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  • Historical and Archaeological Findings in News

    Genetic proof for domestication of sheep in Indian subcontinent

    Researchers at the Central University of Kerala (CUK) have found that domestication of sheep had taken place in the Indian subcontinent, especially in the Indus Valley Civilisation (IVC) regions in the 6th or 7th millennium BC.

    Animal domestication in IVC

    A number of domesticated animal species have been found in excavations at the Harappan cities.

    • The Indian humped cattle (Bos indicus) were most frequently encountered, though whether along with a humpless variety, such as that shown on the seals, is not clearly established.
    • The buffalo (B. bubalis) is less common and may have been wild.
    • Sheep and goats occur, as does the Indian pig (Sus cristatus).
    • The camel is present, as well as the ass (Equus asinus).
    • Bones of domestic fowl are not uncommon; these fowl were domesticated from the indigenous jungle fowl.
    • Finally, the cat and the dog were both evidently domesticated.
    • Present, but not necessarily as a domesticated species, is the elephant.
    • The horse is possibly present but extremely rare and apparently only present in the last stages of the Harappan Period.

    Key findings of the study

    • The study has found genetic evidence that sheep had been domesticated in the region in contrast to the general belief that they were domesticated then in West Asia alone.
    • India ranks second in terms of sheep population, represented by as many as 44 well-described breeds in addition to several nondescript species.
    • It highlights that genetic diversity and phylogeography of Indian sheep breeds remained poorly understood, particularly the south Indian breed.

    How was the classification held?

    • Researchers retrieved the mitochondrial DNA sequences of another 11 breeds for analysis, which further strengthened their study.
    • The researchers analysed these sequences along with published data of domestic and wild sheep from different countries, including India.
    • The haplotype diversity observed was relatively high in Indian sheep, which were classified into the three known major mitochondrial DNA lineages namely A, B, and C.

    Diversity among Indian Sheeps

    • It was found that lineage A was predominant among Indian sheep, whereas lineages B and C were observed at low frequencies.
    • Particularly lineage C was restricted to the breeds of northern and eastern India.
    • The study examined the south Indian breeds, provided strong genetic evidence that the Indian subcontinent was one of the domestication centres of the lineage A sheep.
    • When DNA sequences were compared with other breeds across the world, it was found that the Indian sheep haplotypes were unique and highly diverse.
    • The high genetic diversity and statistical analysis suggest that sheep was domesticated in the country.
    • The wild Sheep, O. vignei blanfordi in Mehrgarh [Pakistan], may be a potential progenitor of domestic sheep lineage.

    Breeds studied

    • Among the south Indian breeds, except for Mandya, all others, notably Bellary, Coimbatore, Hassan, Katchaikatty Black, Nilgri, Ramnad White, and Vembur, were fully encompassed with lineage A.
    • However, Kenguri Kilakarsal, Madras Red, Mecheri, and Tiruchy Black breeds, had very low occurrences of lineage B mitochondria.
    • In contrast, a majority of individuals of Mandya and Sonadi breeds carried a relatively high frequency of lineage B.
    • In terms of the conservation of sheep genetic resources, these two breeds are important with respect to maternal lineages.

    Try answering this PYQ:

    With reference to the difference between the culture of Rigvedic Aryans and Indus Valley people, which of the following statements is/are correct?

    1. Rigvedic Aryans used the coat of mail and helmet in warfare whereas the people of Indus Valley Civilization did not leave any evidence of using them.
    2. Rigvedic Aryans knew gold, silver and copper whereas Indus Valley people knew only copper and iron.
    3. Rigvedic Aryans had domesticated the horse whereas there is no evidence of Indus Valley people having been aware of this animal.

    Select the correct answer using the code given below:

    (a) 1 only

    (b) 2 and 3 only

    (c) 1 and 3 only

    (d) 1, 2 and 3

     

    Post your answers here.

