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  • Foreign Policy Watch: India-ASEAN

    How will the EU elections impact Southeast Asia?

    Why in the news?

    A weak performance by green and left-wing parties, coupled with gains by the far-right, could lead the EU to adopt a more protectionist stance and a less environmentally focused foreign policy.

    What happens in the EU parliament?   

    • Legislative Role and Trade Agreements: The European Parliament must approve all EU free trade agreements. For instance, it is currently involved in negotiations with Southeast Asian countries such as Indonesia, Thailand, and the Philippines. This approval process ensures that any trade agreement aligns with EU standards and regulations.
    • Policy Shifts Due to Election Results: The recent gains by far-right factions in the European Parliament could shift legislative priorities. For example, a more nationalist Parliament may prioritize protectionist policies over liberal trade agreements, potentially imposing tariffs or restrictions on imports from Southeast Asia, as seen with past tariffs on Cambodian and Myanmar rice.
    • Influence on Environmental and Human Rights Policies: With the Greens and Liberals losing seats, the European Parliament may place less emphasis on environmental sustainability and human rights. This shift could affect initiatives like the Just Energy Transition schemes with countries like Vietnam and Indonesia, which rely on EU support for their green agendas. Reduced focus on these areas could hinder such cooperative efforts.

    Changes in the Commission

    • Commission Presidency and Coalition Dynamics: Ursula von der Leyen, the incumbent European Commission President from the centre-right European People’s Party (EPP), faces a challenging re-election. She needs to secure 361 votes from Members of the European Parliament (MEPs).
    • Shift in Policy Focus: The composition of the new Commission will significantly influence EU policy directions. If von der Leyen allies with the Greens, there could be an intensification of green policies and environmental initiatives, such as the European Green Deal.
    • Leadership and Foreign Policy Changes: The departure of EU foreign policy chief Josep Borrell opens the field for new candidates vying to lead the European External Action Service (EEAS). The new leadership could reshape the EU’s foreign policy approach, with potential changes in emphasis on development cooperation and international relations, including those with Southeast Asia. This could affect ongoing initiatives like the Just Energy Transition partnerships with countries like Vietnam and Indonesia.

    Pivot to South Asia

    • Strategic Partnership and Economic Interests: Southeast Asia is an increasingly important economic partner for the EU. The region’s growing markets and economic dynamism offer significant trade opportunities. For instance, the EU is negotiating free trade agreements with countries like Indonesia, Thailand, and the Philippines, which could enhance trade flows and economic cooperation. Strengthening ties with Southeast Asia helps the EU diversify its trade partners and reduce reliance on traditional markets.
    • Environmental and Green Transition Initiatives: Southeast Asia is a crucial region for the EU’s global environmental goals. The EU has invested in green transition initiatives, such as the Just Energy Transition schemes in Vietnam and Indonesia, providing over €20 billion in concessional loans and investments. These initiatives support Southeast Asian countries in adopting sustainable energy practices and combating climate change.
    • Geopolitical and Security Considerations: Southeast Asia’s strategic location and geopolitical significance make it a vital region for the EU’s foreign policy. By engaging more deeply with Southeast Asia, the EU can strengthen its influence in a region where other major powers, such as China and the United States, are also vying for influence.

    Conclusion: The EU’s evolving policies and leadership will shape its economic, environmental, and geopolitical engagement with Southeast Asia, highlighting the region’s strategic importance and potential for cooperation.

     

    Mains PYQ:

    Q Africa was chopped into states artificially created by the accident of European competition. Analyse. (UPSC IAS/2013)

  • Women empowerment issues – Jobs,Reservation and education

    A comprehensive immunisation schedule for women is ready

    Why in the news?

    FOGSI launched a detailed immunization plan for women in Mumbai, featuring essential vaccines and recommended dosages, presented by women’s health advocate Kajal Aggarwal.

