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New Species of Plants and Animals Discovered

Kerala bans Oleander Flowers in Temple Offerings

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Oleander Flowers

Why in the news?

Kerala temple authorities have banned the use of oleander flowers in offerings following the accidental poisoning of a woman who chewed oleander leaves.

What is Oleander?

  • Nerium oleander, commonly known as oleander or rosebay, is a plant cultivated worldwide in tropical, subtropical, and temperate regions. 
  • Known for its drought tolerance, the shrub is often used for ornamental and landscaping purposes.
  • In Kerala, it’s called arali or kanaveeram and is used for natural fencing along highways and beaches.
  • According to the IUCN Red List, Nerium oleander (Oleander) is classified as Least Concern

Traditional Medicinal Uses:

  • Termed as “desert rose” in ancient texts, oleander has been trusted with its medicinal properties such as a hangover cure, in cancer treatments, and as an antiviral.
  • The Ayurvedic Pharmacopoeia of India mentions oleander, particularly the use of oil from the root bark to treat skin diseases.
  • oleander’s use in treating skin diseases, leprosy, wounds, itching, and parasites.

Toxicity of Oleander:

  • Oleander is highly toxic due to cardiac glycosides present in all parts of the plant.
  • Cardiac glycosides like oleandrin and digitoxigenin exert pharmacological effects on the heart, leading to nausea, vomiting, irregular heartbeat, and, in severe cases, death..

PYQ:

[2018] Why is a plant called Prosopis Juliflora often mentioned in the news?

(a) Its extract is widely used in cosmetics

(b) It tends to reduce the biodiversity in the area in which it grow

(c) Its extract is used in the synthesis of pesticides

(d) None of the above

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[10 May 2024] The Hindu Op-ed: The message from U.S. campuses, protesting students

Mains PYQ Relevance: 

Q)“The diverse nature of India as a multi-religious and multi-ethnic society is not immune to the impact of radicalism which is seen in her neighbourhood? Discuss along with strategies to be adopted to counter this environment. (UPSC IAS/2014)

Q) Critically examine the aims and objectives of SCO. What importance does it hold for India?. (UPSC IAS/2021)

Note4Students: 

Subject: GS II (IR)

Prelims: International issues in the news;

Mains: Islamophobia and Anti-Palestinian Racism;

Mentor comments: In 1985, when American campuses were roiling with protests against apartheid South Africa, the legendary African-American feminist poet and philosopher, Audre Lorde, reflected that America was “the most powerful country in the world” but also “a country which stands upon the wrong side of every liberation struggle on earth”. Lorde noted that this filled her with both a sense of dread and a sense of urgency. Dread and urgency, once again, have driven students across campuses in the United States to protest against the catastrophe in Gaza. During the anti-apartheid protests calling for divestment at campuses in the late 1980s — when we were students — university administrators were embarrassed about aligning with the White apartheid state of South Africa. 

Let’s learn

Why in the news? 

Today, with Islamophobia and anti-Palestinian racism so normalized in the U.S., university administrators are proudly aligning with this genocidal war. 

What is Islamophobia and Anti-Palestinian racism?

  • Islamophobia is a form of racism that targets expressions of Muslimness or perceived Muslimness, rooted in racism and involving stereotypes, demonization, and dehumanization of Muslims
  • Anti-Palestinian racism, on the other hand, refers to prejudice, collective hatred, and discrimination directed at the Palestinian people, including silencing, exclusion, erasure, stereotypes, defamation, and dehumanization of Palestinians or their narratives

Student’s protest in the USA:

  • Unified Demands: Student protesters have a unified set of demands, including disclosure and divestment from corporations complicit in the Israeli occupation of Palestine, removal of police from campuses, and protection of pro-Palestinian speech and activism.
    • The call for divestment can be traced back to the Boycott, Divestment, and Sanctions (BDS) movement inspired by the anti-apartheid student movement. The demand for “cops off campus” reflects abolitionist critiques of police as a racist institution, amplified after the George Floyd protests.
  • Education and Activism: Students are educating each other on the history of the Levant, colonialism, racial violence, and the complexities of historic Palestine. They organize teach-ins, study apartheid, analyze the political economy of occupation, and explore Palestinian resistance.
  • University Clampdowns: Many university administrators have instituted disciplinary procedures against pro-Palestine solidarity and activism, banned student organizations, and intensified surveillance and crackdowns on protests.
    • Despite repression, student protests have proliferated, and peaceful encampments have spread to campuses across the country, challenging the complicity of universities in colonialism and imperialism.
  • Intersectional Solidarity: The movement is shaped by other social justice movements like Black Lives Matter and Standing Rock, highlighting connections between racialized police brutality, settler colonialism, and imperialism.
  • Resistance against Repression: Students risk suspensions and arrests to expose and disrupt the ideological and economic ties that bind universities to forces of genocide, inspired by struggles in historic Palestine.

Significance and Impact of the Student’s Protest::

  • Raising Awareness: By organizing teach-ins and spreading information about the history of the Levant, colonialism, and racial violence, these protests can educate people and raise awareness about the plight of Palestinians and the broader issues of imperialism and colonialism.
  • Challenging normalization of Islamophobia and anti-Palestinian: By challenging the normalization of Islamophobia and anti-Palestinian racism, these protests can disrupt the status quo and push for a reevaluation of societal attitudes towards these issues.
  • Inspiring Solidarity: The intersectional nature of these protests, where movements like Black Lives Matter and Standing Rock are involved, can foster solidarity among different marginalized communities and strengthen the broader social justice movement.
  • International Impact: These protests, especially if they gain widespread attention and support, could influence international perceptions and policies towards the Israeli-Palestinian conflict, potentially leading to increased pressure on governments to take action towards a just resolution.

Conclusion: University administrators should engage in open dialogue with protesting students to address their concerns and explore potential solutions. This could involve creating forums for discussion, establishing student-administrator committees, and actively listening to student perspectives.

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Minority Issues – SC, ST, Dalits, OBC, Reservations, etc.

Reservation within Constitutional bounds

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Articles 15 and 16;

Mains level: Reservation and Sub-categorization;

Why in the news?

There’s a big argument between political parties about reservation. The BJP said some exaggerated things about the Congress wanting a caste census, suggesting it’s connected to religion.

Current debates on Reservation and Sub-categorization:

  • Constitutional Provisions: The Constituent Assembly opposed reservation solely based on religion, and the Constitution guarantees prohibition of discrimination based on religion under Articles 15 and 16.
  • History of Sub-categorization in Karnataka: In Karnataka, all Muslim communities are included within the OBC quota, forming the basis for the BJP’s current campaign.
    • Sub-categorization for Muslims within the OBC quota has existed in Karnataka since 1995.
    • The H. D. Deve Gowda-led government introduced it but was later removed by the Basavaraj Bommai-led government. However, the status quo continues after court observation.
  • Reservation for Muslim and Christian Communities: Socially and educationally backward Muslim and Christian communities are provided reservations under the OBC/MBC category in various states, including Karnataka, Kerala, Tamil Nadu, and Andhra Pradesh.
  • Constitutional Language and SC/ST Communities: The Constitution specifies that for SCs, the person should profess Hinduism, Sikhism, or Buddhism, but no such requirement exists for STs.
  • Congress Manifesto Promise: The Congress has promised in its manifesto to work towards removing the 50% cap placed on reservations, suggesting a potential shift in reservation policy if they come into power.