     

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  • Foreign Policy Watch: India-Russia

    NATO fires Russian Diplomats

    NATO has withdrew the accreditation of eight Russian officials to the military alliance in response to a rise in malign activities by Moscow.

    NATO

    • NATO is a military alliance established by the North Atlantic Treaty (also called the Washington Treaty) of April 4, 1949.
    • It sought to create a counterweight to Soviet armies stationed in Central and Eastern Europe after World War II.
    • Its original members were Belgium, Canada, Denmark, France, Iceland, Italy, Luxembourg, the Netherlands, Norway, Portugal, the United Kingdom, and the United States.
    • NATO has spread a web of partners, namely Egypt, Israel, Sweden, Austria, Switzerland and Finland.

    Why was it founded?

    Ans. Communist sweep in Europe post-WWII and rise of Soviet dominance

    • After World War II in 1945, Western Europe was economically exhausted and militarily weak, and newly powerful communist parties had arisen in France and Italy.
    • By contrast, the Soviet Union had emerged from the war with its armies dominating all the states of central and Eastern Europe.
    • By 1948 communists under Moscow’s sponsorship had consolidated their control of the governments of those countries and suppressed all non-communist political activity.
    • What became known as the Iron Curtain, a term popularized by Winston Churchill, had descended over central and Eastern Europe.

    Ideology of NATO

    • The NATO ensures that the security of its European member countries is inseparably linked to that of its North American member countries.
    • It commits the Allies to democracy, individual liberty and the rule of law, as well as to peaceful resolution of disputes.
    • It also provides a unique forum for dialogue and cooperation across the Atlantic.

    The Article 5

    • The heart of NATO is expressed in Article 5, in which the signatory members agree that an armed attack against one or more of them in Europe or North America shall be considered an attack against them all.

    Why in news now?

    • The relationship between NATO and Russia is at its lowest point since the end of the Cold War.
    • The NATO (rather US) sees their aggressive actions, not least against Ukraine, but also the significant military buildup and violations of important arms control agreements.
    • NATO suspended practical cooperation with Russia in 2014 after it annexed Ukraine’s Crimean Peninsula.

     

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  • Animal Husbandry, Dairy & Fisheries Sector – Pashudhan Sanjivani, E- Pashudhan Haat, etc

    [pib] River Ranching Programme

    The Union Minister for Fisheries, Animal Husbandry & Dairying, is set to launch the River Ranching Programme in Uttar Pradesh under the Namami Gange Programme.

    What is River Ranching?

    • River Ranching is a form of aquaculture in which a population of a fish species (such as salmon) is held in captivity for the first stage of their lives.
    • They are then released, and later harvested as adults when they return from the sea to their freshwater birthplace to spawn.

    Objective

    The key objectives of the program are:

    • To sustain and conserve the biodiversity in the river.
    • Facilitate regular stocking of fingerlings of cultivable carps to enhance productivity
    • Increase fish production
    • Enhance income and livelihood opportunities to communities’ dependent on these resources

    Why need such a program?

    • River ranching helps in achieving sustainable fisheries, reducing habitat degradation, conserving biodiversity, maximising social-economic benefits and would also remove factors causing pollution.
    • In this activity, different species of fish are released in the river, which destroy factors that increase the level of nitrogen.
    • These fishes will also aid in maintaining the cleanliness of the river as they feed on organic remnants.

    Where is the scheme being launched?

    • In Uttar Pradesh, about 15 lakh fish fingerlings of native carp species shall be simultaneously released into the river in 12 districts by the department.
    • These districts include Bulandshahr/Hapur, Hardoi, Bijnor, Amroha, Fatehpur, Kanpur, Badayun, Kaushambi, Prayagraj, Mirzapur, Varanasi and Ghazipur.
    • Four other states namely Uttarakhand, Orissa, Tripura and Chhattisgarh will also witness the launching of nationwide River Ranching program.

