💥UPSC 2026, 2027, 2028 UAP Mentorship (March Batch) + Access XFactor Notes & Microthemes PDF

Type: Prelims Only

  • Foreign Policy Watch: India-Russia

    Russia’s Nord Stream 2 Pipeline

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Nord Stream 2 Pipeline

    Mains level: Not Much

    The US government has decided to waive sanctions on the company behind Russia’s Nord Stream 2 pipeline to Europe.

    Nord Stream 2 Pipeline

    • It is a system of offshore natural gas pipelines running under the Baltic Sea from Russia to Germany.
    • It includes two active pipelines running from Vyborg to Lubmin near Greifswald forming the original Nord Stream, and two further pipelines under construction running from Ust-Luga to Lubmin termed Nord Stream 2.
    • In Lubmin the lines connect to the OPAL line to Olbernhau on the Czech border and to the NEL line to Rehden near Bremen.
    • The first line Nord Stream-1 was laid and inaugurated in 2011 and the second line in 2012.
    • At 1,222 km in length, Nord Stream is the longest sub-sea pipeline in the world, surpassing the Langeled pipeline.

    US sanctions

    • Nord Stream projects have been opposed by the United States as well as by several Central and Eastern European countries because of concerns that the pipelines would increase Russia’s influence in the region.
    • The US resistance to Nord Stream 2 is also influenced by the country’s increased production of natural gas, which gives the US economic incentive to resist the Russian supply of gas to the EU, in favour of US shale gas.
  • GI(Geographical Indicator) Tags

    [pib] GI certified Gholvad Sapota

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: GI tags in news

    Mains level: Not Much

     

    In a major boost to exports of Geographical Indication (GI) certified products, a consignment of Dahanu Gholvad Sapota from the Palghar district of Maharashtra was shipped to the United Kingdom.

    Gholvad Sapota

    • GI certification of Ghovad Sapota is held by Maharashtra Rajya Chikoo Utpadak Sangh and the fruit is known for its sweet and unique taste.
    • It is believed that the unique taste is derived from the calcium-rich soil of Gholvad village.
    • Currently, in the Palgahr district, around 5000 hectares of land is under sapota or plantation.
    • Sapota is grown in many states- Karnataka, Gujarat, Maharashtra, Tamil Nadu, West Bengal and Andhra Pradesh.
    • Karnataka is known to be the highest grower of the fruit, followed by Maharashtra.

    Do you know?

    Earlier this month, a consignment of 2.5 Metric Tonne of GI certified Banganapalli & Survarnarekha mangoes sourced from farmers in Krishna & Chittor districts of Andhra Pradesh was exported to South Korea.


    Back2Basics: Geographical Indication (GI)

    • The World Intellectual Property Organisation defines a GI as “a sign used on products that have a specific geographical origin and possess qualities or a reputation that are due to that origin”.
    • GIs are typically used for agricultural products, foodstuffs, handicrafts, industrial products, wines and spirit drinks.
    • Internationally, GIs are covered as an element of intellectual property rights under the Paris Convention for the Protection of Industrial Property.
    • They have also covered under the Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement.
  • Capital Markets: Challenges and Developments

    SEBI proposes framework for Gold Exchange

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Gold Exchange

    Mains level: Gold Exchange and its trading

    The Securities & Exchange Board of India (SEBI) has floated a consultation paper on the proposed framework for Gold Exchange in India.

    Why such a move?

    • According to SEBI, the proposed exchange would bring in more transparency in the gold trading market in terms of spot price discovery, quality of the gold and enable greater integration with the financial markets.

    What is a Gold Exchange?

    • As the name suggests, this would offer trading facilities in the precious metal.
    • Entities like retail investors, banks, foreign portfolio investors (FPIs), jewellers and bullion dealers among others would be allowed to trade on the exchange.
    • While there are existing commodity exchanges that offer trading in gold contracts, those are derivative instruments while the proposed gold exchange would allow trading akin to the spot market.
    • This move assumes significance as India is the second-largest consumer of gold – after China – with an annual demand of around 800-900 tonnes.

    Answer this PYQ:

    Q.What is/are the purpose/purposes of the Government’s ‘Sovereign Gold Bond Scheme’ and ‘Gold Monetization Scheme’?

    1. To bring the idle gold lying with India households into the economy
    2. To promote FDI in the gold and jewellery sector
    3. To reduce India’s dependence on gold imports

    Select the correct answer using the code given below

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

    What are the ways in which one can invest in gold now?