    About the Federation of Obstetric and Gynaecological Societies of India (FOGSI)

    • The Federation of Obstetric and Gynaecological Societies of India (FOGSI) is a prominent professional organization dedicated to advancing the field of obstetrics and gynaecology in India.  
    • Foundation and Scope: FOGSI was established in 1950 and currently represents over 34,000 obstetricians and gynaecologists across India. It serves as a unified platform for healthcare professionals specializing in women’s health.
    • Objectives: The primary objective of FOGSI is to promote the study and practice of obstetrics and gynaecology through education, research, and advocacy. It aims to improve the standards of healthcare delivery for women in India.

    Significance of Preventive Health Care    

    • Early Detection and Intervention: Preventive healthcare emphasizes regular screenings, vaccinations, and health checks to detect potential health issues early. This proactive approach allows healthcare providers to intervene early, often before symptoms appear, which can lead to better treatment outcomes and lower healthcare costs.
    • Promotion of Health and Well-being: By focusing on preventive measures such as healthy lifestyle choices, vaccination against preventable diseases, and routine health screenings, individuals can maintain optimal health and well-being. Preventive healthcare encourages behaviours that reduce the risk of chronic illnesses and promote longevity.
    • Reduction of Healthcare Burden: Investing in preventive healthcare can alleviate the burden on healthcare systems by reducing the prevalence and severity of diseases. By preventing illnesses before they occur or progress, fewer resources are needed for acute care, hospitalizations, and long-term management of chronic conditions.

    Accessing ‘Vulnerable Period’

    • Postpartum Period: The postpartum period, typically defined as the first six weeks after childbirth, is a critical vulnerable period for women. During this time, the body undergoes significant physiological changes, including hormonal fluctuations and potential immune system alterations. These changes can increase susceptibility to infections and other health complications, necessitating close monitoring and appropriate medical interventions.
    • Menopausal Transition: Menopause marks a significant transition in a woman’s life when reproductive hormone levels decline, leading to various physical and psychological changes. This period can be accompanied by symptoms such as hot flashes, mood swings, and changes in bone density. Due to these changes, women may be more vulnerable to conditions like osteoporosis and cardiovascular disease.
    • Chronic Illness Management: Women with chronic conditions such as diabetes, hypertension, or autoimmune disorders may experience periods of vulnerability related to their specific health challenges. Fluctuations in hormone levels, stress, and lifestyle factors can exacerbate these conditions or increase the risk of complications. Healthcare strategies during these vulnerable periods often include personalized treatment plans, regular monitoring, and patient education to optimize disease management and promote overall well-being.

    Conclusion: FOGSI’s launch of a women’s immunization schedule underscores their commitment to advancing women’s health through proactive care, addressing vulnerable periods like postpartum and menopause, and promoting disease prevention and management strategies.

     

    Mains PYQ:

    Q  In order to enhance the prospects of social development, sound and adequate health care policies are needed particularly in the fields of geriatric and maternal health care. Discuss. (UPSC IAS/2020).

  • Medical Education Governance in India

    The allegations over NEET-UG 2024 | Explained

    Why in the news?

    On June 13, the Union government informed the Supreme Court that the scorecards of 1,563 candidates who received compensatory marks in the NEET-UG 2024 exam, held on May 5, will be cancelled.

    About National Testing Agency:

    • National Testing Agency (NTA) has been established as a premier, specialist, autonomous and self-sustained testing organization to conduct entrance examinations for admission/fellowship in higher educational institutions.
    • The NTA was established in 2017 by the Ministry of Education.
    • NTA is responsible for conducting the
      • Joint Entrance Examination – Main (JEE Main)
      • National Eligibility cum Entrance Test-Undergraduate (NEET-UG)
      • National Eligibility Test (NET)
      • Common Management Admission Test (CMAT)
      • Graduate Pharmacy Aptitude Test (GPAT).
    • The NTA is chaired by an eminent educationist who will be appointed by the Ministry of Education.

    Why has the Union government told the Supreme Court that it will cancel the scorecards of candidates who have been awarded grace marks?

    • Technical Issues During Exam: The cancellation stems from petitions challenging the award of grace marks to 1,563 candidates from six NEET centers due to technical issues that did not allow them the full 3.2 hours to complete the exam.
    • Compensatory Marks Controversy: Grace marks were awarded based on a court order and the recommendation of a committee constituted by the National Testing Agency (NTA). This move was challenged as arbitrary and lacking transparency.
    • Skewed Results: The committee found that the compensatory marks led to a skewed situation, thus recommending the cancellation of the scorecards for these candidates and conducting a re-test on June 23.

