (FSSAI) introduced a state-wise index to encourage improvements in food safety, alarming trends have emerged.
    • A significant number of large Indian states have witnessed a drop in their food safety scores in 2023 compared to 2019.
    • This analysis delves into the details of these findings, highlighting the key parameters, their weights, and how the states fared.

    Understanding the State Food Safety Index (SFSI)

    • FSSAI has developed the State Food Safety Index to measure the performance of states on various parameters of Food Safety.
    • It was first rolled in 2018-19.
    • This index is based on the performance of the State/ UT on five significant parameters set by the Health Ministry, namely
    1. Human Resources and Institutional Data
    2. Compliance
    3. Food Testing – Infrastructure and Surveillance
    4. Training & Capacity Building and
    5. Consumer Empowerment
    • In 2023, a new parameter, ‘Improvement in SFSI Rank,’ was added, altering the weightages of existing parameters to maintain a total score of 100.
    • The Index is a dynamic quantitative and qualitative benchmarking model that provides an objective framework for evaluating food safety across all States/UTs.

    Highlights of the 2023 Report

    [A] Steepest Decline in Scores:

    • Maharashtra: Witnessed the most significant drop, with a score of 45 in 2023 compared to 74 in 2019.
    • Bihar: Scored 20.5 in 2023, down from 46 in 2019.
    • Gujarat: Recorded a score of 48.5 in 2023, a sharp decline from 73 in 2019.

    [B] Key Parameter Findings:

    • Food Testing Infrastructure: Witnessed the most substantial decline, with the average score dropping to 7 out of 17 in 2023 from 13 out of 20 in 2019.
    • Compliance: Received the highest weightage in 2023 but experienced a drop in scores for states like Jharkhand, Punjab, Himachal Pradesh, Madhya Pradesh, and Bihar.
    • Consumer Empowerment: Scored the highest in Tamil Nadu, while Bihar saw a significant decrease in this parameter.
    • Human Resources and Institutional Data: Experienced a decline in scores for states like Tamil Nadu and Uttar Pradesh.
    • Training and Capacity Building: Recorded an improvement, with the average score increasing to 5 out of 8 in 2023 from 3.5 out of 10 in 2019.

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  • Climate Change Negotiations – UNFCCC, COP, Other Conventions and Protocols

    CBAM will kill EU Manufacturing: Commerce Minister

    IOCR | Enviro & Biodiversity | Mains Paper 1: Important Geophysical Phenomena

    cbam

    Central Idea

    • Commerce and Industry Minister has strongly criticized the European Union’s (EU) proposed Carbon Tax on imports, deeming it “ill-conceived” and warning of potential consequences for the EU’s manufacturing sector.
    • He asserted that even if the plan, set to take effect in 2026, proceeds, India will counter it by imposing its own carbon tax.

    What is the Carbon Border Adjustment Mechanism (CBAM)?

    Proposed by European Union (EU)
    Purpose To reduce carbon emissions from imported goods and prevent competitive disadvantage against countries with weaker environmental regulations
    Objectives Reduce carbon emissions from imported goods

    Promote a level playing field between the EU and its trading partners

    Protect EU companies that have invested in green technologies

    How does CBAM work?

    Coverage Applies to imported goods that are carbon-intensive
    Integration Covered by the EU’s Emissions Trading System (ETS), which currently covers industries like power generation, steel, and cement
    Implementation CBAM taxes would be imposed on the carbon content of imported goods at the border, and the tax rates would be based on the carbon price in the EU ETS
    Exemptions Possible exemptions for countries that have implemented comparable carbon pricing systems
    Revenue Use Revenue generated from CBAM taxes could be used to fund the EU’s climate objectives, such as financing climate-friendly investments and supporting developing countries’ climate efforts

    Who will be affected by CBAM?

    Details
    Countries Non-EU countries, including India, that export carbon-intensive goods to the EU
    Items Initially covers iron and steel, cement, aluminium, fertilisers, and electric energy production
    Expansion The scope of the CBAM may expand to other sectors in the future

    Advantages offered

    • Encourages non-EU countries to adopt more stringent environmental regulations, reducing global carbon emissions.
    • Prevents carbon leakage by discouraging companies from relocating to countries with weaker environmental regulations.
    • Generates revenue that could be used to support EU climate policies.