Affirmative action as per Constitution:

  • Constitutional Provisions: Articles 15 and 16 of the Constitution ensure equality to all citizens in actions by the state, including admissions to educational institutions and public employment.
    • They also enable the state to make special provisions for advancing socially and educationally backward classes, including OBC, SC, and ST.
  • Classification of Backward Classes: OBC is a collective term for socially and educationally backward castes, with some states also classifying certain castes as Most Backward Classes (MBC). Reservation percentages vary from state to state.
  • Indra Sawhney Case (1992): Supreme Court upheld 27% reservation for OBC. Caste is considered a determinant of class in the Indian context, and backwardness cannot be determined solely on economic criteria.
    • A cap of 50% was fixed for reservations unless there were exceptional circumstances.
  • Total reservation stood at 49.5% for OBC (27%), SC (15%), and ST (7.5%)—creamy layer exclusion from OBC reservation, with an income limit currently at ₹8 lakhs per annum.
    • Exclusion of children of certain government officials from the reservation.
  • Janhit Abhiyan Case (2022): The court upheld the constitutional validity of the reservation for Economically Weaker Sections (EWS). Economic criteria could be a reservation basis, according to the court’s majority opinion.

Affirmative Actions Globally:

  • In the U.S., there is ‘affirmative action’ that consists of government-approved and voluntary private programs granting special consideration to racial minorities like African Americans and Latin Americans.
    • In Fair Admissions vs Harvard case (2023), the U.S. Supreme Court, however, ruled that race-based affirmative action programs in college admissions violate the equal protection clause of the U.S. Constitution.
  • In the U.K., the law enables voluntary ‘positive action’ which allows employers to combat the under-representation of disadvantaged groups.
  • France does not have any affirmative action based on race or ethnicity. It provides educational measures designed to increase opportunities for low-income students.

Way Forward: 

  • Need for Sub-categorization: The Rohini Commission was set up to provide recommendations on sub-categorization among OBC castes, as a significant portion of reserved jobs and seats have been garnered by a small percentage of OBC castes/sub-castes. Similar issues of concentration of benefits persist in the SC and ST categories.
  • Inclusion of Dalit Christians and Muslims: Dalit Christians and Muslims also suffer from discrimination and lack of opportunities. There is a need to extend reservation benefits to these communities and address their marginalization.

Mains PYQ:

Q Whether National Commission for Scheduled Castes (NCSC) can enforce the implementation of constitutional reservation for the Scheduled Castes in the religious minority institutions? Examine.(UPSC IAS/2018)

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Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

Niti Aayog report finds ‘huge gap’ in cancer screening at Ayushman centres

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Ayushman Bharat Scheme

Mains level: Reason behind the 'huge gap' in cancer screening at Ayushman Bharat Health and Wellness Centres (HWCs)

Why in the news? 

Ayushman Bharat insurance scheme reached 5.47 crore users, but cancer screening at Health and Wellness Centers (HWCs) faces significant gaps, reports NITI Aayog.

Objective of Ayushman Bharat Scheme:

  • Besides providing a Rs 5-lakh insurance cover, the scheme aimed to upgrade primary health centers to HWCs, offering annual screening for Non-Communicable Diseases (NCDs) including oral, breast, and cervical cancers for individuals aged 30 years or older.

Coverage of Ayushman Bharat Scheme: 

  • Over 5.47 crore users have utilized the Ayushman Bharat insurance scheme, making it the world’s largest medical insurance scheme.

The ‘huge gap’ in cancer screening at Ayushman Bharat Health and Wellness Centres (HWCs):

  • NITI Aayog Report Findings: A report from NITI Aayog, based on visits to HWCs in 13 states, highlights a significant gap in cancer screening services.
  • Limited NCD Screening: Although NCD screening is underway in most HWCs, yearly screening is largely absent, with less than 10% of facilities completing a single round of NCD screening.

Reason behind the ‘huge gap’ in cancer screening at Ayushman Bharat Health and Wellness Centres (HWCs):

  • Methods of Screening: Official protocol mandates distinct screening methods for oral, cervical, and breast cancers. However, implementation of these methods faces challenges.
  • Lack of Awareness and Capacities: The gap in cancer screening is attributed to low awareness levels and lack of capacities among healthcare providers.
  •  Implementation fell short: Auxiliary Nurse and Midwife (ANMs), medical officers, and staff nurses were supposed to be trained in cancer screening methods, but implementation fell short.
  • Suboptimal Screening Activities: Screening for breast cancer relies on beneficiary education for self-examination, while cervical cancer screening remains to be operationalized. Oral cancer screening is performed on a case-by-case basis.
  • Infrastructure and Basic Devices: HWCs generally adhere to infrastructure standards, with basic devices and medicines available free-of-cost. However, the focus remains on improving cancer screening services to align with the government’s prevention and early detection efforts.

Way forward: 

  • Awareness Campaigns: Launch comprehensive awareness campaigns to educate the public about the importance of cancer screening and early detection. This can involve community outreach programs, workshops, and informational sessions.
  • Utilize Technology: Integrate technology solutions such as telemedicine and mobile applications to facilitate easier access to screening services, especially in remote areas. Digital platforms can also aid in data management and monitoring of screening activities.
  • Performance Monitoring: Implement robust monitoring and evaluation mechanisms to track the implementation of cancer screening programs at HWCs.

Mains PYQ: 

Appropriate local community level healthcare intervention is a prerequisite to achieve ‘Health for All’ in India. Explain.

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Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

Meeting Nutrition challenge: What new guidelines prescribe?

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Data related to disease due to poor dietary habit

Mains level: Concerns and guidelines as per the National Institute of Nutrition (NIN)

Why in the news? 

According to the National Institute of Nutrition (NIN), approximately 56.4% of India’s overall disease burden is linked to poor dietary habits.

Guidelines by the National Institute of Nutrition (NIN): 

The NIN, operating under the Indian Council of Medical Research (ICMR), has issued comprehensive guidelines on nutrition for vulnerable groups, including pregnant and lactating women, children, and the elderly.

  • Preventive Measures: A healthy diet coupled with regular physical activity can prevent 80% of Type 2 diabetes cases and significantly reduce the burden of heart disease and high blood pressure.
  • Nutrition for Mother and Child: Proper nutrition from conception to the age of 2 years is crucial for optimal growth and development, preventing undernutrition, micronutrient deficiencies, and obesity in both mothers and children.
  • Suggested general dietary principles: The guidelines recommend getting required nutrients from at least eight food groups, including vegetables, leafy vegetables, roots and tubers, dairy, nuts, and oils.
  • Group-Specific Guidelines:
  1. Pregnant women: Small frequent meals for those experiencing nausea and vomiting. It recommends the consumption of lots of fruit and vegetables, especially those high in iron and folate content.
  2. Infants and children: For the first six months, infants should only be breastfed, and must not be given honey, glucose, or diluted milk. After the age of 6 months, complementary foods must be included.
  3. Elderly: The elderly should consume foods rich in proteins, calcium, micronutrients, and fiber. Apart from pulses and cereals — with at least one-third as whole grains — at least 200-400 ml of low-fat milk or milk products, a fist full of nuts and oilseeds, and 400-500g of vegetables and fruit should be consumed.