     

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  • Animal Husbandry, Dairy & Fisheries Sector – Pashudhan Sanjivani, E- Pashudhan Haat, etc

    [pib] National Digital Livestock Mission

    The Union Minister of State Fisheries, Animal Husbandry & Dairying unveiled the National Digital Livestock Mission Blueprint.

    National Digital Livestock Mission

    • The NDLM would be a digital platform developed by Dept. of Dairy and Animal Husbandry on the foundation of the existing Information Network for Animal Productivity and Health (INAPH).
    • It aims to create a farmer-centric, technology-enabled ecosystem where the farmers are able to realize better income through livestock activities with the right information.
    • The bedrock of NDLM will be the unique identification of all livestock, which will be the foundation for all the state and national level programmes including domestic and international trade.
    • The farmers will be able to effortlessly access the markets, irrespective of their location or holdings through this digital platform as a wide-range of stake-holders will be connected in this ecosystem.
    • This system will also include robust animal breeding systems, nutrition, disease surveillance, disease control programmes and a traceability mechanism for animals and animal products.

    Why need such mission?

    • The livestock sector has a unique combination of being the backbone of rural livelihood.
    • The growth would have been a lot better if there were concerted efforts to harmonise programmes across the country in order to create an ecosystem that is conducive for growth of the sector.
    • This has been the main idea behind the deployment of NDLM, keeping the welfare of the farmer at the core.

    Back2Basics: National Livestock Mission

    • National Livestock Mission is an initiative of the Ministry of Agriculture and Farmers’ Welfare.
    • The mission, which commenced from 2014-15, has the objective of sustainable development of the livestock sector.
    • NABARD is the subsidy channelising agency for following schemes, under Entrepreneurship Development & Employment Generation (EDEG) component of National Livestock Mission.
    1. Poultry Venture Capital Fund (PVCF)
    2. Integrated Development of Small Ruminants and Rabbit (IDSRR)
    3. Pig Development (PD)
    4. Salvaging and Rearing of Male Buffalo Calves (SRMBC)
    5. Effective Animal Waste Management
    6. Construction of Storage Facility for Feed and Fodder

     

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  • Climate Change Negotiations – UNFCCC, COP, Other Conventions and Protocols

    India joins High Ambition Coalition (HAC)

    India has officially joined the High Ambition Coalition for Nature and People, a group of more than 70 countries encouraging the adoption of the global goal to protect 30×30.

    High Ambition Coalition (HAC)

    Aim: To promote an international agreement to protect at least 30 % the of world’s land and ocean by 2030

    • The HAC is an informal group of approximately 61 countries within the UN Framework Convention on Climate Change (UNFCCC).
    • It is committed to advancing progressive proposals on climate ambition.
    • The HAC was founded by the Republic of the Marshall Islands in 2014 with the aim of ensuring the Paris Agreement, adopted in 2015, was as ambitious as possible.
    • The Republic of the Marshall Islands serves as the convener and secretariat of the HAC.
    • The global 30×30 goal is currently a centerpiece of the treaty.

    Members

    • HAC members currently include a mix of countries in the global north and south; European, Latin American, Africa and Asia countries are among the members.
    • India is the first of the BRICS bloc of major emerging economies (Brazil, Russia, India, China and South Africa) to join the HAC.

     

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  • WTO and India

    WTO & Related issues

    Context

    Created in 1995, during the heyday of neoliberalism, the World Trade Organization (WTO) became a shining example of triumphant free-market capitalism. Now, the WTO is facing a serious existential crisis.

    Challenges facing WTO

    1) Disfunctional appellate body

    • The United States, which played a pivotal role in establishing the WTO, seems to have lost interest in it.
    • The feeling in the US is that the WTO hasn’t served the American national interest by failing to stem China’s rise and regularly indicting the U.S. in several trade disputes.
    • The continuation of the U.S. policy on the WTO is most evident in the sustained crippling of the Appellate Body (AB).
    • Three out of seven AB members serve on any one case.
    • However, since December 2019, the AB has stopped functioning due to rising vacancies.
    • Countries now have an easy option not to comply with the WTO panel decisions by appealing into the void.
    • If no solution is found soon, the WTO’s rules-based order will start crumbling.