    How did the National Testing Agency respond to the various charges against the conduct of the exams?

    • Formation of Committee: In response to the allegations, the NTA constituted a four-member committee to investigate the truth behind the claims, including the award of grace marks and other issues related to the conduct of NEET 2024.
    • Admission of Irregularities: The NTA admitted that the grace marks caused confusion and contributed to skewed results. They acknowledged technical issues and the improper awarding of grace marks.
    • Panel Recommendations: The panel recommended limiting grace marks to the attempted questions and concluded that it would be best to cancel the test for the affected 1,563 students.
    • Explanations for High Scores: NTA officials attributed the unusually high number of perfect scores (67 students scoring 720/720) to an ‘easy paper’, but still took steps to address the fairness and validity of the results by planning a re-test.
    • Addressing Other Allegations: The NTA’s response included acknowledging various logistical issues such as slow distribution of question papers, wrong OMR sheets, and technical delays, and they aimed to ensure better planning and execution in future exams.

    Way forward: 

    • Calls for a Re-test for All Candidates: Students and education experts argue that if the exam can be cancelled for 1,563 candidates, it should be cancelled for all 23 lakh candidates to maintain fairness. They believe that the logical step is to conduct a re-test for everyone who took the May 5 exam.
    • Restoring Faith in the System: The dissatisfaction expressed on social media highlights a loss of faith in the examination system. To restore confidence, students demand comprehensive measures to address the flaws and ensure a fair and transparent testing process for all candidates.
    • Improving Examination Conduct: For an exam of NEET’s scale and history, it is expected that organizational issues should be resolved. The NTA and government agencies need to enhance measures to prevent fraud, ensure the timely distribution of materials, and apply proper judgment to address any technical issues during the exam, aiming for a smooth and reliable process in future examinations.

    Mains PYQ:

    Q National Education Policy 2020 is in conformity with the Sustainable Development Goal-4 (2030). It intends to restructure and reorient the education system in India. Critically examine the statement. (UPSC IAS/2020)

  • Global Geological And Climatic Events

    ‘Cold Lava’ Rivers flow in Philippines after Mount Canlaon eruption

    Why in the News?

    • After Mount Canlaon erupted in the Philippines, cold lava started flowing through streets and rivers.
      • It was followed by ashfall, and dangers like floods and mudflows downstream.

    What is Cold Lava?

    • Cold lava, also known as “lahar,” is a mixture of water and rock fragments that flows rapidly down the slopes of a volcano, often triggered by heavy rainfall or volcanic eruptions.
    • The mixture forms a concrete-like substance that destroys everything in its path.
    • This can also include smooth, glassy textures or rough and jagged textures.

    Another example of cold Lava in the world

    • Mount Merapi, Indonesia (2023): An eruption of Mount Merapi resulted in the deaths of at least 23 climbers and spewed ash up to 3,000 meters into the air, covering towns and villages

    How harmful is Cold Lava?

    • Rain can carry cold lava down the slopes of a volcano during an eruption and into the path of nearby towns or villages.
    • According to the United States Geological Survey, cold lava has the power to crush and bury things in its path.
    • It also moves quickly like wet concrete and is considered more destructive than hot lava.

    About Mount Canlaon

    • Mount Canlaon, located in the Philippines, is an active stratovolcano known for its frequent eruptions and volcanic activity.
    • It is situated on the island of Negros in the Visayas region of the Philippines.
    • It is part of the Pacific Ring of Fire, known for its high volcanic activity.
    • It poses hazards such as ash fall, lava flows, pyroclastic flows, and lahars (mudflows) that can endanger nearby communities and agriculture.

     

    PYQ:

    [2021] Discuss about the vulnerability of India to earthquake-related hazards. Give examples including the salient features of major disasters caused by earthquakes in different parts of India during the last three decades.