Key concerns as per the National Institute of Nutrition (NIN):

  • Rising Noncommunicable Diseases (NCDs) Among Adolescents and Children: Due to poor dietary habits led to diseases like cardiovascular disease, cancers, and diabetes are increasingly affecting adolescents and even children in India.
  • Focus on Healthy Dietary Habits: The guidelines emphasize the importance of reducing salt intake and avoiding highly processed foods like packaged snacks, cookies, and sugary treats, which are linked to unhealthy diets and disease burden.
  • High Prevalence of Lifestyle Conditions: The Comprehensive National Nutrition Survey 2019 highlights a concerning prevalence of lifestyle-related conditions even among children, including overweight or obesity, diabetes, pre-diabetes, and abnormal cholesterol levels.
  • Cholesterol Levels: The survey indicates high levels of bad cholesterol (LDL and triglycerides) in children aged 5-9 and pre-teens and teens aged 10-19, along with low levels of good cholesterol in a significant portion of children and adolescents.

Other concerns related to the “Dual nutrition challenge”

  • Incidence of micronutrient (zinc, iron, vitamins) deficiencies ranged from 13% to 30% of children between ages 1 and 19. But still, the prevalence of anemia is at 40.6%, 23.5%, and 28.4% in children under age 5, ages 5-9, and 10-19 respectively.
  • However severe forms of undernutrition such as marasmus (a deficiency of macronutrients such as carbohydrates and proteins) and kwashiorkor (deficiency of proteins) have disappeared from the country.

Conclusion: Implementing these guidelines effectively can significantly contribute to achieving Sustainable Development Goal (SDG) targets, particularly SDG 2 (Zero Hunger), SDG 3 (Good Health and Well-being), and SDG 12 (Responsible Consumption and Production).

Mains PYQ: 

Q How far do you agree with the view that the focus on the lack of availability of food as the main cause of hunger takes the attention away from ineffective human development policies in India? (15M) UPSC 2018

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Agricultural Sector and Marketing Reforms – eNAM, Model APMC Act, Eco Survey Reco, etc.

Export-Import in the Agricultural sector

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Indian Agricultural trades

Mains level: Reason behind the need for a new export-import policy for agriculture

Why in the news? 

India’s agricultural exports have declined in the fiscal year ended March 31, 2024, on the back of shipment curbs on a host of commodities, from cereals and sugar to onions.

The Need for a New Export-Import Policy for Agriculture:

  • Decline in Agricultural Exports: India’s agricultural exports fell by 8.2% in the fiscal year ended March 31, 2024, due to shipment curbs on various commodities, including cereals, sugar, and onions. This decline highlights the volatility and vulnerability of agricultural trade.
  • Impact on Export Restrictions: Export restrictions imposed by the government, such as bans on sugar and non-basmati rice exports, have led to a significant decrease in export values.
  • Market Stability: Farmers and agri-traders require policy stability and predictability to make informed decisions. Abrupt changes in export-import policies, such as sudden bans or restrictions, can disrupt trade and adversely affect agricultural businesses.
  • Need for comprehensive framework: Export-import policies should strike a balance between the interests of producers and consumers. While export restrictions may benefit consumers by stabilizing prices, they can result in revenue losses for producers. A more predictable and rules-based policy framework is needed to ensure fairness and transparency.
  • Low tariffs on certain commodities: The current import policy, characterized by low on certain commodities like pulses and edible oils, contradicts the government’s objective of promoting crop diversification.

Measures that needs to be taken in the present scenario:

  • Long-Term Goals for the Farm Sector: A new export-import policy should align with the long-term goals of the agricultural sector, including sustainable production practices, crop diversification, and increasing farmer incomes.
    • Balancing short-term consumer needs with long-term agricultural sustainability is essential for the sector’s growth and resilience.
  • Rationalizing Export-Import Policy: The government post-election may need to rationalize the export-import policy by introducing measures such as temporary tariffs instead of outright bans or quantitative restrictions.
    • A rational and coherent policy framework will support the growth and competitiveness of India’s agricultural sector in the global market.
  • Higher Import tariffs: It could incentivize domestic production of pulses and oilseeds, reducing dependence on imports and supporting farmers.

Conclusion: Export-import policies should strike a balance between the interests of producers and consumers. While export restrictions may benefit consumers by stabilizing prices, they can result in revenue losses for producers. A more predictable and rules-based policy framework is needed to ensure fairness and transparency.

Mains PYQ: 

Q In the view of the declining average size of land holdings in India which has made agriculture non – viable for a majority of farmers should contract farming and land leasing be promoted in agriculture? critically evaluate the pros and cons.(UPSC IAS/2015)

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Global Geological And Climatic Events

Positive Indian Ocean Dipole (IOD) to aid Monsoon this year

Note4Students

From UPSC perspective, the following things are important :

Prelims level: IOD and its phases, ENSO;

Why in the News?

Australian weather agencies predict the possible return of a positive Indian Ocean Dipole (IOD) in the latter half of 2024.

What is the Indian Ocean Dipole (IOD)?

  • The IOD is also known as the Indian Nino. It is characterized by the differential heating of ocean waters in the eastern and western parts of the basin.
  • Similar to the El Nino Southern Oscillation (ENSO) in the Pacific, the IOD involves phases of ocean temperatures and atmospheric conditions that affect weather patterns across the region and beyond.
  • There are two main phases of the IOD:
    • Positive Phase: In this phase, the western Indian Ocean becomes warmer than average, and the eastern part cooler than average. This results in greater convection and rainfall over the western Indian Ocean and adjacent land areas like East Africa, while reducing rainfall over the eastern Indian Ocean and places like Indonesia and Australia.
    • Negative Phase: The opposite conditions prevail during this phase, with cooler waters in the western Indian Ocean and warmer waters in the east. This leads to increased rainfall in the eastern Indian Ocean regions and drier conditions in the western part and East Africa.

Back2Basics: El Nino-Southern Oscillation (ENSO)

  • El Nino and La Nina are two opposite phases of the El Nino-Southern Oscillation (ENSO) cycle.
  • ENSO is a naturally occurring phenomenon that involves the interaction between the ocean and atmosphere in the equatorial Pacific.

Here is a detailed comparison of El Nino and La Nina

El Nino La Nina
Definition Warmer-than-normal sea surface temperatures Cooler-than-normal sea surface temperatures
Frequency Every two to seven years Every two to seven years
Duration Several months to a year or more Several months to a year or more
Impact on winds Weakens trade winds, leading to changes in patterns Strengthens trade winds, leading to changes in patterns
Impact on rains Reduces rainfall and can cause droughts Increases rainfall and can cause flooding
Impact on temp. Warmer-than-average temperatures Colder-than-average temperatures
Global effects Droughts in Asia and Africa, floods in Americas Floods in Asia and Africa, droughts in South America

 

Impact on the Indian Monsoon:

The Indian Ocean Dipole has significant impacts on the Indian monsoon system:

  1. Positive IOD often coincides with a stronger Southwest Monsoon, bringing more rainfall to India. This is due to the shift in warm water and accompanying convection towards India, which enhances the monsoon rainfall.
  2. Negative IOD can weaken the Southwest Monsoon, resulting in less rainfall and potential drought conditions in India. The shift of warm water away from India reduces the necessary heat and moisture that drive the monsoon rains.