    2) Public stockholding for food security purposes

    • No solution has been found to the public stockholding for food security purposes despite a clear mandate to do so in the 2015 Nairobi ministerial meeting.
    • This is of paramount concern for countries like India that use Minimum Support Price (MSP)-backed mechanisms to procure foodgrains.
    • With rising prices and the need to do higher procurement to support farmers and provide food to the poor at subsidised prices, India might breach the cap.
    •  Although countries have agreed that legal suits will not be brought if countries breach the cap (the so-called ‘peace clause’), it is imperative to find a permanent solution such as not counting MSP-provided budgetary support as trade-distorting.

    3) Disagreement on TRIPS waiver for Covid-19

    • The WTO member countries continue to disagree on the need of waiving the Trade-Related Aspects of Intellectual Property Rights (TRIPS) agreement for COVID-19 related medical products.
    • It was exactly a year back when India and South Africa proposed a TRIPS waiver to overcome intellectual property (IP)-related obstacles in increasing accessibility of COVID-19 medical products, including vaccines.

    4)  Regulating irrational subsidies provided for fishing

    • Irrational subsidies provided for fishing that has led to the overexploitation of marine resources by countries like China, which is the largest catcher and exporter of fish.
    • The WTO is close to signing a deal on regulating irrational subsidies
    • This agreement should strike a balance between conserving ocean resources and the livelihood concerns of millions of small and marginal fishermen in countries like India.

    5) Fragmentation of global governance due to plurilateral trade agreements

    • The gridlock at the WTO has led to the emergence of mega plurilateral trade agreements like the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) and Regional Comprehensive Economic Partnership (RCEP) agreement.
    • These mega plurilateral agreements not only fragment the global governance on international trade but also push the multilateral order to the margin, converting the WTO to what some call an “institutional zombie”.

    Conclusion

    Notwithstanding its flaws, the WTO is the only forum where developing countries like India, not party to any mega plurilateral trade agreements, can push for evolving an inclusive global trading order that responds to the systemic imbalances of extant globalisation. What is at stake is the future of trade multilateralism and not just an institution, in which India has a huge interest.

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  • Foreign Policy Watch: India-China

    A strategy for India in a world that is adrift

    This article discusses new situations prompted by the tectonic shifts in India’s internal and external environment to take another look at India’s path to power in a world between orders.

    New global order: No Order

    • Multipolarity: The world is today adrift. We are neither in a bipolar Cold War nor in a multipolar world, though perhaps tending towards a world of several power centres.
    • Lack of cohesion: The lack of a coherent international response to the COVID-19 pandemic is proof of an absence of international order and of the ineffectiveness of multilateral institutions.
    • Climate ignorance: So is the ineffective international response to climate change and other transnational threats.

    What are the major shifts in global order?

    • Secular stagnation
    • Retreat from globalisation
    • Regionalisation of trade
    • Shifting balance of power
    • Rise of China and others
    • Structural China-United States strategic rivalry

    All above factors have shifted the geopolitical and economic centres of gravity from the Atlantic to Asia.

    Major Concerns

    • Chauvinism: Inequality between and within states has bred a narrow nationalism and parochialism.
    • Existential threats: We are entering a new polarised information age, and face ecological crises of the Anthropocene, making climate change an existential threat.

    Asia as the nucleus: With focus on China

    • Shift of focus by the US: Over the next decade we expect Asia to remain the cockpit of geopolitical rivalries, and that the US remains the most formidable power, though its relative power is declining.
    • China at the centre: China sees a window of opportunity but acts in a hurry, suggesting that she believes that window may close or is already closing due to push back from the West and others.

    China’s expansionism

    • China’s crowded geography constrains her both on land and at sea.
    • Hence it expects her profile and power to continue expanding, particularly in our periphery.
    • The result is likely continued friction, some cooperation, and quasi-adversarial relations between India and China, which others will take advantage of.
    • Overall, we do not expect conventional conflict between the great powers in Asia, though other forms and levels of violence and contention in the international system will rise, with Taiwan a special case.