  • Festivals, Dances, Theatre, Literature, Art in News

    Cultural significance of Uttarakhand’s Joshimath and Kosiyakutoli 

    Why in the News?

    • The Centre approved the Uttarakhand government’s proposal to rename Joshimath tehsil to Jyotirmath and Kosiyakutoli tehsil to Pargana Shri Kainchi Dham.
      • This decision aims to enhance the religious and cultural significance of these areas, boosting their status as major destinations for religious tourism.

    About Jyotirmath 

    • Jyotirmath, also known as Jyotir Peeth, is one of the four cardinal mathas established by Adi Shankaracharya in the 8th century to promote Advaita Vedanta philosophy.
    • Adi Shankaracharya performed penance under the Amar Kalpavriksha tree here, symbolising his attainment of divine knowledge (Jyoti).
    • Evolution to Joshimath:
      • Name Transition: Originally known as Jyotirmath, the town gradually adopted the name Joshimath over time, influenced by regional languages and dialects.
      • Cultural Evolution: The shift from Jyotirmath to Joshimath reflects a cultural and linguistic evolution rather than a specific historical event.

    About Adi Shankaracharya (c 788 CE-820 CE)

    Details
    Philosopher and Theologian Prominent advocate of ancient Hinduism, known as Sankara (Jagatguru).
    Birthplace Kaladi in Ernakulam, Kerala, soon to be declared a national monument.
    Guru Govinda Bhagavatpada, from whom he learned extensively.
    Philosophies Advocated Advaita Vedanta and established Dashanami Sampradaya.
    Advaita Vedanta
    • Non-dualistic philosophy asserts the identity of Atman (self) and Brahman (ultimate reality).
    • Maya (creative energy) of Brahman creates the world.
    • Liberation through understanding Brahman and overcoming Avidya (ignorance).
    Key Disciples Padmapada, Totakacharya, Hasta Malaka, and Sureshwara – played crucial roles in spreading his teachings.
    Contributions
    • Introduced the Shanmata system and restored the Dashanami structure.
    • Established four Mathas (monastic institutions) across India.
    • Authored commentaries on major Hindu scriptures and composed hymns.
    Mathas Established Sri Sringeri Sharada Peetam (Karnataka), Jyotir Matha (Uttarakhand),

    Kalika Matha (Gujarat), Govardhana Matha (Odisha).

     

    About Kosiyakutoli  

    • Kosiyakutoli, now renamed Pargana Shri Kainchi Dham, aligns with the identity of Neem Karoli Baba’s Kainchi Dham Ashram.
    • “Kosi” refers to the river flowing through the Nainital district, which is crucial for the local ecology and economy.
    • Association with Neem Karoli Baba:
      • The ashram, founded in 1962, continues to draw thousands of visitors annually, including prominent figures like Steve Jobs and Ram Dass.
    PYQ:

    [2014] Which one of the following pairs does not form part of the six systems of Indian Philosophy?

    (a) Mimamsa and Vedanta

    (b) Nyaya and Vaisheshika

    (c) Lokayata and Kapalika

    (d) Sankhya and Yoga

  • Nobel and other Prizes

    Kavli Prize, 2024 Announced

    Why in the News? 

    The winners of the 2024 Kavli Prize were announced, recognising achievements in astrophysics, neuroscience, and nanoscience.

    About Kavli Prize

    • The Kavli Prize celebrates outstanding achievements in astrophysics, neuroscience, and nanoscience.
    • It is established in honour of Norwegian-American businessman and philanthropist Fred Kavli (1927-2013).
    • Awarded biennially, the prize recognizes researchers whose work pushes the boundaries of human knowledge and enhances our understanding of the universe, the brain, and nanoscale phenomena.

    About Fred Kavli

    • Fred Kavli, born in Erejsford, Norway, immigrated to California in 1956 and quickly made a mark in the engineering field.
    • His entrepreneurial journey began in 1958 with the founding of Kavlico, a pioneering company known for its precision pressure sensors used across diverse industries, from aviation to consumer electronics.