PYQ:

[2017] With reference to ‘Indian Ocean Dipole (IOD)’ sometimes mentioned in the news while forecasting Indian monsoon, which of the following statements is/are correct?

1. IOD phenomenon is characterised by a difference in sea surface temperature between tropical Western Indian Ocean and tropical Eastern Pacific Ocean.

2. An IOD phenomenon can influence an El Nino’s impact on the monsoon.

Select the correct answer using the code given below:

(a) 1 only

(b) 2 only

(c) Both 1 and 2

(d) Neither 1 nor 2

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Police Reforms – SC directives, NPC, other committees reports

What is an Interpol Blue Corner Notice?

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Interpol, Blue Corner Notice

Mains level: NA

Why in the news?

  • Karnataka’s political landscape is rocked by accusations of sexual abuse against a sitting MP belonging to a prominent political family.
  • Following explicit video leaks allegedly implicating him, Interpol has issued a Blue Corner notice, as he remains on the run.

INTERPOL’s Notice System:

  • The Interpol issues various types of notices to its member countries about individuals who are either missing or wanted.
  • While these notices aren’t legally binding and countries aren’t required to act on them, they are commonly used to arrest and extradite suspects.

The following entities can request for a notice:

  • Notice request by the Member Country
  • International Criminal Tribunals and the International Criminal Court can also request notices for individuals accused of serious crimes like genocide, war crimes, and crimes against humanity under their jurisdiction.
  • The United Nations can request notices related to enforcing sanctions imposed by the Security Council.

What are Blue Corner Notice?

  • Purpose: Blue corner notice, also known as an “enquiry notice,” facilitates sharing critical crime-related information, including criminal records verification and locating individuals.
  • Example: In January 2020, Interpol issued a blue corner notice to locate fugitive Nithyananda, a self-styled godman.

About INTERPOL (International Criminal Police Organization)

Details
Overview
  • Established in Vienna, Austria (1923), it enables cross-border police cooperation and supports and assists all organizations, authorities and services whose mission is to prevent or combat international crime.
  • An inter-governmental organization comprising 195 member countries,
  • Facilitates better coordination among police forces globally
Functions
  • Enables member countries to share and access data on crimes and criminals
  • Offers technical and operational support to member countries
  • Manages 19 police databases containing information on crimes and criminals, accessible in real-time
  • Provides investigative support, including forensics, analysis, and assistance in locating fugitives worldwide.
Working
  • Run by a Secretary General
  • Headquarters located in Lyon, France
  • Global complex for innovation based in Singapore.
  • Several satellite offices in different regions.

I-24/7 Service: Global Police Communications System that provides a common platform for the member countries’ police organizations to share sensitive and urgent police information.

India’s Membership
  • Joined in June 1956.
Functioning in Member Countries
  • Each member country has a National Central Bureau (NCB), serving as the central point of contact for the general secretariat and other NCBs worldwide
  • NCBs are typically managed by police officials and situated in the government ministry responsible for policing (e.g., CBI in India)
  • Interpol’s databases contain various information, from names and fingerprints to stolen passports, accessible in real-time to member countries
  • Provides investigative support to member countries, aiding in forensic analysis and locating fugitives globally.
Notices Interpol issues seven types of notices:

  1. Red Notice: Seeks the location and provisional arrest of fugitives.
  2. Blue Notice: Requests information about a person’s identity or activities.
  3. Green Notice: Warns about individuals likely to repeat crimes.
  4. Yellow Notice: Aids in locating missing persons.
  5. Black Notice: Seeks information about unidentified bodies.
  6. Orange Notice: Warns of imminent threats to public safety.
  7. Purple Notice: Seeks or provides information on criminal methods.

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Zoonotic Diseases: Medical Sciences Involved & Preventive Measures

FLiRT Variants: Latest Twist in the COVID-19 Saga

Note4Students

From UPSC perspective, the following things are important :

Prelims level: FLiRT Covid Variant

Why in the news?

The emergence of new variants KP.2 and KP1.1, known as the FLiRT variants, has raised global concerns.

  • Despite vaccination efforts, these variants pose challenges, leading to concerns about a potential rise in COVID-19 cases.

What are the FLiRT Variants of COVID-19?

  • KP.2 and KP1.1, dubbed ‘FLiRT’ variants, are descendants of the Omicron JN.1 which spread globally over the winter last year.

Features and Differences from Other Variants

  • New Spike Mutations: The FLiRT group includes two specific mutations that are believed to enhance the virus’s ability to infect human cells.
  • Transmission and Evasion: Preliminary studies suggest that KP.2, the more prevalent of the two, may possess enhanced capabilities to evade immune responses generated by vaccines and previous infections.

Are FLiRT Variants Riskier than JN.1?

  • Increased Immune Evasion: Research indicates that KP.2 shows a significant ability to escape immunity from both the latest vaccines and previous infections.
  • Reproduction Number: The reproduction number of KP.2 may be higher than that of JN.1, indicating a potentially greater ability to spread.
  • No definitive evidence: While there’s no definitive evidence that FLiRT variants cause more severe illness, their ability to circumvent immune defences can lead to more infections and, by extension, potential increases in hospitalizations.

PYQ:

[2022] In the context of vaccines manufactured to prevent COVID-19 pandemic, consider the following statements:

  1. The Serum Institute of India produced COVID-19 vaccine named Covishield using mRNA platform.
  2. Sputnik V vaccine is manufactured using vector based platform.
  3. COVAXIN is an inactivated pathogen based vaccine.

Which of the statements given above are correct?

(a) 1 and 2 only

(b) 2 and 3 only

(c) 1 and 3 only

(d) 1, 2 and 3

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Innovations in Sciences, IT, Computers, Robotics and Nanotechnology

Artificial Rain through Cloud Seeding

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Cloud Seeding, Seeding Agents

Why in the news?

The Uttarakhand government faced scrutiny from the Supreme Court following Forest fires that claimed lives in the state.

  • Justices highlighted the inefficacy of relying solely on cloud-seeding or rain gods to address the crisis.

Case Study: Experimenting Artificial Rain in India

  • A recent study published in the Bulletin of the American Meteorological Society (BAMS) highlighted the success of a cloud seeding trial in Maharashtra’s Solapur region, which resulted in an 18% increase in rainfall compared to normal patterns.
  • Scientists from the Indian Institute of Tropical Meteorology in Pune and other institutes conducted this study.
  • The experiment targeted warm convective clouds with a height above zero degrees Celsius, releasing calcium chloride particles to stimulate rainfall.
  • Spanning from 2017 to 2019, the experiment analyzed 276 clouds using advanced tools like automatic rain gauges, radars, radiometers, and aircraft.
  • Glaciogenic seeding, attempted in clouds containing both ice and water, did not significantly impact rainfall at the seeding location, according to the study’s findings.