    • For those wanting to buy physical gold, a visit to the neighbourhood jeweller would suffice.
    • Meanwhile, there are online platforms such as Paytm, Kuvera and Indiagold among others that allow an individual to buy gold in digital form.
    • The advantage of buying gold in digital form is that one can put in a very small amount as well with some platforms allowing a minimum investment of just Rs 100.
    • Digital gold products have become quite popular among millennials. Then there are sovereign gold bonds issued by the government.
    • One can even look at Gold ETFs or gold funds by mutual funds.
    • Even gold derivative contracts traded on the exchanges have the option of physical settlement, which means investors can get physical delivery of gold.

    How can one trade on a gold exchange?

    • The SEBI has proposed an instrument called ‘Electronic Gold Receipt’, or EGR.
    • The gold exchange, along with intermediaries like the vault manager and the clearing corporation, would facilitate the creation of EGR and its trading.
    • So, participants can convert their physical gold into EGR, which can then be bought or sold on the exchange like any normal equity share of a listed company.
    • The EGR can even be converted back into physical gold. As part of the draft regulations, SEBI has proposed three denominations of EGR – one kilogram, 100 grams and 50 grams.
    • It has, however, added that EGRs of five grams or 10 grams can also be allowed for trading to increase the liquidity of the market and attract more participants.

    How can one convert physical gold into EGRs?

    • An entity that intends to convert physical gold into EGR will have to go to a ‘Vault Manager’.
    • According to the proposed framework, any entity registered in India and with a net worth of at least Rs 50 crore can apply to become a vault manager.
    • After the receipt of the gold, the vault manager would create an EGR for which the depository will assign an International Securities Identification Number, or ISIN, which is a unique code to identify the specific security.
    • Once the ISIN is issued, the EGR can be traded on the gold exchange just like any other tradable security.

    Can EGRs be again converted into physical gold?

    • To convert an EGR into physical gold, the owner of the EGR will have to surrender the EGR to the vault manager who will deliver the gold and extinguish the electronic receipt.
    • Considering the logistics and delivery challenges, it has been proposed that conversion of an EGR into physical gold should be allowed only if a minimum of 50 grams of gold has been accumulated in electronic form.

    Issues with gold exchange

    • Since the EGRs would be traded on an exchange, Securities Transaction Tax (STT) would be levied. Also, GST would be applicable when EGRs are converted into physical gold for withdrawal.
    • If in case the buyer and seller are from different states then levying state GST could be cumbersome. SEBI is mulling if only IGST or Integrated Goods and Services Tax can be levied to resolve this issue.
    • As far as transactions are concerned, SEBI working groups have suggested that an entire transaction be divided into three tranches.
  • International Space Agencies – Missions and Discoveries

    Tianwen-1 lands successfully on Mars

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Tianwen 1 and various Mars missions

    Mains level: Mars mission worldwide and their success

    China landed a spacecraft on Mars carrying its first Mars rover in a big boost to its space ambitions.

    UPSC may ask an MCQ asking: Which of the following is/are the space missions related to Mars? It may throw up 4-5 options (which we all get confused at after few months) like Cassini , InSight , Messanger, Voyager etc.

    Tianwen-1 Mission

    • The mission is named after the ancient Chinese poem ‘Questions to Heaven’, the Tianwen-1.
    • It is an all-in-one orbiter; lander and rover will search the Martian surface for water, ice, investigate soil characteristics, and study the atmosphere, among completing other objectives.
    • It will be the first to place ground-penetrating radar on the Martian surface, which will be able to study local geology, as well as rock, ice, and dirt distribution.
    • The lander descended successfully onto the surface of the red planet carrying a rover named Zhurong, named after a god of fire for a planet known in Chinese as the planet of fire.
    • Only the Soviet Union and the United States had previously carried out a successful landing on Mars.

    Back2Basics: Various missions on Mars

    • The USSR in 1971 became the first country to carry out a Mars landing– its ‘Mars 3’ lander being able to transmit data for 20 seconds from the Martian surface before failing.
    • The country made it’s second and Mars landing two years later in 1973.
    • The second country to reach Mars’s surface, the US, holds the record for the most number of Mars landings.
    • Since 1976, it has achieved 8 successful Mars landings, the latest being the ‘InSight’ in 2019 (launched in 2018).
    • India and the European Space Agency have been able to place their spacecraft in Mars’s orbit.
    • India’s Mars Orbiter Mission (MOM) or ‘Mangalyaan’ was able to do so in September 2014, almost a year after its launch from the Satish Dhawan Space Centre in Andhra Pradesh.
    • The Chinese mission now is expected to take off around the same time when NASA is launching its own Mars mission– the ambitious ‘Perseverance’ which aims to collect Martian samples and bring them back.
  • Zoonotic Diseases: Medical Sciences Involved & Preventive Measures

    Mucormycosis infection in COVID-19 patients

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Mucormycosis

    Mains level: Post covid hazards

    Hospitals across the country have started to report a number of cases of Mucormycosis, an invasive fungal infection affecting patients who have recently recovered from COVID-19.