    Challenges with CBAM

    • Difficulty in accurately measuring the carbon emissions of imported goods, especially for countries without comprehensive carbon accounting systems.
    • Potential for trade tensions with the EU’s trading partners, especially if other countries implement retaliatory measures.

    Consequences for EU Manufacturing

    • Auto Sector Impact: The minister suggested that the European auto sector could be one of the first casualties, particularly affecting steel and aluminum usage.
    • Opportunity for India: Goyal saw this as an opportunity for India to develop a robust auto sector, leveraging cost advantages in the global market.

    India’s Response and Carbon Tax Strategy

    • Counteractive Measures: India intends to neutralize the impact of the EU’s carbon tax by imposing its own.
    • Investing in Green Energy: Revenue from the Indian carbon tax would be channelled into the country’s green energy transition, which, indirectly, could help exporters transition to cleaner energy and reduce their carbon footprint.
    • Negotiations with EU: The government is engaged in dialogues with EU counterparts regarding the levy’s fairness and pricing disparities.

    Conclusion

    • The EU’s proposed Carbon Tax and India’s counterstrategy highlight the complexities of international trade, environmental concerns, and the potential consequences for various industries.
    • India’s strong stance underscores its commitment to safeguarding its economic interests while engaging in constructive negotiations with the EU to ensure a fair and mutually beneficial outcome.

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  • Innovation Ecosystem in India

    Lessons in how to build an innovation ecosystem

    op-ed snap | Science Tech | Mains Paper 3: Achievements Of Indians In S&T

    Central idea

    India’s innovation journey, seen in Global Innovation Index (GII) progress and Amul’s community success, faces challenges in maintaining Atal Tinkering Labs (ATLs). Collaborative clusters like ATL Sarthi highlight the need for a community-driven shift. The way forward involves community ownership, dialogue, and resource provision for continued success in innovation.

    Key Facts:

    • ATL Sarthi Impact: Over 90% of schools in clusters demonstrating high attendance and performance.
    • Green and White Revolutions: Past successes serving as inspiration for future triumphs.
    • ATL Utilization: Challenge of uniform and effective utilization addressed in the ATL Sarthi experiment.
    • Government Vision: Push towards liberating innovation and entrepreneurship from complex processes.

    Key Terms:

    • GII: Global Innovation Index, measuring a nation’s innovation capabilities.
    • ATL: Atal Tinkering Labs, fostering innovation in middle and high schools.
    • ATL Sarthi: Clusters of ATLs overseen by a guidance committee for efficiency.
    • Neoteric Innovators: Term defining students keeping pace with rapidly changing technology.

    Key highlights of India’s innovation landscape

    • GII Leap: From 81 to 40 India’s substantial improvement in the Global Innovation Index showcases a dedicated commitment to fostering innovation.
    • Community-Driven Success Lessons from Amul: Examining the cooperative model of Amul as a testament to the power of community-driven initiatives in achieving global milestones.
    • ATLs Nurturing the Next Generation Innovators : Understanding the role of Atal Tinkering Labs (ATLs) in cultivating a million “neoteric innovators” among middle and high school students.
    • Government’s Vision of Liberating Innovation and Entrepreneurship: Analyzing the impact of the government’s push towards liberating innovation and entrepreneurship from complex processes.

    Key Data:

    • GII Progress: India’s notable rise from 81 to 40 in the Global Innovation Index.
    • ATL Impact: Over 10,000 Atal Tinkering Labs (ATLs) engaging more than 75 lakh students.
    • Rural Emphasis: 60% of ATLs strategically located in rural areas.
    • ATL Sarthi Clusters: Implementation in states like Karnataka, Andhra Pradesh, and Jammu and Kashmir.

    Challenges in Innovation Infrastructure

    • Infrastructure Expansion: The challenge of efficiently expanding and maintaining the infrastructure of Atal Tinkering Labs (ATLs).
    • Rural-Urban Disparities: The disparities in ATL infrastructure between urban and rural areas, with 60% of ATLs located in remote regions.
    • Ensuring Effective Use of ATLs: The challenge of uniform and effective utilization of ATLs, particularly in schools facing economic and geographical constraints.
    • Innovation Hubs: The ATL Sarthi experiment, exploring the creation of clusters overseen by a guidance committee to enhance ATL efficiency.