    The Kavli Foundation:

    • In 2000, after selling Kavlico for $340 million, Fred Kavli established the Kavli Foundation.
    • This philanthropic organisation supports fundamental research aimed at improving global quality of life.
    • The foundation operates 20 institutes worldwide dedicated to astrophysics, neuroscience, nanoscience, and theoretical physics.

    Prize Structure and Prestige:

    1. Comparison with Nobel Prize: The Kavli Prize mirrors the Nobel Prize in its prestige and international recognition but differs by not limiting awards to achievements within the preceding year, allowing broader scope and longevity in selection criteria.
    2. Award Ceremony: Each Kavli Prize includes a $1 million cash award per field, a scroll, and a 7 cm diameter medal. The ceremony, held at the Oslo Concert Hall and attended by global scientific leaders, features a red-carpet event, emphasizing its significance in the scientific community.
    3. Selection Process:
    • Committees: Three international committees nominate and review candidates, providing a unanimous recommendation to the Norwegian Academy of Science and Letters.
    • Nominees: Nominees come from prestigious institutions worldwide, ensuring a diverse and comprehensive evaluation process.

    Winners of the 2024 Kavli Prize:

    Field Winners Contributions
    Astrophysics David Charbonneau (Harvard University), Sara Seager (Massachusetts Institute of Technology) Pioneering methods for detecting atomic species in planetary atmospheres and measuring their thermal infrared emission, are crucial for identifying molecular fingerprints in atmospheres of exoplanets.
    Nanoscience Robert Langer (MIT), Armand Paul Alivisatos (University of Chicago), Chad Mirkin (Northwestern University) Langer: Nano-engineering for controlled drug delivery systems.

    Alivisatos: Development of semiconductor quantum dots for bio-imaging.

    Mirkin: Concept of spherical nucleic acids (SNAs) for applications in gene regulation and immunotherapy.

    Neuroscience Nancy Kanwisher (MIT), Winrich Freiwald (Rockefeller University), Doris Tsao (University of California, Berkeley) Mapping brain functions related to facial recognition using neuroimaging and neuronal recording techniques, identifying brain centers and neural architectures involved in face processing.

     

    PYQ:

    [2021] The Nobel Prize in Physics of 2014 was jointly awarded to Akasaki, Amano and Nakamura for the invention of Blue LEDs in the 1990s. How has this invention impacted the everyday life of human beings?

    [2018] Discuss the work of ‘Bose-Einstein Statistics’ done by Prof. Satyendra Nath Bose and show how it revolutionized the field of Physics.

    [2008] Nobel Prize-winning scientist James D. Watson is known for his work in which area? (2008)

    (a) Metallurgy

    (b) Meteorology

    (c) Environmental protection

    (d) Genetics

  • Nobel and other Prizes

    Longitude Prize on Antimicrobial Resistance (AMR)

    Why in the News?

    Sysmex Astrego, a Sweden-based diagnostic company, won the £10 million Longitude Prize for developing a high-tech UTI (Urinary Tract Infection) test called the PA-100 AST System. 

    What is Antimicrobial Resistance?

    • Antimicrobial Resistance (AMR) occurs when bacteria, viruses, fungi, and parasites change so that medicines no longer work against them.
    • This makes infections harder to treat and can lead to more severe illness and even death.
    • AMR can occur naturally through genetic changes or when one type of microorganism picks up resistance from another.
    • It can also occur randomly due to mutations or when resistant genes spread between different organisms.
    • The main reasons for AMR are antibiotics incorrectly or too often, not having access to clean water and good hygiene, not doing enough to prevent infections, and people not knowing how to use antibiotics properly.

    Global Impact of AMR

    • Global Threat: Antibiotic-resistant infections caused nearly 1.3 million deaths in 2019, with projections to exceed cancer-related deaths by 2050.
    • Economic Impact: The global economy faces potential losses of up to 4 trillion by 2030 and 100 trillion by 2050 due to the AMR crisis.