About Cloud-Seeding

  • Cloud seeding is a weather modification technique aimed at altering precipitation patterns by dispersing substances into clouds to stimulate rainfall or snowfall.
  • It is used to mitigate hail, disperse fog, and either induce precipitation or prevent it from occurring in subsequent days.
  • It involves the dispersal of substances like silver iodide, potassium iodide, dry ice, and hygroscopic materials such as table salt into the atmosphere.
  • Techniques include:
  1. Static seeding: promotes ice particle formation in supercooled clouds, and
  2. Dynamic seeding: enhances convective cloud development through the release of latent heat.
  • Dispersion methods range from aircraft and ground-based generators to newer approaches like drones delivering electric charges or infrared laser pulses.

Limitations: Impact on Environment and Health

  • Concerns persist regarding the potential accumulation of seeding agents in sensitive ecosystems, although detailed studies have shown negligible impacts.
  • The chemicals used, such as silver iodide, may potentially damage the environment and cause health issues like iodine poisoning in high concentrations

PYQ:

[2019] In the context of which of the following do some scientists suggest the use of cirrus cloud thinning technique and the injection of sulphate aerosol into stratosphere?

(a) Creating the artificial rains in some regions

(b) Reducing the frequency and intensity of tropical cyclones

(c) Reducing the adverse effects of solar wind on the Earth

(d) Reducing the global warming

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Oil and Gas Sector – HELP, Open Acreage Policy, etc.

The Socio-ecological effects of LPG price hikes

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Government Initiatives and Programmes;

Mains level: Issues related to affordability of LPG gas;

Why in the News? 

The ACCESS survey (2014-2015), conducted by the Council on Energy, Environment and Water, found LPG’s cost to be the foremost barrier to its adoption and continued use in rural poor households.

Government Initiatives for LPG Fuel:

  • Government Initiatives: The Indian government has promoted using LPG (liquefied petroleum gas) as a clean cooking fuel, particularly in rural households.
    • These initiatives include the Rajiv Gandhi Gramin LPG Vitrak scheme, the ‘PAHAL’ scheme for direct benefit transfers, and the Pradhan Mantri Ujjwala Yojana (PMUY) aimed at providing LPG connections to below-poverty-line households.
  • Subsidies and Incentives: The government has provided subsidies and incentives to encourage the adoption of LPG without subsidies for the people who can afford it.
    • For example, the ‘Give it Up’ program encouraged consumers to voluntarily surrender their LPG subsidies, which were transferred to below-poverty-line households.

Challenges:

  • Affordability: Despite government efforts, the affordability of LPG remains a challenge for many households, especially those in rural and below-poverty-line communities. Reports indicate that LPG prices in India were among the highest globally around ₹300/litre.
  • Dependency on Traditional Fuels: Studies, such as the one conducted in the Jalpaiguri district of West Bengal, highlight the continued dependency of local communities on traditional fuelwood for cooking.
  • Forest Dependency: The persistent use of fuelwood has implications for forest conservation and livelihoods, particularly in regions with degraded forests like Jalpaiguri.

Way Forward: 

  • Need for Comprehensive Solutions: While government initiatives have aimed to promote LPG use, addressing affordability issues and ensuring access to clean cooking fuels for marginalized communities require comprehensive solutions.
  • Targeted Subsidies: Implement targeted subsidies for LPG cylinders to make them more affordable for rural and below-poverty-line communities. These subsidies can be based on income levels or geographic locations to ensure that those most in need receive assistance.

Mains PYQ: 

Q In what way could replacement of price subsidy with direct benefit Transfer (DBT) change the scenario of subsidies in India? Discuss.(UPSC IAS/2015)

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Solar Energy – JNNSM, Solar Cities, Solar Pumps, etc.

India is now Third-Largest Producer of Solar Power

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Global Rankings; Trends of solar energy production;

Mains level: Factors contributed to India becoming the third-largest producer of solar power in 2023.

Why in the News? 

In 2023, India overtook Japan to become the world’s third-highest producer of solar power, according to a report by the International Energy Analytics Agency Ember.

Global Solar Energy Production:

  • The leading producer of solar power in the world is China which produced 584 BU of solar power in 2024 – more than the next four countries combined (the United States, Japan, Germany and India).
  • India generated 113 billion units (BU) of solar power in 2023 compared to Japan’s 110 BU.
    • The installed solar energy capacity has increased by 30 times in the last 9 years and stands at 81.81 GW as of Mar 2024.
    • India’s solar energy potential is estimated to be 748 GWp as estimated by National Institute of Solar Energy (NISE).
  • Power demand in Japan decreased by 2% (2 BU) in 2023 after rising in 2021 and 2022, thus allowing India to overtake Japan.

Other factors to make India the third-largest Solar power producer in 2023:

  • Government Initiatives: India has implemented various policies and initiatives to promote renewable energy, particularly solar power.
    • The government launched the Jawaharlal Nehru National Solar Mission (JNNSM) in 2010, aiming to promote the development and use of solar energy in the country.
    • Subsequently, various state-level policies and incentives were introduced to encourage solar power generation.
    • For example Gujarat Solar Energy Policy (Target is 36 GW of solar energy by 2036).
  • Investment and Financing: There has been significant investment in the solar power sector in India, both from domestic and international sources.
    • For example PM Surya Ghar, Muft Bijli Yojana, the scheme is projected to entail an investment of ₹75,000 crore.
  • Favorable Geography: India has abundant sunlight throughout the year, making it well-suited for solar power generation. About 5,000 trillion kWh per year of energy is incident over India’s land area with most parts receiving 4-7 kWh per sqm/day.
  • Increasing Energy Demand: India’s growing population and economy have led to a rising demand for energy. Electricity demand in India rose 7% in 2023 and is likely to average growth of 6% a year through 2026 on higher economic activity, according to the International Energy Agency.
  • International Collaboration: India has collaborated with various countries and international organizations to leverage expertise, technology transfer, and funding for solar projects. For example  International Solar Alliance (ISA).

Way Forward:

  • Invest in High-Efficiency Panels: Choose solar panels with high-efficiency cells, such as monocrystalline photovoltaic cells, which can convert a greater percentage of sunlight into usable electricity
  • Use Energy Storage Solutions: Consider integrating energy storage systems, such as batteries, to store excess energy generated during the day and use it at night or during periods of low sunlight, thereby increasing the overall efficiency of the solar energy system.

Mains PYQ: 

Q Describe the benefits of deriving electric energy from sunlight in contrast to the conventional energy generation. What are the initiatives offered by our government for this purpose? (UPSC IAS/2020)

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Labour, Jobs and Employment – Harmonization of labour laws, gender gap, unemployment, etc.

Unemployment Vs Wages

Note4Students

From UPSC perspective, the following things are important :

Prelims level: NA

Mains level: Issues related to Unemployment vs Wages;

Why in the news?

Recently, there have been contentious talks regarding Pakistan’s unemployment being lower than India’s.

According to Keynes, lower wage rate will lead to lower income of workers and thus to lower demand of goods. Lower demand will lower output that in turn will lower employment.