    Way Forward

    • Unlocking Maximum Potential: Emphasizing the timeless lesson that community ownership is essential to unlock the maximum potential of government-led initiatives.
    • Green and White Revolutions Redux: Drawing parallels with past successes like the Green and White Revolutions, envisioning a similar triumph in the age of innovations.
    • Fostering Dialogue: Advocating for the importance of fostering dialogue between government bodies, schools, and communities for sustained success.
    • Resources and Support: Exploring the need for providing resources and support to communities, ensuring their active participation in the innovation ecosystem.

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  • India’s Bid to a Permanent Seat at United Nations

    Is the United Nations toothless in ending wars?

    op-ed snap | International Relations | Mains Paper 2: Bilateral, Regional and Global Groupings and agreements involving India

    Central idea 

    The article discusses the escalating conflicts in the Israel-Hamas and Russia-Ukraine situations, questioning the UN’s effectiveness in maintaining global peace. It highlights challenges such as the post-Cold War dilemma, erosion of the liberal order, and veto impasse, emphasizing the need for innovative conflict resolution mechanisms, UN reforms, and global public engagement to address the complexities in today’s geopolitical landscape.

    Key Highlights:

    • Escalating Conflicts: Israel-Hamas clashes intensify post-October 7 attack. Simultaneous Russia-Ukraine conflict adds global complexity.
    • Strategic Dialogue: Rakesh Sood and Vivek Katju discuss UN’s peacekeeping challenges. Moderated by Kallol Bhattacherjee, the dialogue addresses current geopolitical unrest.
    • Global Impact: UN’s role questioned in resolving modern conflicts. Increasing doubts about UN’s effectiveness in maintaining global peace.
    • Diverse Perspectives: Perspectives on the liberal international order and its alleged demise. Shift from unipolarity to multipolarity examined in the post-Cold War era.

    Challenges:

    • Post-Cold War Dilemma: Diminished UN conflict resolution post-Cold War. Major powers’ discord paralyzes UN decision-making.
    • Erosion of Liberal Order: Dispute over the existence of a liberal international rules-based order. Unipolar moment disappears by 2008, raising concerns.
    • Veto Impasse: UNSC’s efficacy hampered by veto powers. National interests obstruct addressing conflicts effectively.
    • Internal Israeli Complexities: Netanyahu’s divisive leadership influences Israel’s stance. Domestic protests and judicial reforms contribute to complexity.
    • Global Power Discord: Lack of consensus among major powers hinders UN efforts. Veto powers in the UNSC obstruct conflict resolution.
    • Nuances in Israel’s Approach: Israel’s response to Hamas extends beyond national security. Commitment to eliminating Hamas reflects deep resolve.
    • UN’s Passive Role: Criticism for UN’s passive role in recent conflicts. Major powers’ differences render the UN a bystander.
    • Shift to Multipolarity: Multipolarity after 2008 presents challenges. Multipolarity without multilateralism leads to chaos.

    Concerns:

    • Global Power Discord: Lack of consensus hinders UN’s conflict resolution. Veto powers impede the organization’s ability to act decisively.
    • Nuances in Israel’s Approach: Israel’s response to Hamas goes beyond national security. Commitment to eliminating Hamas reflects a profound resolve.
    • UN’s Passive Role: UN criticized for passive role in recent conflicts. Major powers’ differences render UN a bystander.
    • Shift to Multipolarity: Transition to a multipolar world after 2008 presents challenges. Multipolarity without effective multilateralism leads to chaos.

    Analysis:

    • Inert UN Dynamics: UN’s perceived ineffectiveness raises questions. Major powers’ disagreements cripple the UN’s active role.
    • Multipolarity Challenges: Emergence of a multipolar world introduces complexities. Lack of a new order suited for a multipolar world contributes to global unrest.
    • Strategic US Interventions: US interventions post-Cold War questioned for legitimacy. Iraq, Afghanistan, Mali, and Libya conflicts showcase UN’s limited role.
    • Dilemmas in Conflict Resolution: Complexities in resolving conflicts beyond traditional UN approaches. Calls for exploring alternative mechanisms acknowledging evolving geopolitical landscapes.