    About the Longitude Prize

    • The Longitude Prize, valued at £8 million (₹85 crore), was recently awarded for its profound implications in combating antimicrobial resistance (AMR).
    • The prize launched in 2014, aims to revolutionize infection management globally.
    • Historical Context:  
      • Origins: Established in 1714 to solve the maritime longitude problem, demonstrating the critical need for accurate navigation.
      • Modern Application: The 21st-century Longitude Prize addresses pressing global challenges like AMR, incentivizing innovative solutions.
    • Goal of the Prize:
      •  Aims to replace current lab-based diagnostic methods with rapid tests that guide targeted antibiotic therapies, combating AMR effectively.

    About PA-100 AST System 

    • Technology Breakthrough: Developed by Sysmex Astrego, this system uses a phenotypic test that identifies UTI bacteria and performs antibiotic susceptibility testing in under 45 minutes.
    • Operation: A single-use cartridge processes less than half a milliliter of urine, using microfluidic traps and phase-contrast imaging in a shoe box-sized reader instrument.
    • Clinical Impact: Provides rapid “sensitive” or “resistant” results for antibiotics, aiding doctors in immediate, accurate treatment decisions at the point of care.

    Current Challenges in UTI Diagnosis

    • Limited Accuracy: Current options include urine dipstick tests for quick results but limited accuracy (50-60%) and lab cultures with 2-3 day turnaround times.
    • Impact on Treatment: Delayed diagnosis often leads to empirical antibiotic use, contributing to antibiotic resistance worldwide.

    Significance for India

    • Healthcare Burden: In India, millions seek treatment for UTIs annually, impacting lives and healthcare systems significantly.
    • Potential: Rapid, accurate point-of-care tests could revolutionize UTI management globally, saving lives and reducing healthcare costs.

    PYQ:

    [2014] Can overuse and free availability of antibiotics without a Doctor’s prescription be contributors to the emergence of drug-resistant diseases in India? What are the available mechanisms for monitoring and control? Critically discuss the various issues involved.

    [2019] Which of the following are the reasons for the occurrence of multi-drug resistance in microbial pathogens in India?

    1. Genetic predisposition of some people
    2. Taking incorrect doses of antibiotics to cure diseases
    3. Using antibiotics in livestock farming
    4. Multiple chronic diseases in some people

    Select the correct answer using the code given below.

    (a) 1 and 2
    (b) 2 and 3 only
    (c) 1, 3 and 4
    (d) 2, 3 and 4

  • Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

    Tackling the Fatty Liver Disease Epidemic

    Why in the news?

    This year’s theme for International Fatty Liver Day, an awareness initiative observed annually in June, is ‘Act Now, Screen Today’. This theme holds more urgency now than ever before.

    Liver Diseases in recent times

    • Liver diseases have long been primarily linked to excessive alcohol consumption, which continues to be a major cause of advanced chronic liver disease.
    • However, in recent years, a new and quietly escalating threat to liver health has emerged: non-alcoholic fatty liver disease.

    India’s Growing Burden of Fatty Liver Disease

    Note: MASLD, or Metabolic dysfunction-associated steatotic liver disease, is a reclassification of what was previously known as non-alcoholic fatty liver disease (NAFLD). 

    • High Prevalence Rates: The global prevalence of Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated at 25-30%. In India, a 2022 meta-analysis revealed that the pooled prevalence of fatty liver among adults was 38.6%. Among obese children in India, the prevalence was around 36%.
    • Progression of Disease: The continuous damage caused by fatty liver leads to more severe conditions such as steatohepatitis and cirrhosis, often requiring liver transplants.

    Causes of Growing Burden of Fatty Liver Disease

    • Lack of Early Detection: Fatty liver disease often goes undetected in early stages due to lack of symptoms. Diagnosis usually occurs at an advanced stage, when significant liver damage has already taken place.
    • Diet and Insulin Resistance: Excessive consumption of carbohydrates, especially refined carbs and sugars, leads to metabolic problems. High carbohydrate intake results in persistently high insulin levels and insulin resistance, promoting the conversion of excess glucose into fatty acids, which are then stored in the liver.