    Opportunities in disguise for India

    • The uncertainty and changing geopolitical environment clearly pose considerable challenges to Indian policy.
    • However, it also throws up certain opportunities, enhancing our strategic options and diplomatic space, if we adjust policies internally and externally, particularly in the subcontinent.

    How can India reap the benefits?

    • Enhancing ties with the US: Increasing security congruence with the US could enable growing cooperation in fields significant for India’s transformation: energy, trade, investment, education and health.
    • Climate cooperation: Other areas in which India and the U.S. could increase cooperation are: climate change and energy, tech solutions for renewable energy, and on digital cooperation.
    • Neighbourhood first: Several middle powers like Sri Lanka, Bangladesh, Indonesia in the neighbourhood are now India’s natural partners.
    • Digital space: This time of transition between orders is also when new standards and norms are being developed, particularly in the digital space. India can and must be present at the creation.
    • Maritime cooperation: At sea, the balance is today more favourable to us than before, possibly more so than on the continent. India must bat for the creation of a Maritime Commission in IOR.

    Bottlenecks in India’s neighbourhood policy

    • Over securitisation of policy: towards our neighbours has driven trade underground, criminalised our borders.
    • Conducive environment for entry of China: This has enabled the large-scale entry of Chinese goods destroying local industry in the northeast.
    • Lack of self-strengthening: While lessening dependence on China, and seeking external balancing, our primary effort has to concentrate on self-strengthening.
    • Lack of socio-political enterprise: If there is one country which in terms of its size, population, economic potential, scientific and technological capabilities can match or even surpass China, it is India.

    Way forward for India

    (A) Bringing multipolarity in Asia.

    • The way forward should be based on the core strategic principles in Non-Alignment 2.0 which are still relevant: independent judgement, developing our capacities, and creating an equitable and enabling international order for India’s transformation.
    • Today’s situation makes India’s strategic autonomy all the more essential.

    (B) Making an issue-based coalition

    • India must adjust to changing circumstances. We have no choice but to engage with this uncertain and more volatile world.
    • One productive way to do so would be through issue-based coalitions including different actors, depending on who has an interest and capability.

    (C) Reviving SAARC

    • India must craft and reinvigorate regional institutions and processes in the neighbourhood, reviving the South Asian Association for Regional Cooperation (SAARC) for instance.
    • India could be the primary source of both prosperity and security in the neighbourhood — the subcontinent and the Indian Ocean Region.

    Conclusion

    • Economic policy must match political and strategic engagement.
    • Globalisation has been central to India’s growth.
    • A more active regional and international role for India is incompatible with a position on the margins of the global economy.
    • Self-reliance in today’s world and technologies can only be realised as part of the global economy.
    • We should not imitate China’s claims to being a civilisational state and its adoption of victimhood.
    • Instead, we should affirm our own strength and historic national identity.

     

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  • Minority Issues – SC, ST, Dalits, OBC, Reservations, etc.

    Government asks Supreme Court to set norms for quota in promotions

    The Union government has urged the Supreme Court to do away with the requirement of collecting quantifiable data by the Centre and states to determine the representation of people belonging to Scheduled Castes (SCs) and Scheduled Tribes (STs) while implementing reservation in promotion.

    Supreme Court directive on Quota in Promotions

    Background

    • The top court has called it “disturbing” that the Union government did not discontinue reservation in promotion for people belonging to SC/STs.
    • It referred to their numbers exceeded the upper ceiling of 15% and 7.5% respectively, of positions in some classes of central government jobs.

    Quota in Promotions: A timeline

    What was the case?