    Key Terms:

    • UN, Israel-Hamas conflict, Russia-Ukraine crisis, liberal international order, multipolarity, major powers, ceasefire.

    Way Forward:

    • Revamping Conflict Resolution: Urgency in exploring innovative conflict resolution mechanisms. Recognition of complexities beyond traditional UN paradigms in today’s geopolitical scenario.
    • India’s Global Role: Acknowledges India’s increasing global significance. Emphasizes the need for realistic expectations given the superior dynamics at play.
    • Multilateral Diplomacy: Strengthening multilateral diplomatic efforts for conflict resolution. Encouraging dialogue and cooperation among major powers to overcome discord.
    • UN Reforms: Advocating reforms in UN structures for increased agility. Addressing veto-related challenges to enhance the UN’s role in global peacekeeping.
    • Global Public Engagement: Fostering global public engagement in conflict resolution. Leveraging public sentiment to influence diplomatic decisions and encourage peaceful solutions.

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  • Climate Change Impact on India and World – International Reports, Key Observations, etc.

    Biosphere reserves are evolving as pockets of hope

    op-ed snap | Enviro & Biodiversity | Mains Paper 3: Conservation, Environmental Pollution & Degradation, Eia

    Central idea 

    World Biosphere Reserve Day on November 3 emphasizes the global importance of UNESCO-designated reserves in conserving biodiversity and mitigating climate change. With 748 reserves in 134 countries, challenges like deforestation persist, necessitating local collaboration, sustainable tourism, and international cooperation for effective conservation.

    Key Highlights:

    • World Biosphere Reserve Day: Annual celebration on November 3 to raise awareness and promote the conservation of biosphere reserves.
    • UNESCO Designation: Biosphere reserves designated by UNESCO for biodiversity conservation, sustainable development, and research.
    • Global Impact: 748 biosphere reserves in 134 countries, influencing the lives of over 250 million people.
    • Transboundary Collaboration: 22 transboundary sites fostering cooperation between neighboring countries.

    Key Organizations:

    • UNESCO (United Nations Educational, Scientific and Cultural Organization): Initiator and supporter of the Man and the Biosphere (MAB) Programm Designates and recognizes biosphere reserves globally, promoting conservation and sustainable development.
    • United Nations Development Programme (UNDP): Collaborates with biosphere reserves to support sustainable development initiatives.
    • United Nations Environment Programme (UNEP): Engages in activities to enhance environmental sustainability within biosphere reserves.
    • International Union for Conservation of Nature (IUCN): Supports UNESCO in biodiversity conservation efforts and sustainable development.
      Prelims focus

      UNESCO MAB Award:

        • The Gulf of Mannar Biosphere Reserve Trust received the UNESCO Michel Batisse Award for Biosphere Reserve Management in 2023, recognizing exemplary efforts in conservation.

      Origin of Man and the Biosphere (MAB) Programme:

       

      Inception: Established by UNESCO (United Nations Educational, Scientific and Cultural Organization) in 1971.

      Inspiration: Evolved from the recommendations of the International Biological Programme (IBP), recognizing the need for a comprehensive approach to address the human-environment relationship.

      MAB’s Foundation: Launched during the 16th session of the UNESCO General Conference in 1971, with the primary goal of integrating natural and social sciences for sustainable development and biodiversity conservation.

      Key Drivers: Emerged as a response to growing concerns about the impact of human activities on the environment and the need for a coordinated effort to balance conservation and development.

       

       

    Challenges and Concerns:

    • Anthropogenic Pressures: Human-induced pressures on biosphere reserves, such as pollution, habitat destruction, and overexploitation, pose significant threats to biodiversity.
    • Climate Change Impact: The increasing impacts of climate change, including rising temperatures and extreme weather events, challenge the resilience of biosphere reserves and their ability to support diverse ecosystems.
    • Lack of Funding: Many biosphere reserves face financial constraints, hindering effective conservation efforts and the implementation of sustainable development projects. Adequate funding is crucial for long-term success.
    • Deforestation, invasive species, and land use changes like mining pose significant challenges.
    • Urbanization and population growth contribute to increased exploitation.