Issues related to Unemployment vs Wages

  • Questioning on Data Accuracy and Interpretation: There is skepticism about the accuracy of unemployment data, particularly regarding the CMIE Consumer Pyramids Household survey. This raises questions about the basis of claims regarding unemployment rates and the subsequent policy responses.
  • Labor Force Participation: Concerns are raised about the significant withdrawal of individuals from India’s labor force, indicating potential issues with labor force participation rather than solely unemployment rates.
  • Youth Unemployment: The high youth unemployment rate of 45% is highlighted as a significant concern, suggesting challenges in integrating young people into the workforce and addressing their employment needs.
  • Informal Employment: The prevalence of informal employment, such as subsistence agriculture and informal wage employment, is noted as a structural issue in the labor market, potentially impacting wages and job quality.
  • Wage Levels: Despite low reported unemployment rates, there are concerns about the adequacy of wages, particularly for the poor. This raises questions about the quality of employment and the extent of underemployment or disguised unemployment.
  • Policy misalignment: Certain policy proposals, such as increasing public sector employment or implementing fiscal job guarantees, are critiqued for potentially misdiagnosing the problem and offering unsustainable solutions that may not address underlying wage issues.

Steps taken by the Government: 

  • Pradhan Mantri Rojgar Protsahan Yojana (PMRPY): This scheme incentivizes employers to generate employment by having the government pay the entire 12% employer’s contribution to the Employees’ Provident Fund and Employees’ Pension Scheme for new employees for the first three years of their employment
  • Pradhan Mantri Mudra Yojana (PMMY): This scheme provides collateral-free loans up to ₹10 lakh to micro and small businesses and individuals to help them set up or expand their enterprises, thereby promoting self-employment.
  • Aatmanirbhar Bharat Package: This economic stimulus package, announced in response to the COVID-19 pandemic, includes various long-term schemes and policies aimed at making India self-reliant and creating employment opportunities.
  • Garib Kalyan Rojgar Abhiyaan: This 125-day campaign was launched to boost employment and livelihood opportunities for migrant workers and others affected in 116 districts across 6 states.
  • PM GatiShakti: This is a multi-modal connectivity plan that aims to create infrastructure and generate employment opportunities in sectors like roads, railways, airports, ports, and logistics.

Way forward: 

  • Addressing Labor Force Participation: Implement policies aimed at increasing labor force participation, particularly among youth and marginalized groups, by creating more formal employment opportunities.
  • Improving Informal Employment Conditions: Develop strategies to formalize the informal sector by providing incentives for informal employers to register their businesses, improve working conditions, and ensure compliance with labor laws.
  • Enhancing Wage Levels: Take steps to improve wage levels, particularly for low-skilled workers engaged in subsistence agriculture, marginal self-employment, and informal wage employment.

Mains PYQ:

Q Besides the welfare schemes, India needs deft management of inflation and unemployment to serve the poor and the underprivileged sections of the society. Discuss.

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Human Development Report by UNDP

Giving primacy to Human Development

Note4Students

From UPSC perspective, the following things are important :

Prelims level: HDI Index;

Mains level: Key issues related to Human Development;

Why in the News?

Two recent reports reveal some important facets of India’s Development.

  • The Human Development Report 2023-24, published by the UNDP, takes a comparative perspective and maps the achievements in the area of human development.
  • A paper published by the World Inequality Lab in March 2024 provides long-term trends in income and wealth inequality in India between 1922 and 2023.

About HDI:

The Human Development Index (HDI) is a measurement system used by the United Nations to evaluate the level of individual human development in each country. It was introduced by the U.N. in 1990.

How is the HDI measured?

The HDI is the geometric mean of the three dimensions above, with indices calculated separately for each country using data on life expectancy, schooling and per capita income. The final result always gives a value between 0 and 1 which defines, according to the UNDP, the four degrees of human development detailed below:

  • Very high: countries with a HDI above 0.80.
  • High: countries with a HDI between 0.70 and 0.80.
  • Medium: countries with a HDI between 0.55 and 0.70. (India is here)
  • Low: countries with a HDI below 0.55.

India’s poor ranking in HDI:

  • Regional Trends: India’s HDI ranking has improved marginally over the years, but it still lags behind several countries, including Bhutan, Bangladesh, Sri Lanka, and China. In 2022, India ranked 134 out of 193 countries.
  • Low HDI Value: Despite the incremental improvement in ranking, India’s HDI value remains relatively low. The HDI value increased from 0.633 in 2021 to 0.644 in 2022.
  • Gender Inequality Index (GII): While India showed improvement in its GII ranking in 2022, moving from 122 out of 191 countries in 2021 to 108 out of 193 countries in 2022, significant gender disparities persist. Notably, India faces one of the largest gender gaps in labor force participation rates, with a substantial difference between men (76.1%) and women (28.3%).
  • Medium Human Development Categories: India’s HDI ranking places it within the medium human development category alongside countries like Myanmar, Ghana, Kenya, Congo, and Angola.

Key concerns related to Human Development:

  • Increasing Disparity Between Countries: The report underscores a concerning trend of growing inequality between countries, particularly between those at the upper and lower ends of the Human Development Index (HDI).
  • Economic Concentration: The concentration of economic power in a few countries is exacerbating global inequality. Nearly 40% of the global trade in goods is controlled by just three or fewer countries
  • Tech Company Dominance: The dominance of large technology companies further exacerbates inequality, with the market capitalization of the top three companies surpassing the GDP of the majority of countries.

Widening inequality:

  • Income Disparities in India: The study from the World Inequality Lab reveals stark income disparities in India, with the bottom 50% of the population receiving only 15% of the national income.
    • Conversely, the top 1% earns on average 23 times more than the average Indian, and the top 10,000 individuals earn 2,069 times the average Indian.
  • Reduction of Middle-Class size: During the period from 2014 to 2022, the incomes of the middle 40% of the income distribution have grown slower than the bottom 50%. This trend suggests a potential reduction in the size of the ‘middle class.
  • High Household Debt and Low Savings: Household debt levels in India have reached a record high of 40% of GDP, while net financial savings have plunged to 5.2% of GDP.

Way Forward: 

  • Promote Inclusive Growth Policies: Implement policies that prioritize inclusive growth, focusing on reducing income disparities, and enhancing access to education, healthcare, and economic opportunities for all segments of society.
  • Enhance Social Safety Nets: Strengthen social safety nets to provide support to vulnerable populations, including targeted welfare programs, universal healthcare coverage, and unemployment benefits.

Mains PYQ: 

Q Despite the consistent experience of high growth, India still goes with the lowest indicators of human development. Examine the issues that make balanced and inclusive development elusive.(UPSC IAS/2019)

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Tiger Conservation Efforts – Project Tiger, etc.

Tiger Translocation in Sahyadri-Konkan Wildlife Corridor  

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Sahyadri-Konkan Wildlife Corridor, Tadoba-Andhari TR

Mains level: NA

Why in the news?

Maharashtra’s plan to increase tigers count in Sahyadri-Konkan Wildlife Corridor by translocating tigers from Tadoba-Andhari Tiger Reserve (TATR) (Chandrapur, Maharashtra) underscores the critical role of wildlife corridors in conservation efforts.