    • The Union government has been pressing for reservation in promotion proportionate to the population of SCs and STs as per a 1995 judgment by the top court in the RK Sabharwal case.
    • It wants it to be left open to the Centre and states to decide on promotional avenues for SCs and STs.
    • It claims that the condition regarding collection of quantifiable data to show inadequacy of representation of SCs/STs is “vague”.
    • Advocates representing general category have contended that the reservation cannot be for an indefinite period and that it must stop as soon as the upper ceiling has been reached.
    • Further, they have emphasised that reservation in promotion should be cadre-based only after quantifiable data is collected and the creamy layer has been excluded.

    Defying the need for quantifiable data

    • Attorney General sought to convince the court that the roster system, based on the proportionate population of SCs/STs, has been working quite well in all government departments.
    • The condition of collecting quantifiable data on inadequacy of representation of SCs/STs may not be required at all.
    • He urged that there is no need to verify any further or collect quantifiable data after the roster system.

    Referring to the Nagraj Case

    • Article 16(4A) of Indian Constitution allows reservations to SCs and STs in promotions, as long as the government believes that they are not adequately represented in government services.
    • In 2006, a Constitution bench’s ruling in the M Nagaraj case made it incumbent upon the state to collect quantifiable data showing inadequacy of representation in public employment.
    • This was to be done in addition to maintaining overall administrative efficiency.

    Why such demand by the Centre?

    • The Attorney General has said that it is tough for a member of the SC/ST to reach the ‘Group A’ category jobs.
    • The time has come for the apex court to firm up and draw the basis for reservation in promotions for SC/ST candidates to fill up vacancies in top jobs.
    • The Bench referred to records filed before it to note that there was low representation of SC/ST category in Group A jobs.
    • Instead of improving the situation in the Group A ranks, the court said, efforts are on to ensure adequate representation in Groups B and C. This was not fair, it remarked.

    Must read:

    [Burning Issue] SC judgement on Reservation not being a Fundamental Right

     

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  • Nobel and other Prizes

    Nobel Prize 2021

    (1) Nobel Prize for Economic Sciences, 2021

    The 2021 Nobel Prize in Economic Sciences has been awarded in one half to Canadian-born David Card and the other half jointly to Israeli-American Joshua D Angrist and Dutch-American Guido W Imbens.

    • David Card has been awarded for his empirical contributions to labor economics. Joshua D Angrist and Guido W Imbens won the award “for their methodological contributions to the analysis of causal relationships.”
    • The 2020 Nobel Prize in Economic Sciences was awarded to Paul R Milgrom and Robert B Wilson “for improvements to auction theory and inventions of new auction formats”.

    Contributions

    • David Card: He has analyzed how minimum wages, immigration and education impact the labor market.
      • One of the significant findings of this research was that“increasing the minimum wage does not necessarily lead to fewer jobs”.
      • It also led to the understanding that“people who were born in a country can benefit from new immigration, while people who immigrated at an earlier time risk being negatively affected”.
      • It also illuminated the role of resources available in school in shaping the future of students in the labor market.
    • Joshua Angrist and Guido Imbens: They were rewarded for their “methodological contributions” to the research tool.
      • Their work demonstrated “how precise conclusions about cause and effect can be drawn from natural experiments”.

     (2) Nobel Prize for Chemistry, 2021

    The 2021 Nobel Prize in Chemistry was awarded to Benjamin List and David MacMillan for the development of asymmetric organocatalysis.

    • Last year, the honour went to Frenchwoman Emmanuelle Charpentier and American Jennifer Doudna, for developing the gene-editing technique known as CRISPR-Cas9 – DNA snipping “scissors”.