    Analysis:

    • Role as Carbon Sinks: Biosphere reserves play a crucial role as carbon sinks, absorbing carbon dioxide and contributing to climate change mitigation.
    • Economic and Biodiversity Significance: Provide a foundation for sustainable economic development and protect diverse biodiversity.

    Key facts:

    • World Biosphere Reserve Day: Celebrated on November 3 annually to raise awareness about biosphere reserves.
    • Biosphere Reserves Globally: Currently, 748 biosphere reserves across 134 countries.
    • Transboundary Sites: 22 transboundary biosphere reserve sites, fostering cooperation between neighboring countries.
    • Global Impact: Biosphere reserves impact the lives of over 250 million people in 134 countries.
    • Local Initiatives: Examples include the Sundarban Biosphere Reserve in India, where local communities manage mangrove forests, and the Gulf of Mannar Biosphere Reserve, introducing ‘plastic checkpoints’ for waste management.

    Key Terms:

    • Biosphere Reserves: Designated by UNESCO for conservation, sustainable development, and research.
    • Carbon Sinks: Areas like forests and the ocean that absorb carbon dioxide from the atmosphere.
    • World Biosphere Reserve Day: Annual celebration on November 3 to raise awareness about biosphere reserves.

    Way Forward:

    • Local Collaboration for Conservation: Emphasize the importance of local collaboration for effective conservation efforts. Encourage the active involvement of local communities in biodiversity protection and sustainable practices.
    • Addressing Specific Threats: Develop targeted strategies to address diverse threats such as deforestation, invasive species, and land use changes. Implement policies and practices that mitigate the impact of urbanization and population growth on biosphere reserves.
    • Promoting Sustainable Tourism: Encourage sustainable tourism practices within biosphere reserves to minimize negative environmental impacts. Educate tourists and local communities about responsible tourism to ensure the long-term well-being of these ecosystems.
    • International Cooperation: Strengthen international cooperation for the conservation of transboundary biosphere reserves. Facilitate knowledge exchange and collaborative initiatives to address global environmental challenges.

    This World Biosphere Reserve Day serves as a crucial moment to reflect on the significance of these natural treasures and the collective responsibility to ensure their preservation for future generations.

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  • Indian Ocean Power Competition

    Isthmus of Kra Land Bridge Project

    Prelims Only | International Relations | Mains Paper 2: Bilateral, Regional and Global Groupings and agreements involving India

    Isthmus of Kra

    Central Idea

    • Thailand, with its distinctive geography resembling a plume of smoke rising from the sea, is considering a bold and historic project – the creation of an Isthmus of Kra Land Bridge.
    • This project aims to revolutionize global trade routes and significantly impact Thailand’s economy.

    About the Isthmus of Kra

    Details
    Location Southern Thailand, separating the Malay Peninsula
    Width Approximately 44 km
    Geographic Features Connects Andaman Sea (west) to South China Sea (east)
    Strategic Importance Historical trade route; potential shortcut for maritime trade

     

    The Land Bridge Project: A Historical Dream

    • Centuries-Old Idea: The dream of connecting Thailand’s two coasts across the Isthmus of Kra dates back to King Narai the Great of the Ayutthaya Kingdom in 1677.
    • Early Efforts: British and French colonial interests led to surveys and studies in the 19th century to create a maritime channel through the isthmus.
    • Modern Proposal: In 2021, Thailand introduced a new proposal, envisioning a land bridge instead of a canal.

    Current Vision

    • Reducing Shipping Distance: Thai PM envisions a 90-kmland bridge with road and rail networks, connecting deep-sea ports on both coasts.
    • Strait of Malacca Alternative: This project could offer a shorter, safer, and cost-effective route, saving approximately 1,200 km and 2 to 3 days of travel compared to the congested Strait of Malacca.
    • Economic Benefits: It aims to stimulate economic growth, create jobs, and reduce transport time, benefiting Thailand’s economy and its position in Southeast Asia.