    What is Mucormycosis?

    • Mucormycosis is an aggressive and invasive fungal infection caused by a group of moulds called micromycetes.
    • It can affect various organs but is currently manifesting as invasive rhino-orbito-cerebral disease, crawling through the sinus and working its way to the brain, affecting the ear, nose, throat, and mouth.
    • While it is not contagious, it can cause a lot of damage internally and can be fatal if not detected early.
    • It is an old disease; perhaps new and concerning is the sudden increase in the invasive form of the sinus variant, which involves the orbit, and at times the brain, leading to blindness, stroke or death.

    What causes the disease?

    • Diabetes mellitus is the most common underlying cause, followed by haematological malignancies and solid-organ transplants.
    • Diabetes mellitus was reported in 54% to 76% of cases, according to a report.
    • What seems to be triggering Mucormycosis in patients post COVID-19 is indiscriminate use of a high dose of steroids in COVID-19 patients, sometimes even in minimally symptomatic patients.
    • This leads to spikes in the sugar level among diabetics, which, in turn, renders them vulnerable.

    Symptoms

    • The symptoms to watch out for are a stuffy nose, bloody, blackish, or brown discharge from the nose etc.
    • Other symptoms include blackish discolouration of the skin, swelling or numbness around the cheek, one-sided facial pain, toothache or jaw pain, drooping of the eyelids or eyelid swelling, double vision, redness of eyes, and sudden decrease in vision.

    Treatment

    • The mainline of treatment is an anti-fungal drug called amphotericin B, which is given over an extended period of time under the strict observation of a physician.
    • Rational use of steroids is necessary, and constant monitoring of sugar levels and resorting to insulin use to control these levels if required is essential.
    • Surgery to remove the fungus growth might also be warranted.

    Preventive measures

    • It is important to keep blood sugar levels under control and ensure that appropriate calibration of oral drugs or insulin is done from time to time.
    • Further, recognising the symptoms and seeking treatment early if there are two or three symptoms at a time is key.
    • Like most illnesses, if detected early, Mucormycosis can be cured.
  • Zoonotic Diseases: Medical Sciences Involved & Preventive Measures

    2-DG: DRDO’s new oral drug for Covid-19

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: 2DG

    Mains level: COVID-19 Treatment

    Defence Minister has released the first batch of the indigenously developed anti-Covid-19 drug, 2-deoxy-D-glucose or ‘2-DG’.

    What is the news?

    • The Drugs Controller General of India (DCGI) had cleared the formulation on May 1 for emergency use as an adjunct therapy in moderate to severe Covid-19 patients.

    What is 2-DG?

    • 2-DG has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), New Delhi, a lab of the DRDO in collaboration with Hyderabad-based pharma company Dr Reddy’s Laboratories (DRL).
    • The 2-DG anti-Covid drug is expected to reduce dependence on medical oxygen in Covid-19 infected patients.
    • The pseudo glucose molecule in the drug stops the virus in the tracts.
    • Hence, it has been prescribed for Coronavirus infected patients requiring critical medical oxygen.

    How does it work?

    • Clinical trial data show that the molecule helps in faster recovery of patients hospitalized with Covid-19, and reduces their dependence on supplemental oxygen.
    • The drug accumulates in virus-infected cells, and prevents the growth of the virus by stopping viral synthesis and energy production.
    • Its selective accumulation in virally-infected cells makes this drug unique.

    Advantages

    • 2-DG being a generic molecule and an analogue of glucose, it can be easily produced and made available in large quantities.
    • The drug is available in powder form in a sachet, and can be taken orally after dissolving in water.
  • Rajasthan to use MLA fund for vaccination

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: MLA-LAD scheme

    Mains level: Paper 2- Using MLA-LAD funds for Covid vaccination

    MLA-LAD Fund for buying vaccine

    • As part of the efforts to mobilise financial resources for COVID-19 vaccination, Rajasthan Chief Minister has approved a proposal to provide ₹3 crore each from the MLA Local Area Development (LAD) Fund.
    • For meeting the expenses, the fund for each legislator has been increased from ₹2.25 crore to ₹5 crore a year.
    • The 200 MLAs in the State will contribute a total of ₹600 crore to the vaccination fund account under the Chief Minister’s Relief Fund.
    • From the remaining ₹2 crore in the MLA-LAD Fund, ₹1 crore will be spent on strengthening the medical infrastructure, purchase of equipment and setting up of model community health centres.

    About MLA-LAD Fund

    • Member of Legislative Assembly Local Area Development is a scheme that enables each MLA to undertake small developmental works in his/her constituency.
    • The MLALAD Scheme is intended to be utilised for small but essential projects/works based on the felt needs of the local public.
    • Under this scheme, funds will be provided in the State’s Plan Budget every year.
  • Health Sector – UHC, National Health Policy, Family Planning, Health Insurance, etc.