    About the Development

    • They have developed a new and ingenious tool for molecule building: organocatalysis.
      • Many research areas and industries are dependent on chemists’ ability to construct molecules that can form elastic and durable materials, store energy in batteries or inhibit the progression of diseases. This work requires catalysts.
      • According to researchers, there were just two types of catalysts available: metals and enzymes. Catalysts are any substance that increases the rate of a reaction without itself being consumed.
    • In 2000, they, independent of each other, developed a third type of catalysis. It is called asymmetric organocatalysis and builds upon small organic molecules.
    • Significance:
      • Its uses include research into new pharmaceuticals and it has also helped make chemistry greener.
      • Both these sets of catalysts (metals and enzymes) had limitations.
      • Heavier metals are expensive, difficult to mine, and toxic to humans and the environment.
        • Despite the best processes, traces remained in the end product; this posed problems in situations where compounds of very high purity were required, like in the manufacture of medicines.
        • Also, metals required an environment free of water and oxygen, which was difficult to ensure on an industrial scale.
      • Enzymes on the other hand, work best when water is used as a medium for the chemical reaction. But that is not an environment suitable for all kinds of chemical reactions.

    Organocatalysis

      • Organic compounds are mostly naturally-occurring substances, built around a framework of carbon atoms and usually containing hydrogen, oxygen, nitrogen, sulphur, or phosphorus.
      • Life-supporting chemicals like proteins, which are long chains of amino acids (carbon compounds containing nitrogen and oxygen) are organic.
      • Enzymes are also proteins, and therefore, organic compounds. These are responsible for many essential biochemical reactions.
      • Organocatalysts allow several steps in a production process to be performed in an unbroken sequence, considerably reducing waste in chemical manufacturing.
      • Organocatalysis has developed at an astounding speed since 2000. Benjamin List and David MacMillan remain leaders in the field, and have shown that organic catalysts can be used to drive multitudes of chemical reactions.
        • Using these reactions, researchers can now more efficiently construct anything from new pharmaceuticals to molecules that can capture light in solar cells.

    Asymmetric Organocatalysis

      • The process called asymmetric organocatalysis has made it much easier to produce asymmetric molecules – chemicals that exist in two versions, where one is a mirror image of the other.
      • Chemists often just want one of these mirror images – particularly when producing medicines – but it has been difficult to find efficient methods for doing this.
      • Some molecules with mirror versions have different properties. An example is the chemical called carvone, which has one form that smells like spearmint and a counterpart that smells like the herb, dill.
      • Different versions of the same molecule might have different effects when ingested. Then it becomes important to be able to make only the mirror image of a drug that has the desired physiological effect.

    (3) Nobel Prize in Physics, 2021

    The 2021 Nobel Prize in Physics is awarded with one half jointly to Syukuro Manabe, Klaus Hasselmann and the other half to Giorgio Parisi “for groundbreaking contributions to our understanding of complex physical systems.”

    • This is the first time climate scientists (Manabe and Hasselmann) have been awarded the Physics Nobel. Last year, the award was given for the research into black holes.

    Manabe and Hasselmann

    • Awarded for work in physical modelling of Earth’s climate, quantifying variability and reliably predicting global warming.
    • Demonstrated how increases in the amount of carbon dioxide in the atmosphere would increase global temperatures, laying the foundations for current climate models.

    Parisi

    • Awarded for “the discovery of the interplay of disorder and fluctuations in physical systems from atomic to planetary scales.”
    • He “built a deep physical and mathematical model” that made it possible to understand complex systems in fields such as mathematics, biology, neuroscience and machine learning.

    (4) Nobel Prize for Physiology/Medicine, 2021

    Recently, two United States-based scientists, David Julius and Ardem Patapoutian have been awarded the 2021 Nobel Prize for Physiology/Medicine for their discoveries of receptors for temperature and touch.

    • They have focused their work on the field of somatosensation, that is the ability of specialized organs such as eyes, ears and skin to see, hear and feel.

    About the Discoveries

    David Julius:

    • He discovered TRPV1, a heat-sensing receptor.
    • His findings on the skin’s sense of temperature was based on how certain cells react to capsaicin, the molecule that makes chili peppers spicy, by simulating a false sensation of heat.

    Ardem Patapoutian

    • He discovered two mechanosensitive ion channels known as the Piezo channels.
      • The Piezo1 is named after the Greek word for pressure, ‘píesi’.
    • He is credited for finding the cellular mechanism and the underlying gene that translates a mechanical force on our skin into an electric nerve signal.