    Conclusion

    • Thailand’s proposal to create an Isthmus of Kra Land Bridge reflects its ambition to redefine global trade routes, boost its economy, and strengthen its role in Southeast Asia.
    • While financial, geopolitical, and environmental challenges loom large, this project symbolizes Thailand’s determination to shape its future on the world stage.

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  • Festivals, Dances, Theatre, Literature, Art in News

    Gwalior, Kozhikode join UNESCO Creative Cities Network

    Prelims Only | History | Mains Paper 1: Arts & Culture

    creative cities

    Central Idea

    • Gwalior and Kozhikode from India are among the 55 new cities which have joined the UNESCO Creative Cities Network.
    • Earlier, Srinagar was designated the creative city in the field of Crafts and Folk Arts.

    Inclusion in the UNESCO Creative Cities Network

    [A] Gwalior’s Musical Heritage

    • Category: Gwalior, located in Madhya Pradesh, earned its spot in the ‘Music’ category, showcasing its rich musical heritage.
    • Cultural Significance: Gwalior, home to the Gwalior Gharana and synonymous with musicians like Baiju Bawra and Tansen was acknowledged for being a popular destination for learning Indian classical music from musicians in the Guru-Shishya Parampara.

    [B] Kozhikode’s Literary Excellence

    • Category: Kozhikode, situated in Kerala, made its mark in the ‘Literature’ category, highlighting its literary achievements.
    • Literary Legacy: Kozhikode carried the distinction of of being home to over 500 libraries.

    About UNESCO Creative Cities Network

    Purpose To promote cooperation among cities for cultural and creative industries development
    Initiation Established by UNESCO in 2004
    Seven Categories Design, Film, Gastronomy, Literature, Media Arts, Music, and Crafts & Folk Art
    Member Cities Over 250 cities from around the world
    Objectives Foster innovation, cultural diversity, and sustainable urban development
    Activities Collaborative projects, cultural events, and initiatives
    Selection Process Cities apply and are designated by UNESCO based on criteria related to creativity
    Network Coordination UNESCO provides coordination and support
    Impact Enhances cities’ cultural identity, economy, and international visibility
    Other Indian Cities in UCCN
    • Srinagar- Crafts and Folk Arts (2022)
    • Jaipur- Crafts and Folk Arts (2015)
    • Varanasi- Creative city of Music (2015)
    • Chennai- Creative city of Music (2017)
    • Mumbai- Film (2019)
    • Hyderabad- Gastronomy/Food (2019)

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  • Innovations in Biotechnology and Medical Sciences

    NexCAR19: India’s own CAR-T Cell Therapy

    Prelims Only | Science Tech | Mains Paper 3: Achievements Of Indians In S&T

    car-t cart cell therapy

    Central Idea

    • India has achieved a significant milestone in the field of cancer treatment with the approval of NexCAR19, its first indigenous CAR-T Cell Therapy, by the Central Drugs Standard Control Organisation (CDSCO).
    • Developed by ImmunoACT, an incubated company of IIT Bombay, NexCAR19 is set to transform cancer treatment in India and make it more affordable.

    What is CAR-T Cell Therapy?

    • Revolutionary Approach: CAR-T cell therapy involves modifying T-cells, a type of white blood cell, into potent cancer-fighting cells.
    • Targeting Cancer: These genetically enhanced cells are reintroduced into the patient’s body, where they identify and eliminate cancer cells, particularly effective against blood cancers like leukemia and lymphomas.
    • Game-Changer: Unlike chemotherapy or immunotherapy, CAR-T therapy offers the potential for a cure and lifelong benefits, making it a transformative treatment option.

    NexCAR19: India’s Indigenously Developed CAR-T Therapy

    • NexCAR19 is designed to target cancer cells carrying the CD19 protein, a marker on cancer cells, enhancing precision in treatment.
    • India joins a select group of nations with its own CAR-T and gene therapy platform, reducing dependence on imports.
    • Initially approved for patients aged 15 and above with B-cell lymphomas who did not respond to standard treatments, leading to relapse or recurrence.

    Effectiveness and Unique Features

    • Approximately 70% of patients respond to NexCAR19 treatment, with some achieving complete remission.
    • Lab and animal studies indicate lower drug-related toxicities, including reduced neurotoxicity and Cytokine Release Syndrome (CRS).
    • Trials for paediatric patients are underway at Tata Memorial Hospital, ensuring broader applicability.