About Tadoba-Andhari Tiger Reserve (TATR)

  • Tadoba became one of India’s earliest national parks when it was declared in 1955, alongside Kanha National Park.
  • The name “Tadoba” is derived from the deity “Tadoba” or “Taru,” worshipped by local Gond Tribals, and “Andhari” refers to the Andhari River flowing through the reserve.
  • It was later expanded and officially merged with the Andhari Wildlife Sanctuary in 1993 to form the TATR.
  • TATR is regarded as one of the world’s most preferred destinations for tiger sightings and is a critical part of Project Tiger, aimed at conserving tigers in India.
  • The reserve has 115 tigers, including 88 within the forest and 27 in the areas immediately surrounding the reserve.

About Sahyadri-Konkan Wildlife Corridor  

  • The Sahyadri-Konkan corridor (Sahyadri-Radhanagari-Goa-Karnataka), plays a vital role in conserving wildlife, particularly tigers, in the northern Western Ghats region.
  • It spans throughout the states of Maharashtra, Goa, and Karnataka, specifically through the Western Ghats, one of the world’s eight biodiversity hotspots.
  • Protected Areas Connected:
  1. Sahyadri Tiger Reserve (includes Koyna Wildlife Sanctuary (WLS) and Chandoli National Park) and Radhanagari Wildlife Sanctuary (Maharashtra);
  2. Bhimgad Wildlife Sanctuary and Kali Tiger Reserve (includes Anshi National Park and Dandeli WLS) in (Karnataka);
  3. Mollem National Park, Netravali Wildlife Sanctuary (Goa).
  • Fauna: Tiger (Panthera tigris), Indian leopard (Panthera pardus), dhole (Cuon alpinus), and sloth bear (Melursus ursinus), etc.
  • The Western Ghats, including parts of the corridor, are designated as a UNESCO World Heritage Site in 2012 due to their outstanding universal value in terms of biodiversity and endemic species.

PYQ:

[2020] Among the following Tiger Reserves, which one has the largest area under “Critical Tiger Habitat”?

(a) Corbett

(b) Ranthambore

(c) Nagarjunsagar-Srisailam

(d) Sunderbans

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New Species of Plants and Animals Discovered

Glyptothorax punyabratai: A New Catfish Species discovered  

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Glyptothorax punyabratai and its natural habitat

Mains level: NA

Why in the news?

Glyptothorax punyabratai, a new catfish species, has been discovered in the Brahmaputra River drainage in Arunachal Pradesh.

  • The discovery was made by the ICAR-National Bureau of Fish Genetic Resources (ICAR-NBFGR), Lucknow, and published in the journal Ichthyological Exploration of Freshwaters.

Glyptothorax punyabratai

  • It was collected from the Tung Stream, a tributary of the Tissa River, within the Brahmaputra River basin.
  • It has a unique rhomboidal-shaped thoracic adhesive apparatus, which is a specialized structure that helps the fish adhere to surfaces.
  • The holotype and paratype specimens are housed at the National Fish Museum-cum-Repository of the ICAR-NBFGR, Lucknow.
    • This discovery underscores the potential for both utilization and conservation of fish biodiversity in unexplored areas.

PYQ:

[2019]  Consider the following pairs

Wildlife Naturally found in
1. Blue-finned Mahseer Cauvery River
2. Irrawaddy Dolphin Chambal River
3. Rusty-spotted Cat Eastern Ghats

Which of the pairs given correctly matched?

(a) 1 and 2 only

(b) 2 and 3 only

(c) 1 and 3 only

(d) 1, 2 and 3

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Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

Widal Test: Flaws of Typhoid Diagnosis  

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Diseases; Widal Test, Salmonella Typhi Bacteria;

Mains level: NA

Why in the news?

Patients with fever in India often undergo testing and treatment for typhoid fever, primarily relying on the Widal test.

  • The Widal test, though widely used, has several limitations that affect its accuracy and reliability.

Typhoid diagnosis using Widal Test

  • The Widal test is used primarily to diagnose typhoid fever.
  • Typhoid fever, caused by Salmonella Typhi and related bacteria, presents with symptoms like high fever, stomach pain, weakness, and gastrointestinal issues.
  • It detects antibodies in the patient’s blood against the O (somatic) and H (flagellar) antigens of Salmonella Typhi.
  • Procedure:
  1. The presence of these antibodies is detected through an agglutination reaction.
  2. The test involves serial dilution of the patient’s serum.
  3. The highest dilution at which agglutination occurs indicates the antibody titer, with higher titers suggesting an active infection.

Diagnostic Challenges:

  • The gold standard for diagnosing typhoid involves isolating the bacteria from blood or bone marrow cultures, which is time-consuming and resource-intensive.
  • Widal test is commonly used due to its convenience and accessibility. However, the Widal test’s interpretation is complicated by factors like the need for multiple serum samples, variations in cutoff values, and potential cross-reactivity with antibodies from other infections or vaccines.

Challenges with Widal Test:

  • Impractical: A single positive Widal test does not confirm typhoid.
  • Complicated result interpretation: High background antibody levels and variability in test cutoff values.
  • Cross-reactivity with antibodies from other infections and false negatives due to prior antibiotic therapy undermine test reliability.

Consequences of Widal Test Use:

  • Erroneous results obscure the true burden of typhoid in India, leading to inappropriate treatment and financial strain on patients.
  • Overuse of antibiotics based on Widal test results contributes to antimicrobial resistance, exacerbating the challenge of treating typhoid.

PYQ:

[2016] Which of the following statements is/are correct?

Viruses can infect

1. Bacteria

2. Fungi

3. Plants

Select the correct answer using the code given below.

(a) 1 and 2 only

(b) 3 only

(c) 1 and 3 only

(d) 1, 2 and 3

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Innovations in Biotechnology and Medical Sciences

CRISPR’s Breakthrough in Treating Blindness

Note4Students

From UPSC perspective, the following things are important :

Prelims level: LCA, CRISPR Cas9;

Mains level: NA

Why in the news?

Scientists have successfully used CRISPR-Cas9 gene editing to restore vision in individuals with a rare form of inherited or congenital blindness.

  • The groundbreaking clinical trial, named “BRILLIANCE,” demonstrated promising results in improving vision and quality of life for participants with Leber congenital amaurosis (LCA), a severe vision disorder.

What is Leber Congenital Amaurosis (LCA)?

  • LCA is a rare genetic disorder that primarily affects the retina the ‘light-sensitive’ tissue at the back of the eye. It leads to severe visual impairment or blindness at birth or within the first few months of life.
  • It is inherited in an autosomal recessive manner, meaning a child needs to inherit one defective gene from each parent to develop the condition.
  • There are several genes associated with LCA, with mutations in at least 14 different genes known to cause the disorder.
  • These genes generally affect the development and function of photoreceptors or the retinal pigment.