    Risk of mucormycosis in Covid-19 patients

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Mucormycosis

    Mains level: Paper 2- Mucormycosis infection risk in Covid-19 patients

    About mucormycosis

    • Mucormycosis is a fungal infection that has a high mortality rate of 50 per cent.
    • An increasing number of Covid-19 patients have been developing this infection while still at the hospital or after discharge.
    • The disease often manifests in the skin and also affects the lungs and the brain.
    • Some of the common symptoms include sinusitis, blackish nasal discharge, facial pain, headaches, and pain around the eyes.

    Who is at risk

    • Patients who have been hospitalised for Covid-19 and particularly those who require oxygen therapy during Covid-19 illness are at a much higher risk of mucormycosis.
    • However, there are some cases of mucormycosis in patients with asymptomatic Covid-19 infection.
    • Before the pandemic, patients with uncontrolled diabetes were at a higher risk of mucormycosis.
    • The risk of mucormycosis rises for these patients for two reasons.
    • First is that Covid-19 further impairs their immune system.
    • Second, they are given corticosteroids for their treatment it leads to a rise in their blood sugar level thus increasing their risk of mucormycosis.

    Treatment

    • Today, we have a number of drugs and anti-fungal medicines that can treat mucormycosis.
    • These are given by IV or taken orally.
    • Surgery is needed to remove the affected dead tissues along with antifungal therapy.
  • ISRO Missions and Discoveries

    NASA’s OSIRIS-REx begins journey back from asteroid

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: Asteroid Bennu

    Mains level: Paper 3- OSIRIS-REx starts journey back to the earth

    On May 11, NASA’s Origins, Spectral Interpretation, Resource Identification, Security, Regolith Explorer (OSIRIS-REx) spacecraft will depart asteroid Bennu, and start its two-year-long journey back to Earth.

    About OSIRIS-REx

    • OSIRIS-REx is NASA’s first mission to visit a near-Earth asteroid, survey its surface and collect a sample from it.
    • The mission was launched in 2016, it reached its target in 2018 and since then, the spacecraft has been trying to match the velocity of the asteroid using small rocket thrusters.
    • It also utilised this time to survey the surface and identify potential sites to take samples.
    • In October 2020, the spacecraft briefly touched asteroid Bennu, from where it collected samples of dust and pebbles. 
    • Once the surface was disturbed, the spacecraft’s robotic arm captured some samples.
    • The spacecraft’s engineers have also confirmed that shortly after the spacecraft made contact with the surface, it fired its thrusters and “safely backed away from Bennu”.

    About Bennu

    • Bennu is considered to be an ancient asteroid that has not gone through a lot of composition-altering change through billions of years, which means that below its surface lie chemicals and rocks from the birth of the solar system.
    • Around 20-40 percent of Bennu’s interior is empty space and scientists believe that it was formed in the first 10 million years of the solar system’s creation, implying that it is roughly 4.5 billion years old.
    • Bennu is a B-type asteroid, implying that it contains significant amounts of carbon and various other minerals.
    • Because of its high carbon content, the asteroid reflects about four percent of the light that hits it, which is very low when compared with a planet.
    • Bennu is named after an Egyptian deity.
    • The asteroid was discovered by a team from the NASA-funded Lincoln Near-Earth Asteroid Research team in 1999.
  • Pharma Sector – Drug Pricing, NPPA, FDC, Generics, etc.

    What is 2-deoxy-D-glucose (2-DG) and is it effective against Covid?

    Note4Students

    From UPSC perspective, the following things are important:

    Prelims level: 2-DG

    Mains level: Paper 3- Drug developed by DRDO approved for Covid treatment

    About the drug

    • DRDO’s new anti-Covid oral drug, 2-deoxy-D-glucose (2-DG), was recently granted emergency use approval by the Drug Controller General of India (DCGI).
    •  2-DG halts the spread of COVID-19 inside the body cells.
    • Clinical trial results have shown that this molecule helps in faster recovery of hospitalised patients and reduces supplemental oxygen dependence.
    • In efficacy trends, the patients treated with 2-DG showed faster symptomatic cure than Standard of Care (SoC) on various endpoints.
    • A significantly favourable trend (2.5 days difference) was seen in terms of the median time to achieving normalisation of specific vital signs parameters when compared to SoC.

    How 2-DG reduces dependence on oxygen

    • The 2 DG drug, like glucose, spreads through the body, reaches the virus-infected cells and prevents virus growth by stopping viral synthesis and destroys the protein’s energy production.
    • The drug also works on virus infection spread into lungs which help us to decrease patients dependability on oxygen.