    Significance of Discoveries

      • The findings have allowed us to understand how heat, cold and mechanical force can initiate the nerve impulses that allow us to perceive and adapt to the world around us.
      • This knowledge is being used to develop treatments for a wide range of disease conditions, including chronic pain.

    Back To Basics: About Nobel Prizes

    • The will of the Swedish scientist Alfred Nobel established the five Nobel prizes in 1895.
    • The Nobel Prizes are a set of recognition given to fields of Chemistry, Literature, Peace, Physics, and Physiology or Medicine by The Nobel Foundation.
      • The Nobel Foundation is a private institution established in 1900, has ultimate responsibility for fulfilling the intentions in Alfred Nobel’s will.
    • The prizes in Chemistry, Literature, Peace, Physics, and Physiology or Medicine were first awarded in 1901.
    • In 1968, Sveriges Riksbank established the Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel.

     

  • Innovations in Biotechnology and Medical Sciences

    Mosquirix: First malaria vaccine to get WHO nod

    In a historic move, the World Health Organization (WHO) has endorsed the first anti-malarial vaccine, as mankind enters a key turning point in a battle waged relentlessly over decades between man and mosquito, the vector.

    Mosquirix

    • RTS,S/ASO1 (RTS.S), trade name Mosquirix acts against P. falciparum, the most deadly malaria parasite globally, and the most prevalent in Africa.
    • The vaccine was able to prevent approximately 4 in 10 cases of malaria over a 4-year period in Africa.
    • This is the first malaria vaccine that has completed the clinical development process.
    • It is also the first malaria vaccine to be introduced by three national ministries of health through their childhood immunization programs — more than 800,000 children in Ghana, Kenya, and Malawi.
    • have been vaccinated, and are benefiting from the added protection provided by the vaccine as part of a pilot program.

    How the vaccine can help?

    • WHO’s recommendation is based on the advice of its two global advisory bodies, one for immunization and the other for malaria.
    • WHO has recommended that in the context of comprehensive malaria control, the RTS,S/AS01 malaria vaccine be used for the prevention of P. falciparum malaria in children living in regions with moderate to high transmission as defined by it.
    • The malaria vaccine should be provided in a schedule of 4 doses in children from 5 months of age for the reduction of malaria disease and burden.

    Back2Basics: Malaria

    • Malaria is caused by the bite of the female Anopheles mosquito if the mosquito itself is infected with a malarial parasite.
    • There are five kinds of malarial parasites — Plasmodium falciparum, Plasmodium vivax (the commonest ones), Plasmodium malariae, Plasmodium ovale and Plasmodium knowlesi.
    • Therefore, to say that someone has contracted the Plasmodium ovale type of malaria means that the person has been infected by that particular parasite.
    • Malaria is treated with prescription drugs to kill the parasite. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug.

    Countries that have eliminated malaria

    • Globally, the elimination net is widening, with more countries moving towards the goal of zero malaria.
    • In 2019, 27 countries reported fewer than 100 indigenous cases of the disease, up from 6 countries in 2000.
    • Countries that have achieved at least 3 consecutive years of zero indigenous cases of malaria are eligible to apply for the WHO certification of malaria elimination.
    • 11 countries have been certified as malaria-free: United Arab Emirates (2007), Morocco (2010), Turkmenistan (2010), Armenia (2011), Sri Lanka (2016), Kyrgyzstan (2016), Paraguay (2018), Uzbekistan (2018), Algeria (2019), Argentina (2019), and El Salvador (2021).

    Burden of Malaria in India

    • In 2018, the National Vector-borne Disease Control Programme (NVBDCP) estimated that approximately 5 lakh people suffered from malaria.
    • 63% of the cases were of Plasmodium falciparum.
    • The recent World Malaria Report 2020 said cases in India dropped from about 20 million in 2000 to about 5.6 million in 2019.

     

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