    Availability and Affordability

    • ImmunoACT is in the process of securing licenses and partnering with hospitals, including Tata Memorial, Nanavati, Fortis, and Jaslok, across multiple cities.
    • CAR-T therapy is expected to be available in a matter of weeks to a few months, pending final government approvals.
    • Initially priced at Rs 30-40 lakh, ImmunoACT aims to eventually reduce the cost to Rs 10-20 lakh, making the therapy more accessible.
    • Approval by regulatory agencies like CDSCO should lead to insurance coverage, but the extent may vary, and discussions with insurers and the government are ongoing.

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  • Innovations in Biotechnology and Medical Sciences

    Haemoglobin isn’t used only in Blood: Scientists

    Prelims Only | Science Tech | Mains Paper 3: Awareness in various sc and tech fields

    Haemoglobin

    Central Idea

    • A groundbreaking study published in Nature has unveiled an unexpected revelation: haemoglobin is not exclusive to RBCs.
    • Scientists from China have discovered that chondrocytes, the cells responsible for cartilage production, also produce haemoglobin, which appears vital for their survival.
    • For decades, textbooks have taught that haemoglobin resides solely in red blood cells (RBCs), responsible for making blood red and transporting oxygen.
    Cartilage: A tough, flexible connective tissue found throughout the human body, providing structural support and reducing friction between bones.

    About Haemoglobin

    Fact Description
    Definition A protein found in red blood cells that transports oxygen from the lungs to tissues and organs.
    Molecular Structure Composed of four subunits: two alpha-globin chains and two beta-globin chains.
    Iron-Binding Each subunit contains an iron atom that binds to oxygen, forming oxy-hemoglobin.
    Oxygen Transport Carries oxygen from the lungs to tissues and releases oxygen for cellular respiration.
    Color Gives red blood cells their red color when oxygenated and appears bluish when deoxygenated.
    Carbon Dioxide Transport Aids in transporting carbon dioxide and hydrogen ions from tissues back to the lungs for exhalation.
    Hemoglobin Variants Different types of hemoglobin, with HbA being the most common. Variants can result from genetic mutations.
    Hemoglobin Levels Vary by individual and are measured in grams per deciliter (g/dL). Normal levels range from 12 to 18 g/dL.
    Hemoglobin Disorders Genetic disorders like sickle cell disease and thalassemia are characterized by abnormal hemoglobin production.
    Iron Metabolism Adequate iron levels are essential for hemoglobin synthesis. Iron is a key component of heme in hemoglobin.
    Fetal Hemoglobin Fetal hemoglobin (HbF) has a higher oxygen affinity and aids in oxygen transfer from mother to fetus.
    Hemoglobin Tests Used for diagnosing anemia, assessing health, and monitoring medical conditions.
    Oxygen Saturation Measured as the percentage of hemoglobin molecules bound to oxygen, often using a pulse oximeter.

    New Breakthrough: Haemoglobin Bodies (Hedy)

    • Pathologists in China researching bone development, stumbled upon spherical structures resembling RBCs within chondrocytes.
    • These structures, termed “haemoglobin bodies” or Hedy, contained haemoglobin and formed large, membraneless blobs, akin to phase separation in oil and water.

    Functionality of Hedy

    • Essential for Survival: Experiments on genetically modified mice revealed that chondrocytes without haemoglobin experienced cell death, emphasizing Hedy’s vital role.
    • Oxygen Transport: Similar to RBCs, haemoglobin in chondrocytes likely serves as an oxygen store and supplier, preventing hypoxic stress (low-oxygen conditions) in cartilage cells.

    Haemoglobin’s Broader Implications

    • New Research Avenues: The discovery bridges gaps between haematology and skeletal biology, paving the way for further exploration into the relationship between haemoglobin and stem cell fate in growth plates.
    • Potential for Joint Disease Insights: Functional haemoglobin in cartilage raises possibilities of its involvement in joint diseases and bone deformities, offering fresh insights into disease mechanisms.

    Try this PYQ:

    Excessive release of the pollutant carbon monoxide (CO) into the air may produce a condition in which oxygen supply in the human body decrease. What causes this condition?