    Initiatives Taken by the Government

    • Integration with NPCDCS: The Ministry of Health & Family Welfare launched operational guidelines for integrating NAFLD with the National Programme for Prevention & Control of Cancer, Diabetes, Cardiovascular Diseases and Stroke (NPCDCS) in February 2021.
    • Health Promotion and Prevention: The Ayushman Bharat- Health and Wellness Centres (AB-HWCs) are being used to promote healthy living and screen for hypertension, diabetes, and other common NCDs.

    Personalization is the Key

    • Tailored Screening Tests: The selection of screening tests and their frequency should be based on individual risk factors, including family history, lifestyle, and pre-existing health conditions.
    • Avoiding Generic Assumptions: Clinicians should not rely solely on age or physical markers; instead, they should consider a comprehensive risk profile. Non-communicable diseases are increasingly affecting diverse populations, including children.
    • Integrated Health Strategies: Combining dietary modifications, regular physical activity, and effective weight management to mitigate liver disease risks.
    • Frequent Screenings: Regular monitoring of liver health through non-invasive tools like vibration-controlled transient elastography. Continuous assessment of liver stiffness to detect early stages of liver fibrosis and monitor treatment responses.
    • Active Health Management: Emphasis on the importance of individuals taking control of their health by being aware of their diet and lifestyle choices.Encouragement of frequent health screenings to detect and manage liver disease early.

    Way Forward:

    • Awareness Campaigns: Government initiatives focus on raising awareness about the importance of liver health and the risks associated with MASLD.
    • Health Screenings: Programs promoting comprehensive health screenings that include physical examinations, blood tests, and abdomen ultrasounds to detect liver diseases early.

    Mains PYQ

    Q The public health system has limitations in providing universal health coverage. Do you think that the private sector can help in bridging the gap? What other viable alternatives do you suggest? (UPSC IAS/2015)

  • Innovations in Biotechnology and Medical Sciences

    Scientists back new Alzheimer’s drug: Benefits vs Risks

    Why in the News?

    Donanemab, a new Alzheimer’s disease therapy developed by Eli Lilly, has gained unanimous support from independent scientists advising the US Food and Drug Administration (FDA), moving it closer to clinical use.

    What is Donanemab?

    • Donanemab is a monoclonal antibody, which means it is a laboratory-produced molecule designed to function like antibodies in the immune system.
    • It is specifically developed for individuals in the early stages of Alzheimer’s disease, including those with mild cognitive impairment or mild dementia.

    How Does Donanemab Work?

    • It targets amyloid beta proteins in the brain. Amyloid beta plaques are one of the defining features of Alzheimer’s disease.
    • Mechanism of Action: The drug binds to amyloid beta plaques and promotes their removal from the brain. This action is intended to slow down the progression of Alzheimer’s disease by reducing the accumulation of these toxic plaques.

    How do the benefits of the drug stack up against its risks?

    • Target Population: The drug is intended for those in the early stages of Alzheimer’s disease (mild cognitive impairment or mild dementia).
    • Benefits: Significant clinically meaningful slowing of the disease, allowing patients to retain their functions for a longer time. Phase 3 study shows a 35.1% slowdown in cognitive decline in early Alzheimer’s patients over 76 weeks.
    • Risks: Main adverse effects include brain swelling (24%) and brain bleeds (19.7%), with most cases being asymptomatic.Three treatment-related deaths reported.Amyloid-related imaging abnormalities (ARIA) like brain bleeds and seizures were mostly non-serious and resolved after discontinuation of therapy.
    • Risk Management: The key risks can be mitigated through appropriate labeling and clinical monitoring. Further risks will be characterized through post-authorization studies.

    Why is a breakthrough of this kind important?

    • Rising Burden of Alzheimer’s: The global population is ageing, leading to an increased burden of diseases like Alzheimer’s. In India, 5.3 million people are currently living with dementia, expected to rise to 14 million by 2050.
    • Lack of Effective Treatments: There are limited options for disease-modifying treatments for Alzheimer’s. Innovations like donanemab are crucial for providing new hope and potential therapies.
    • Economic Considerations: While the drug is expensive, it offers the potential for several more years of quality life for patients.

    Why was the approval for the drug delayed?