Key highlights of the BRILLIANCE trial:

  • The BRILLIANCE trial involved 12 adults and two children diagnosed with LCA, a condition characterized by early-onset vision loss.
  • Participants received a single dose of a CRISPR gene therapy called EDIT-101, designed to correct mutations in the CEP290 gene responsible for LCA.
  • In this case, CRISPR-Cas9 cuts out the faulty DNA segment in the CEP290 gene and replaces it with a healthy DNA sequence, restoring the function of the CEP290 protein crucial for vision.
  • Out of 14 participants, 11 experienced improved vision without serious side effects.

Back2Basics: CRISPR-Cas9 Gene Editing

  • CRISPR-Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated protein 9.
  • It is a technology that allows geneticists and researchers to edit parts of the genome by altering sections of the DNA sequence.
  • Emmanuelle Charpentier and Jennifer Doudna’s work on CRISPR-Cas9 as a ‘molecular scissor’ earned them the 2020 Nobel Prize in chemistry.
  • The system consists of two key components:
  1. Cas9: This is the enzyme that acts like a pair of molecular scissors. It is responsible for cutting the DNA strand at a specific location, allowing for the removal, addition, or alteration of DNA at that site.
  2. Guide RNA (gRNA): This is a piece of RNA that is designed to find and bind to a specific sequence of DNA that matches its code. The gRNA guides the Cas9 enzyme to the exact spot in the genome where an edit is desired.
  • Mechanism:
    • The process begins with the design of a gRNA that matches the DNA sequence where an edit is needed.
    • Once inside the cell, the Cas9 enzyme and the gRNA form a complex that can identify and bind to the target DNA sequence.
    • The Cas9 then cuts the DNA at this location.
    • After the DNA is cut, the cell’s natural repair mechanisms can be harnessed to add or remove genetic material, or to make specific changes to the DNA.

 

PYQ:

[2019] What is Cas9 Protein that is often mentioned in news?

(a) A molecular scissors used in targeted gene editing

(b) A biosensor used in the accurate detection of pathogens in patients

(c) A gene that makes plants pest-resistant

(d) A herbicidal substance synthesized in genetically modified crops

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Wildlife Conservation Efforts

Orangutan uses Plant to treat wound

Note4Students

From UPSC perspective, the following things are important :

Prelims level: Orangutan and its natural habitat

Mains level: NA

Why in the news?

An orangutan was observed treating a wound with medicine from a tropical plant, showcasing how some animals employ natural remedies to alleviate their ailments.

  • This behavior, documented in a recent study published in Scientific Reports, represents a novel instance of self-medication among wild animals.

About Orangutans

  • Orangutans, are distinguished by their vivid red fur, are the largest arboreal mammals and spend the majority of their time in trees and forests.
  • The name “orangutan” translates to “man of the forest” in Malay.
  • They possess long, powerful arms and grasping hands and feet that facilitate movement through the branches.
  • Highly intelligent, these great apes share 96.4% of genetic makeup of modern man.
  • Orangutans primarily inhabit the tropical rainforests of Southeast Asia, specifically on the islands of Borneo and Sumatra.
  • Conservation Status: Critically Endangered (IUCN Red list)
  • Population: Bornean (Approximately 104,700); Sumatran (Approximately 13,846); Tapanuli (Around 800);
  • Behavioral Features:
    • These apes lead mostly solitary lives in the lowland forests, dining on wild fruits such as lychees, mangosteens, and figs, and drinking water collected in tree cavities.
    • Orangutans are mainly frugivorous, they primarily eat fruits, and consume leaves, bark, insects, and occasionally small animals.
    • They construct nests in trees with vegetation for sleeping at night and resting during the day.
    • And, now they are found treating a wound with medicine from a Tropical plant.

PYQ:

[2013] Consider the following:

  1. Star tortoise
  2. Monitor lizard
  3. Pygmy hog
  4. Spider monkey

Which of the above are naturally found in India?

(a) 1, 2 and 3 only

(b) 2 and 3 only

(c) 1 and 4 only

(d) 1, 2 and 3 and 4

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Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

The unseen effects of Climate Change on Mental Health

Note4Students

From UPSC perspective, the following things are important :

Prelims level: What is schizophrenia?

Mains level: Key concerns on health due to Extreme Heat as per the report

Why in the News? 

Studies show that individuals with schizophrenia are more likely to experience fatal effects from extreme heat compared to those with kidney or heart problems as per Geo Health report.

What is schizophrenia? 

As per the National Institute of Mental Health, Schizophrenia is a serious mental illness that affects how a person thinks, feels, and behaves. People with schizophrenia may seem like they have lost touch with reality, which can be distressing for them and their family and friends.

Effects of Extreme Heat  as per the Geo Health Report:

  • Schizophrenia Heat-Related Deaths: GeoHealth in 2023 revealed that an extreme heat event in British Columbia in 2021 led to more fatalities among individuals with schizophrenia compared to those with kidney and heart diseases.
  • Mental Health Conditions: People with mental health conditions, including schizophrenia, anxiety, and bipolar disorder, were identified as being at higher risk of succumbing to heat-related deaths during extreme heat events.
  • Impact of Extreme Heat Event: British Columbia experienced an eight-day extreme heat event in 2021, with temperatures soaring as high as 40 degrees celsius, significantly above the average temperature of around 20 degrees celsius. The region recorded approximately 740 excess deaths during this heat wave.
    • Researchers analyzed the data based on various medical conditions, including heart disease, schizophrenia, chronic kidney disease, dementia, depression, Parkinson’s disease, and osteoporosis.
  • Higher Risk of Schizophrenia: Contrary to expectations, the study reported a 200% increase in the prevalence of schizophrenia diagnoses during the extreme heat event in 2021 compared to a summer without recorded heat waves.

 Key challenges for treating Schizophrenia:

  • Dysfunction of the Hypothalamus: The dysfunction of the hypothalamus, a structure deep in the brain responsible for maintaining bodily homeostasis, may contribute to increased vulnerability to heat stress among individuals with schizophrenia.
  • Impact of Antipsychotic Medications: Certain antipsychotic medications prescribed for schizophrenia can interfere with the functioning of the hypothalamus, potentially raising body temperature. This side effect, when combined with high ambient temperatures, can lead to fatal outcomes.
  • Psychotic Symptoms and Anosognosia (unable to be aware of the symptoms): Individuals with schizophrenia often experience psychotic symptoms such as hallucinations, delusions, disorganized thinking, and memory loss. The anosognosia, a condition where individuals are unaware of their illness can further complicate treatment efforts.

Way Forward:

  • Enhanced Monitoring and Support Systems: Implement enhanced monitoring and support systems for individuals with schizophrenia during extreme heat events.
  • Education and Awareness Campaigns: Conduct education and awareness campaigns to inform individuals with schizophrenia and their caregivers about the risks of heat-related distress and the importance of staying cool and hydrated during extreme heat events.
  • Tailored Treatment Plans: Develop tailored treatment plans for individuals with schizophrenia that take into account the potential impact of antipsychotic medications on body temperature regulation.

Mains PYQ 

Q Public health system has limitation in providing universal health coverage. Do you think that private sector can help in bridging the gap? What other viable alternatives do you suggest? (UPSC IAS/2015)

With inputs from:

https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2022GH000729

https://www.nimh.nih.gov/health/topics/schizophrenia#:~:text=What%20is%20schizophrenia%3F,for%20their%20family%20and%20friends

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