    (a) When inhaled into the human body, CO is converted into CO2

    (b) The inhaled CO has much higher affinity for haemoglobin as compared to oxygen

    (c) The inhaled CO destroys the chemical structure of hemoglobin

    (d) The inhaled CO adversely affects the respiratory center in the brain

     

    Post your answers here.

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  • Electoral Reforms In India

    SC flags Selective Confidentiality in Electoral Bonds

    SC JudgementsSchemes | Governance | Mains Paper 2: Governance, Transparency & Accountability, Citizens Charters

    Electoral Bonds

    Central Idea

    • The Supreme Court expressed concerns about the selective confidentiality of the electoral bonds scheme, which allows the ruling party to discover the identities of donors to opposition parties.
    • The court questioned the government’s presumption of confidentiality and explored the potential disadvantages faced by opposition parties in the electoral process.

    About Electoral Bond Scheme

    Definition Banking instruments for political party donations with donor anonymity.
    Purchase Method Available to Indian citizens and Indian-incorporated companies from select State Bank of India branches. Can be bought digitally or via cheque.
    Donation Process Purchasers can donate these bonds to eligible political parties of their choice.
    Denominations Available in multiples of ₹1,000, ₹10,000, ₹10 lakh, and ₹1 crore.
    KYC Requirements Purchasers must fulfill existing KYC norms and pay from a bank account.
    Lifespan of Bonds Bonds have a 15-day life to prevent them from becoming a parallel currency.
    Identity Disclosure Donors contributing less than ₹20,000 need not provide identity details like PAN.
    Redemption Electoral Bonds can be encashed only by eligible political parties through an Authorized Bank.
    Eligibility of Parties Only parties meeting specific criteria, including securing at least 1% of votes in the last General Election, can receive Electoral Bonds.
    Restrictions Lifted Foreign and Indian companies can now donate without disclosing contributions as per the Companies Act.
    Objective To enhance transparency in political funding and ensure funds collected by political parties are accounted or clean money.

    Selective Confidentiality Challenges

    • Justice Khanna’s Address: The Judge pointed out that the ruling party had easier access to information about contributions to opposition parties, creating an imbalance in transparency.
    • State Bank of India’s Role: CJI Chandrachud questioned whether the SBI, through which electoral bonds were purchased, had a statutory obligation to maintain confidentiality.

    Government’s Defense

    • Confidentiality Key: The solicitor-General argued that confidentiality regarding donor identities and contributions was crucial to the electoral bonds scheme. He contended that eliminating the scheme would revert the country to a period when political donations were made in unaccounted cash, leading to black money circulation.
    • Economic Impact: He emphasized that the scheme aimed to channel clean money into the electoral system, reducing the influence of black money. He referred to a report highlighting the increase in income from unknown sources to political parties and the discovery of shell companies during the previous donation regime.

    Concerns Raised by CJI

    • Information Blackhole: The CJI noted that while the scheme aimed to bring white money into the electoral process, it introduced opacity, creating an “information blackhole.” He emphasized the need for proportionality in achieving the scheme’s objectives.
    • Expectations of Donors: Chandrachud questioned how substantial donations were consistently made to the ruling party, implying certain expectations from donors.
    • Donations Not Charity: Solicitor-General Mehta clarified that donors were primarily motivated by their own interests, often related to business or market-driven factors. He argued that larger donations to a party did not necessarily indicate an issue with the scheme.
    • Right to Privacy: Mehta argued that revealing the political affiliations of donors would infringe on their right to privacy.

    Transparency and Quid Pro Quo Concerns

    • Justice Khanna’s Query: Justice Khanna raised concerns about how confidentiality in the electoral bonds scheme could prevent quid pro quo arrangements between political parties and donors.
    • Proxy Donations: The judge questioned the possibility of parties funneling unaccounted money back into the system through proxy political donations.

    Conclusion

    • The Supreme Court’s scrutiny of the electoral bonds scheme centers on issues of transparency, confidentiality, and potential imbalances in the electoral process.
    • The court’s questions and concerns highlight the importance of ensuring fairness and proportionality in political funding mechanisms.

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