    • Additional Data Requirements: The USFDA wanted to understand further the data relating to the therapy, especially regarding the limited dosing protocol used during trials.
    • Limited Dosing Protocol: During the trial, therapy was stopped in patients who achieved a certain level of amyloid beta plaque clearance, which is a distinguishing feature of donanemab compared to other therapies.
    • Previous Drug Approval Irregularities: Scrutiny increased after irregularities were found in the approval process of the first drug, aducanumab, which involved close collaboration between the regulator and the drugmaker and approval despite negative trial outcomes. The second drug, lecanemab, also had cautious optimism from doctors due to its demonstrated efficacy with fewer side effects.

    Conclusion: Ensure rigorous and transparent review processes for new Alzheimer’s treatments, incorporating comprehensive data analysis and post-authorization studies to monitor long-term safety and efficacy.

    Mains PYQ:

    Q Stem cell therapy is gaining popularity in India to treat a wide variety of medical conditions including leukaemia, Thalassemia, damaged cornea and several burns. Describe briefly what stem cell therapy is and what advantages it has over other treatments? (UPSC IAS/2017)

  • Disasters and Disaster Management – Sendai Framework, Floods, Cyclones, etc.

    Why heatwaves have not been included as a notified disaster in the Disaster Management Act?

    Why in the news?

    The current period of intense heat in several regions has once more sparked debates about the potential inclusion of heatwaves as officially recognized disasters under the Disaster Management (DM) Act of 2005.

    What are Notified Disasters?

    • According to the Disaster Management (DM) Act, 2005, a disaster is defined as a “catastrophe, mishap, calamity, or grave occurrence” arising from natural or man-made causes that result in substantial loss of life, destruction of property, or environmental damage and is beyond the coping capacity of the affected community.
    • Funds: The DM Act allows states to draw money from the National Disaster Response Fund (NDRF) and the State Disaster Response Fund (SDRF) for managing these disasters.
    • Current Notified Disasters: There are currently 12 categories of notified disasters: cyclones, drought, earthquake, fire, flood, tsunamis, hailstorms, landslides, avalanches, cloudbursts, pest attacks, and frost and cold waves.

    Why Heatwaves Were Not Included as Notified Disasters?

    • Common Occurrence: Heatwaves were historically considered regular events during summer months in many parts of India. They were not seen as exceptional or unusual disasters warranting specific disaster management provisions under the DM Act, 2005.
    • Perception of Predictability: Unlike sudden-onset disasters such as earthquakes or cyclones, heatwaves were perceived as relatively predictable and part of seasonal weather patterns. This perception led to a belief that they could be managed through general public awareness and local interventions rather than formal disaster response mechanisms.
    • Not fit in definition of Disaster: When the DM Act was formulated, disasters were defined as events that caused substantial loss of life, property, or environmental damage beyond the coping capacity of the affected community. At that time, the impacts of heatwaves were typically viewed as localized health issues rather than widespread disasters.
    • Lack of Urgency: There was a lack of urgency in recognizing heatwaves as disasters requiring national-level response frameworks. The focus of disaster management efforts initially leaned towards more acute and visible calamities like cyclones, floods, and earthquakes.

    Why is the Centre Not Adding Heatwaves as a Notified Disaster Now?

    • Financial Concerns: One of the primary concerns is the potential financial burden of declaring heat waves as a notified disaster. Under the current provisions, the government is obligated to provide monetary compensation for lives lost during notified disasters, which is set at Rs 4 lakh per victim.
    • The reluctance of Finance Commissions: Despite requests from various states, the 15th Finance Commission has not recommended adding heatwaves to the list of notified disasters. They argue that the existing categories adequately cover disaster response needs, and they have provided provisions for states to utilize a portion of the State Disaster Response Fund (SDRF) for local disasters like heatwaves.

    Conclusion: Engage with the Finance Commission and other relevant bodies to reassess the inclusion of heatwaves as a notified disaster. Highlight the evolving nature of heat waves, their increasing frequency, and the need for dedicated funding and support mechanisms.

    Mains PYQ: 

    Q Climate change’ is a global problem. How India will be affected by climate change? How Himalayan and coastal states of India will be affected by climate change?  (UPSC IAS/2017)

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